Journal
ONCOIMMUNOLOGY
Volume 4, Issue 12, Pages -Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/2162402X.2015.1052932
Keywords
immune suppression; dendritic cells; cancer immunotherapy; Wnt; beta-catenin; retionic acid; regulatory T cells
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Funding
- NIDDK NIH HHS [R01 DK097271] Funding Source: Medline
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK097271] Funding Source: NIH RePORTER
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Tumors promote immune suppression and dendritic cells (DCs) play a key role in this. However, signaling networks that program DCs to induce immune suppression are unknown. In our recent study, we showed that tumors activate beta-catenin/TCF4 in DCs programming them to a regulatory state, which promotes T regulatory responses while suppresses effector T cell responses. Thus, targeting DCs-beta-catenin pathway represents a promising target for anticancer immunotherapy.
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