Metabolic Reprogramming in Cancer Cells: Emerging Molecular Mechanisms and Novel Therapeutic Approaches
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Title
Metabolic Reprogramming in Cancer Cells: Emerging Molecular Mechanisms and Novel Therapeutic Approaches
Authors
Keywords
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Journal
Pharmaceutics
Volume 14, Issue 6, Pages 1303
Publisher
MDPI AG
Online
2022-06-20
DOI
10.3390/pharmaceutics14061303
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Note: Only part of the references are listed.- Fatty Acids, CD36, Thrombospondin-1, and CD47 in Glioblastoma: Together and/or Separately?
- (2022) Cristiana Tanase et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Hallmarks of Cancer: New Dimensions
- (2022) Douglas Hanahan Cancer Discovery
- Telomerase in Cancer: Function, Regulation, and Clinical Translation
- (2022) Nathaniel J. Robinson et al. Cancers
- Pathophysiological Integration of Metabolic Reprogramming in Breast Cancer
- (2022) Roberto Corchado-Cobos et al. Cancers
- Metabolic Reprogramming in Gastric Cancer: Trojan Horse Effect
- (2022) Yu-Ling Bin et al. Frontiers in Oncology
- Glucose transporters as markers of diagnosis and prognosis in cancer diseases
- (2022) Leszek Szablewski Oncology Reviews
- Transsulfuration, minor player or crucial for cysteine homeostasis in cancer
- (2022) Hai-Feng Zhang et al. TRENDS IN CELL BIOLOGY
- The cancer metabolic reprogramming and immune response
- (2021) Longzheng Xia et al. Molecular Cancer
- Activation of MAT2A-RIP1 signaling axis reprograms monocytes in gastric cancer
- (2021) Yan Zhang et al. Journal for ImmunoTherapy of Cancer
- Oncometabolite in Cancer: Current Understanding and Challenges
- (2021) Yang Liu et al. CANCER RESEARCH
- Cancer statistics for the year 2020: An overview
- (2021) Jacques Ferlay et al. INTERNATIONAL JOURNAL OF CANCER
- The Interplay between Dysregulated Ion Transport and Mitochondrial Architecture as a Dangerous Liaison in Cancer
- (2021) Stine F. Pedersen et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Role of Intra- and Extracellular Lipid Signals in Cancer Stemness and Potential Therapeutic Strategy
- (2021) Jianming Hu et al. Frontiers in Pharmacology
- Glucose Transporters as a Target for Anticancer Therapy
- (2021) Monika Pliszka et al. Cancers
- Lipid Metabolism Regulates Oxidative Stress and Ferroptosis in RAS-Driven Cancers: A Perspective on Cancer Progression and Therapy
- (2021) Caterina Bartolacci et al. Frontiers in Molecular Biosciences
- Molecular Mechanisms and Cellular Contribution from Lung Fibrosis to Lung Cancer Development
- (2021) Anna Valeria Samarelli et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Lipid Catabolism and ROS in Cancer: A Bidirectional Liaison
- (2021) Serena Castelli et al. Cancers
- Alterations of Ion Homeostasis in Cancer Metastasis: Implications for Treatment
- (2021) Gulimirerouzi Fnu et al. Frontiers in Oncology
- HIF-1α Is a Rational Target for Future Ovarian Cancer Therapies
- (2021) Xin Wang et al. Frontiers in Oncology
- Emerging agents that target signaling pathways to eradicate colorectal cancer stem cells
- (2021) Valdenizia R. Silva et al. Cancer Communications
- Discovery of novel glyceraldehyde-3-phosphate dehydrogenase inhibitor via docking-based virtual screening
- (2020) Ting Li et al. BIOORGANIC CHEMISTRY
- The master regulators Myc and p53 cellular signaling and functions in polycystic kidney disease
- (2020) Almira Kurbegovic et al. CELLULAR SIGNALLING
- SLMP53-1 Inhibits Tumor Cell Growth through Regulation of Glucose Metabolism and Angiogenesis in a P53-Dependent Manner
- (2020) Helena Ramos et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Antitumor effects of rafoxanide in diffuse large B cell lymphoma via the PTEN/PI3K/Akt and JNK/c-Jun pathways
- (2020) Wan He et al. LIFE SCIENCES
- Pan-cancer analysis of whole genomes
- (2020) NATURE
- 2-Hydroxyglutarate Metabolism Is Altered in an in vivo Model of LPS Induced Endotoxemia
- (2020) Susan F. Fitzpatrick et al. Frontiers in Physiology
- Ginsenoside 20(S)‐Rg3 upregulates HIF‐1α‐targeting miR‐519a‐5p to inhibit the Warburg effect in ovarian cancer cells
- (2020) Jiaojiao Lu et al. CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
- Novel roles of phosphoinositides in signaling, lipid transport, and disease
- (2020) Gerald R.V. Hammond et al. CURRENT OPINION IN CELL BIOLOGY
- Oncogene-induced senescence: From biology to therapy
- (2020) Haoran Zhu et al. MECHANISMS OF AGEING AND DEVELOPMENT
- Metformin: A Possible Option in Cancer Chemotherapy
- (2020) Chidiebere V. Ugwueze et al. Analytical Cellular Pathology
- Anti-Aging Effect of Metformin: A Molecular and Therapeutical Perspective
- (2020) Wheeler Torres et al. CURRENT PHARMACEUTICAL DESIGN
- Dual PI3K/mTOR inhibitor PKI-402 suppresses the growth of ovarian cancer cells by degradation of Mcl-1 through autophagy
- (2020) Xiaoqing Hu et al. BIOMEDICINE & PHARMACOTHERAPY
- Phase 1 study of mTORC1/2 inhibitor sapanisertib (TAK-228) in advanced solid tumours, with an expansion phase in renal, endometrial or bladder cancer
- (2020) Martin H. Voss et al. BRITISH JOURNAL OF CANCER
- The tumor microenvironment
- (2020) Nicole M. Anderson et al. CURRENT BIOLOGY
- Glutamine reliance in cell metabolism
- (2020) Hee Chan Yoo et al. EXPERIMENTAL AND MOLECULAR MEDICINE
- Apatinib exhibits synergistic effect with pyrotinib and reverses acquired pyrotinib resistance in HER2-positive gastric cancer via stem cell factor/c-kit signaling and its downstream pathways
- (2020) Beibei Su et al. Gastric Cancer
- Fatty Acid Synthase: An Emerging Target in Cancer
- (2020) Chee Wai Fhu et al. MOLECULES
- Targeting Glutaminolysis: New Perspectives to Understand Cancer Development and Novel Strategies for Potential Target Therapies
- (2020) Zhefang Wang et al. Frontiers in Oncology
- Metabolic reprogramming in the pathogenesis of glioma: Update
- (2019) Kenta Masui et al. NEUROPATHOLOGY
- Effect of PTEN loss on metabolic reprogramming in prostate cancer cells
- (2019) Xin Zhou et al. Oncology Letters
- Metabolic Reprogramming in Breast Cancer and Its Therapeutic Implications
- (2019) Nishant Gandhi et al. Cells
- CB-839, a glutaminase inhibitor, in combination with cabozantinib in patients with clear cell and papillary metastatic renal cell cancer (mRCC): Results of a phase I study.
- (2019) Funda Meric-Bernstam et al. JOURNAL OF CLINICAL ONCOLOGY
- Crocin inhibits the migration, invasion, and epithelial-mesenchymal transition of gastric cancer cells via miR-320/KLF5/HIF-1α signaling
- (2019) Ying Zhou et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Inactivating the ubiquitin ligase Parkin suppresses cell proliferation and induces apoptosis in human keloids
- (2019) Rui Lei et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Mitochondrial metabolism is inhibited by the HIF1α-MYC-PGC-1β axis in BRAF V600E thyroid cancer
- (2019) Yanyan Gao et al. FEBS Journal
- Gluconeogenesis in cancer cells – Repurposing of a starvation-induced metabolic pathway?
- (2019) Gabriele Grasmann et al. BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
- Cancer cells change their glucose metabolism to overcome increased ROS: One step from cancer cell to cancer stem cell?
- (2019) Zahra Ghanbari Movahed et al. BIOMEDICINE & PHARMACOTHERAPY
- Lipid metabolism in cancer cells under metabolic stress
- (2019) Rimsha Munir et al. BRITISH JOURNAL OF CANCER
- Glucose-6-phosphate dehydrogenase blockade potentiates tyrosine kinase inhibitor effect on breast cancer cells through autophagy perturbation
- (2019) Luigi Mele et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Therapeutic targeting of glutaminolysis as an essential strategy to combat cancer
- (2019) José M. Matés et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- Warburg Effects in Cancer and Normal Proliferating Cells: Two Tales of the Same Name
- (2019) Huiyan Sun et al. GENOMICS PROTEOMICS & BIOINFORMATICS
- The dual PI3K/mTOR inhibitor BEZ235 restricts the growth of lung cancer tumors regardless of EGFR status, as a potent accompanist in combined therapeutic regimens
- (2019) Yi-Ying Wu et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- HER2 recruits AKT1 to disrupt STING signalling and suppress antiviral defence and antitumour immunity
- (2019) Shiying Wu et al. NATURE CELL BIOLOGY
- Glutamine as an Essential Amino Acid for KRas-Driven Cancer Cells
- (2019) Elyssa Bernfeld et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Correlation and expression analysis of hypoxia‑inducible factor�1α, glucose transporter 1 and lactate dehydrogenase�5 in human gastric cancer
- (2019) Lang‑Song Hao et al. Oncology Letters
- Starve Cancer Cells of Glutamine: Break the Spell or Make a Hungry Monster?
- (2019) Jie Jiang et al. Cancers
- The MYC Oncogene Cooperates with Sterol-Regulated Element-Binding Protein to Regulate Lipogenesis Essential for Neoplastic Growth
- (2019) Arvin M. Gouw et al. Cell Metabolism
- Nuclear Glycogenolysis Modulates Histone Acetylation in Human Non-Small Cell Lung Cancers
- (2019) Ramon C. Sun et al. Cell Metabolism
- Glycolytic enzyme hexokinase II is a putative therapeutic target in B cell malignant lymphoma
- (2019) Kei Nakajima et al. EXPERIMENTAL HEMATOLOGY
- A phase II study to assess the safety and efficacy of the dual mTORC1/2 inhibitor vistusertib in relapsed, refractory DLBCL
- (2019) Toby A. Eyre et al. HEMATOLOGICAL ONCOLOGY
- Dihydroartemisinin suppresses glycolysis of LNCaP cells by inhibiting PI3K/AKT pathway and downregulating HIF-1α expression
- (2019) Wenhe Zhu et al. LIFE SCIENCES
- PTEN/AKT signaling mediates chemoresistance in refractory acute myeloid leukemia through enhanced glycolysis
- (2019) Min Ryu et al. ONCOLOGY REPORTS
- The Potential Effect of Metformin on Cancer: An Umbrella Review
- (2019) Hong Yu et al. Frontiers in Endocrinology
- KRAS-Driven Metabolic Rewiring Reveals Novel Actionable Targets in Cancer
- (2019) Emanuela Pupo et al. Frontiers in Oncology
- The Role of Glutaminase in Cancer
- (2019) Brendah K. Masisi et al. HISTOPATHOLOGY
- Preclinical Evidence for Targeting PI3K/mTOR Signaling with Dual-Inhibitors as a Therapeutic Strategy against Cutaneous T-Cell Lymphoma
- (2019) Antonella Bresin et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- A MYC–GCN2–eIF2α negative feedback loop limits protein synthesis to prevent MYC-dependent apoptosis in colorectal cancer
- (2019) Stefanie Schmidt et al. NATURE CELL BIOLOGY
- LKB1/AMPK Pathway and Drug Response in Cancer: A Therapeutic Perspective
- (2019) Francesco Ciccarese et al. Oxidative Medicine and Cellular Longevity
- Glutamine Anabolism Plays a Critical Role in Pancreatic Cancer by Coupling Carbon and Nitrogen Metabolism
- (2019) Alex J. Bott et al. Cell Reports
- Lactate in the Regulation of Tumor Microenvironment and Therapeutic Approaches
- (2019) Karen G. de la Cruz-López et al. Frontiers in Oncology
- New aspects of amino acid metabolism in cancer
- (2019) Lisa Vettore et al. BRITISH JOURNAL OF CANCER
- Reprogramming of fatty acid metabolism in cancer
- (2019) Nikos Koundouros et al. BRITISH JOURNAL OF CANCER
- Phase 2 study of LY3023414 in patients with advanced endometrial cancer harboring activating mutations in the PI3K pathway
- (2019) Maria M. Rubinstein et al. CANCER
- Targeting the pentose phosphate pathway increases reactive oxygen species and induces apoptosis in thyroid cancer cells
- (2019) Chien-Liang Liu et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- Glutamine-fructose-6-phosphate transaminase 2 (GFPT2) promotes the EMT of serous ovarian cancer by activating the hexosamine biosynthetic pathway to increase the nuclear location of β-catenin
- (2019) Lin Zhou et al. PATHOLOGY RESEARCH AND PRACTICE
- Combined Metabolomics and Genome-Wide Transcriptomics Analyses Show Multiple HIF1α-Induced Changes in Lipid Metabolism in Early Stage Clear Cell Renal Cell Carcinoma
- (2019) Johannes C. van der Mijn et al. Translational Oncology
- Sanguinarine inhibits epithelial–mesenchymal transition via targeting HIF-1α/TGF-β feed-forward loop in hepatocellular carcinoma
- (2019) Qi Su et al. Cell Death & Disease
- BRAFV600E-mutated ovarian serous borderline tumors are at relatively low risk for progression to serous carcinoma
- (2019) M. Herman Chui et al. Oncotarget
- Oncogene-induced senescence: a double edged sword in cancer
- (2018) Xue-ling Liu et al. ACTA PHARMACOLOGICA SINICA
- Cancer cell cannibalism: Multiple triggers emerge for entosis
- (2018) J. Durgan et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Metabolic reprogramming for cancer cells and their microenvironment: Beyond the Warburg Effect
- (2018) Linchong Sun et al. BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
- Oncogene-Driven Metabolic Alterations in Cancer
- (2018) Hye-Young Min et al. Biomolecules & Therapeutics
- Aldolase B-Mediated Fructose Metabolism Drives Metabolic Reprogramming of Colon Cancer Liver Metastasis
- (2018) Pengcheng Bu et al. Cell Metabolism
- A First-in-Human Phase 1 Study of LY3023414, an Oral PI3K/mTOR Dual Inhibitor, in Patients with Advanced Cancer
- (2018) Johanna C. Bendell et al. CLINICAL CANCER RESEARCH
- A phase II study of the dual mTOR inhibitor MLN0128 in patients with metastatic castration resistant prostate cancer
- (2018) Laura Graham et al. INVESTIGATIONAL NEW DRUGS
- Post-translational regulation of metabolism in fumarate hydratase deficient cancer cells
- (2018) Emanuel Gonçalves et al. METABOLIC ENGINEERING
- STAT3-induced lncRNA HAGLROS overexpression contributes to the malignant progression of gastric cancer cells via mTOR signal-mediated inhibition of autophagy
- (2018) Jin-Fei Chen et al. Molecular Cancer
- Everolimus inhibits breast cancer cell growth through PI3K/AKT/mTOR signaling pathway
- (2018) Liyan Du et al. Molecular Medicine Reports
- Notch Signaling Enhances Stemness by Regulating Metabolic Pathways Through Modifying p53, NF-κB, and HIF-1α
- (2018) Hiroyuki Moriyama et al. STEM CELLS AND DEVELOPMENT
- An important role of SREBP-1 in HBV and HCV co-replication inhibition by PTEN
- (2018) Qi Wu et al. VIROLOGY
- The carnitine system and cancer metabolic plasticity
- (2018) Mariarosa Anna Beatrice Melone et al. Cell Death & Disease
- Pharmacodynamics of mutant-IDH1 inhibitors in glioma patients probed by in vivo 3D MRS imaging of 2-hydroxyglutarate
- (2018) Ovidiu C. Andronesi et al. Nature Communications
- CD44 positive and sorafenib insensitive hepatocellular carcinomas respond to the ATP-competitive mTOR inhibitor INK128
- (2018) Mohamed Badawi et al. Oncotarget
- Consumption of NADPH for 2-HG Synthesis Increases Pentose Phosphate Pathway Flux and Sensitizes Cells to Oxidative Stress
- (2018) Susan J. Gelman et al. Cell Reports
- PTEN: Tumor Suppressor and Metabolic Regulator
- (2018) Chien-Yu Chen et al. Frontiers in Endocrinology
- Influence of the Tumor Microenvironment on Cancer Cells Metabolic Reprogramming
- (2018) Victoire Gouirand et al. Frontiers in Oncology
- Glutaminase isoenzymes in the metabolic therapy of cancer
- (2018) José M. Matés et al. BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
- Pazopanib in patients with von Hippel-Lindau disease: a single-arm, single-centre, phase 2 trial
- (2018) Eric Jonasch et al. LANCET ONCOLOGY
- Cancer cell plasticity: Impact on tumor progression and therapy response
- (2018) Victoria da Silva-Diz et al. SEMINARS IN CANCER BIOLOGY
- Glucose starvation induces LKB1-AMPK-mediated MMP-9 expression in cancer cells
- (2018) Hitoshi Endo et al. Scientific Reports
- The MYC transcription factor network: balancing metabolism, proliferation and oncogenesis
- (2018) Patrick A. Carroll et al. Frontiers of Medicine
- Oncogenic KRAS supports pancreatic cancer through regulation of nucleotide synthesis
- (2018) Naiara Santana-Codina et al. Nature Communications
- Discovery and development of small molecule modulators targeting glutamine metabolism
- (2018) Lei Li et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Inhibition of glycolysis by a novel EGFR/HER2 inhibitor KU004 suppresses the growth of HER2+ cancer
- (2017) Chongchong Tian et al. EXPERIMENTAL CELL RESEARCH
- A tale of two glutaminases: homologous enzymes with distinct roles in tumorigenesis
- (2017) William P Katt et al. Future Medicinal Chemistry
- Metabolic reprogramming ensures cancer cell survival despite oncogenic signaling blockade
- (2017) Hui-wen Lue et al. GENES & DEVELOPMENT
- PTEN Down-Regulation Promotes β-Oxidation to Fuel Hypertrophic Liver Growth After Hepatectomy in Mice
- (2017) Ekaterina Kachaylo et al. HEPATOLOGY
- 2-Methoxyestradiol enhances radiosensitivity in radioresistant melanoma MDA-MB-435R cells by regulating glycolysis via HIF-1α/PDK1 axis
- (2017) Hong Zhao et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Pan-mTOR inhibitor MLN0128 is effective against intrahepatic cholangiocarcinoma in mice
- (2017) Shanshan Zhang et al. JOURNAL OF HEPATOLOGY
- Comparison of two doses of intravenous temsirolimus in patients with relapsed/refractory mantle cell lymphoma
- (2017) Wojciech Jurczak et al. LEUKEMIA & LYMPHOMA
- LKB1 promotes metabolic flexibility in response to energy stress
- (2017) Seth J. Parker et al. METABOLIC ENGINEERING
- EGFR modulates monounsaturated fatty acid synthesis through phosphorylation of SCD1 in lung cancer
- (2017) Jiqin Zhang et al. Molecular Cancer
- Caveolae-Mediated Endocytosis as a Novel Mechanism of Resistance to Trastuzumab Emtansine (T-DM1)
- (2017) Matthew Sung et al. MOLECULAR CANCER THERAPEUTICS
- Phase II Study of BEZ235 versus Everolimus in Patients with Mammalian Target of Rapamycin Inhibitor‐Naïve Advanced Pancreatic Neuroendocrine Tumors
- (2017) Ramon Salazar et al. ONCOLOGIST
- Metabolic recycling of ammonia via glutamate dehydrogenase supports breast cancer biomass
- (2017) Jessica B. Spinelli et al. SCIENCE
- Osteopontin–integrin engagement induces HIF-1α–TCF12-mediated endothelial-mesenchymal transition to exacerbate colorectal cancer
- (2017) Chi-Shuan Fan et al. Oncotarget
- Fumarate Hydratase Loss Causes Combined Respiratory Chain Defects
- (2017) Petros A. Tyrakis et al. Cell Reports
- Teaching the basics of cancer metabolism: Developing antitumor strategies by exploiting the differences between normal and cancer cell metabolism
- (2017) Balaraman Kalyanaraman Redox Biology
- A phase IIa study of PEGylated glutaminase (PEG-PGA) plus 6-diazo-5-oxo-L-norleucine (DON) in patients with advanced refractory solid tumors
- (2017) C. Mueller et al. JOURNAL OF CLINICAL ONCOLOGY
- The Emerging Hallmarks of Cancer Metabolism
- (2016) Natalya N. Pavlova et al. Cell Metabolism
- Amino Acids Rather than Glucose Account for the Majority of Cell Mass in Proliferating Mammalian Cells
- (2016) Aaron M. Hosios et al. DEVELOPMENTAL CELL
- Fenofibrate Suppresses Oral Tumorigenesis via Reprogramming Metabolic Processes: Potential Drug Repurposing for Oral Cancer
- (2016) Chia-Ing Jan et al. International Journal of Biological Sciences
- A new mechanism of trastuzumab resistance in gastric cancer: MACC1 promotes the Warburg effect via activation of the PI3K/AKT signaling pathway
- (2016) Jing Liu et al. Journal of Hematology & Oncology
- Identification and Preclinical Evaluation of SC144, a Novel Pyrroloquinoxaline Derivative with Broad-Spectrum Anticancer Activity
- (2016) Fedora Grande et al. MINI-REVIEWS IN MEDICINAL CHEMISTRY
- A causal link from ALK to hexokinase II overexpression and hyperactive glycolysis in EML4-ALK-positive lung cancer
- (2016) Y Ma et al. ONCOGENE
- Hyperglycemia and Phosphatidylinositol 3-Kinase/Protein Kinase B/Mammalian Target of Rapamycin (PI3K/AKT/mTOR) Inhibitors in Phase I Trials: Incidence, Predictive Factors, and Management
- (2016) Khurum H. Khan et al. ONCOLOGIST
- Distinctive interrelation of p53 with SCO2, COX, and TIGAR in human gastric cancer
- (2016) Sang Hyun Kim et al. PATHOLOGY RESEARCH AND PRACTICE
- Carnitine palmitoyltransferase 1C: From cognition to cancer
- (2016) Núria Casals et al. PROGRESS IN LIPID RESEARCH
- Loss of Tuberous Sclerosis Complex 2 (TSC2) as a Predictive Biomarker of Response to mTOR Inhibitor Treatment in Patients with Hepatocellular Carcinoma
- (2016) Jinhyun Cho et al. Translational Oncology
- The Warburg Effect: How Does it Benefit Cancer Cells?
- (2016) Maria V. Liberti et al. TRENDS IN BIOCHEMICAL SCIENCES
- Hypoxia-responsive miR-210 promotes self-renewal capacity of colon tumor-initiating cells by repressing ISCU and by inducing lactate production
- (2016) Pit Ullmann et al. Oncotarget
- PTEN dephosphorylates AKT to prevent the expression of GLUT1 on plasmamembrane and to limit glucose consumption in cancer cells
- (2016) Suratchanee Phadngam et al. Oncotarget
- Fundamentals of cancer metabolism
- (2016) R. J. DeBerardinis et al. Science Advances
- The Glutaminase-1 Inhibitor 968 Enhances Dihydroartemisinin-Mediated Antitumor Efficacy in Hepatocellular Carcinoma Cells
- (2016) Diancheng Wang et al. PLoS One
- Toward rapamycin analog (rapalog)-based precision cancer therapy
- (2015) Ling-hua Meng et al. ACTA PHARMACOLOGICA SINICA
- Targeting LKB1 in cancer – exposing and exploiting vulnerabilities
- (2015) M Momcilovic et al. BRITISH JOURNAL OF CANCER
- IDH1 Mutation Induces Reprogramming of Pyruvate Metabolism
- (2015) J. L. Izquierdo-Garcia et al. CANCER RESEARCH
- Metabolic reprogramming and dysregulated metabolism: cause, consequence and/or enabler of environmental carcinogenesis?
- (2015) R.Brooks Robey et al. CARCINOGENESIS
- First-in-Human Pharmacokinetic and Pharmacodynamic Study of the Dual m-TORC 1/2 Inhibitor AZD2014
- (2015) B. Basu et al. CLINICAL CANCER RESEARCH
- First-in-Human Study of PF-05212384 (PKI-587), a Small-Molecule, Intravenous, Dual Inhibitor of PI3K and mTOR in Patients with Advanced Cancer
- (2015) G. I. Shapiro et al. CLINICAL CANCER RESEARCH
- Metabolic Dependencies in RAS-Driven Cancers
- (2015) A. C. Kimmelman CLINICAL CANCER RESEARCH
- Therapeutic Targeting of Anaplastic Lymphoma Kinase in Lung Cancer: A Paradigm for Precision Cancer Medicine
- (2015) R. Katayama et al. CLINICAL CANCER RESEARCH
- Signaling through the Phosphatidylinositol 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Axis Is Responsible for Aerobic Glycolysis mediated by Glucose Transporter in Epidermal Growth Factor Receptor (EGFR)-mutated Lung Adenocarcinoma
- (2015) Hideki Makinoshima et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Telomerase regulates MYC-driven oncogenesis independent of its reverse transcriptase activity
- (2015) Cheryl M. Koh et al. JOURNAL OF CLINICAL INVESTIGATION
- Loss of Tuberous Sclerosis Complex 2 (TSC2) Is Frequent in Hepatocellular Carcinoma and Predicts Response to mTORC1 Inhibitor Everolimus
- (2015) H. Huynh et al. MOLECULAR CANCER THERAPEUTICS
- Mitochondrial Phosphoenolpyruvate Carboxykinase Regulates Metabolic Adaptation and Enables Glucose-Independent Tumor Growth
- (2015) Emma E. Vincent et al. MOLECULAR CELL
- PI3K/AKT signaling pathway and cancer: an updated review
- (2014) Miriam Martini et al. ANNALS OF MEDICINE
- mTOR ATP-competitive inhibitor INK128 inhibits neuroblastoma growth via blocking mTORC signaling
- (2014) Huiyuan Zhang et al. APOPTOSIS
- Phase 2 trial of everolimus and carboplatin combination in patients with triple negative metastatic breast cancer
- (2014) Jasmeet Chadha Singh et al. BREAST CANCER RESEARCH
- Rapamycin: One Drug, Many Effects
- (2014) Jing Li et al. Cell Metabolism
- Use of Antidiabetic Drugs in the U.S., 2003–2012
- (2014) Christian Hampp et al. DIABETES CARE
- Sodium channel blockers: a patent review (2010 – 2014)
- (2014) Valentina Zuliani et al. EXPERT OPINION ON THERAPEUTIC PATENTS
- MLN0128, an ATP-Competitive mTOR Kinase Inhibitor with Potent In Vitro and In Vivo Antitumor Activity, as Potential Therapy for Bone and Soft-Tissue Sarcoma
- (2014) E. K. Slotkin et al. MOLECULAR CANCER THERAPEUTICS
- Cl- and K+ channels and their role in primary brain tumour biology
- (2014) K. L. Turner et al. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
- Ion channels and apoptosis in cancer
- (2014) C. D. Bortner et al. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
- Ginsenoside 20(S)-Rg3 Targets HIF-1α to Block Hypoxia-Induced Epithelial-Mesenchymal Transition in Ovarian Cancer Cells
- (2014) Ting Liu et al. PLoS One
- Loss of the tumor suppressor LKB1 promotes metabolic reprogramming of cancer cells via HIF-1
- (2014) B. Faubert et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Optimization of potent and selective dual mTORC1 and mTORC2 inhibitors: The discovery of AZD8055 and AZD2014
- (2013) Kurt G. Pike et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- A Phase II Trial of Temsirolimus in Men With Castration-Resistant Metastatic Prostate Cancer
- (2013) Andrew J. Armstrong et al. Clinical Genitourinary Cancer
- Inhibition of glutaminase selectively suppresses the growth of primary acute myeloid leukemia cells with IDH mutations
- (2013) Ashkan Emadi et al. EXPERIMENTAL HEMATOLOGY
- Everolimus for Previously Treated Advanced Gastric Cancer: Results of the Randomized, Double-Blind, Phase III GRANITE-1 Study
- (2013) Atsushi Ohtsu et al. JOURNAL OF CLINICAL ONCOLOGY
- Metformin Therapy and Risk of Cancer in Patients with Type 2 Diabetes: Systematic Review
- (2013) Monica Franciosi et al. PLoS One
- Persistent Current Blockers of Voltage-Gated Sodium Channels: A Clinical Opportunity for Controlling Metastatic Disease
- (2013) Mustafa B.A. Djamgoz et al. Recent Patents on Anti-Cancer Drug Discovery
- Metformin targets ovarian cancer stem cells in vitro and in vivo
- (2012) Jessica J. Shank et al. GYNECOLOGIC ONCOLOGY
- Safety and tolerability of AZD8055 in Japanese patients with advanced solid tumors; a dose-finding phase I study
- (2012) Hajime Asahina et al. INVESTIGATIONAL NEW DRUGS
- Design, Synthesis, and Pharmacological Evaluation of Bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl Sulfide 3 (BPTES) Analogs as Glutaminase Inhibitors
- (2012) Krupa Shukla et al. JOURNAL OF MEDICINAL CHEMISTRY
- hERG K+ Channels: Structure, Function, and Clinical Significance
- (2012) Jamie I. Vandenberg et al. PHYSIOLOGICAL REVIEWS
- Hallmarks of Cancer: The Next Generation
- (2011) Douglas Hanahan et al. CELL
- Rapamycin passes the torch: a new generation of mTOR inhibitors
- (2011) Don Benjamin et al. NATURE REVIEWS DRUG DISCOVERY
- Current development of the second generation of mTOR inhibitors as anticancer agents
- (2011) Hong-Yu Zhou et al. Chinese Journal of Cancer
- Metformin and Cancer Risk in Diabetic Patients: A Systematic Review and Meta-analysis
- (2010) A. DeCensi et al. Cancer Prevention Research
- Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1
- (2010) Katrin Düvel et al. MOLECULAR CELL
- Effective and selective targeting of leukemia cells using a TORC1/2 kinase inhibitor
- (2010) Matthew R Janes et al. NATURE MEDICINE
- Targeting mTOR: prospects for mTOR complex 2 inhibitors in cancer therapy
- (2010) C A Sparks et al. ONCOGENE
- FDA Approval Summary: Temsirolimus as Treatment for Advanced Renal Cell Carcinoma
- (2010) V. E. Kwitkowski et al. ONCOLOGIST
- Therapeutic potential of KCa3.1 blockers: recent advances and promising trends
- (2010) Heike Wulff et al. Expert Review of Clinical Pharmacology
- AZD8055 Is a Potent, Selective, and Orally Bioavailable ATP-Competitive Mammalian Target of Rapamycin Kinase Inhibitor with In vitro and In vivo Antitumor Activity
- (2009) C. M. Chresta et al. CANCER RESEARCH
- An Unexpected Role for Ion Channels in Brain Tumor Metastasis
- (2008) Harald Sontheimer EXPERIMENTAL BIOLOGY AND MEDICINE
- A RNA antagonist of hypoxia-inducible factor-1 , EZN-2968, inhibits tumor cell growth
- (2008) L. M. Greenberger et al. MOLECULAR CANCER THERAPEUTICS
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