Transsulfuration, minor player or crucial for cysteine homeostasis in cancer

Ferroptosis inducers are a novel therapeutic approach for advanced prostate cancer

(2021) Ali Ghoochani et al.   CANCER RESEARCH

Phospholipase iPLA2β averts ferroptosis by eliminating a redox lipid death signal

(2021) Wan-Yang Sun et al.   Nature Chemical Biology

Understanding the role of cysteine in ferroptosis: progress & paradoxes

(2021) Carson D. Poltorack et al.   FEBS Journal

DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer

(2021) Chao Mao et al.   NATURE

Organelle-specific regulation of ferroptosis

(2021) Xin Chen et al.   CELL DEATH AND DIFFERENTIATION

iPLA2β-mediated lipid detoxification controls p53-driven ferroptosis independent of GPX4

(2021) Delin Chen et al.   Nature Communications

Proteomic screens for suppressors of anoikis identify IL1RAP as a promising surface target in Ewing sarcoma

(2021) Hai-Feng Zhang et al.   Cancer Discovery

Cystathionine β-synthase mediated PRRX2/IL-6/STAT3 inactivation suppresses Tregs infiltration and induces apoptosis to inhibit HCC carcinogenesis

(2021) Yu-Fu Zhou et al.   Journal for ImmunoTherapy of Cancer

SLC25A39 is necessary for mitochondrial glutathione import in mammalian cells

(2021) Ying Wang et al.   NATURE

The Thioredoxin System: a Promising Target for Cancer Drug Development

(2020) Norman Metanis et al.   CHEMISTRY-A EUROPEAN JOURNAL

DJ-1 suppresses ferroptosis through preserving the activity of S-adenosyl homocysteine hydrolase

(2020) Ji Cao et al.   Nature Communications

Cystine transporter regulation of pentose phosphate pathway dependency and disulfide stress exposes a targetable metabolic vulnerability in cancer

(2020) Xiaoguang Liu et al.   NATURE CELL BIOLOGY

Cysteine depletion induces pancreatic tumor ferroptosis in mice

(2020) Michael A. Badgley et al.   SCIENCE

Single cell transcriptomes of normal endometrial derived organoids uncover novel cell type markers and cryptic differentiation of primary tumours

(2020) Dawn R. Cochrane et al.   JOURNAL OF PATHOLOGY

Metabolic determinants of cancer cell sensitivity to canonical ferroptosis inducers

(2020) Mariluz Soula et al.   Nature Chemical Biology

Emerging Mechanisms and Disease Relevance of Ferroptosis

(2020) Brent R. Stockwell et al.   TRENDS IN CELL BIOLOGY

HNF4α regulates sulfur amino acid metabolism and confers sensitivity to methionine restriction in liver cancer

(2020) Qing Xu et al.   Nature Communications

xCT: A Critical Molecule That Links Cancer Metabolism to Redox Signaling

(2020) Jinyun Liu et al.   MOLECULAR THERAPY

Systematic identification of a nuclear receptor-enriched predictive signature for erastin-induced ferroptosis

(2020) Ok-Seon Kwon et al.   Redox Biology

Non-canonical Glutamate-Cysteine Ligase Activity Protects against Ferroptosis

(2020) Yun Pyo Kang et al.   Cell Metabolism

Signaling by hydrogen sulfide and polysulfides via protein S-sulfuration

(2019) Hideo Kimura   BRITISH JOURNAL OF PHARMACOLOGY

Deubiquitinases Maintain Protein Homeostasis and Survival of Cancer Cells upon Glutathione Depletion

(2019) Isaac S. Harris et al.   Cell Metabolism

Cystine/glutamate antiporter xCT (SLC7A11) facilitates oncogenic RAS transformation by preserving intracellular redox balance

(2019) Jonathan K. M. Lim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quantification of microenvironmental metabolites in murine cancers reveals determinants of tumor nutrient availability

(2019) Mark R Sullivan et al.   eLife

The Non-Essential Amino Acid Cysteine Becomes Essential for Tumor Proliferation and Survival

(2019) Joseph A. Combs et al.   Cancers

Intercellular interaction dictates cancer cell ferroptosis via NF2–YAP signalling

(2019) Jiao Wu et al.   NATURE

Dysregulation of cystathionine γ‐lyase promotes prostate cancer progression and metastasis

(2019) Yi‐Hsiang Wang et al.   EMBO REPORTS

Transsulfuration Activity Can Support Cell Growth upon Extracellular Cysteine Limitation

(2019) Jiajun Zhu et al.   Cell Metabolism

FSP1 is a glutathione-independent ferroptosis suppressor

(2019) Sebastian Doll et al.   NATURE

The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis

(2019) Kirill Bersuker et al.   NATURE

Activation of the reverse transsulfuration pathway through NRF2/CBS confers erastin-induced ferroptosis resistance

(2019) Nan Liu et al.   BRITISH JOURNAL OF CANCER

Activation of Oxidative Stress Response in Cancer Generates a Druggable Dependency on Exogenous Non-essential Amino Acids

(2019) Sarah E. LeBoeuf et al.   Cell Metabolism

Selective Persulfide Detection Reveals Evolutionarily Conserved Antiaging Effects of S-Sulfhydration

(2019) Jasmina Zivanovic et al.   Cell Metabolism

Suppression of the SLC7A11/glutathione axis causes synthetic lethality in KRAS-mutant lung adenocarcinoma

(2019) Kewen Hu et al.   JOURNAL OF CLINICAL INVESTIGATION

Coenzyme A, protein CoAlation and redox regulation in mammalian cells

(2018) Ivan Gout   BIOCHEMICAL SOCIETY TRANSACTIONS

Regulators of the Transsulfuration Pathway

(2018) Juan I Sbodio et al.   BRITISH JOURNAL OF PHARMACOLOGY

Homocysteine and Hyperhomocysteinaemia

(2018) Bozidarka L. Zaric et al.   CURRENT MEDICINAL CHEMISTRY

Disruption of De Novo Serine Synthesis in Müller Cells Induced Mitochondrial Dysfunction and Aggravated Oxidative Damage

(2018) Ting Zhang et al.   MOLECULAR NEUROBIOLOGY

Golgi stress response reprograms cysteine metabolism to confer cytoprotection in Huntington’s disease

(2018) Juan I. Sbodio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glutathione transferases: substrates, inihibitors and pro-drugs in cancer and neurodegenerative diseases

(2018) Nerino Allocati et al.   Oncogenesis

BAP1 links metabolic regulation of ferroptosis to tumour suppression

(2018) Yilei Zhang et al.   NATURE CELL BIOLOGY

A pharmacological probe identifies cystathionine β-synthase as a new negative regulator for ferroptosis

(2018) Li Wang et al.   Cell Death & Disease

Cysteine reactivity across the subcellular universe

(2018) Daniel W Bak et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

The glutamate/cystine antiporter SLC7A11/xCT enhances cancer cell dependency on glucose by exporting glutamate

(2017) Pranavi Koppula et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Clear cell and endometrioid carcinomas: are their differences attributable to distinct cells of origin?

(2017) Dawn R Cochrane et al.   JOURNAL OF PATHOLOGY

A Metabolic Function for Phospholipid and Histone Methylation

(2017) Cunqi Ye et al.   MOLECULAR CELL

mTORC2 Regulates Amino Acid Metabolism in Cancer by Phosphorylation of the Cystine-Glutamate Antiporter xCT

(2017) Yuchao Gu et al.   MOLECULAR CELL

Cystathionine β-synthase deficiency: Of mice and men

(2017) Warren D. Kruger   MOLECULAR GENETICS AND METABOLISM

NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis

(2017) Samantha W. Alvarez et al.   NATURE

Oncogenic PI3K promotes methionine dependency in breast cancer cells through the cystine-glutamate antiporter xCT

(2017) Evan C. Lien et al.   Science Signaling

The glutamate/cystine xCT antiporter antagonizes glutamine metabolism and reduces nutrient flexibility

(2017) Chun-Shik Shin et al.   Nature Communications

Environmental cystine drives glutamine anaplerosis and sensitizes cancer cells to glutaminase inhibition

(2017) Alexander Muir et al.   eLife

Activation of the NRF2 antioxidant program generates an imbalance in central carbon metabolism in cancer

(2017) Volkan I Sayin et al.   eLife

Oncogenic PI3K promotes methionine dependency in breast cancer cells through the cystine-glutamate antiporter xCT

(2017) Evan C. Lien et al.   Science Signaling

NRF2 Promotes Tumor Maintenance by Modulating mRNA Translation in Pancreatic Cancer

(2016) Iok In Christine Chio et al.   CELL

Reductive carboxylation supports redox homeostasis during anchorage-independent growth

(2016) Lei Jiang et al.   NATURE

Systemic depletion of L-cyst(e)ine with cyst(e)inase increases reactive oxygen species and suppresses tumor growth

(2016) Shira L Cramer et al.   NATURE MEDICINE

Transcriptional control of amino acid homeostasis is disrupted in Huntington’s disease

(2016) Juan I. Sbodio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial dysfunction remodels one-carbon metabolism in human cells

(2016) Xiaoyan Robert Bao et al.   eLife

Glutathione and Thioredoxin Antioxidant Pathways Synergize to Drive Cancer Initiation and Progression

(2015) Isaac S. Harris et al.   CANCER CELL

Human Pancreatic Cancer Tumors Are Nutrient Poor and Tumor Cells Actively Scavenge Extracellular Protein

(2015) J. J. Kamphorst et al.   CANCER RESEARCH

Endogenous Hydrogen Sulfide Production Is Essential for Dietary Restriction Benefits

(2015) Christopher Hine et al.   CELL

Loss of cysteinyl-tRNA synthetase (CARS) induces the transsulfuration pathway and inhibits ferroptosis induced by cystine deprivation

(2015) M Hayano et al.   CELL DEATH AND DIFFERENTIATION

Oxidative stress inhibits distant metastasis by human melanoma cells

(2015) Elena Piskounova et al.   NATURE

Ferroptosis as a p53-mediated activity during tumour suppression

(2015) Le Jiang et al.   NATURE

Antioxidants can increase melanoma metastasis in mice

(2015) Kristell Le Gal et al.   Science Translational Medicine

Dietary methionine can sustain cytosolic redox homeostasis in the mouse liver

(2015) Sofi Eriksson et al.   Nature Communications

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

Cystathionine γ-lyase deficiency mediates neurodegeneration in Huntington’s disease

(2014) Bindu D. Paul et al.   NATURE

Characterization of the Usage of the Serine Metabolic Network in Human Cancer

(2014) Mahya Mehrmohamadi et al.   Cell Reports

Pharmacological inhibition of cystine–glutamate exchange induces endoplasmic reticulum stress and ferroptosis

(2014) Scott J Dixon et al.   eLife

Integrated analysis of genome-wide copy number alterations and gene expression in microsatellite stable, CpG island methylator phenotype-negative colon cancer

(2013) Lenora W. M. Loo et al.   GENES CHROMOSOMES & CANCER

Platelet-derived growth factor-BB induces cystathionine γ-lyase expression in rat mesangial cells via a redox-dependent mechanism

(2012) Mohamed I. Hassan et al.   BRITISH JOURNAL OF PHARMACOLOGY

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Integrated Stress Response Modulates Cellular Redox State via Induction of Cystathionine γ-Lyase

(2012) Jeffrey G. Dickhout et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells

(2012) Oliver D. K. Maddocks et al.   NATURE

Stromal control of cystine metabolism promotes cancer cell survival in chronic lymphocytic leukaemia

(2012) Wan Zhang et al.   NATURE CELL BIOLOGY

Frequent Epigenetic Silencing of the Folate-Metabolising Gene Cystathionine-Beta-Synthase in Gastrointestinal Cancer

(2012) Hong Zhao et al.   PLoS One

The oxidative stress-inducible cystine/glutamate antiporter, system x c − : cystine supplier and beyond

(2011) Marcus Conrad et al.   AMINO ACIDS

A critical life-supporting role for cystathionine γ-lyase in the absence of dietary cysteine supply

(2011) Sarathi Mani et al.   FREE RADICAL BIOLOGY AND MEDICINE

Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis

(2011) Gina M. DeNicola et al.   NATURE

Increased transsulfuration mediates longevity and dietary restriction in Drosophila

(2011) H. Kabil et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cystathionine γ-Lyase-deficient Mice Require Dietary Cysteine to Protect against Acute Lethal Myopathy and Oxidative Injury

(2010) Isao Ishii et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment

(2009) Zachary T. Schafer et al.   NATURE

Association of reactive oxygen species levels and radioresistance in cancer stem cells

(2009) Maximilian Diehn et al.   NATURE

Identification of copy number gain and overexpressed genes on chromosome arm 20q by an integrative genomic approach in cervical cancer: Potential role in progression

(2008) Luigi Scotto et al.   GENES CHROMOSOMES & CANCER