Astrocytes deliver CK1 to neurons via extracellular vesicles in response to inflammation promoting the translation and amyloidogenic processing of APP

Glial activation and inflammation along the Alzheimer’s disease continuum

(2019) Kaja Nordengen et al.   Journal of Neuroinflammation

Systemic inflammation impairs microglial Aβ clearance through NLRP 3 inflammasome

(2019) Dario Tejera et al.   EMBO JOURNAL

BIN1 favors the spreading of Tau via extracellular vesicles

(2019) Andrea Crotti et al.   Scientific Reports

Association of Extracellular Vesicle Biomarkers With Alzheimer Disease in the Baltimore Longitudinal Study of Aging

(2019) Dimitrios Kapogiannis et al.   JAMA Neurology

Stimulus-dependent modifications in astrocyte-derived extracellular vesicle cargo regulate neuronal excitability

(2019) Amrita Datta Chaudhuri et al.   GLIA

Alzheimer’s disease pathology propagation by exosomes containing toxic amyloid-beta oligomers

(2018) Maitrayee Sardar Sinha et al.   ACTA NEUROPATHOLOGICA

High complement levels in astrocyte-derived exosomes of Alzheimer disease

(2018) Edward J. Goetzl et al.   ANNALS OF NEUROLOGY

Deficient neurotrophic factors of CSPG4-type neural cell exosomes in Alzheimer disease

(2018) Edward J. Goetzl et al.   FASEB JOURNAL

Declining levels of functionally specialized synaptic proteins in plasma neuronal exosomes with progression of Alzheimer’s disease

(2018) Edward J. Goetzl et al.   FASEB JOURNAL

Peripheral inflammation in prodromal Alzheimer’s and Lewy body dementias

(2017) Eleanor King et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

Astrocyte-shed extracellular vesicles regulate the peripheral leukocyte response to inflammatory brain lesions

(2017) Alex M. Dickens et al.   Science Signaling

Astrocyte-shed extracellular vesicles regulate the peripheral leukocyte response to inflammatory brain lesions

(2017) Alex M. Dickens et al.   Science Signaling

Microglial response to LPS increases in wild-type mice during aging but diminishes in an Alzheimer's mouse model: Implication of TLR4 signaling in disease progression

(2016) Michelle Go et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cargo proteins of plasma astrocyte-derived exosomes in Alzheimer’s disease

(2016) Edward J. Goetzl et al.   FASEB JOURNAL

Improvement of neuronal cell survival by astrocyte-derived exosomes under hypoxic and ischemic conditions depends on prion protein

(2016) Kathrin Guitart et al.   GLIA

Extracellular Vesicles Containing P301L Mutant Tau Accelerate Pathological Tau Phosphorylation and Oligomer Formation but Do Not Seed Mature Neurofibrillary Tangles in ALZ17 Mice

(2016) Siân Baker et al.   JOURNAL OF ALZHEIMERS DISEASE

Exosomal cellular prion protein drives fibrillization of amyloid beta and counteracts amyloid beta-mediated neurotoxicity

(2016) Clemens Falker et al.   JOURNAL OF NEUROCHEMISTRY

Inhibition of Wnt signaling induces amyloidogenic processing of amyloid precursor protein and the production and aggregation of Amyloid-β (Aβ)42peptides

(2016) Cheril Tapia-Rojas et al.   JOURNAL OF NEUROCHEMISTRY

Neutral Sphingomyelinase-2 Deficiency Ameliorates Alzheimer's Disease Pathology and Improves Cognition in the 5XFAD Mouse

(2016) Michael B. Dinkins et al.   JOURNAL OF NEUROSCIENCE

Identification of preclinical Alzheimer's disease by a profile of pathogenic proteins in neurally derived blood exosomes: A case-control study

(2015) Massimo S. Fiandaca et al.   Alzheimers & Dementia

Chromatin Landscape Defined by Repressive Histone Methylation during Oligodendrocyte Differentiation

(2015) J. Liu et al.   JOURNAL OF NEUROSCIENCE

Depletion of microglia and inhibition of exosome synthesis halt tau propagation

(2015) Hirohide Asai et al.   NATURE NEUROSCIENCE

Altered lysosomal proteins in neural-derived plasma exosomes in preclinical Alzheimer disease

(2015) Edward J. Goetzl et al.   NEUROLOGY

Factors affecting longitudinal trajectories of plasma sphingomyelins: the Baltimore Longitudinal Study of Aging

(2014) Michelle M. Mielke et al.   AGING CELL

Casein kinase 1 and Wnt/β-catenin signaling

(2014) Cristina-Maria Cruciat   CURRENT OPINION IN CELL BIOLOGY

A potential function for neuronal exosomes: Sequestering intracerebral amyloid-β peptide

(2014) Kohei Yuyama et al.   FEBS LETTERS

Decreased Amyloid-β Pathologies by Intracerebral Loading of Glycosphingolipid-enriched Exosomes in Alzheimer Model Mice

(2014) Kohei Yuyama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of TRPML1 Clears Intraneuronal A  in Preclinical Models of HIV Infection

(2014) M. Bae et al.   JOURNAL OF NEUROSCIENCE

Exosome reduction in vivo is associated with lower amyloid plaque load in the 5XFAD mouse model of Alzheimer's disease

(2014) Michael B. Dinkins et al.   NEUROBIOLOGY OF AGING

Multifaceted effects of oligodendroglial exosomes on neurons: impact on neuronal firing rate, signal transduction and gene regulation

(2014) D. Frohlich et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Microglia convert aggregated amyloid-β into neurotoxic forms through the shedding of microvesicles

(2013) P Joshi et al.   CELL DEATH AND DIFFERENTIATION

Elevated CNS Inflammation in Patients with Preclinical Alzheimer's Disease

(2013) Nancy L Monson et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Transporting cargo from A to B

(2013) Sian Lewis   NATURE REVIEWS NEUROSCIENCE

Wnt Signaling through Inhibition of β-Catenin Degradation in an Intact Axin1 Complex

(2012) Vivian S.W. Li et al.   CELL

Wnt/β-Catenin Signaling and Disease

(2012) Hans Clevers et al.   CELL

Astrocytes Secrete Exosomes Enriched with Proapoptotic Ceramide and Prostate Apoptosis Response 4 (PAR-4)

(2012) Guanghu Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Exosome Secretory Pathway Transports Amyloid Precursor Protein Carboxyl-terminal Fragments from the Cell into the Brain Extracellular Space

(2012) Rocio Perez-Gonzalez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sphingolipid-modulated Exosome Secretion Promotes Clearance of Amyloid-β by Microglia

(2012) Kohei Yuyama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The complex world of WNT receptor signalling

(2012) Christof Niehrs   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Toward defining the preclinical stages of Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Reisa A. Sperling et al.   Alzheimers & Dementia

Synapsin I Is an Oligomannose-Carrying Glycoprotein, Acts As an Oligomannose-Binding Lectin, and Promotes Neurite Outgrowth and Neuronal Survival When Released via Glia-Derived Exosomes

(2011) S. Wang et al.   JOURNAL OF NEUROSCIENCE

hnRNP C promotes APP translation by competing with FMRP for APP mRNA recruitment to P bodies

(2010) Eun Kyung Lee et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

CD14 and Toll-Like Receptors 2 and 4 Are Required for Fibrillar A -Stimulated Microglial Activation

(2009) E. G. Reed-Geaghan et al.   JOURNAL OF NEUROSCIENCE

Expression of inflammatory genes induced by beta-amyloid peptides in human brain endothelial cells and in Alzheimer's brain is mediated by the JNK-AP1 signaling pathway

(2009) Vanja Vukic et al.   NEUROBIOLOGY OF DISEASE

Systemic inflammation and disease progression in Alzheimer disease

(2009) C. Holmes et al.   NEUROLOGY

Inhibition of γ-secretase causes increased secretion of amyloid precursor protein C-terminal fragments in association with exosomes

(2008) Robyn A. Sharples et al.   FASEB JOURNAL

Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes

(2008) K. Trajkovic et al.   SCIENCE