Paired Helical Filaments from Alzheimer Disease Brain Induce Intracellular Accumulation of Tau Protein in Aggresomes

Binding of Tau Protein to the Ends of ex vivo Paired Helical Filaments

(2017) Ismael Santa-Maria et al.   JOURNAL OF ALZHEIMERS DISEASE

Grape Seed Polyphenolic Extract as a Potential Novel Therapeutic Agent in Tauopathies

(2017) Lap Ho et al.   JOURNAL OF ALZHEIMERS DISEASE

Bioavailability of Gallic Acid and Catechins from Grape Seed Polyphenol Extract is Improved by Repeated Dosing in Rats: Implications for Treatment in Alzheimer's Disease

(2017) Mario G. Ferruzzi et al.   JOURNAL OF ALZHEIMERS DISEASE

Grape Derived Polyphenols Attenuate Tau Neuropathology in a Mouse Model of Alzheimer's Disease

(2017) Jun Wang et al.   JOURNAL OF ALZHEIMERS DISEASE

Brain-Targeted Proanthocyanidin Metabolites for Alzheimer's Disease Treatment

(2012) J. Wang et al.   JOURNAL OF NEUROSCIENCE

Propagation of Tau Pathology in a Model of Early Alzheimer's Disease

(2012) Alix de Calignon et al.   NEURON

Trans-Synaptic Spread of Tau Pathology In Vivo

(2012) Li Liu et al.   PLoS One

Proteostasis of tau. Tau overexpression results in its secretion via membrane vesicles

(2011) Diana Simón et al.   FEBS LETTERS

Seeding of Normal Tau by Pathological Tau Conformers Drives Pathogenesis of Alzheimer-like Tangles

(2011) Jing L. Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exosome-associated Tau Is Secreted in Tauopathy Models and Is Selectively Phosphorylated in Cerebrospinal Fluid in Early Alzheimer Disease

(2011) Sudad Saman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteasome Inhibition Drives HDAC6-Dependent Recruitment of Tau to Aggresomes

(2011) Chris R. Guthrie et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

In Vivo Microdialysis Reveals Age-Dependent Decrease of Brain Interstitial Fluid Tau Levels in P301S Human Tau Transgenic Mice

(2011) K. Yamada et al.   JOURNAL OF NEUROSCIENCE

Ultrastructural alterations of Alzheimer's disease paired helical filaments by grape seed-derived polyphenols

(2011) Hanna Ksiezak-Reding et al.   NEUROBIOLOGY OF AGING

GSPE interferes with tau aggregation in vivo: implication for treating tauopathy

(2011) Ismael Santa-Maria et al.   NEUROBIOLOGY OF AGING

Multiple Aggregates and Aggresomes of C-Terminal Truncated Human αA-Crystallins in Mammalian Cells and Protection by αB-Crystallin

(2011) Ilangovan Raju et al.   PLoS One

Protein Secretion: Unconventional Exit by Exophagy

(2010) Hilde Abrahamsen et al.   CURRENT BIOLOGY

Pathways of unconventional protein secretion

(2010) Walter Nickel   CURRENT OPINION IN BIOTECHNOLOGY

Secretion of human tau fragments resembling CSF-tau in Alzheimer's disease is modulated by the presence of the exon 2 insert

(2010) WonHee Kim et al.   FEBS LETTERS

Development of a grape seed polyphenolic extract with anti-oligomeric activity as a novel treatment in progressive supranuclear palsy and other tauopathies

(2010) Giulio Maria Pasinetti et al.   JOURNAL OF NEUROCHEMISTRY

Cell-Produced  -Synuclein Is Secreted in a Calcium-Dependent Manner by Exosomes and Impacts Neuronal Survival

(2010) E. Emmanouilidou et al.   JOURNAL OF NEUROSCIENCE

Exosomes: Extracellular organelles important in intercellular communication

(2010) Suresh Mathivanan et al.   Journal of Proteomics

Tau-directed drug discovery for Alzheimer's disease and related tauopathies: A focus on tau assembly inhibitors

(2009) Kurt R. Brunden et al.   EXPERIMENTAL NEUROLOGY

Propagation of Tau Misfolding from the Outside to the Inside of a Cell

(2009) Bess Frost et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular mechanisms of clathrin-independent endocytosis

(2009) C. G. Hansen et al.   JOURNAL OF CELL SCIENCE

Tau - an inhibitor of deacetylase HDAC6 function

(2009) Mar Perez et al.   JOURNAL OF NEUROCHEMISTRY

The Cochaperone BAG2 Sweeps Paired Helical Filament- Insoluble Tau from the Microtubule

(2009) D. C. Carrettiero et al.   JOURNAL OF NEUROSCIENCE

Transmission and spreading of tauopathy in transgenic mouse brain

(2009) Florence Clavaguera et al.   NATURE CELL BIOLOGY

Cytoplasmic penetration and persistent infection of mammalian cells by polyglutamine aggregates

(2009) Pei-Hsien Ren et al.   NATURE CELL BIOLOGY

Role of the Aggresome Pathway in Cancer: Targeting Histone Deacetylase 6-Dependent Protein Degradation

(2008) A. Rodriguez-Gonzalez et al.   CANCER RESEARCH

Aggresome Formation and Neurodegenerative Diseases: Therapeutic Implications

(2008) L. Chin et al.   CURRENT MEDICINAL CHEMISTRY

Autophagy-mediated clearance of aggresomes is not a universal phenomenon

(2008) Esther S.P. Wong et al.   HUMAN MOLECULAR GENETICS

Assembly-dependent endocytosis and clearance of extracellular a-synuclein

(2008) He-Jin Lee et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Nucleation-dependent Tau Filament Formation

(2008) Erin E. Congdon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Extracellular tau promotes intracellular calcium increase through M1 and M3 muscarinic receptors in neuronal cells

(2008) A. Gómez-Ramos et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Proteomic profiling of exosomes: Current perspectives

(2008) Richard J. Simpson et al.   PROTEOMICS