Extracellular vesicles in the study of Alzheimer's and Parkinson's diseases: Methodologies applied from cells to biofluids

Extracellular Vesicles Derived From Plasma of Patients With Neurodegenerative Disease Have Common Transcriptomic Profiling

(2022) Daisy Sproviero et al.   Frontiers in Aging Neuroscience

Human neural cell type‐specific extracellular vesicle proteome defines disease‐related molecules associated with activated astrocytes in Alzheimer's disease brain

(2022) Yang You et al.   Journal of Extracellular Vesicles

Exosomes Mediate APP Dysregulation via APP-miR-185-5p Axis

(2022) Lu Ding et al.   Frontiers in Cell and Developmental Biology

Extracellular Vesicle Delivery of Neferine for the Attenuation of Neurodegenerative Disease Proteins and Motor Deficit in an Alzheimer’s Disease Mouse Model

(2022) Bin Tang et al.   Pharmaceuticals

Diagnostic Test to Identify Parkinson’s Disease from the Blood Sera of Chinese Population: A Cross-Sectional Study

(2022) Guangan Tong et al.   Parkinsons Disease

Differential Effects of APOE Genotype on MicroRNA Cargo of Cerebrospinal Fluid Extracellular Vesicles in Females With Alzheimer’s Disease Compared to Males

(2022) Ursula S. Sandau et al.   Frontiers in Cell and Developmental Biology

Plasma and serum exosome markers analyzed by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry coupled with electron multiplier

(2022) Liang Shan et al.   TALANTA

Astrocytes deliver CK1 to neurons via extracellular vesicles in response to inflammation promoting the translation and amyloidogenic processing of APP

(2021) Zhigang Li et al.   Journal of Extracellular Vesicles

Different miRNA Profiles in Plasma Derived Small and Large Extracellular Vesicles from Patients with Neurodegenerative Diseases

(2021) Daisy Sproviero et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A Comprehensive Review on Factors Influences Biogenesis, Functions, Therapeutic and Clinical Implications of Exosomes

(2021) Sangiliyandi Gurunathan et al.   International Journal of Nanomedicine

Enrichment of Neurodegenerative Microglia Signature in Brain-Derived Extracellular Vesicles Isolated from Alzheimer’s Disease Mouse Models

(2021) Satoshi Muraoka et al.   JOURNAL OF PROTEOME RESEARCH

Potential of extracellular vesicles in the Parkinson's disease – Pathological mediators and biomarkers

(2021) Yuan Zhao et al.   NEUROCHEMISTRY INTERNATIONAL

ABCA1-Labeled Exosomes in Serum Contain Higher MicroRNA-193b Levels in Alzheimer’s Disease

(2021) Chen-Geng Liu et al.   Biomed Research International

Cytokine Profile in Plasma Extracellular Vesicles of Parkinson’s Disease and the Association with Cognitive Function

(2021) Lung Chan et al.   Cells

Profiling Inflammatory Extracellular Vesicles in Plasma and Cerebrospinal Fluid: An Optimized Diagnostic Model for Parkinson’s Disease

(2021) Elena Vacchi et al.   Biomedicines

Proteomics Profiling of Neuron-Derived Small Extracellular Vesicles from Human Plasma: Enabling Single-Subject Analysis

(2021) Federica Anastasi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Exosomal Aβ-Binding Proteins Identified by “In Silico” Analysis Represent Putative Blood-Derived Biomarker Candidates for Alzheimer´s Disease

(2021) Tânia Soares Martins et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Validation of α‐Synuclein in L1CAM ‐Immunocaptured Exosomes as a Biomarker for the Stratification of Parkinsonian Syndromes

(2021) Cheng Jiang et al.   MOVEMENT DISORDERS

Preparation of a CaTiO3/Al3+/Pr3+/Sm3+ nanocomposite for enrichment of exosomes in human serum

(2021) Guangyao Wu et al.   TALANTA

Protein Binding Partners of Dysregulated miRNAs in Parkinson’s Disease Serum

(2021) Wolfgang P. Ruf et al.   Cells

Neuronal and Astrocytic Extracellular Vesicle Biomarkers in Blood Reflect Brain Pathology in Mouse Models of Alzheimer’s Disease

(2021) Francheska Delgado-Peraza et al.   Cells

Plasma Extracellular Vesicle α-Synuclein Level in Patients with Parkinson’s Disease

(2021) Chen-Chih Chung et al.   Biomolecules

Investigation of α-Synuclein Species in Plasma Exosomes and the Oligomeric and Phosphorylated α-Synuclein as Potential Peripheral Biomarker of Parkinson’s Disease

(2021) Hengxing Zheng et al.   NEUROSCIENCE

microRNA-106b-containing extracellular vesicles affect autophagy of neurons by regulating CDKN2B in Parkinson’s disease

(2021) Xue Bai et al.   NEUROSCIENCE LETTERS

Decreased Exosomal Acetylcholinesterase Activity in the Plasma of Patients With Parkinson’s Disease

(2021) Kyu Hwan Shim et al.   Frontiers in Aging Neuroscience

Aberrant Expression of Circulating MicroRNA Leads to the Dysregulation of Alpha-Synuclein and Other Pathogenic Genes in Parkinson’s Disease

(2021) Meng Cai et al.   Frontiers in Cell and Developmental Biology

Aging induces abnormal accumulation of Aβ in extracellular vesicle and/or intraluminal membrane vesicle-rich fractions in nonhuman primate brain

(2021) Shingo Koinuma et al.   NEUROBIOLOGY OF AGING

Exosomes isolated during dopaminergic neuron differentiation suppressed neuronal inflammation in a rodent model of Parkinson’s disease

(2021) Yongang Li et al.   NEUROSCIENCE LETTERS

Exosomal miRNA as peripheral biomarkers in Parkinson's disease and progressive supranuclear palsy: A pilot study

(2021) Ida Manna et al.   PARKINSONISM & RELATED DISORDERS

Adipose Mesenchymal Stem Cell-Derived Exosomes Enhance PC12 Cell Function through the Activation of the PI3K/AKT Pathway

(2021) Yong Xie et al.   Stem Cells International

Multi-Omics Analysis of Microglial Extracellular Vesicles From Human Alzheimer’s Disease Brain Tissue Reveals Disease-Associated Signatures

(2021) Whitaker Cohn et al.   Frontiers in Pharmacology

Mitochondrial Electron Transport Chain Protein Abnormalities Detected in Plasma Extracellular Vesicles in Alzheimer’s Disease

(2021) Pamela J. Yao et al.   Biomedicines

Detection of multiplex exosomal miRNAs for clinically accurate diagnosis of Alzheimer’s disease using label-free plasmonic biosensor based on DNA-Assembled advanced plasmonic architecture

(2021) Sojin Song et al.   BIOSENSORS & BIOELECTRONICS

Melatonin affects the release of exosomes and tau-content in in vitro amyloid-beta toxicity model

(2020) Mehmet Ozansoy et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Profile of Pathogenic Proteins and MicroRNAs in Plasma-derived Extracellular Vesicles in Alzheimer’s Disease: A Pilot Study

(2020) Fang Li et al.   NEUROSCIENCE

Cryo-electron microscopy of extracellular vesicles from cerebrospinal fluid

(2020) Anton Emelyanov et al.   PLoS One

Mitochondrial Signatures in Circulating Extracellular Vesicles of Older Adults with Parkinson’s Disease: Results from the EXosomes in PArkiNson’s Disease (EXPAND) Study

(2020) Anna Picca et al.   Journal of Clinical Medicine

Microglial exosomes facilitate α-synuclein transmission in Parkinson’s disease

(2020) Min Guo et al.   BRAIN

A longitudinal study on α‐synuclein in plasma neuronal exosomes as a biomarker for Parkinson’s disease development and progression

(2020) M. Niu et al.   EUROPEAN JOURNAL OF NEUROLOGY

Endothelial‐derived plasma exosome proteins in Alzheimer’s disease angiopathy

(2020) Erin L. Abner et al.   FASEB JOURNAL

Elevated plasma levels of exosomal BACE1‑AS combined with the volume and thickness of the right entorhinal cortex may serve as a biomarker for the detection of Alzheimer's disease

(2020) Dewei Wang et al.   Molecular Medicine Reports

Plasma exosomal prion protein levels are correlated with cognitive decline in PD patients

(2020) Bing Leng et al.   NEUROSCIENCE LETTERS

Intrastriatal Administration of Exosome-Associated Pathological Alpha-Synuclein Is Not Sufficient by Itself to Cause Pathology Transmission

(2020) Mantia Karampetsou et al.   Frontiers in Neuroscience

Differential Expression of Plasma Exo-miRNA in Neurodegenerative Diseases by Next-Generation Sequencing

(2020) Chao Nie et al.   Frontiers in Neuroscience

Extracellular vesicle biomarkers of Alzheimer's disease associated with sub‐clinical cognitive decline in late middle age

(2020) Erden Eren et al.   Alzheimers & Dementia

Extracellular vesicles: where the amyloid precursor protein carboxyl-terminal fragments accumulate and amyloid-β oligomerizes

(2020) Rocío Pérez-González et al.   FASEB JOURNAL

Serum Tau Proteins as Potential Biomarkers for the Assessment of Alzheimer’s Disease Progression

(2020) Eunjoo Nam et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Diagnostic and therapeutic potential of exosomes in Alzheimer’s disease

(2020) Tânia Soares Martins et al.   JOURNAL OF NEUROCHEMISTRY

TDP-43 Is Elevated in Plasma Neuronal-Derived Exosomes of Patients With Alzheimer’s Disease

(2020) Nan Zhang et al.   Frontiers in Aging Neuroscience

Elevated matrix metalloproteinase‐9 levels in neuronal extracellular vesicles in Alzheimer’s disease

(2020) Dongmei Gu et al.   Annals of Clinical and Translational Neurology

Astrocyte- and Neuron-Derived Extracellular Vesicles from Alzheimer’s Disease Patients Effect Complement-Mediated Neurotoxicity

(2020) Carlos J. Nogueras-Ortiz et al.   Cells

MiRNA Profiling in Plasma Neural-Derived Small Extracellular Vesicles from Patients with Alzheimer’s Disease

(2020) Maria Serpente et al.   Cells

Immune profiling of plasma-derived extracellular vesicles identifies Parkinson disease

(2020) Elena Vacchi et al.   Neurology-Neuroimmunology & Neuroinflammation

Differential expression and significance of miRNAs in plasma extracellular vesicles of patients with Parkinson’s disease

(2020) Shishuai Xie et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Transfer of pathological α-synuclein from neurons to astrocytes via exosomes causes inflammatory responses after METH exposure

(2020) Yunle Meng et al.   TOXICOLOGY LETTERS

Differential Diagnosis of Multiple System Atrophy-Parkinsonism and Parkinson's Disease Using α-Synuclein and External Anal Sphincter Electromyography

(2020) Zhentang Cao et al.   Frontiers in Neurology

Proteomic Profiling of Extracellular Vesicles Derived from Cerebrospinal Fluid of Alzheimer’s Disease Patients: A Pilot Study

(2020) Satoshi Muraoka et al.   Cells

Plasma Exosomal Brain-Derived Neurotrophic Factor Correlated with the Postural Instability and Gait Disturbance–Related Motor Symptoms in Patients with Parkinson’s Disease

(2020) Chen Chih Chung et al.   Diagnostics

Alzheimer’s disease brain-derived extracellular vesicles spread tau pathology in interneurons

(2020) Zhi Ruan et al.   BRAIN

Altered Insulin Receptor Substrate 1 Phosphorylation in Blood Neuron-Derived Extracellular Vesicles From Patients With Parkinson’s Disease

(2020) Szu-Yi Chou et al.   Frontiers in Cell and Developmental Biology

Increased DJ-1 and α-Synuclein in Plasma Neural-Derived Exosomes as Potential Markers for Parkinson’s Disease

(2019) Zhen-Hua Zhao et al.   Frontiers in Aging Neuroscience

Utility of Neuronal-Derived Exosomes to Examine Molecular Mechanisms That Affect Motor Function in Patients With Parkinson Disease

(2019) Dilan Athauda et al.   JAMA Neurology

Manganese promotes the aggregation and prion-like cell-to-cell exosomal transmission of α-synuclein

(2019) Dilshan S. Harischandra et al.   Science Signaling

Involvement of exosomes in dopaminergic neurodegeneration by microglial activation in midbrain slice cultures

(2019) Reiho Tsutsumi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mitochondrial-Derived Vesicles as Candidate Biomarkers in Parkinson’s Disease: Rationale, Design and Methods of the EXosomes in PArkiNson Disease (EXPAND) Study

(2019) Anna Picca et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A novel L1CAM isoform with angiogenic activity generated by NOVA2-mediated alternative splicing

(2019) Francesca Angiolini et al.   eLife

Review of the Isolation, Characterization, Biological Function, and Multifarious Therapeutic Approaches of Exosomes

(2019) Sangiliyandi Gurunathan et al.   Cells

Association of Extracellular Vesicle Biomarkers With Alzheimer Disease in the Baltimore Longitudinal Study of Aging

(2019) Dimitrios Kapogiannis et al.   JAMA Neurology

Concordance between the assessment of Aβ42, T-tau, and P-T181-tau in peripheral blood neuronal-derived exosomes and cerebrospinal fluid

(2019) Longfei Jia et al.   Alzheimers & Dementia

Differential Effects of Extracellular Vesicles of Lineage-Specific Human Pluripotent Stem Cells on the Cellular Behaviors of Isogenic Cortical Spheroids

(2019) Mark Marzano et al.   Cells

Exosome/microvesicle content is altered in leucine‐rich repeat kinase 2 mutant induced pluripotent stem cell‐derived neural cells

(2019) Kate M. Candelario et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Differential proteomic analysis of serum exosomes reveals alterations in progression of Parkinson disease

(2019) Ruilai Jiang et al.   MEDICINE

Profile of pathogenic proteins in total circulating extracellular vesicles in mild cognitive impairment and during the progression of Alzheimer’s disease

(2019) Morgane Perrotte et al.   NEUROBIOLOGY OF AGING

miR-212 and miR-132 Are Downregulated in Neurally Derived Plasma Exosomes of Alzheimer’s Patients

(2019) Diana J. Cha et al.   Frontiers in Neuroscience

Biological membranes in EV biogenesis, stability, uptake, and cargo transfer: an ISEV position paper arising from the ISEV membranes and EVs workshop

(2019) Ashley E. Russell et al.   Journal of Extracellular Vesicles

Integrated analysis of exosomal lncRNA and mRNA expression profiles reveals the involvement of lnc‐MKRN2‐42:1 in the pathogenesis of Parkinson's disease

(2019) Qiao Wang et al.   CNS Neuroscience & Therapeutics

The Regulatory Functionality of Exosomes Derived from hUMSCs in 3D Culture for Alzheimer's Disease Therapy

(2019) Lingyan Yang et al.   Small

Exosome Production Is Key to Neuronal Endosomal Pathway Integrity in Neurodegenerative Diseases

(2019) Paul M. Mathews et al.   Frontiers in Neuroscience

Higher levels of lysosomal associated membrane protein-2 (LAMP-2) in plasma exosomes from Alzheimer’s disease: An exploratory study from South India

(2019) Geethu Krishna et al.   Asian Journal of Psychiatry

Aβ42 Protofibrils Interact with and Are Trafficked through Microglial-Derived Microvesicles

(2018) Lisa K. Gouwens et al.   ACS Chemical Neuroscience

High complement levels in astrocyte-derived exosomes of Alzheimer disease

(2018) Edward J. Goetzl et al.   ANNALS OF NEUROLOGY

Autophagy inhibition promotes SNCA/alpha-synuclein release and transfer via extracellular vesicles with a hybrid autophagosome-exosome-like phenotype

(2018) Georgia Minakaki et al.   Autophagy

Tau in Alzheimer's Disease: Mechanisms and Therapeutic Strategies

(2018) Yu Gao et al.   Current Alzheimer Research

Deficient neurotrophic factors of CSPG4-type neural cell exosomes in Alzheimer disease

(2018) Edward J. Goetzl et al.   FASEB JOURNAL

Declining levels of functionally specialized synaptic proteins in plasma neuronal exosomes with progression of Alzheimer’s disease

(2018) Edward J. Goetzl et al.   FASEB JOURNAL

Detection of Aggregation-Competent Tau in Neuron-Derived Extracellular Vesicles

(2018) Francesc Guix et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

An optimized method for enrichment of whole brain-derived extracellular vesicles reveals insight into neurodegenerative processes in a mouse model of Alzheimer’s disease

(2018) Stephanie N. Hurwitz et al.   JOURNAL OF NEUROSCIENCE METHODS

Plasma α-synuclein and cognitive impairment in the Parkinson's Associated Risk Syndrome: A pilot study

(2018) Hua Wang et al.   NEUROBIOLOGY OF DISEASE

Serum Exosomal miR-223 Serves as a Potential Diagnostic and Prognostic Biomarker for Dementia

(2018) Hong Wei et al.   NEUROSCIENCE

Environmental neurotoxicant manganese regulates exosome-mediated extracellular miRNAs in cell culture model of Parkinson's disease: Relevance to α-synuclein misfolding in metal neurotoxicity

(2018) Dilshan S. Harischandra et al.   NEUROTOXICOLOGY

Distinct expression of the neurotoxic microRNA family let-7 in the cerebrospinal fluid of patients with Alzheimer's disease

(2018) Katja Derkow et al.   PLoS One

The Exosomal/Total α-Synuclein Ratio in Plasma Is Associated With Glucocerebrosidase Activity and Correlates With Measures of Disease Severity in PD Patients

(2018) Silvia Cerri et al.   Frontiers in Cellular Neuroscience

miRNA-based signatures in cerebrospinal fluid as potential diagnostic tools for early stage Parkinson’s disease

(2018) Marcia Cristina T. dos Santos et al.   Oncotarget

The Role of Insulin/IGF-1/PI3K/Akt/GSK3β Signaling in Parkinson's Disease Dementia

(2018) Liying Yang et al.   Frontiers in Neuroscience

Apoptotic Cell-Derived Extracellular Vesicles: More Than Just Debris

(2018) Sarah Caruso et al.   Frontiers in Immunology

Proteomic Profiling of Exosomal Proteins for Blood-based Biomarkers in Parkinson's Disease

(2018) Yuki Kitamura et al.   NEUROSCIENCE

Fetal Bovine Serum-Derived Extracellular Vesicles Persist within Vesicle-Depleted Culture Media

(2018) Brandon Lehrich et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Quantification of brain-derived extracellular vesicles in plasma as a biomarker to diagnose Parkinson's and related diseases

(2018) Takuma Ohmichi et al.   PARKINSONISM & RELATED DISORDERS

α-Synuclein in salivary extracellular vesicles as a potential biomarker of Parkinson’s disease

(2018) Zhentang Cao et al.   NEUROSCIENCE LETTERS

Exosomal biomarkers of brain insulin resistance associated with regional atrophy in Alzheimer's disease

(2017) Roger J. Mullins et al.   HUMAN BRAIN MAPPING

MicroRNA biomarkers of Parkinson’s disease in serum exosome-like microvesicles

(2017) Xiang-Yang Cao et al.   NEUROSCIENCE LETTERS

Progress in Exosome Isolation Techniques

(2017) Pin Li et al.   Theranostics

Exosomes Mediate Mobilization of Autocrine Wnt10b to Promote Axonal Regeneration in the Injured CNS

(2017) Nardos G. Tassew et al.   Cell Reports

Plasma Exosomes Spread and Cluster Around β-Amyloid Plaques in an Animal Model of Alzheimer’s Disease

(2017) Tingting Zheng et al.   Frontiers in Aging Neuroscience

Investigation of Endocytic Pathways for the Internalization of Exosome-Associated Oligomeric Alpha-Synuclein

(2017) Marion Delenclos et al.   Frontiers in Neuroscience

CNS tau efflux via exosomes is likely increased in Parkinson's disease but not in Alzheimer's disease

(2016) Min Shi et al.   Alzheimers & Dementia

Decreased synaptic proteins in neuronal exosomes of frontotemporal dementia and Alzheimer’s disease

(2016) Edward J. Goetzl et al.   FASEB JOURNAL

Cargo proteins of plasma astrocyte-derived exosomes in Alzheimer’s disease

(2016) Edward J. Goetzl et al.   FASEB JOURNAL

Extracellular Vesicles Isolated from the Brains of rTg4510 Mice Seed Tau Protein Aggregation in a Threshold-dependent Manner

(2016) Juan Carlos Polanco et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effects of pramipexole treatment on the α-synuclein content in serum exosomes of Parkinson's disease patients

(2016) He-Ting Luo et al.   Experimental and Therapeutic Medicine

Induction of α-synuclein aggregate formation by CSF exosomes from patients with Parkinson’s disease and dementia with Lewy bodies

(2015) Anne Stuendl et al.   BRAIN

Depletion of microglia and inhibition of exosome synthesis halt tau propagation

(2015) Hirohide Asai et al.   NATURE NEUROSCIENCE

Altered lysosomal proteins in neural-derived plasma exosomes in preclinical Alzheimer disease

(2015) Edward J. Goetzl et al.   NEUROLOGY

Altered microRNA profiles in cerebrospinal fluid exosome in Parkinson disease and Alzheimer disease

(2015) YaXing Gui et al.   Oncotarget

Plasma Exosomal miRNAs in Persons with and without Alzheimer Disease: Altered Expression and Prospects for Biomarkers

(2015) Giovanni Lugli et al.   PLoS One

Acceleration of α-Synuclein Aggregation by Exosomes

(2014) Marie Grey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteomic analysis of cerebrospinal fluid extracellular vesicles: A comprehensive dataset

(2014) Davide Chiasserini et al.   Journal of Proteomics

MicroRNA-193b is a regulator of amyloid precursor protein in the blood and cerebrospinal fluid derived exosomal microRNA-193b is a biomarker of Alzheimer’s disease

(2014) CHEN-GENG LIU et al.   Molecular Medicine Reports

Prognostic serum miRNA biomarkers associated with Alzheimer’s disease shows concordance with neuropsychological and neuroimaging assessment

(2014) L Cheng et al.   MOLECULAR PSYCHIATRY

Increased DJ-1 in Urine Exosome of Korean Males with Parkinson’s Disease

(2014) Dong Hwan Ho et al.   Biomed Research International

LRRK2 secretion in exosomes is regulated by 14-3-3

(2013) K. B. Fraser et al.   HUMAN MOLECULAR GENETICS

Astrocytes Secrete Exosomes Enriched with Proapoptotic Ceramide and Prostate Apoptosis Response 4 (PAR-4)

(2012) Guanghu Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Exosome Secretory Pathway Transports Amyloid Precursor Protein Carboxyl-terminal Fragments from the Cell into the Brain Extracellular Space

(2012) Rocio Perez-Gonzalez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Paired Helical Filaments from Alzheimer Disease Brain Induce Intracellular Accumulation of Tau Protein in Aggresomes

(2012) Ismael Santa-Maria et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exosome-associated Tau Is Secreted in Tauopathy Models and Is Selectively Phosphorylated in Cerebrospinal Fluid in Early Alzheimer Disease

(2011) Sudad Saman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY