The Regulatory Functionality of Exosomes Derived from hUMSCs in 3D Culture for Alzheimer's Disease Therapy

Exosomes derived from hypoxia-preconditioned mesenchymal stromal cells ameliorate cognitive decline by rescuing synaptic dysfunction and regulating inflammatory responses in APP/PS1 mice

(2018) Guo-Hong Cui et al.   FASEB JOURNAL

Memory Loss and the Onset of Alzheimer’s Disease Could Be Under the Control of Extracellular Heat Shock Proteins

(2018) Nelson Arispe et al.   JOURNAL OF ALZHEIMERS DISEASE

Exosomes and microRNAs: New potential therapeutic candidates in Alzheimer disease therapy

(2018) Elmira Iranifar et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Exosomes Isolated From Human Umbilical Cord Mesenchymal Stem Cells Alleviate Neuroinflammation and Reduce Amyloid-Beta Deposition by Modulating Microglial Activation in Alzheimer’s Disease

(2018) Mao Ding et al.   NEUROCHEMICAL RESEARCH

Visualization of Alzheimer’s Disease Related α-/β-/γ-Secretase Ternary Complex by Bimolecular Fluorescence Complementation Based Fluorescence Resonance Energy Transfer

(2018) Xin Wang et al.   Frontiers in Molecular Neuroscience

Mesenchymal stem cell-derived extracellular vesicles: a glimmer of hope in treating Alzheimer’s disease

(2017) Lee Chuen Liew et al.   INTERNATIONAL IMMUNOLOGY

microRNA 221 Targets ADAM10 mRNA and is Downregulated in Alzheimer’s Disease

(2017) Patricia R. Manzine et al.   JOURNAL OF ALZHEIMERS DISEASE

Insulin-Degrading Enzyme Sorting in Exosomes: A Secretory Pathway for a Key Brain Amyloid-β Degrading Protease

(2017) Ayelén Bulloj et al.   JOURNAL OF ALZHEIMERS DISEASE

Three-Dimensional Stiff Graphene Scaffold on Neural Stem Cells Behavior

(2016) Qinqin Ma et al.   ACS Applied Materials & Interfaces

Enhanced Migration of Neural Stem Cells by Microglia Grown on a Three-Dimensional Graphene Scaffold

(2016) Ziyun Jiang et al.   ACS Applied Materials & Interfaces

Replenishment of microRNA-188-5p restores the synaptic and cognitive deficits in 5XFAD Mouse Model of Alzheimer’s Disease

(2016) Kihwan Lee et al.   Scientific Reports

Exosomes from Human Umbilical Cord Mesenchymal Stem Cells: Identification, Purification, and Biological Characteristics

(2016) Bin Zhang et al.   Stem Cells International

Conditioned medium from the stem cells of human dental pulp improves cognitive function in a mouse model of Alzheimer’s disease

(2015) Tsuneyuki Mita et al.   BEHAVIOURAL BRAIN RESEARCH

3D scaffold alters cellular response to graphene in a polymer composite for orthopedic applications

(2015) Sachin Kumar et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS

Exosomes as drug delivery vehicles for Parkinson's disease therapy

(2015) Matthew J. Haney et al.   JOURNAL OF CONTROLLED RELEASE

Peripheral Blood MicroRNA Expression Profiles in Alzheimer’s Disease: Screening, Validation, Association with Clinical Phenotype and Implications for Molecular Mechanism

(2015) Ru-Jing Ren et al.   MOLECULAR NEUROBIOLOGY

Exosomes and exosomal miRNAs in cardiovascular protection and repair

(2015) Costanza Emanueli et al.   VASCULAR PHARMACOLOGY

Secreted miR-34a in astrocytic shedding vesicles enhanced the vulnerability of dopaminergic neurons to neurotoxins by targeting Bcl-2

(2015) Susu Mao et al.   Protein & Cell

Anti-inflammatory effects of three-dimensional graphene foams cultured with microglial cells

(2014) Qin Song et al.   BIOMATERIALS

Early induction of oxidative stress in a mouse model of Alzheimer’s disease with heme oxygenase activity

(2014) SANLI XING et al.   Molecular Medicine Reports

MicroRNA-144 Is Regulated by Activator Protein-1 (AP-1) and Decreases Expression of Alzheimer Disease-related A Disintegrin and Metalloprotease 10 (ADAM10)

(2013) Cong Cheng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Three-dimensional graphene foams promote osteogenic differentiation of human mesenchymal stem cells

(2013) Spencer W. Crowder et al.   Nanoscale

Choroid plexus transcytosis and exosome shuttling deliver folate into brain parenchyma

(2013) Marcel Grapp et al.   Nature Communications

Human adipose tissue-derived mesenchymal stem cells secrete functional neprilysin-bound exosomes

(2013) Takeshi Katsuda et al.   Scientific Reports

Three-dimensional graphene foam as a biocompatible and conductive scaffold for neural stem cells

(2013) Ning Li et al.   Scientific Reports

Human umbilical cord mesenchymal stem cell-derived neuron-like cells rescue memory deficits and reduce amyloid-beta deposition in an AβPP/PS1 transgenic mouse model

(2013) Hui Yang et al.   Stem Cell Research & Therapy

Alzheimer Mechanisms and Therapeutic Strategies

(2012) Yadong Huang et al.   CELL

Exosome-Mediated Transfer of miR-133b from Multipotent Mesenchymal Stromal Cells to Neural Cells Contributes to Neurite Outgrowth

(2012) Hongqi Xin et al.   STEM CELLS

Human umbilical cord blood-derived mesenchymal stem cells improve neuropathology and cognitive impairment in an Alzheimer's disease mouse model through modulation of neuroinflammation

(2010) Hyun Ju Lee et al.   NEUROBIOLOGY OF AGING

Decreased Clearance of CNS  -Amyloid in Alzheimer's Disease

(2010) K. G. Mawuenyega et al.   SCIENCE

Stem cell fate dictated solely by altered nanotube dimension

(2009) S. Oh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intracerebral Transplantation of Bone Marrow-Derived Mesenchymal Stem Cells Reduces Amyloid-Beta Deposition and Rescues Memory Deficits in Alzheimer's Disease Mice by Modulation of Immune Responses

(2009) Jong Kil Lee et al.   STEM CELLS