Inhibition of β-catenin/B cell lymphoma 9 protein−protein interaction using α-helix–mimicking sulfono-γ-AApeptide inhibitors

De Novo Left-Handed Synthetic Peptidomimetic Foldamers

(2018) Fengyu She et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

SOX7 Suppresses Wnt Signaling by Disrupting β-Catenin/BCL9 Interaction

(2018) Rong Fan et al.   DNA AND CELL BIOLOGY

Structure-Based Optimization of Small-Molecule Inhibitors for the β-Catenin/B-Cell Lymphoma 9 Protein–Protein Interaction

(2018) Min Zhang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Hydrogen-Bonding-Driven 3D Supramolecular Assembly of Peptidomimetic Zipper

(2018) Peng Teng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Versatile Method to Determine the Cellular Bioavailability of Small-Molecule Inhibitors

(2017) Kevin B. Teuscher et al.   JOURNAL OF MEDICINAL CHEMISTRY

One-Bead–Two-Compound Thioether Bridged Macrocyclic γ-AApeptide Screening Library against EphA2

(2017) Yan Shi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Right-Handed Helical Foldamers Consisting of De Novo d-AApeptides

(2017) Peng Teng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Constitutive scaffolding of multiple Wnt enhanceosome components by Legless/BCL9

(2017) Laurens M van Tienen et al.   eLife

γ-AApeptides: Design, Structure, and Applications

(2016) Yan Shi et al.   ACCOUNTS OF CHEMICAL RESEARCH

γ-AApeptides as a New Class of Peptidomimetics

(2016) Peng Teng et al.   CHEMISTRY-A EUROPEAN JOURNAL

Length-Dependent Formation of Transmembrane Pores by 310-Helical α-Aminoisobutyric Acid Foldamers

(2016) Jennifer E. Jones et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structure-Based Design of 1,4-Dibenzoylpiperazines as β-Catenin/B-Cell Lymphoma 9 Protein–Protein Interaction Inhibitors

(2016) John A. Wisniewski et al.   ACS Medicinal Chemistry Letters

AlphaScreen selectivity assay for β-catenin/B-cell lymphoma 9 inhibitors

(2015) Min Zhang et al.   ANALYTICAL BIOCHEMISTRY

Selective and Potent Proteomimetic Inhibitors of Intracellular Protein-Protein Interactions

(2015) Anna Barnard et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Structure-Based Design of Inhibitors of Protein-Protein Interactions: Mimicking Peptide Binding Epitopes

(2015) Marta Pelay-Gimeno et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Rational Design of Selective Small-Molecule Inhibitors for β-Catenin/B-Cell Lymphoma 9 Protein–Protein Interactions

(2015) Logan R. Hoggard et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Shaping quaternary assemblies of water-soluble non-peptide helical foldamers by sequence manipulation

(2015) Gavin W. Collie et al.   Nature Chemistry

The synthesis of head-to-tail cyclic sulfono-γ-AApeptides

(2015) Haifan Wu et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Building Proficient Enzymes with Foldamer Prostheses

(2014) Clemens Mayer et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

miR-30-5p Functions as a Tumor Suppressor and Novel Therapeutic Tool by Targeting the Oncogenic Wnt/β-Catenin/BCL9 Pathway

(2014) Jian-Jun Zhao et al.   CANCER RESEARCH

Small-Molecule Inhibitors of Protein-Protein Interactions: Progressing toward the Reality

(2014) Michelle R. Arkin et al.   CHEMISTRY & BIOLOGY

Rapid Access to Multiple Classes of Peptidomimetics from Common γ-AApeptide Building Blocks

(2014) Haifan Wu et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Design and High-Resolution Structure of a β3-Peptide Bundle Catalyst

(2014) Pam S. P. Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Backbone modification of a polypeptide drug alters duration of action in vivo

(2014) Ross W Cheloha et al.   NATURE BIOTECHNOLOGY

Structure of a Complex Formed by a Protein and a Helical Aromatic Oligoamide Foldamer at 2.1 Å Resolution

(2013) Jérémie Buratto et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Proline Primed Helix Length as a Modulator of the Nuclear Receptor–Coactivator Interaction

(2013) Sascha Fuchs et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Inhibition of α-helix-mediated protein–protein interactions using designed molecules

(2013) Valeria Azzarito et al.   Nature Chemistry

Inhibition of oncogenic Wnt signaling through direct targeting of  -catenin

(2012) T. N. Grossmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeted Disruption of the BCL9/ -Catenin Complex Inhibits Oncogenic Wnt Signaling

(2012) K. Takada et al.   Science Translational Medicine

An intrinsically labile α-helix abutting the BCL9-binding site of β-catenin is required for its inhibition by carnosic acid

(2012) Marc de la Roche et al.   Nature Communications

Design of Triazole-Stapled BCL9 α-Helical Peptides to Target the β-Catenin/B-Cell CLL/lymphoma 9 (BCL9) Protein–Protein Interaction

(2011) Steven A. Kawamoto et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Wnt/ -Catenin Pathway Is Required for the Development of Leukemia Stem Cells in AML

(2010) Y. Wang et al.   SCIENCE

Analysis of the Interaction of BCL9 with β-Catenin and Development of Fluorescence Polarization and Surface Plasmon Resonance Binding Assays for this Interaction

(2009) Steven A. Kawamoto et al.   BIOCHEMISTRY

Inhibition of protein–protein interactions using designed molecules

(2009) Andrew J. Wilson   CHEMICAL SOCIETY REVIEWS

Helical Aromatic Oligoamide Foldamers as Organizational Scaffolds for Photoinduced Charge Transfer

(2009) Martin Wolffs et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The function of BCL9 in Wnt/β-catenin signaling and colorectal cancer cells

(2008) Marc de la Roche et al.   BMC CANCER