Starve Cancer Cells of Glutamine: Break the Spell or Make a Hungry Monster?

p53 Promotes Cancer Cell Adaptation to Glutamine Deprivation by Upregulating Slc7a3 to Increase Arginine Uptake

(2019) Xazmin H. Lowman et al.   Cell Reports

LKB1 and KEAP1/NRF2 pathways cooperatively promote metabolic reprogramming with enhanced glutamine dependence in KRAS-mutant lung adenocarcinoma

(2019) Ana Galan-Cobo et al.   CANCER RESEARCH

As Extracellular Glutamine Levels Decline, Asparagine Becomes an Essential Amino Acid

(2018) Natalya N. Pavlova et al.   Cell Metabolism

Asparagine bioavailability governs metastasis in a model of breast cancer

(2018) Simon R. V. Knott et al.   NATURE

Pharmacological blockade of ASCT2-dependent glutamine transport leads to antitumor efficacy in preclinical models

(2018) Michael L Schulte et al.   NATURE MEDICINE

Cytosolic Aspartate Availability Determines Cell Survival When Glutamine Is Limiting

(2018) H. Furkan Alkan et al.   Cell Metabolism

A Role for p53 in the Adaptation to Glutamine Starvation through the Expression of SLC1A3

(2018) Mylène Tajan et al.   Cell Metabolism

Stromal epigenetic alterations drive metabolic and neuroendocrine prostate cancer reprogramming

(2018) Rajeev Mishra et al.   JOURNAL OF CLINICAL INVESTIGATION

The tumor suppressor menin prevents effector CD8 T-cell dysfunction by targeting mTORC1-dependent metabolic activation

(2018) Junpei Suzuki et al.   Nature Communications

Distinct Regulation of Th17 and Th1 Cell Differentiation by Glutaminase-Dependent Metabolism

(2018) Marc O. Johnson et al.   CELL

Tumor-Stroma Mechanics Coordinate Amino Acid Availability to Sustain Tumor Growth and Malignancy

(2018) Thomas Bertero et al.   Cell Metabolism

Biosynthetic energy cost for amino acids decreases in cancer evolution

(2018) Hong Zhang et al.   Nature Communications

CCCTC-Binding Factor Translates Interleukin 2- and α-Ketoglutarate-Sensitive Metabolic Changes in T Cells into Context-Dependent Gene Programs

(2017) Danielle A. Chisolm et al.   IMMUNITY

Keap1 loss promotes Kras-driven lung cancer and results in dependence on glutaminolysis

(2017) Rodrigo Romero et al.   NATURE MEDICINE

Metabolic Interactions in the Tumor Microenvironment

(2017) Costas A. Lyssiotis et al.   TRENDS IN CELL BIOLOGY

A Critical Role of Glutamine and Asparagine γ-Nitrogen in Nucleotide Biosynthesis in Cancer Cells Hijacked by an Oncogenic Virus

(2017) Ying Zhu et al.   mBio

Pharmacologic or Genetic Targeting of Glutamine Synthetase Skews Macrophages toward an M1-like Phenotype and Inhibits Tumor Metastasis

(2017) Erika M. Palmieri et al.   Cell Reports

Arginine Deprivation Inhibits the Warburg Effect and Upregulates Glutamine Anaplerosis and Serine Biosynthesis in ASS1-Deficient Cancers

(2017) Jeff Charles Kremer et al.   Cell Reports

Plasma-free amino acid profiles are predictors of cancer and diabetes development

(2017) X Bi et al.   Nutrition & Diabetes

Environmental cystine drives glutamine anaplerosis and sensitizes cancer cells to glutaminase inhibition

(2017) Alexander Muir et al.   eLife

Targeting Stromal Glutamine Synthetase in Tumors Disrupts Tumor Microenvironment-Regulated Cancer Cell Growth

(2016) Lifeng Yang et al.   Cell Metabolism

The Emerging Hallmarks of Cancer Metabolism

(2016) Natalya N. Pavlova et al.   Cell Metabolism

Environment Impacts the Metabolic Dependencies of Ras-Driven Non-Small Cell Lung Cancer

(2016) Shawn M. Davidson et al.   Cell Metabolism

Regional glutamine deficiency in tumours promotes dedifferentiation through inhibition of histone demethylation

(2016) Min Pan et al.   NATURE CELL BIOLOGY

Arginine dependence of tumor cells: targeting a chink in cancer’s armor

(2016) M D Patil et al.   ONCOGENE

Asparagine promotes cancer cell proliferation through use as an amino acid exchange factor

(2016) Abigail S. Krall et al.   Nature Communications

Inhibition of the Polyamine Synthesis Pathway Is Synthetically Lethal with Loss of Argininosuccinate Synthase 1

(2016) Matthew Locke et al.   Cell Reports

Human Pancreatic Cancer Tumors Are Nutrient Poor and Tumor Cells Actively Scavenge Extracellular Protein

(2015) J. J. Kamphorst et al.   CANCER RESEARCH

Diversion of aspartate in ASS1-deficient tumours fosters de novo pyrimidine synthesis

(2015) Shiran Rabinovich et al.   NATURE

Glutamine synthetase activity fuels nucleotide biosynthesis and supports growth of glutamine-restricted glioblastoma

(2015) Saverio Tardito et al.   NATURE CELL BIOLOGY

ASCT2/SLC1A5 controls glutamine uptake and tumour growth in triple-negative basal-like breast cancer

(2015) M van Geldermalsen et al.   ONCOGENE

Differential regulation of mTORC1 by leucine and glutamine

(2015) J. L. Jewell et al.   SCIENCE

Glutamine-dependent α-ketoglutarate production regulates the balance between T helper 1 cell and regulatory T cell generation

(2015) Dorota Klysz et al.   Science Signaling

Glutamine-dependent α-ketoglutarate production regulates the balance between T helper 1 cell and regulatory T cell generation

(2015) Dorota Klysz et al.   Science Signaling

Inflammatory T Cell Responses Rely on Amino Acid Transporter ASCT2 Facilitation of Glutamine Uptake and mTORC1 Kinase Activation

(2014) Mako Nakaya et al.   IMMUNITY

Nitrogen Source Activates TOR (Target of Rapamycin) Complex 1 via Glutamine and Independently of Gtr/Rag Proteins

(2014) Daniele Stracka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Antitumor Activity of the Glutaminase Inhibitor CB-839 in Triple-Negative Breast Cancer

(2014) M. I. Gross et al.   MOLECULAR CANCER THERAPEUTICS

Asparagine Plays a Critical Role in Regulating Cellular Adaptation to Glutamine Depletion

(2014) Ji Zhang et al.   MOLECULAR CELL

Intracellular α-ketoglutarate maintains the pluripotency of embryonic stem cells

(2014) Bryce W. Carey et al.   NATURE

Arginine Starvation Impairs Mitochondrial Respiratory Function in ASS1-Deficient Breast Cancer Cells

(2014) F. Qiu et al.   Science Signaling

Asparagine synthetase: regulation by cell stress and involvement in tumor biology

(2013) Mukundh N. Balasubramanian et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Glutamine Sensitivity Analysis Identifies the xCT Antiporter as a Common Triple-Negative Breast Tumor Therapeutic Target

(2013) Luika A. Timmerman et al.   CANCER CELL

Glutamine-driven oxidative phosphorylation is a major ATP source in transformed mammalian cells in both normoxia and hypoxia

(2013) J. Fan et al.   Molecular Systems Biology

Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway

(2013) Jaekyoung Son et al.   NATURE

ATF4 Regulates MYC-Mediated Neuroblastoma Cell Death upon Glutamine Deprivation

(2012) Guoliang Qing et al.   CANCER CELL

Analysis of Tumor Metabolism Reveals Mitochondrial Glucose Oxidation in Genetically Diverse Human Glioblastomas in the Mouse Brain In Vivo

(2012) Isaac Marin-Valencia et al.   Cell Metabolism

Glutaminolysis Activates Rag-mTORC1 Signaling

(2012) Raúl V. Durán et al.   MOLECULAR CELL

Asparaginase revisited

(2011) Henk van den Berg   LEUKEMIA & LYMPHOMA

Bidirectional Transport of Amino Acids Regulates mTOR and Autophagy

(2009) Paul Nicklin et al.   CELL

Tumor suppressors and cell metabolism: a recipe for cancer growth

(2009) R. G. Jones et al.   GENES & DEVELOPMENT