The MYC transcription factor network: balancing metabolism, proliferation and oncogenesis

Enhancer invasion shapes MYCN-dependent transcriptional amplification in neuroblastoma

(2018) Rhamy Zeid et al.   NATURE GENETICS

Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas

(2018) Franz X. Schaub et al.   Cell Systems

Metabolic gatekeeper function of B-lymphoid transcription factors

(2017) Lai N. Chan et al.   NATURE

PCGF6-PRC1 suppresses premature differentiation of mouse embryonic stem cells by regulating germ cell-related genes

(2017) Mitsuhiro Endoh et al.   eLife

MNT and Emerging Concepts of MNT‐MYC Antagonism

(2017) Guang Yang et al.   Genes

The Interaction of Myc with Miz1 Defines Medulloblastoma Subgroup Identity

(2016) BaoHan T. Vo et al.   CANCER CELL

MLX Is a Transcriptional Repressor of the Mammalian Golgi Stress Response

(2016) Mai Taniguchi et al.   CELL STRUCTURE AND FUNCTION

Myc/Mycn-mediated glycolysis enhances mouse spermatogonial stem cell self-renewal

(2016) Mito Kanatsu-Shinohara et al.   GENES & DEVELOPMENT

Ordering of mutations in acute myeloid leukemia with partial tandem duplication of MLL (MLL-PTD)

(2016) Q-Y Sun et al.   LEUKEMIA

Loss of MAX results in meiotic entry in mouse embryonic and germline stem cells

(2016) Ayumu Suzuki et al.   Nature Communications

Mondo complexes regulate TFEB via TOR inhibition to promote longevity in response to gonadal signals

(2016) Shuhei Nakamura et al.   Nature Communications

Different promoter affinities account for specificity in MYC-dependent gene regulation

(2016) Francesca Lorenzin et al.   eLife

Functional interactions among members of the MAX and MLX transcriptional network during oncogenesis

(2015) Daniel Diolaiti et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Interactions between Myc and MondoA transcription factors in metabolism and tumourigenesis

(2015) Blake R Wilde et al.   BRITISH JOURNAL OF CANCER

Deregulated Myc Requires MondoA/Mlx for Metabolic Reprogramming and Tumorigenesis

(2015) Patrick A. Carroll et al.   CANCER CELL

MYC Disrupts the Circadian Clock and Metabolism in Cancer Cells

(2015) Brian J. Altman et al.   Cell Metabolism

The glucose-sensing transcription factor MLX promotes myogenesis via myokine signaling

(2015) Liam C. Hunt et al.   GENES & DEVELOPMENT

Interaction with WDR5 Promotes Target Gene Recognition and Tumorigenesis by MYC

(2015) Lance R. Thomas et al.   MOLECULAR CELL

DNA-dependent formation of transcription factor pairs alters their binding specificity

(2015) Arttu Jolma et al.   NATURE

Metabolic reprogramming in triple-negative breast cancer through Myc suppression of TXNIP

(2015) Liangliang Shen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Taming of the beast: shaping Myc-dependent amplification

(2015) Elmar Wolf et al.   TRENDS IN CELL BIOLOGY

Mondo-Mlx Mediates Organismal Sugar Sensing through the Gli-Similar Transcription Factor Sugarbabe

(2015) Jaakko Mattila et al.   Cell Reports

Mga is essential for the survival of pluripotent cells during peri-implantation development

(2014) A. J. Washkowitz et al.   DEVELOPMENT

Extraembryonic Signals under the Control of MGA, Max, and Smad4 Are Required for Dorsoventral Patterning

(2014) Yuhua Sun et al.   DEVELOPMENTAL CELL

Response of BRAF-Mutant Melanoma to BRAF Inhibition Is Mediated by a Network of Transcriptional Regulators of Glycolysis

(2014) T. J. Parmenter et al.   Cancer Discovery

MYC Degradation

(2014) A. S. Farrell et al.   Cold Spring Harbor Perspectives in Medicine

MYC Activation Is a Hallmark of Cancer Initiation and Maintenance

(2014) M. Gabay et al.   Cold Spring Harbor Perspectives in Medicine

MYC Cofactors: Molecular Switches Controlling Diverse Biological Outcomes

(2014) S. R. Hann   Cold Spring Harbor Perspectives in Medicine

An Overview of MYC and Its Interactome

(2014) M. Conacci-Sorrell et al.   Cold Spring Harbor Perspectives in Medicine

Two main genetic pathways lead to the transformation of chronic lymphocytic leukemia to Richter syndrome

(2013) E. Chigrinova et al.   BLOOD

Transcription Factor Binding in Human Cells Occurs in Dense Clusters Formed around Cohesin Anchor Sites

(2013) Jian Yan et al.   CELL

Master Transcription Factors and Mediator Establish Super-Enhancers at Key Cell Identity Genes

(2013) Warren A. Whyte et al.   CELL

MAX Inactivation in Small Cell Lung Cancer Disrupts MYC-SWI/SNF Programs and Is Synthetic Lethal with BRG1

(2013) O. A. Romero et al.   Cancer Discovery

The Role of MIZ-1 in MYC-Dependent Tumorigenesis

(2013) K. E. Wiese et al.   Cold Spring Harbor Perspectives in Medicine

Mondo/ChREBP-Mlx-Regulated Transcriptional Network Is Essential for Dietary Sugar Tolerance in Drosophila

(2013) Essi Havula et al.   PLoS Genetics

Fructose 2,6-bisphosphate is essential for glucose-regulated gene transcription of glucose-6-phosphatase and other ChREBP target genes in hepatocytes

(2012) Catherine Arden et al.   BIOCHEMICAL JOURNAL

High-resolution genomic profiling of chronic lymphocytic leukemia reveals new recurrent genomic alterations

(2012) J. Edelmann et al.   BLOOD

c-Myc Is a Universal Amplifier of Expressed Genes in Lymphocytes and Embryonic Stem Cells

(2012) Zuqin Nie et al.   CELL

Transcriptional Amplification in Tumor Cells with Elevated c-Myc

(2012) Charles Y. Lin et al.   CELL

MGA, a suppressor ofMYC, is recurrently inactivated in high risk chronic lymphocytic leukemia

(2012) Lorenzo De Paoli et al.   LEUKEMIA & LYMPHOMA

Glucose Induces Protein Targeting to Glycogen in Hepatocytes by Fructose 2,6-Bisphosphate-Mediated Recruitment of MondoA to the Promoter

(2012) J. L. Petrie et al.   MOLECULAR AND CELLULAR BIOLOGY

PCGF Homologs, CBX Proteins, and RYBP Define Functionally Distinct PRC1 Family Complexes

(2012) Zhonghua Gao et al.   MOLECULAR CELL

CircadiOmics: integrating circadian genomics, transcriptomics, proteomics and metabolomics

(2012) Vishal R Patel et al.   NATURE METHODS

A Novel N-Terminal Domain May Dictate the Glucose Response of Mondo Proteins

(2012) Lisa G. McFerrin et al.   PLoS One

A critical role for Mnt in Myc-driven T-cell proliferation and oncogenesis

(2012) J. M. Link et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An extended Myc network contributes to glucose homeostasis in cancer and diabetes

(2011) Christopher et al.   Frontiers in Bioscience-Landmark

Evolution of the Max and Mlx Networks in Animals

(2011) Lisa G. McFerrin et al.   Genome Biology and Evolution

The Transcription Factor Myc Controls Metabolic Reprogramming upon T Lymphocyte Activation

(2011) Ruoning Wang et al.   IMMUNITY

Exome sequencing identifies MAX mutations as a cause of hereditary pheochromocytoma

(2011) Iñaki Comino-Méndez et al.   NATURE GENETICS

Regulatory gene network circuits underlying T cell development from multipotent progenitors

(2011) Hao Yuan Kueh et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

Combinatorial Regulation of Neuroblastoma Tumor Progression by N-Myc and Hypoxia Inducible Factor HIF-1 

(2010) G. Qing et al.   CANCER RESEARCH

Downregulation of c-MYC Protein Levels Contributes to Cancer Cell Survival under Dual Deficiency of Oxygen and Glucose

(2010) H. Okuyama et al.   CANCER RESEARCH

Myc-Nick: A Cytoplasmic Cleavage Product of Myc that Promotes α-Tubulin Acetylation and Cell Differentiation

(2010) Maralice Conacci-Sorrell et al.   CELL

c-Myc Regulates Transcriptional Pause Release

(2010) Peter B. Rahl et al.   CELL

Basic helix-loop-helix transcription factor gene family phylogenetics and nomenclature

(2010) Michael K. Skinner et al.   DIFFERENTIATION

Glucose Controls Nuclear Accumulation, Promoter Binding, and Transcriptional Activity of the MondoA-Mlx Heterodimer

(2010) C. W. Peterson et al.   MOLECULAR AND CELLULAR BIOLOGY

A genome-wide RNAi screen identifies a new transcriptional module required for self-renewal

(2009) G. Hu et al.   GENES & DEVELOPMENT

Genomic and Proteomic Analysis Reveals a Threshold Level of MYC Required for Tumor Maintenance

(2008) C. M. Shachaf et al.   CANCER RESEARCH

An Extended Transcriptional Network for Pluripotency of Embryonic Stem Cells

(2008) Jonghwan Kim et al.   CELL

Myc's broad reach

(2008) M. Eilers et al.   GENES & DEVELOPMENT

Max-independent functions of Myc in Drosophila melanogaster

(2008) Dominik Steiger et al.   NATURE GENETICS

Activation of PI3K/Akt and MAPK pathways regulates Myc-mediated transcription by phosphorylating and promoting the degradation of Mad1

(2008) J. Zhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glucose sensing by MondoA:Mlx complexes: A role for hexokinases and direct regulation of thioredoxin-interacting protein expression

(2008) C. A. Stoltzman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Drosophila growth and development in the absence of dMyc and dMnt

(2007) Sarah B. Pierce et al.   DEVELOPMENTAL BIOLOGY