The Role of Insulin/IGF-1/PI3K/Akt/GSK3β Signaling in Parkinson's Disease Dementia

Cross-sectional and longitudinal associations of motor fluctuations and non-motor predominance with cerebrospinal τ and Aβ as well as dementia-risk in Parkinson's disease

(2017) Raluca Modreanu et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Intranasal insulin protects against substantia nigra dopaminergic neuronal loss and alleviates motor deficits induced by 6-OHDA in rats

(2016) Y. Pang et al.   NEUROSCIENCE

Parkinson’s disease dementia: a neural networks perspective

(2015) James Gratwicke et al.   BRAIN

Plasma Insulin-Like Growth Factor 1 Is Associated with Cognitive Impairment in Parkinson's Disease

(2015) Jianfang Ma et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

The molecular mechanism of rotenone-induced α-synuclein aggregation: Emphasizing the role of the calcium/GSK3β pathway

(2015) Yu-he Yuan et al.   TOXICOLOGY LETTERS

Insulin, incretins and other growth factors as potential novel treatments for Alzheimer's and Parkinson's diseases

(2014) Christian Hölscher   BIOCHEMICAL SOCIETY TRANSACTIONS

Hippocampal Lewy pathology and cholinergic dysfunction are associated with dementia in Parkinson’s disease

(2014) Hélène Hall et al.   BRAIN

GSK-3βInhibition Attenuates CLP-Induced Liver Injury by Reducing Inflammation and Hepatic Cell Apoptosis

(2014) Hui Zhang et al.   MEDIATORS OF INFLAMMATION

Insulin-like growth factor-1 and risk of Alzheimer dementia and brain atrophy

(2014) A. J. Westwood et al.   NEUROLOGY

Extracellular α-Synuclein Leads to Microtubule Destabilization via GSK-3β-Dependent Tau Phosphorylation in PC12 Cells

(2014) Magdalena Gąssowska et al.   PLoS One

Parkinson's Disease-Associated Dj-1 Mutations Increase Abnormal Phosphorylation of Tau Protein through Akt/Gsk-3β Pathways

(2013) Yangang Wang et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Parkinson's disease dementia: convergence of α-synuclein, tau and amyloid-β pathologies

(2013) David J. Irwin et al.   NATURE REVIEWS NEUROSCIENCE

The Significance of α-Synuclein, Amyloid-β and Tau Pathologies in Parkinson's Disease Progression and Related Dementia

(2013) Yaroslau Compta et al.   Neurodegenerative Diseases

Glycogen synthase kinase-3 inhibitors: Rescuers of cognitive impairments

(2013) Margaret K. King et al.   PHARMACOLOGY & THERAPEUTICS

Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

(2012) Konrad Talbot et al.   JOURNAL OF CLINICAL INVESTIGATION

Dementia is associated with Insulin Resistance in patients with Parkinson's Disease

(2012) Domenico Bosco et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Reciprocal Induction Between α-Synuclein and β-Amyloid in Adult Rat Neurons

(2012) Shohreh Majd et al.   NEUROTOXICITY RESEARCH

Intranasal Insulin Therapy for Alzheimer Disease and Amnestic Mild Cognitive Impairment

(2011) Suzanne Craft   ARCHIVES OF NEUROLOGY

Insulin-like growth factor 1 protects human neuroblastoma cells SH-EP1 against MPP+-induced apoptosis by AKT/GSK-3β/JNK signaling

(2010) Lei Wang et al.   APOPTOSIS

Absence of α-synuclein pathology in postencephalitic parkinsonism

(2009) Kurt A. Jellinger   ACTA NEUROPATHOLOGICA

Rescue of α-synuclein cytotoxicity by insulin-like growth factors

(2009) Shyan-Yuan Kao   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

RTP801 Is Induced in Parkinson's Disease and Mediates Neuron Death by Inhibiting Akt Phosphorylation/Activation

(2009) C. Malagelada et al.   JOURNAL OF NEUROSCIENCE

Measures of striatal insulin resistance in a 6-hydroxydopamine model of Parkinson's disease

(2008) J.K. Morris et al.   BRAIN RESEARCH

α-Synuclein enhances secretion and toxicity of amyloid beta peptides in PC12 cells

(2008) Anna Kazmierczak et al.   NEUROCHEMISTRY INTERNATIONAL