Article
Biology
Pierre Jacquet, Angelique Stephanou
Summary: Using the right terminology is crucial in accurately describing biological phenomena, as inappropriate use may lead to biases in understanding, which can have negative consequences. This article focuses on the term "reprogramming" associated with cancer cell metabolism, highlighting inconsistencies in its usage and criticizing the overemphasis on the role of mutations in metabolic adaptation. With the growing interest in metabolism and the Warburg effect in cancer research, it is important to discuss these terms and concepts in detail.
Review
Nutrition & Dietetics
Boning Li, Long Sui
Summary: Metabolic reprogramming is a key feature of malignant tumors, and advances in omics studies have greatly contributed to our understanding of cancer metabolism. Cervical cancer, being prevalent globally, can be influenced by virus-associated factors like HPV. Metabolomics approaches have shown potential in identifying biomarkers for cervical disease diagnosis and therapy.
NUTRITION & METABOLISM
(2021)
Review
Oncology
Lisha Bao, Tong Xu, Xixuan Lu, Ping Huang, Zongfu Pan, Minghua Ge
Summary: Metabolism differs significantly between tumor and normal cells, with tumor cells showing enhanced aerobic glycolysis and anabolism. Understanding the metabolic changes between tumor cells and the tumor microenvironment may provide novel ideas for the treatment of tumors.
FRONTIERS IN ONCOLOGY
(2021)
Article
Endocrinology & Metabolism
Marta Mascaraque-Checa, Maria Gallego-Rentero, Jimena Nicolas-Morala, Mikel Portillo-Esnaola, Jose M. Cuezva, Salvador Gonzalez, Yolanda Gilaberte, Angeles Juarranz
Summary: This study investigates the resistance of skin squamous cell carcinoma to photodynamic therapy and identifies metabolic reprogramming as a contributing factor. The findings suggest that the adjuvant use of metformin can enhance the efficacy of photodynamic therapy.
MOLECULAR METABOLISM
(2022)
Article
Cell Biology
Merve Kulbay, Bruno Johnson, Guillaume Ricaud, Marie-Noelle Seguin-Grignon, Jacques Bernier
Summary: This study reveals that DFF40 may regulate cell metabolism and mitochondrial integrity during cell death. DFF40-deficient cells exhibit increased resistance to apoptosis and display the Warburg effect phenotype. Additionally, DFF40 can translocate to the mitochondria following apoptosis induction.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Xin Yi, Meng-ling Chang, Zeng-ding Zhou, Lei Yi, Hao Yuan, Jin Qi, Lei Yi, Jing-ning Huan, Xiao-qin Huang
Summary: This study investigates the metabolic changes in human umbilical vein endothelial cells (HUVECs) after lipopolysaccharide (LPS) stimulation and explores the effects on endothelial cell function. The results reveal alterations in central metabolism, sphingolipid metabolic pathways, and the upregulation of sphingosine-1-phosphatase 2 (SGPP2) in LPS-stimulated endothelial cells and zebrafish models. The overexpression of SGPP2 improves cell barrier function and enhances mitochondrial respiration capacity but also leads to oxidative respiration chain uncoupling. These findings provide insights into the metabolic-related mechanisms of LPS-induced endothelial injury and potential therapeutic targets for inflammation and inflammation-related diseases.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Review
Medicine, Research & Experimental
Zhenzhen Li, Chanjun Sun, Zhihai Qin
Summary: Cancer cells adapt their metabolism to proliferate and survive in harsh environments, with a close relationship between tumor microenvironment and cancer-associated fibroblasts (CAFs) playing key roles in tumor growth and metastasis. CAFs act as major regulators in shaping tumor metabolism, especially through dysregulation of metabolic pathways, influencing cancer cell behavior and response to therapy. The interaction and crosstalk between cancer cells and CAFs contribute to metabolic reprogramming that impacts cancer cell growth and progression.
Review
Oncology
Assunta Sellitto, Giovanni Pecoraro, Giorgio Giurato, Giovanni Nassa, Francesca Rizzo, Pasquale Saggese, Cesar A. Martinez, Claudio Scafoglio, Roberta Tarallo
Summary: Long non-coding RNAs (lncRNAs) play a crucial role in the metabolic reprogramming of cancer, forming a complex network of interactions. They are considered promising diagnostic and prognostic biomarkers, providing a novel approach for personalized therapy.
Review
Agriculture, Multidisciplinary
Asifa Khan, Shumaila Siddiqui, Syed Akhtar Husain, Sybille Mazurek, Mohammad Askandar Iqbal
Summary: The article discusses the differences in metabolism between cancer cells and normal cells, as well as the role of plant-based compounds in modulating cancer metabolism. It proposes a therapeutic strategy of targeting metabolic vulnerabilities of cancer using plant-based compounds.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Review
Cell Biology
Chelsea Schiliro, Bonnie L. Firestein
Summary: Cancer cells alter metabolic processes to sustain their rapid growth, including shifting from oxidative phosphorylation to aerobic glycolysis, and increasing other pathways to generate necessary molecules.
Article
Oncology
Mohammad Askandar Iqbal, Shumaila Siddiqui, Asad Ur Rehman, Farid Ahmad Siddiqui, Prithvi Singh, Bhupender Kumar, Daman Saluja
Summary: The study identified the significant roles of CBX2 and CBX7 in breast tumor metabolism, showing contrasting effects in glucose metabolism. These two isoforms are strongly correlated with breast tumor subtype aggressiveness and proliferation markers, with CBX2 being upregulated and CBX7 being downregulated in breast tumors compared to normal tissues.
MOLECULAR ONCOLOGY
(2021)
Review
Gastroenterology & Hepatology
Chiara Raggi, Maria Letizia Taddei, Colin Rae, Chiara Braconi, Fabio Marra
Summary: Metabolic reprogramming is a characteristic of cancer, allowing tumor cells to survive and proliferate in resource-limited conditions. Cholangiocarcinoma, the second most common form of primary liver cancer, is associated with metabolic alterations such as increased aerobic glycolysis and glutamine anaplerosis. Therapeutic interventions targeting these metabolic changes may have potential benefits for treating cholangiocarcinoma.
JOURNAL OF HEPATOLOGY
(2022)
Review
Cell Biology
Veronica Marabitti, Manuela Giansanti, Francesca De Mitri, Francesca Gatto, Angela Mastronuzzi, Francesca Nazio
Summary: Tumor-specific alterations in metabolism are crucial for sustaining cell growth and survival in various cancers, but the heterogeneous nature of metabolism poses challenges for effective anticancer therapies. Medulloblastoma is a highly heterogeneous pediatric brain tumor with complex intratumoral cellular diversity. This review highlights the mechanisms through which medulloblastoma cells rewire their metabolism and energy production networks to support rapid growth, resistance to stress, invasion, metastasis, and therapy. The potential clinical benefits of targeting energy metabolism in suppressing medulloblastoma progression and enhancing current therapies are also discussed.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Oncology
Yu-Ling Bin, Hong-Sai Hu, Feng Tian, Zhen-Hua Wen, Mei-Feng Yang, Ben-Hua Wu, Li-Sheng Wang, Jun Yao, De-Feng Li
Summary: This review summarizes the impact of metabolic reprogramming on the tumor microenvironment and overcoming drug resistance in gastric cancer, and discusses clinical studies on combination treatments with conventional chemotherapy or molecular targeted therapy.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Lian E. M. Stadhouders, Jonathon A. B. Smith, Brendan M. Gabriel, Sander A. J. Verbrugge, Tim D. Hammersen, Detmar Kolijn, Ilse S. P. Vogel, Abdalla D. Mohamed, Gerard M. J. de Wit, Carla Offringa, Willem M. H. Hoogaars, Sebastian Gehlert, Henning Wackerhage, Richard T. Jaspers
Summary: The Warburg effect, commonly associated with cancer, was investigated in relation to muscle hypertrophy, showing that glycolysis and non-essential amino acid synthesis play important roles in the process. Inhibiting glycolysis or key enzymes in the serine biosynthesis pathway decreased myotube size, while promoting glycolytic flux increased myotube size, suggesting a reprogramming of metabolism to facilitate anabolism in hypertrophying muscle cells.
EXPERIMENTAL CELL RESEARCH
(2023)