Metabolic Reprogramming in Breast Cancer and Its Therapeutic Implications

Transketolase Regulates the Metabolic Switch to Control Breast Cancer Cell Metastasis via the α-Ketoglutarate Signaling Pathway

(2018) Chien-Wei Tseng et al.   CANCER RESEARCH

FGFR4 Links Glucose Metabolism and Chemotherapy Resistance in Breast Cancer

(2018) Min Xu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Uncoupling effects of estrogen receptor α on LKB1/AMPK interaction upon adiponectin exposure in breast cancer

(2018) Loredana Mauro et al.   FASEB JOURNAL

BRCA1 through Its E3 Ligase Activity Regulates the Transcription Factor Oct1 and Carbohydrate Metabolism

(2018) Karina Vázquez-Arreguín et al.   MOLECULAR CANCER RESEARCH

Adipocyte/breast cancer cell crosstalk in obesity interferes with the anti-proliferative efficacy of tamoxifen

(2018) Lauriane Bougaret et al.   PLoS One

Multifaceted Roles of Interleukin-6 in Adipocyte–Breast Cancer Cell Interaction

(2018) Jones Gyamfi et al.   Translational Oncology

Global metabolite profiling analysis of lipotoxicity in HER2/neu-positive breast cancer cells

(2018) Jan Baumann et al.   Oncotarget

Metabolic Frugality Marks Cancer Cells for Immune Targeting

(2018) Lucas B. Sullivan   CELL

Urea Cycle Dysregulation Generates Clinically Relevant Genomic and Biochemical Signatures

(2018) Joo Sang Lee et al.   CELL

Intratumor lactate levels reflect HER2 addiction status in HER2-positive breast cancer

(2018) Lorenzo Castagnoli et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Elucidating the novel BRCA1 function as a non-genomic metabolic restraint in ER-positive breast cancer cell lines

(2018) Moses Koobotse et al.   Oncotarget

Inhibition of glycolysis by a novel EGFR/HER2 inhibitor KU004 suppresses the growth of HER2+ cancer

(2017) Chongchong Tian et al.   EXPERIMENTAL CELL RESEARCH

Neuromedin U alters bioenergetics and expands the cancer stem cell phenotype in HER2-positive breast cancer

(2017) Vanesa G. Martinez et al.   INTERNATIONAL JOURNAL OF CANCER

Post-transcriptional regulation of ERBB2 by miR26a/b and HuR confers resistance to tamoxifen in estrogen receptor-positive breast cancer cells

(2017) Sheng Tan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metabolic shifts in residual breast cancer drive tumor recurrence

(2017) Kristina M. Havas et al.   JOURNAL OF CLINICAL INVESTIGATION

Estrogen Receptor β as a Therapeutic Target in Breast Cancer Stem Cells

(2017) Ran Ma et al.   JNCI-Journal of the National Cancer Institute

Effect of Mutant p53 Proteins on Glycolysis and Mitochondrial Metabolism

(2017) Matilda Eriksson et al.   MOLECULAR AND CELLULAR BIOLOGY

Nuclear Acetyl-CoA Production by ACLY Promotes Homologous Recombination

(2017) Sharanya Sivanand et al.   MOLECULAR CELL

The branched-chain amino acid transaminase 1 sustains growth of antiestrogen-resistant and ERα-negative breast cancer

(2017) V Thewes et al.   ONCOGENE

Metabolic recycling of ammonia via glutamate dehydrogenase supports breast cancer biomass

(2017) Jessica B. Spinelli et al.   SCIENCE

The receptor tyrosine kinase EphA2 promotes glutamine metabolism in tumors by activating the transcriptional coactivators YAP and TAZ

(2017) Deanna N. Edwards et al.   Science Signaling

Proline metabolism supports metastasis formation and could be inhibited to selectively target metastasizing cancer cells

(2017) Ilaria Elia et al.   Nature Communications

Citrate Suppresses Tumor Growth in Multiple Models through Inhibition of Glycolysis, the Tricarboxylic Acid Cycle and the IGF-1R Pathway

(2017) Jian-Guo Ren et al.   Scientific Reports

Acetate Recapturing by Nuclear Acetyl-CoA Synthetase 2 Prevents Loss of Histone Acetylation during Oxygen and Serum Limitation

(2017) Vinay Bulusu et al.   Cell Reports

Targeting Metabolic Remodeling in Triple Negative Breast Cancer in a Murine Model

(2017) Verónica García-Castillo et al.   Journal of Cancer

Estrogen Receptor β as a Therapeutic Target in Breast Cancer Stem Cells

(2017) Ran Ma et al.   JNCI-Journal of the National Cancer Institute

The receptor tyrosine kinase EphA2 promotes glutamine metabolism in tumors by activating the transcriptional coactivators YAP and TAZ

(2017) Deanna N. Edwards et al.   Science Signaling

Estrogen Receptor-β Modulation of the ERα-p53 Loop Regulating Gene Expression, Proliferation, and Apoptosis in Breast Cancer

(2017) Wenwen Lu et al.   Hormones & Cancer

The miR-29 transcriptome in endocrine-sensitive and resistant breast cancer cells

(2017) Penn Muluhngwi et al.   Scientific Reports

Inhibition of 6-phosphofructo-2-kinase (PFKFB3) suppresses glucose metabolism and the growth of HER2+ breast cancer

(2016) Julie O’Neal et al.   BREAST CANCER RESEARCH AND TREATMENT

Repression of phosphoglycerate dehydrogenase sensitizes triple-negative breast cancer to doxorubicin

(2016) Xia Zhang et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

HER2 Signaling Drives DNA Anabolism and Proliferation through SRC-3 Phosphorylation and E2F1-Regulated Genes

(2016) Bryan C. Nikolai et al.   CANCER RESEARCH

TP53 mutation, mitochondria and cancer

(2016) William M Kamp et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Nuclear respiratory factor-1 and bioenergetics in tamoxifen-resistant breast cancer cells

(2016) Brandie N. Radde et al.   EXPERIMENTAL CELL RESEARCH

p53 as guardian of the mitochondrial genome

(2016) Ji-Hoon Park et al.   FEBS LETTERS

DNAJA1 controls the fate of misfolded mutant p53 through the mevalonate pathway

(2016) Alejandro Parrales et al.   NATURE CELL BIOLOGY

Inhibition of fatty acid oxidation as a therapy for MYC-overexpressing triple-negative breast cancer

(2016) Roman Camarda et al.   NATURE MEDICINE

Cancer metabolism: a therapeutic perspective

(2016) Ubaldo E. Martinez-Outschoorn et al.   Nature Reviews Clinical Oncology

Phosphoglycerate mutase 1 promotes cancer cell migration independent of its metabolic activity

(2016) D Zhang et al.   ONCOGENE

The somatic mutation profiles of 2,433 breast cancers refines their genomic and transcriptomic landscapes

(2016) Bernard Pereira et al.   Nature Communications

Self-renewal of CD133hi cells by IL6/Notch3 signalling regulates endocrine resistance in metastatic breast cancer

(2016) Pasquale Sansone et al.   Nature Communications

ERβ decreases the invasiveness of triple-negative breast cancer cells by regulating mutant p53 oncogenic function

(2016) Igor Bado et al.   Oncotarget

Germline BRCA1 mutation reprograms breast epithelial cell metabolism towards mitochondrial-dependent biosynthesis: evidence for metformin-based “starvation” strategies in BRCA1 carriers

(2016) Elisabet Cuyàs et al.   Oncotarget

Fatty Acid Oxidation-Driven Src Links Mitochondrial Energy Reprogramming and Oncogenic Properties in Triple-Negative Breast Cancer

(2016) Jun Hyoung Park et al.   Cell Reports

Fundamentals of cancer metabolism

(2016) R. J. DeBerardinis et al.   Science Advances

Collagen Matrix Density Drives the Metabolic Shift in Breast Cancer Cells

(2016) Brett A. Morris et al.   EBioMedicine

Acetyl-CoA Synthetase 2 Promotes Acetate Utilization and Maintains Cancer Cell Growth under Metabolic Stress

(2015) Zachary T. Schug et al.   CANCER CELL

Glutathione and Thioredoxin Antioxidant Pathways Synergize to Drive Cancer Initiation and Progression

(2015) Isaac S. Harris et al.   CANCER CELL

Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression

(2015) Chih-Hao Chang et al.   CELL

PDK1-Dependent Metabolic Reprogramming Dictates Metastatic Potential in Breast Cancer

(2015) Fanny Dupuy et al.   Cell Metabolism

Mitochondrial Genome Acquisition Restores Respiratory Function and Tumorigenic Potential of Cancer Cells without Mitochondrial DNA

(2015) An S. Tan et al.   Cell Metabolism

Aerobic glycolysis tunes YAP/TAZ transcriptional activity

(2015) E. Enzo et al.   EMBO JOURNAL

p53 in survival, death and metabolic health: a lifeguard with a licence to kill

(2015) Flore Kruiswijk et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Estrogen receptor-α directly regulates the hypoxia-inducible factor 1 pathway associated with antiestrogen response in breast cancer

(2015) Jun Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolic reprogramming in triple-negative breast cancer through Myc suppression of TXNIP

(2015) Liangliang Shen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolic Plasticity of Metastatic Breast Cancer Cells: Adaptation to Changes in the Microenvironment

(2015) Rui V. Simões et al.   NEOPLASIA

Differential Expression of Lipid Metabolism-Related Proteins in Different Breast Cancer Subtypes

(2015) Sewha Kim et al.   PLoS One

Inhibition of Aerobic Glycolysis Represses Akt/mTOR/HIF-1α Axis and Restores Tamoxifen Sensitivity in Antiestrogen-Resistant Breast Cancer Cells

(2015) Yu Mi Woo et al.   PLoS One

Tissue-specific isoform switch and DNA hypomethylation of the pyruvate kinase PKM gene in human cancers

(2015) Shruti Desai et al.   Oncotarget

SLC25A1, or CIC, is a novel transcriptional target of mutant p53 and a negative tumor prognostic marker.

(2015) Vamsi K. Kolukula et al.   Oncotarget

Pre-clinical study of drug combinations that reduce breast cancer burden due to aberrant mTOR and metabolism promoted by LKB1 loss

(2015) Rafaela Andrade-Vieira et al.   Oncotarget

Metabolic characterization of triple negative breast cancer

(2014) Maria D Cao et al.   BMC CANCER

ERβ1: characterization, prognosis, and evaluation of treatment strategies in ERα-positive and -negative breast cancer

(2014) Jordan M Reese et al.   BMC CANCER

Gain of Glucose-Independent Growth upon Metastasis of Breast Cancer Cells to the Brain

(2014) J. Chen et al.   CANCER RESEARCH

Invasive Lobular Carcinoma Cell Lines Are Characterized by Unique Estrogen-Mediated Gene Expression Patterns and Altered Tamoxifen Response

(2014) M. J. Sikora et al.   CANCER RESEARCH

Akt-Dependent Metabolic Reprogramming Regulates Tumor Cell Histone Acetylation

(2014) Joyce V. Lee et al.   Cell Metabolism

BRCA1 And Estrogen/Estrogen Receptor In Breast Cancer: Where They Interact?

(2014) Li Wang et al.   International Journal of Biological Sciences

Estradiol Stimulates Glucose Metabolism via 6-Phosphofructo-2-kinase (PFKFB3)

(2014) Yoannis Imbert-Fernandez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gain-of-Function Mutant p53 Promotes Cell Growth and Cancer Cell Metabolism via Inhibition of AMPK Activation

(2014) Ge Zhou et al.   MOLECULAR CELL

Fructose-1,6-bisphosphatase opposes renal carcinoma progression

(2014) Bo Li et al.   NATURE

PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis

(2014) Valerie S. LeBleu et al.   NATURE CELL BIOLOGY

Isocitrate Dehydrogenase 1 (IDH1) Mutation in Breast Adenocarcinoma Is Associated With Elevated Levels of Serum and Urine 2-Hydroxyglutarate

(2014) A. T. Fathi et al.   ONCOLOGIST

BRCA1 Induces Major Energetic Metabolism Reprogramming in Breast Cancer Cells

(2014) Maud Privat et al.   PLoS One

Ribosomal protein-Mdm2-p53 pathway coordinates nutrient stress with lipid metabolism by regulating MCD and promoting fatty acid oxidation

(2014) Y. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A DERL3-associated defect in the degradation of SLC2A1 mediates the Warburg effect

(2014) Paula Lopez-Serra et al.   Nature Communications

Targeting Arginine-Dependent Cancers with Arginine-Degrading Enzymes: Opportunities and Challenges

(2014) Melissa M. Phillips et al.   Cancer Research and Treatment

Bromodomain Protein BRD4 Is Required for Estrogen Receptor-Dependent Enhancer Activation and Gene Transcription

(2014) Sankari Nagarajan et al.   Cell Reports

Loss of FBP1 by Snail-Mediated Repression Provides Metabolic Advantages in Basal-like Breast Cancer

(2013) Chenfang Dong et al.   CANCER CELL

Optical Metabolic Imaging Identifies Glycolytic Levels, Subtypes, and Early-Treatment Response in Breast Cancer

(2013) A. J. Walsh et al.   CANCER RESEARCH

Antioxidant Enzymes Mediate Survival of Breast Cancer Cells Deprived of Extracellular Matrix

(2013) C. A. Davison et al.   CANCER RESEARCH

Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis

(2013) Chih-Hao Chang et al.   CELL

p53-dependent regulation of metabolic function through transcriptional activation of pantothenate kinase-1 gene

(2013) Shang-Jui Wang et al.   CELL CYCLE

Depletion of the novel p53-target gene carnitine palmitoyltransferase 1C delays tumor growth in the neurofibromatosis type I tumor model

(2013) N Sanchez-Macedo et al.   CELL DEATH AND DIFFERENTIATION

Support of a bi-faceted role of estrogen receptor β (ERβ) in ERα-positive breast cancer cells

(2013) Philip Jonsson et al.   ENDOCRINE-RELATED CANCER

A bi-faceted role of estrogen receptor β in breast cancer

(2013) Etienne Leygue et al.   ENDOCRINE-RELATED CANCER

MYC-driven accumulation of 2-hydroxyglutarate is associated with breast cancer prognosis

(2013) Atsushi Terunuma et al.   JOURNAL OF CLINICAL INVESTIGATION

Tumor suppressor p53 and estrogen receptors in nuclear–mitochondrial communication

(2013) Nadi T. Wickramasekera et al.   MITOCHONDRION

Increased Oxidative Metabolism in the Li–Fraumeni Syndrome

(2013) Ping-Yuan Wang et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mitochondrial retrograde signaling induces epithelial–mesenchymal transition and generates breast cancer stem cells

(2013) M Guha et al.   ONCOGENE

Crosstalk from Non-Cancerous Mitochondria Can Inhibit Tumor Properties of Metastatic Cells by Suppressing Oncogenic Pathways

(2013) Benny Abraham Kaipparettu et al.   PLoS One

JMJD5 regulates PKM2 nuclear translocation and reprograms HIF-1 -mediated glucose metabolism

(2013) H.-J. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Somatic loss of p53 leads to stem/progenitor cell amplification in both mammary epithelial compartments, basal and luminal

(2013) Aurélie Chiche et al.   STEM CELLS

Manganese superoxide dismutase promotes anoikis resistance and tumor metastasis

(2013) S Kamarajugadda et al.   Cell Death & Disease

Tumour-associated mutant p53 drives the Warburg effect

(2013) Cen Zhang et al.   Nature Communications

Estrogen receptor β activation impairs mitochondrial oxidative metabolism and affects malignant mesothelioma cell growth in vitro and in vivo

(2013) A G Manente et al.   Oncogenesis

Glutamine fuels a vicious cycle of autophagy in the tumor stroma and oxidative mitochondrial metabolism in epithelial cancer cells

(2012) Ying-Hui Ko et al.   CANCER BIOLOGY & THERAPY

Tumor Suppression in the Absence of p53-Mediated Cell-Cycle Arrest, Apoptosis, and Senescence

(2012) Tongyuan Li et al.   CELL

The Skp2-SCF E3 Ligase Regulates Akt Ubiquitination, Glycolysis, Herceptin Sensitivity, and Tumorigenesis

(2012) Chia-Hsin Chan et al.   CELL

Mutant p53 Disrupts Mammary Tissue Architecture via the Mevalonate Pathway

(2012) William A. Freed-Pastor et al.   CELL

BRCA1 mutations drive oxidative stress and glycolysis in the tumor microenvironment

(2012) Ubaldo E. Martinez-Outschoorn et al.   CELL CYCLE

Glucose Oxidation Modulates Anoikis and Tumor Metastasis

(2012) S. Kamarajugadda et al.   MOLECULAR AND CELLULAR BIOLOGY

Research Resource: Transcriptional Profiling in a Cellular Model of Breast Cancer Reveals Functional and Mechanistic Differences Between Clinically Relevant SERM and Between SERM/Estrogen Complexes

(2012) Suzanne E. Wardell et al.   MOLECULAR ENDOCRINOLOGY

Estrogen Modulates Metabolic Pathway Adaptation to Available Glucose in Breast Cancer Cells

(2012) Fiona O'Mahony et al.   MOLECULAR ENDOCRINOLOGY

Whole-genome analysis informs breast cancer response to aromatase inhibition

(2012) Matthew J. Ellis et al.   NATURE

The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups

(2012) Christina Curtis et al.   NATURE

The gain of function of p53 cancer mutant in promoting mammary tumorigenesis

(2012) X Lu et al.   ONCOGENE

Differential Gene Expression in Tamoxifen-Resistant Breast Cancer Cells Revealed by a New Analytical Model of RNA-Seq Data

(2012) Kathryn J. Huber-Keener et al.   PLoS One

Estrogen receptor prevents p53-dependent apoptosis in breast cancer

(2012) S. T. Bailey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A new role of p53 in regulating lipid metabolism

(2012) Xingwu Wang et al.   Journal of Molecular Cell Biology

Receptor tyrosine kinase ErbB2 translocates into mitochondria and regulates cellular metabolism

(2012) Yan Ding et al.   Nature Communications

Cooperativity of Rb, Brca1, and p53 in Malignant Breast Cancer Evolution

(2012) Prashant Kumar et al.   PLoS Genetics

SIRT3 Opposes Reprogramming of Cancer Cell Metabolism through HIF1α Destabilization

(2011) Lydia W.S. Finley et al.   CANCER CELL

p53 Negatively Regulates Transcription of the Pyruvate Dehydrogenase Kinase Pdk2

(2011) T. Contractor et al.   CANCER RESEARCH

Overcoming Trastuzumab Resistance in Breast Cancer by Targeting Dysregulated Glucose Metabolism

(2011) Y. Zhao et al.   CANCER RESEARCH

Cancer-Associated Adipocytes Exhibit an Activated Phenotype and Contribute to Breast Cancer Invasion

(2011) B. Dirat et al.   CANCER RESEARCH

A Rapid, Extensive, and Transient Transcriptional Response to Estrogen Signaling in Breast Cancer Cells

(2011) Nasun Hah et al.   CELL

The reverse Warburg effect: Aerobic glycolysis in cancer associated fibroblasts and the tumor stroma

(2011) Stephanos Pavlides et al.   CELL CYCLE

ROS-Mediated p53 Induction of Lpin1 Regulates Fatty Acid Oxidation in Response to Nutritional Stress

(2011) Wissam Assaily et al.   MOLECULAR CELL

p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase

(2011) Peng Jiang et al.   NATURE CELL BIOLOGY

Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth

(2011) Kristin M Nieman et al.   NATURE MEDICINE

Aberrant Promoter CpG Methylation Is a Mechanism for Impaired PHD3 Expression in a Diverse Set of Malignant Cells

(2011) Trenton L. Place et al.   PLoS One

Estrogen Receptor Silencing Induces Epithelial to Mesenchymal Transition in Human Breast Cancer Cells

(2011) Sanaa Al Saleh et al.   PLoS One

Parkin, a p53 target gene, mediates the role of p53 in glucose metabolism and the Warburg effect

(2011) C. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ER -Dependent E2F Transcription Can Mediate Resistance to Estrogen Deprivation in Human Breast Cancer

(2011) T. W. Miller et al.   Cancer Discovery

Functional effects of cancer mitochondria on energy metabolism and tumorigenesis: utility of transmitochondrial cybrids

(2010) Benny Abraham Kaipparettu et al.   Annals of the New York Academy of Sciences

BRCA1-mutated and basal-like breast cancers have similar aCGH profiles and a high incidence of protein truncating TP53 mutations

(2010) Henne Holstege et al.   BMC CANCER

The Common Feature of Leukemia-Associated IDH1 and IDH2 Mutations Is a Neomorphic Enzyme Activity Converting α-Ketoglutarate to 2-Hydroxyglutarate

(2010) Patrick S. Ward et al.   CANCER CELL

The autophagic tumor stroma model of cancer

(2010) Stephanos Pavlides et al.   CELL CYCLE

Oxidative stress in cancer associated fibroblasts drives tumor-stroma co-evolution

(2010) Ubaldo E. Martinez-Outschoorn et al.   CELL CYCLE

IDH1 mutations in patients with myelodysplastic syndromes are associated with an unfavorable prognosis

(2010) F. Thol et al.   HAEMATOLOGICA

17β-estradiol supplementation attenuates ovariectomy-induced increases in ATGL signaling and reduced perilipin expression in visceral adipose tissue

(2010) Lindsay M. Wohlers et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

American Society of Clinical Oncology/College of American Pathologists Guideline Recommendations for Immunohistochemical Testing of Estrogen and Progesterone Receptors in Breast Cancer

(2010) M. Elizabeth H. Hammond et al.   JOURNAL OF CLINICAL ONCOLOGY

17 -Estradiol Augments 18F-FDG Uptake and Glycolysis of T47D Breast Cancer Cells via Membrane-Initiated Rapid PI3K-Akt Activation

(2010) B.-H. Ko et al.   JOURNAL OF NUCLEAR MEDICINE

IDH1 and IDH2 mutation analysis in chronic- and blast-phase myeloproliferative neoplasms

(2010) A Pardanani et al.   LEUKEMIA

Parenteral 17beta-estradiol decreases fasting blood glucose levels in non-obese mice with short-term ovariectomy

(2010) Ju-Young Kim et al.   LIFE SCIENCES

Genome-Wide Analysis of Estrogen Receptor   DNA Binding and Tethering Mechanisms Identifies Runx1 as a Novel Tethering Factor in Receptor-Mediated Transcriptional Activation

(2010) J. D. Stender et al.   MOLECULAR AND CELLULAR BIOLOGY

Minireview: Estrogen Receptor-β: Mechanistic Insights from Recent Studies

(2010) Bonnie J. Deroo et al.   MOLECULAR ENDOCRINOLOGY

Mechanisms of estrogen receptor antagonism toward p53 and its implications in breast cancer therapeutic response and stem cell regulation

(2010) S. D. Konduri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species

(2010) S. Suzuki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function

(2010) W. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The regulation of energy metabolism and the IGF-1/mTOR pathways by the p53 protein

(2010) Zhaohui Feng et al.   TRENDS IN CELL BIOLOGY

Metastasis suppression by adiponectin

(2010) Neeraj K. Saxena et al.   Cell Adhesion & Migration

Type and frequency of IDH1 and IDH2 mutations are related to astrocytic and oligodendroglial differentiation and age: a study of 1,010 diffuse gliomas

(2009) Christian Hartmann et al.   ACTA NEUROPATHOLOGICA

Participation of ERα and ERβ in glucose homeostasis in skeletal muscle and white adipose tissue

(2009) Rodrigo P. A. Barros et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Mitochondrial dysfunction in human breast cancer cells and their transmitochondrial cybrids

(2009) Yewei Ma et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Transcriptional Regulation of Estrogen Receptor-  by p53 in Human Breast Cancer Cells

(2009) S. H. Shirley et al.   CANCER RESEARCH

Positive Cross-Talk between Estrogen Receptor and NF- B in Breast Cancer

(2009) J. Frasor et al.   CANCER RESEARCH

Blinded by the Light: The Growing Complexity of p53

(2009) Karen H. Vousden et al.   CELL

The Tumor Suppressor p53 Regulates Polarity of Self-Renewing Divisions in Mammary Stem Cells

(2009) Angelo Cicalese et al.   CELL

p53 Improves Aerobic Exercise Capacity and Augments Skeletal Muscle Mitochondrial DNA Content

(2009) Joon-Young Park et al.   CIRCULATION RESEARCH

Pleiotropic combinatorial transcriptomes of human breast cancer cells exposed to mixtures of dietary phytoestrogens

(2009) Ramiro Dip et al.   FOOD AND CHEMICAL TOXICOLOGY

Targeting glucose metabolism with 2-deoxy-D-glucose for improving cancer therapy

(2009) BS Dwarakanath et al.   Future Oncology

IDH1mutations at residue p.R132 (IDH1R132) occur frequently in high-grade gliomas but not in other solid tumors

(2009) Fonnet E. Bleeker et al.   HUMAN MUTATION

Genome-Wide Dynamics of Chromatin Binding of Estrogen Receptors α and β: Mutual Restriction and Competitive Site Selection

(2009) Tze Howe Charn et al.   MOLECULAR ENDOCRINOLOGY

Upregulation of lactate dehydrogenase A by ErbB2 through heat shock factor 1 promotes breast cancer cell glycolysis and growth

(2009) Y H Zhao et al.   ONCOGENE

MUC1-induced alterations in a lipid metabolic gene network predict response of human breast cancers to tamoxifen treatment

(2009) S. P. Pitroda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Luteolin as a glycolysis inhibitor offers superior efficacy and lesser toxicity of doxorubicin in breast cancer cells

(2008) Gang-Jun Du et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cancer Cell Metabolism: Warburg and Beyond

(2008) Peggy P. Hsu et al.   CELL

Nuclear and Cytoplasmic Expression of ER 1, ER 2, and ER 5 Identifies Distinct Prognostic Outcome for Breast Cancer Patients

(2008) A. M. Shaaban et al.   CLINICAL CANCER RESEARCH

Glucose deprivation inhibits multiple key gene expression events and effector functions in CD8+ T cells

(2008) Candace M. Cham et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Clinical Importance of Estrogen Receptor-β Evaluation in Breast Cancer Patients Treated With Adjuvant Tamoxifen Therapy

(2008) Naoko Honma et al.   JOURNAL OF CLINICAL ONCOLOGY

Estrogen receptor alpha negative breast cancer patients: Estrogen receptor beta as a therapeutic target

(2008) George P. Skliris et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

AKT Alters Genome-Wide Estrogen Receptor   Binding and Impacts Estrogen Signaling in Breast Cancer

(2008) P. Bhat-Nakshatri et al.   MOLECULAR AND CELLULAR BIOLOGY

Estrogen Receptors α and β as Determinants of Gene Expression: Influence of Ligand, Dose, and Chromatin Binding

(2008) Edmund C. Chang et al.   MOLECULAR ENDOCRINOLOGY

p53 regulates glucose metabolism through an IKK-NF-κB pathway and inhibits cell transformation

(2008) Keiko Kawauchi et al.   NATURE CELL BIOLOGY

Altered mammary gland development in the p53+/m mouse, a model of accelerated aging

(2007) Catherine E. Gatza et al.   DEVELOPMENTAL BIOLOGY

Estradiol Stimulates Transcription of Nuclear Respiratory Factor-1 and Increases Mitochondrial Biogenesis

(2007) Kathleen A. Mattingly et al.   MOLECULAR ENDOCRINOLOGY