Human neural cell type‐specific extracellular vesicle proteome defines disease‐related molecules associated with activated astrocytes in Alzheimer's disease brain

Enrichment of Neurodegenerative Microglia Signature in Brain-Derived Extracellular Vesicles Isolated from Alzheimer’s Disease Mouse Models

(2021) Satoshi Muraoka et al.   JOURNAL OF PROTEOME RESEARCH

L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma

(2021) Maia Norman et al.   NATURE METHODS

Assessment of separation methods for extracellular vesicles from human and mouse brain tissues and human cerebrospinal fluids

(2020) Satoshi Muraoka et al.   METHODS

A comparison of methods for the isolation and separation of extracellular vesicles from protein and lipid particles in human serum

(2020) K. Brennan et al.   Scientific Reports

Proteomic and biological profiling of extracellular vesicles from Alzheimer's disease human brain tissues

(2020) Satoshi Muraoka et al.   Alzheimers & Dementia

LRP1 is a master regulator of tau uptake and spread

(2020) Jennifer N. Rauch et al.   NATURE

Large-scale proteomic analysis of Alzheimer’s disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation

(2020) Erik C. B. Johnson et al.   NATURE MEDICINE

Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers

(2020) Ayuko Hoshino et al.   CELL

Oligodendrocytes Provide Antioxidant Defense Function for Neurons by Secreting Ferritin Heavy Chain

(2020) Chaitali Mukherjee et al.   Cell Metabolism

CD49f Is a Novel Marker of Functional and Reactive Human iPSC-Derived Astrocytes

(2020) Lilianne Barbar et al.   NEURON

Alzheimer’s Patient Microglia Exhibit Enhanced Aging and Unique Transcriptional Activation

(2020) Karpagam Srinivasan et al.   Cell Reports

Astrocyte- and Neuron-Derived Extracellular Vesicles from Alzheimer’s Disease Patients Effect Complement-Mediated Neurotoxicity

(2020) Carlos J. Nogueras-Ortiz et al.   Cells

P2RX7 inhibitor suppresses exosome secretion and disease phenotype in P301S tau transgenic mice

(2020) Zhi Ruan et al.   Molecular Neurodegeneration

Proteomic Profiling of Extracellular Vesicles Derived from Cerebrospinal Fluid of Alzheimer’s Disease Patients: A Pilot Study

(2020) Satoshi Muraoka et al.   Cells

Neuroimmune Crosstalk through Extracellular Vesicles in Health and Disease

(2019) Jean-Christophe Delpech et al.   TRENDS IN NEUROSCIENCES

S100 Proteins in Alzheimer’s Disease

(2019) Joana S. Cristóvão et al.   Frontiers in Neuroscience

TMTpro: Design, Synthesis, and Initial Evaluation of a Proline-Based Isobaric 16-Plex Tandem Mass Tag Reagent Set

(2019) Andrew Thompson et al.   ANALYTICAL CHEMISTRY

Emerging roles of extracellular vesicles in neurodegenerative disorders

(2019) Yang You et al.   NEUROBIOLOGY OF DISEASE

Plasma biomarkers of astrocytic and neuronal dysfunction in early‐ and late‐onset Alzheimer's disease

(2019) Fanny M. Elahi et al.   Alzheimers & Dementia

Activated human astrocyte-derived extracellular vesicles modulate neuronal uptake, differentiation and firing

(2019) Yang You et al.   Journal of Extracellular Vesicles

Alzheimer’s disease pathology propagation by exosomes containing toxic amyloid-beta oligomers

(2018) Maitrayee Sardar Sinha et al.   ACTA NEUROPATHOLOGICA

NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease

(2018) Clifford R. Jack et al.   Alzheimers & Dementia

High complement levels in astrocyte-derived exosomes of Alzheimer disease

(2018) Edward J. Goetzl et al.   ANNALS OF NEUROLOGY

Detection of Aggregation-Competent Tau in Neuron-Derived Extracellular Vesicles

(2018) Francesc Guix et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Shedding light on the cell biology of extracellular vesicles

(2018) Guillaume van Niel et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A transcriptomic atlas of aged human microglia

(2018) Marta Olah et al.   Nature Communications

Candidate-based screening via gene modulation in human neurons and astrocytes implicates FERMT2 in Aβ and TAU proteostasis

(2018) Sarah E Sullivan et al.   HUMAN MOLECULAR GENETICS

Global, regional, and national burden of Alzheimer's disease and other dementias, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

(2018) Emma Nichols et al.   LANCET NEUROLOGY

Development and validation of a simplified method to generate human microglia from pluripotent stem cells

(2018) Amanda McQuade et al.   Molecular Neurodegeneration

Inactivation of Nitric Oxide Synthesis Exacerbates the Development of Alzheimer Disease Pathology in APPPS1 Mice (Amyloid Precursor Protein/Presenilin-1)Novelty and Significance

(2017) Diana Cifuentes et al.   HYPERTENSION

The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases

(2017) Susanne Krasemann et al.   IMMUNITY

Astrocytic LRP1 Mediates Brain Aβ Clearance and Impacts Amyloid Deposition

(2017) Chia-Chen Liu et al.   JOURNAL OF NEUROSCIENCE

Multiscale network modeling of oligodendrocytes reveals molecular components of myelin dysregulation in Alzheimer’s disease

(2017) Andrew T. McKenzie et al.   Molecular Neurodegeneration

iPSC-Derived Human Microglia-like Cells to Study Neurological Diseases

(2017) Edsel M. Abud et al.   NEURON

Rapid and efficient generation of oligodendrocytes from human induced pluripotent stem cells using transcription factors

(2017) Marc Ehrlich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neurons and neuronal activity control gene expression in astrocytes to regulate their development and metabolism

(2017) Philip Hasel et al.   Nature Communications

Fine-mapping of the human leukocyte antigen locus as a risk factor for Alzheimer disease: A case–control study

(2017) Natasha Z. R. Steele et al.   PLOS MEDICINE

Alzheimer's Disease: The Role of Microglia in Brain Homeostasis and Proteopathy

(2017) Kevin A. Clayton et al.   Frontiers in Neuroscience

An Efficient Platform for Astrocyte Differentiation from Human Induced Pluripotent Stem Cells

(2017) Julia TCW et al.   Stem Cell Reports

A Multi-network Approach Identifies Protein-Specific Co-expression in Asymptomatic and Symptomatic Alzheimer’s Disease

(2017) Nicholas T. Seyfried et al.   Cell Systems

Amyloid β-induced astrogliosis is mediated by β1-integrin via NADPH oxidase 2 in Alzheimer's disease

(2016) Ane Wyssenbach et al.   AGING CELL

Cargo proteins of plasma astrocyte-derived exosomes in Alzheimer’s disease

(2016) Edward J. Goetzl et al.   FASEB JOURNAL

Extracellular vesicles in neurodegenerative disease — pathogenesis to biomarkers

(2016) Alexander G. Thompson et al.   Nature Reviews Neurology

Extracellular vesicles round off communication in the nervous system

(2016) Vivian Budnik et al.   NATURE REVIEWS NEUROSCIENCE

Identification of preclinical Alzheimer's disease by a profile of pathogenic proteins in neurally derived blood exosomes: A case-control study

(2015) Massimo S. Fiandaca et al.   Alzheimers & Dementia

Cell type– and brain region–resolved mouse brain proteome

(2015) Kirti Sharma et al.   NATURE NEUROSCIENCE

Depletion of microglia and inhibition of exosome synthesis halt tau propagation

(2015) Hirohide Asai et al.   NATURE NEUROSCIENCE

Altered lysosomal proteins in neural-derived plasma exosomes in preclinical Alzheimer disease

(2015) Edward J. Goetzl et al.   NEUROLOGY

The Role of Ion Channels in Microglial Activation and Proliferation – A Complex Interplay between Ligand-Gated Ion Channels, K+ Channels, and Intracellular Ca2+

(2015) Martin James Stebbing et al.   Frontiers in Immunology

Proteomic analysis of cerebrospinal fluid extracellular vesicles: A comprehensive dataset

(2014) Davide Chiasserini et al.   Journal of Proteomics

Transcriptomic Meta-Analysis of Multiple Sclerosis and Its Experimental Models

(2014) Barbara B. R. Raddatz et al.   PLoS One

Rapid Single-Step Induction of Functional Neurons from Human Pluripotent Stem Cells

(2013) Yingsha Zhang et al.   NEURON

GO-Elite: a flexible solution for pathway and ontology over-representation

(2012) Alexander C. Zambon et al.   BIOINFORMATICS

Metabolic Dysfunction in Alzheimers Disease and Related Neurodegenerative Disorders

(2012) Huan Cai et al.   Current Alzheimer Research

Integrins as receptor targets for neurological disorders

(2012) Xin Wu et al.   PHARMACOLOGY & THERAPEUTICS

MS3 eliminates ratio distortion in isobaric multiplexed quantitative proteomics

(2011) Lily Ting et al.   NATURE METHODS

Network medicine: a network-based approach to human disease

(2010) Albert-László Barabási et al.   NATURE REVIEWS GENETICS

ToppCluster: a multiple gene list feature analyzer for comparative enrichment clustering and network-based dissection of biological systems

(2010) V. Kaimal et al.   NUCLEIC ACIDS RESEARCH

WGCNA: an R package for weighted correlation network analysis

(2008) Peter Langfelder et al.   BMC BIOINFORMATICS

A Systems Level Analysis of Transcriptional Changes in Alzheimer's Disease and Normal Aging

(2008) J. A. Miller et al.   JOURNAL OF NEUROSCIENCE