LKB1/AMPK Pathway and Drug Response in Cancer: A Therapeutic Perspective

Senolytics and senostatics as adjuvant tumour therapy

(2019) Susan Short et al.   EBioMedicine

LKB1 and Tumor Metabolism: The Interplay of Immune and Angiogenic Microenvironment in Lung Cancer

(2019) Laura Bonanno et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Arsenic trioxide induces autophagic cell death in osteosarcoma cells via the ROS-TFEB signaling pathway

(2018) Bowen Wu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

NRF2 addiction in cancer cells

(2018) Hiroshi Kitamura et al.   CANCER SCIENCE

Autophagy Facilitates Metadherin-Induced Chemotherapy Resistance Through the AMPK/ATG5 Pathway in Gastric Cancer

(2018) Guoqing Pei et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Hypoxia-dependent mitochondrial fission regulates endothelial progenitor cell migration, invasion, and tube formation

(2018) Da Yeon Kim et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

AMP kinase promotes glioblastoma bioenergetics and tumour growth

(2018) Rishi Raj Chhipa et al.   NATURE CELL BIOLOGY

Chloroquine inhibits cell growth in human A549 lung cancer cells by blocking autophagy and inducing mitochondrial‑mediated apoptosis

(2018) Likun Liu et al.   ONCOLOGY REPORTS

Aspirin induces autophagy via inhibition of the acetyltransferase EP300

(2018) Francesca Castoldi et al.   Oncotarget

Expression of miR-34a in T-Cells Infected by Human T-Lymphotropic Virus 1

(2018) Varun K. Sharma et al.   Frontiers in Microbiology

Involvement of NADPH Oxidase 1 in Liver Kinase B1-Mediated Effects on Tumor Angiogenesis and Growth

(2018) Elisabetta Zulato et al.   Frontiers in Oncology

LKB1 loss is associated with glutathione deficiency under oxidative stress and sensitivity of cancer cells to cytotoxic drugs and γ-irradiation

(2018) E. Zulato et al.   BIOCHEMICAL PHARMACOLOGY

Metformin Enhances Cisplatin-Induced Apoptosis and Prevents Resistance to Cisplatin in Co-mutated KRAS/LKB1 NSCLC

(2018) Massimo Moro et al.   Journal of Thoracic Oncology

Autophagy Governs Protumorigenic Effects of Mitotic Slippage–induced Senescence

(2018) Rekha Jakhar et al.   MOLECULAR CANCER RESEARCH

Lung-Enriched Mutations in the p53 Tumor Suppressor: A Paradigm for Tissue-Specific Gain of Oncogenic Function

(2018) Julie A. Barta et al.   MOLECULAR CANCER RESEARCH

Selective killing of human T-ALL cells: an integrated approach targeting redox homeostasis and the OMA1/OPA1 axis

(2018) Micol Silic-Benussi et al.   Cell Death & Disease

Co-occurring KRAS mutation/LKB1 loss in non-small cell lung cancer cells results in enhanced metabolic activity susceptible to caloric restriction: an in vitro integrated multilevel approach

(2018) Elisa Caiola et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

The critical role of AMPK in driving Akt activation under stress, tumorigenesis and drug resistance

(2018) Fei Han et al.   Nature Communications

Lkb1 deletion in murine B lymphocytes promotes cell death and cancer

(2017) George P. Souroullas et al.   EXPERIMENTAL HEMATOLOGY

AMPK activation serves a critical role in mitochondria quality control via modulating mitophagy in the heart under chronic hypoxia

(2017) Huagang Zhang et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Curcumin synergizes with 5-fluorouracil by impairing AMPK/ULK1-dependent autophagy, AKT activity and enhancing apoptosis in colon cancer cells with tumor growth inhibition in xenograft mice

(2017) Pan Zhang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Genotoxic Damage Activates the AMPK-α1 Isoform in the Nucleus via Ca 2+ /CaMKK2 Signaling to Enhance Tumor Cell Survival

(2017) Diana Vara-Ciruelos et al.   MOLECULAR CANCER RESEARCH

LKB1 pro-oncogenic activity triggers cell survival in circulating tumor cells

(2017) Elisabeth Katharina Trapp et al.   Molecular Oncology

Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK

(2017) Chen-Song Zhang et al.   NATURE

AMPK: guardian of metabolism and mitochondrial homeostasis

(2017) Sébastien Herzig et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Betulinic Acid Induces Apoptosis in Differentiated PC12 Cells Via ROS-Mediated Mitochondrial Pathway

(2017) Xi Wang et al.   NEUROCHEMICAL RESEARCH

Tracking the Evolution of Non–Small-Cell Lung Cancer

(2017) Mariam Jamal-Hanjani et al.   NEW ENGLAND JOURNAL OF MEDICINE

Study protocol of a phase IB/II clinical trial of metformin and chloroquine in patients with IDH1 -mutated or IDH2 -mutated solid tumours

(2017) Remco J Molenaar et al.   BMJ Open

AMPK Maintains Cellular Metabolic Homeostasis through Regulation of Mitochondrial Reactive Oxygen Species

(2017) Rebecca C. Rabinovitch et al.   Cell Reports

Escaping Death: Mitochondrial Redox Homeostasis in Cancer Cells

(2017) Francesco Ciccarese et al.   Frontiers in Oncology

AMPK activation protects cells from oxidative stress-induced senescence via autophagic flux restoration and intracellular NAD+elevation

(2016) Xiaojuan Han et al.   AGING CELL

A Transcriptional Signature Identifies LKB1 Functional Status as a Novel Determinant of MEK Sensitivity in Lung Adenocarcinoma

(2016) Jacob M. Kaufman et al.   CANCER RESEARCH

AMPK Facilitates Nuclear Accumulation of Nrf2 by Phosphorylating at Serine 550

(2016) Min Sung Joo et al.   MOLECULAR AND CELLULAR BIOLOGY

Inhibition of acetyl-CoA carboxylase suppresses fatty acid synthesis and tumor growth of non-small-cell lung cancer in preclinical models

(2016) Robert U Svensson et al.   NATURE MEDICINE

AMPK Activation Prevents and Reverses Drug-Induced Mitochondrial and Hepatocyte Injury by Promoting Mitochondrial Fusion and Function

(2016) Sun Woo Sophie Kang et al.   PLoS One

AMP-activated protein kinase mediates mitochondrial fission in response to energy stress

(2016) E. Q. Toyama et al.   SCIENCE

LKB1 is a DNA damage response protein that regulates cellular sensitivity to PARP inhibitors

(2016) Yi-Shu Wang et al.   Oncotarget

A novel autophagy/mitophagy inhibitor liensinine sensitizes breast cancer cells to chemotherapy through DNM1L-mediated mitochondrial fission

(2015) Jing Zhou et al.   Autophagy

Metformin: a modulator of bevacizumab activity in cancer? A case report

(2015) Stefano Indraccolo et al.   CANCER BIOLOGY & THERAPY

LKB1 Inactivation Elicits a Redox Imbalance to Modulate Non-small Cell Lung Cancer Plasticity and Therapeutic Response

(2015) Fuming Li et al.   CANCER CELL

AMPK Promotes Aberrant PGC1β Expression To Support Human Colon Tumor Cell Survival

(2015) Kurt W. Fisher et al.   MOLECULAR AND CELLULAR BIOLOGY

Chromatin to Clinic: The Molecular Rationale for PARP1 Inhibitor Function

(2015) Felix Y. Feng et al.   MOLECULAR CELL

Skp2-Dependent Ubiquitination and Activation of LKB1 Is Essential for Cancer Cell Survival under Energy Stress

(2015) Szu-Wei Lee et al.   MOLECULAR CELL

Co-occurring Genomic Alterations Define Major Subsets of KRAS-Mutant Lung Adenocarcinoma with Distinct Biology, Immune Profiles, and Therapeutic Vulnerabilities

(2015) F. Skoulidis et al.   Cancer Discovery

Honokiol activates LKB1-miR-34a axis and antagonizes the oncogenic actions of leptin in breast cancer

(2015) Dimiter B. Avtanski et al.   Oncotarget

Pre-clinical study of drug combinations that reduce breast cancer burden due to aberrant mTOR and metabolism promoted by LKB1 loss

(2015) Rafaela Andrade-Vieira et al.   Oncotarget

Chloroquine potentiates the anti-cancer effect of lidamycin on non-small cell lung cancer cells in vitro

(2014) Fang Liu et al.   ACTA PHARMACOLOGICA SINICA

LKB1 Loss at Transcriptional Level Promotes Tumor Malignancy and Poor Patient Outcomes in Colorectal Cancer

(2014) Tsung-Ying He et al.   ANNALS OF SURGICAL ONCOLOGY

LKB1 inactivation sensitizes non-small cell lung cancer to pharmacological aggravation of ER stress

(2014) Landon J. Inge et al.   CANCER LETTERS

VEGF-Targeted Therapy Stably Modulates the Glycolytic Phenotype of Tumor Cells

(2014) M. Curtarello et al.   CANCER RESEARCH

Lipoprotein internalisation induced by oncogenic AMPK activation is essential to maintain glioblastoma cell growth

(2014) M. Ríos et al.   EUROPEAN JOURNAL OF CANCER

Loss of LKB1 disrupts breast epithelial cell polarity and promotes breast cancer metastasis and invasion

(2014) Juan Li et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

LKB1 Loss Induces Characteristic Patterns of Gene Expression in Human Tumors Associated with NRF2 Activation and Attenuation of PI3K-AKT

(2014) Jacob M. Kaufman et al.   Journal of Thoracic Oncology

Metabolic-Stress-Induced Rearrangement of the 14-3-3  Interactome Promotes Autophagy via a ULK1- and AMPK-Regulated 14-3-3  Interaction with Phosphorylated Atg9

(2014) V. K. Weerasekara et al.   MOLECULAR AND CELLULAR BIOLOGY

Temozolomide induces autophagy via ATM-AMPK-ULK1 pathways in glioma

(2014) YUHUI ZOU et al.   Molecular Medicine Reports

A highly potent and selective Vps34 inhibitor alters vesicle trafficking and autophagy

(2014) Baptiste Ronan et al.   Nature Chemical Biology

LKB1 reduces ROS-mediated cell damage via activation of p38

(2014) H-G Xu et al.   ONCOGENE

Elimination of damaged mitochondria through mitophagy reduces mitochondrial oxidative stress and increases tolerance to trichothecenes

(2014) M. A. Bin-Umer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Radiation induces senescence and a bystander effect through metabolic alterations

(2014) E-C Liao et al.   Cell Death & Disease

LKB1 and AMPK and the cancer-metabolism link - ten years after

(2013) D Hardie et al.   BMC BIOLOGY

LKB1 Inactivation Dictates Therapeutic Response of Non-Small Cell Lung Cancer to the Metabolism Drug Phenformin

(2013) David B. Shackelford et al.   CANCER CELL

AMPK: A Contextual Oncogene or Tumor Suppressor?

(2013) J. Liang et al.   CANCER RESEARCH

Systematic Identification of Molecular Subtype-Selective Vulnerabilities in Non-Small-Cell Lung Cancer

(2013) Hyun Seok Kim et al.   CELL

Low concentration of metformin induces a p53-dependent senescence in hepatoma cells via activation of the AMPK pathway

(2013) GAO YI et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

The Autophagy Inhibitor Chloroquine Overcomes the Innate Resistance of Wild-Type EGFR Non-Small-Cell Lung Cancer Cells to Erlotinib

(2013) Yiyu Zou et al.   Journal of Thoracic Oncology

Proteasome Inhibitors Block DNA Repair and Radiosensitize Non-Small Cell Lung Cancer

(2013) Kyle R. Cron et al.   PLoS One

Metabolic and Functional Genomic Studies Identify Deoxythymidylate Kinase as a Target in LKB1-Mutant Lung Cancer

(2013) Y. Liu et al.   Cancer Discovery

Curcumin and synthetic analogs induce reactive oxygen species and decreases specificity protein (Sp) transcription factors by targeting microRNAs

(2012) Shruti U Gandhy et al.   BMC CANCER

AMPK Is a Negative Regulator of the Warburg Effect and Suppresses Tumor Growth In Vivo

(2012) Brandon Faubert et al.   Cell Metabolism

AMP-Activated Protein Kinase: A Target for Drugs both Ancient and Modern

(2012) D. Grahame Hardie et al.   CHEMISTRY & BIOLOGY

Reactive oxygen species in apoptosis induced by cisplatin: review of physiopathological mechanisms in animal models

(2012) Celia Casares et al.   EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY

SIRT3 Protein Deacetylates Isocitrate Dehydrogenase 2 (IDH2) and Regulates Mitochondrial Redox Status

(2012) Wei Yu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Physiological Roles of Mitochondrial Reactive Oxygen Species

(2012) Laura A. Sena et al.   MOLECULAR CELL

Systematic identification of genomic markers of drug sensitivity in cancer cells

(2012) Mathew J. Garnett et al.   NATURE

AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress

(2012) Sang-Min Jeon et al.   NATURE

Defects in Mitochondrial Fission Protein Dynamin-Related Protein 1 Are Linked to Apoptotic Resistance and Autophagy in a Lung Cancer Model

(2012) Kelly Jean Thomas et al.   PLoS One

A ROS rheostat for cell fate regulation

(2012) Maria Maryanovich et al.   TRENDS IN CELL BIOLOGY

Chloroquine enhances the cytotoxicity of topotecan by inhibiting autophagy in lung cancer cells

(2012) Yao Wang et al.   Chinese Journal of Cancer

Regulation of PGC-1α, a nodal regulator of mitochondrial biogenesis

(2011) Pablo J Fernandez-Marcos et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

AMPK-mediated increase of glycolysis as an adaptive response to oxidative stress in human cells: Implication of the cell survival in mitochondrial diseases

(2011) Shi-Bei Wu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

AMP-activated protein kinase--an energy sensor that regulates all aspects of cell function

(2011) D. G. Hardie   GENES & DEVELOPMENT

The AMPK signalling pathway coordinates cell growth, autophagy and metabolism

(2011) Maria M. Mihaylova et al.   NATURE CELL BIOLOGY

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Frequent homozygous deletion of the LKB1/STK11 gene in non-small cell lung cancer

(2011) R K Gill et al.   ONCOGENE

The LKB1/AMPK signaling pathway has tumor suppressor activity in acute myeloid leukemia through the repression of mTOR-dependent oncogenic mRNA translation

(2010) A. S. Green et al.   BLOOD

Metformin and Other Biguanides in Oncology: Advancing the Research Agenda

(2010) M. Pollak   Cancer Prevention Research

Lkb1 inactivation is sufficient to drive endometrial cancers that are aggressive yet highly responsive to mTOR inhibitor monotherapy

(2010) C. M. Contreras et al.   Disease Models & Mechanisms

Ionizing Radiation Activates AMP-Activated Kinase (AMPK): A Target for Radiosensitization of Human Cancer Cells

(2010) Toran Sanli et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Therapy-Induced Senescence in Cancer

(2010) Jonathan A. Ewald et al.   JNCI-Journal of the National Cancer Institute

Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells

(2010) Daisuke Nakada et al.   NATURE

The Lkb1 metabolic sensor maintains haematopoietic stem cell survival

(2010) Sushma Gurumurthy et al.   NATURE

Lkb1 regulates quiescence and metabolic homeostasis of haematopoietic stem cells

(2010) Boyi Gan et al.   NATURE

Mitochondrial reactive oxygen species regulate cellular signaling and dictate biological outcomes

(2010) Robert B. Hamanaka et al.   TRENDS IN BIOCHEMICAL SCIENCES

LKB1 and AMP-activated protein kinase control of mTOR signalling and growth

(2009) R. J. Shaw   Acta Physiologica

Expression of LKB1 tumor suppressor in non–small cell lung cancer determines sensitivity to 2-deoxyglucose

(2009) Landon J. Inge et al.   JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY

Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

(2009) Dunyaporn Trachootham et al.   NATURE REVIEWS DRUG DISCOVERY

TSC1 loss synergizes with KRAS activation in lung cancer development in the mouse and confers rapamycin sensitivity

(2009) M-C Liang et al.   ONCOGENE

Somatic LKB1 Mutations Promote Cervical Cancer Progression

(2009) Shana N. Wingo et al.   PLoS One

mTOR and HIF-1 -mediated tumor metabolism in an LKB1 mouse model of Peutz-Jeghers syndrome

(2009) D. B. Shackelford et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vitro and in vivo induction of apoptosis by capsaicin in pancreatic cancer cells is mediated through ROS generation and mitochondrial death pathway

(2008) Ruifen Zhang et al.   APOPTOSIS

Mutations in the LKB1 tumour suppressor are frequently detected in tumours from Caucasian but not Asian lung cancer patients

(2008) J P Koivunen et al.   BRITISH JOURNAL OF CANCER

Autophagic cell death: the story of a misnomer

(2008) Guido Kroemer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Etoposide Induces ATM-Dependent Mitochondrial Biogenesis through AMPK Activation

(2008) Xuan Fu et al.   PLoS One