Metabolic reprogramming and dysregulated metabolism: cause, consequence and/or enabler of environmental carcinogenesis?

Epigenetics and cancer metabolism

(2015) Christelle Johnson et al.   CANCER LETTERS

Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead

(2015) William H. Goodson et al.   CARCINOGENESIS

The Histone Deacetylase SIRT6: At the Crossroads Between Epigenetics, Metabolism and Disease

(2015) Jean-Pierre Etchegaray et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

TIGAR's promiscuity: Figure 1

(2014) Juan P. Bolaños   BIOCHEMICAL JOURNAL

Identification of TP53-induced glycolysis and apoptosis regulator (TIGAR) as the phosphoglycolate-independent 2,3-bisphosphoglycerate phosphatase

(2014) Isabelle Gerin et al.   BIOCHEMICAL JOURNAL

Releasing Pressure in Tumors: What Do We Know So Far and Where Do We Go from Here? A Review

(2014) A. B. Ariffin et al.   CANCER RESEARCH

CRISPR-Cas systems for editing, regulating and targeting genomes

(2014) Jeffry D Sander et al.   NATURE BIOTECHNOLOGY

AMPK regulates histone H2B O-GlcNAcylation

(2014) Qiuran Xu et al.   NUCLEIC ACIDS RESEARCH

Cancer Stem Cell-Specific Scavenger Receptor CD36 Drives Glioblastoma Progression

(2014) James S. Hale et al.   STEM CELLS

S100A11 is required for efficient plasma membrane repair and survival of invasive cancer cells

(2014) Jyoti K. Jaiswal et al.   Nature Communications

Role of amino acid transporters in amino acid sensing

(2013) Peter M Taylor   AMERICAN JOURNAL OF CLINICAL NUTRITION

Asparagine synthetase: regulation by cell stress and involvement in tumor biology

(2013) Mukundh N. Balasubramanian et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

O-GlcNAc in cancer biology

(2013) Zhiyuan Ma et al.   AMINO ACIDS

Metabolic Regulation of T Lymphocytes

(2013) Nancie J. MacIver et al.   Annual Review of Immunology

AMPK: opposing the metabolic changes in both tumour cells and inflammatory cells?

(2013) Madhumita Dandapani et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Parallels between embryo and cancer cell metabolism

(2013) Danielle G. Smith et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Cancer cells incorporate and remodel exogenous palmitate into structural and oncogenic signaling lipids

(2013) Sharon M. Louie et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Increased cancer burden among pesticide applicators and others due to pesticide exposure

(2013) Michael C. R. Alavanja et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Releasing the Block: Setting Differentiation Free with Mutant IDH Inhibitors

(2013) Christopher J. Pirozzi et al.   CANCER CELL

Hexokinase 2 Is Required for Tumor Initiation and Maintenance and Its Systemic Deletion Is Therapeutic in Mouse Models of Cancer

(2013) Krushna C. Patra et al.   CANCER CELL

Drinking Water Arsenic in Northern Chile: High Cancer Risks 40 Years after Exposure Cessation

(2013) C. M. Steinmaus et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

AMPK: A Contextual Oncogene or Tumor Suppressor?

(2013) J. Liang et al.   CANCER RESEARCH

Mechanisms Governing Metastatic Dormancy and Reactivation

(2013) Filippo G. Giancotti   CELL

Metabolic Regulation by p53 Family Members

(2013) Celia R. Berkers et al.   Cell Metabolism

A metabonomic investigation of the effects of 60days exposure of rats to two types of pyrethroid insecticides

(2013) Yu-Jie Liang et al.   CHEMICO-BIOLOGICAL INTERACTIONS

TIGAR Is Required for Efficient Intestinal Regeneration and Tumorigenesis

(2013) Eric C. Cheung et al.   DEVELOPMENTAL CELL

Aldose reductase regulates acrolein-induced cytotoxicity in human small airway epithelial cells

(2013) Umesh C.S. Yadav et al.   FREE RADICAL BIOLOGY AND MEDICINE

What a difference a hydroxyl makes: mutant IDH, (R)-2-hydroxyglutarate, and cancer

(2013) J.-A. Losman et al.   GENES & DEVELOPMENT

Biochemistry and pathophysiology of intravascular and intracellular lipolysis

(2013) S. G. Young et al.   GENES & DEVELOPMENT

From human genome to cancer genome: The first decade

(2013) D. A. Wheeler et al.   GENOME RESEARCH

Translesion Synthesis Past Acrolein-derived DNA Adducts by Human Mitochondrial DNA Polymerase γ

(2013) Rajesh Kasiviswanathan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

How Metabolism Generates Signals during Innate Immunity and Inflammation

(2013) Anne F. McGettrick et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of the Protein Deacetylase SIRT6 by Long-chain Fatty Acids and Widespread Deacylation by Mammalian Sirtuins

(2013) Jessica L. Feldman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial complex I activity and NAD+/NADH balance regulate breast cancer progression

(2013) Antonio F. Santidrian et al.   JOURNAL OF CLINICAL INVESTIGATION

Glutamine and cancer: cell biology, physiology, and clinical opportunities

(2013) Christopher T. Hensley et al.   JOURNAL OF CLINICAL INVESTIGATION

HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations

(2013) Gregg L. Semenza   JOURNAL OF CLINICAL INVESTIGATION

Sirtuin deacylases: a molecular link between metabolism and immunity

(2013) Nicolas Preyat et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Metals and Breast Cancer

(2013) Celia Byrne et al.   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

Does Cancer Start in the Womb? Altered Mammary Gland Development and Predisposition to Breast Cancer due to in Utero Exposure to Endocrine Disruptors

(2013) Ana M. Soto et al.   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

TNFα and IL-17 cooperatively stimulate glucose metabolism and growth factor production in human colorectal cancer cells

(2013) Daniel S Straus   Molecular Cancer

Energy Management by Enhanced Glycolysis in G1-phase in Human Colon Cancer Cells In Vitro and In Vivo

(2013) Y. Bao et al.   MOLECULAR CANCER RESEARCH

The Tangled Circuitry of Metabolism and Apoptosis

(2013) Joshua L. Andersen et al.   MOLECULAR CELL

Mutational heterogeneity in cancer and the search for new cancer-associated genes

(2013) Michael S. Lawrence et al.   NATURE

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

(2013) G. M. Tannahill et al.   NATURE

Heterogeneity of tumor-induced gene expression changes in the human metabolic network

(2013) Jie Hu et al.   NATURE BIOTECHNOLOGY

Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids

(2013) J. J. Kamphorst et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Strengthened glycolysis under hypoxia supports tumor symbiosis and hexosamine biosynthesis in pancreatic adenocarcinoma

(2013) F. Guillaumond et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipogenesis and lipolysis: The pathways exploited by the cancer cells to acquire fatty acids

(2013) Nousheen Zaidi et al.   PROGRESS IN LIPID RESEARCH

Supercomplex Assembly Determines Electron Flux in the Mitochondrial Electron Transport Chain

(2013) E. Lapuente-Brun et al.   SCIENCE

An Inhibitor of Mutant IDH1 Delays Growth and Promotes Differentiation of Glioma Cells

(2013) D. Rohle et al.   SCIENCE

Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells

(2013) Ophir Shalem et al.   SCIENCE

Genetic Screens in Human Cells Using the CRISPR-Cas9 System

(2013) Tim Wang et al.   SCIENCE

Allosteric Regulation of PKM2 Allows Cellular Adaptation to Different Physiological States

(2013) D. Y. Gui et al.   Science Signaling

Mitochondria as a Target of Environmental Toxicants

(2013) Joel N. Meyer et al.   TOXICOLOGICAL SCIENCES

Cracking the O-GlcNAc code in metabolism

(2013) Hai-Bin Ruan et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Resistance to hypoxia-induced necroptosis is conferred by glycolytic pyruvate scavenging of mitochondrial superoxide in colorectal cancer cells

(2013) C-Y Huang et al.   Cell Death & Disease

Oncogenic Isocitrate Dehydrogenase Mutations: Mechanisms, Models, and Clinical Opportunities

(2013) R. A. Cairns et al.   Cancer Discovery

Transport metabolons with carbonic anhydrases

(2013) Joachim W. Deitmer et al.   Frontiers in Physiology

Dual roles of PKM2 in cancer metabolism

(2012) S. Wu et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Risk of Total and Aggressive Prostate Cancer and Pesticide Use in the Agricultural Health Study

(2012) Stella Koutros et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Preventability of Cancer: The Relative Contributions of Biologic and Social and Physical Environmental Determinants of Cancer Mortality

(2012) Graham A. Colditz et al.   Annual Review of Public Health

AMP-activated protein kinase: new regulation, new roles?

(2012) David Carling et al.   BIOCHEMICAL JOURNAL

Autophagy: Emerging roles in lipid homeostasis and metabolic control

(2012) Patricia Christian et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Moonlighting is mainstream: Paradigm adjustment required

(2012) Shelley D. Copley   BIOESSAYS

Identification of mammary epithelial cells subject to chronic oxidative stress in mammary epithelium of young women and teenagers living in USA

(2012) Judith Weisz et al.   CANCER BIOLOGY & THERAPY

MYC on the Path to Cancer

(2012) Chi V. Dang   CELL

Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism

(2012) Haoqiang Ying et al.   CELL

Glucose-Independent Glutamine Metabolism via TCA Cycling for Proliferation and Survival in B Cells

(2012) Anne Le et al.   Cell Metabolism

Hormones and Endocrine-Disrupting Chemicals: Low-Dose Effects and Nonmonotonic Dose Responses

(2012) Laura N. Vandenberg et al.   ENDOCRINE REVIEWS

Oxidative stress and metal carcinogenesis

(2012) Jeong-Chae Lee et al.   FREE RADICAL BIOLOGY AND MEDICINE

Resurgence of Serine: An Often Neglected but Indispensable Amino Acid

(2012) Satish C. Kalhan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Acetyl-CoA Carboxylase Regulates Global Histone Acetylation

(2012) Luciano Galdieri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy and cancer - issues we need to digest

(2012) E. Y. Liu et al.   JOURNAL OF CELL SCIENCE

Oncogenic Viruses and Tumor Glucose Metabolism: Like Kids in a Candy Store

(2012) E. Noch et al.   MOLECULAR CANCER THERAPEUTICS

Pyruvate Kinase M2 Regulates Gene Transcription by Acting as a Protein Kinase

(2012) Xueliang Gao et al.   MOLECULAR CELL

IDH mutation impairs histone demethylation and results in a block to cell differentiation

(2012) Chao Lu et al.   NATURE

p53 mutations in cancer

(2012) Patricia A. J. Muller et al.   NATURE CELL BIOLOGY

Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

(2012) Marco Gerlinger et al.   NEW ENGLAND JOURNAL OF MEDICINE

Lactate, a product of glycolytic metabolism, inhibits histone deacetylase activity and promotes changes in gene expression

(2012) Tom Latham et al.   NUCLEIC ACIDS RESEARCH

Resistance to Fluid Shear Stress Is a Conserved Biophysical Property of Malignant Cells

(2012) J. Matthew Barnes et al.   PLoS One

Mitochondrial localization of TIGAR under hypoxia stimulates HK2 and lowers ROS and cell death

(2012) E. C. Cheung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In Vitro Perturbations of Targets in Cancer Hallmark Processes Predict Rodent Chemical Carcinogenesis

(2012) Nicole C. Kleinstreuer et al.   TOXICOLOGICAL SCIENCES

Rocking cell metabolism: revised functions of the key glycolytic regulator PKM2 in cancer

(2012) Barbara Chaneton et al.   TRENDS IN BIOCHEMICAL SCIENCES

Genetically-defined metabolic reprogramming in cancer

(2012) Andrew R. Mullen et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Emerging roles of PKM2 in cell metabolism and cancer progression

(2012) Weibo Luo et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Hallmarks of cancer: of all cancer cells, all the time?

(2012) Sébastien L. Floor et al.   TRENDS IN MOLECULAR MEDICINE

Cancer Cell Metabolism: One Hallmark, Many Faces

(2012) Jason R. Cantor et al.   Cancer Discovery

Decreased Mitochondrial DNA Mutagenesis in Human Colorectal Cancer

(2012) Nolan G. Ericson et al.   PLoS Genetics

Cancer cell growth and survival as a system-level property sustained by enhanced glycolysis and mitochondrial metabolic remodeling

(2012) Lilia Alberghina et al.   Frontiers in Physiology

Interactions between epigenetics and metabolism in cancers

(2012) Jihye Yun et al.   Frontiers in Oncology

Mitochondrial recoupling: a novel therapeutic strategy for cancer?

(2011) G Baffy et al.   BRITISH JOURNAL OF CANCER

Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1

(2011) Weibo Luo et al.   CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Metabolic Flux and the Regulation of Mammalian Cell Growth

(2011) Jason W. Locasale et al.   Cell Metabolism

Exploring the Boundaries of Additivity: Mixtures of NADH:Quinone Oxidoreductase Inhibitors

(2011) Jonathan Boyd et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Elucidation of Cellular Metabolism Via Metabolomics and Stable-Isotope Assisted Metabolomics

(2011) Karsten Hiller et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis

(2011) J. Y. Guo et al.   GENES & DEVELOPMENT

Lipoprotein Lipase Links Dietary Fat to Solid Tumor Cell Proliferation

(2011) N. B. Kuemmerle et al.   MOLECULAR CANCER THERAPEUTICS

ROS-Mediated p53 Induction of Lpin1 Regulates Fatty Acid Oxidation in Response to Nutritional Stress

(2011) Wissam Assaily et al.   MOLECULAR CELL

Oncogenic K-Ras decouples glucose and glutamine metabolism to support cancer cell growth

(2011) D. Gaglio et al.   Molecular Systems Biology

Functional genomics reveal that the serine synthesis pathway is essential in breast cancer

(2011) Richard Possemato et al.   NATURE

Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis

(2011) Jason W Locasale et al.   NATURE GENETICS

Layers of epistasis: genome-wide regulatory networks and network approaches to genome-wide association studies

(2011) Richard Cowper-Sal·lari et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

A mutant telomerase defective in nuclear-cytoplasmic shuttling fails to immortalize cells and is associated with mitochondrial dysfunction

(2010) Olga A. Kovalenko et al.   AGING CELL

The Role of Mitochondria in Reactive Oxygen Species Metabolism and Signaling

(2010) Anatoly A. Starkov   Annals of the New York Academy of Sciences

Mitochondrial Energetics and Therapeutics

(2010) Douglas C. Wallace et al.   Annual Review of Pathology-Mechanisms of Disease

Towards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson’s, Huntington’s, Alzheimer’s, prions, bactericides, chemical toxicology and others as examples

(2010) Douglas B. Kell   ARCHIVES OF TOXICOLOGY

De novo Lipogenesis Protects Cancer Cells from Free Radicals and Chemotherapeutics by Promoting Membrane Lipid Saturation

(2010) E. Rysman et al.   CANCER RESEARCH

AACR Centennial Series: The Biology of Cancer Metastasis: Historical Perspective

(2010) J. E. Talmadge et al.   CANCER RESEARCH

Impact of Environmental Chemicals on Key Transcription Regulators and Correlation to Toxicity End Points within EPA’s ToxCast Program

(2010) Matthew T. Martin et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Autophagy regulation by p53

(2010) Maria Chiara Maiuri et al.   CURRENT OPINION IN CELL BIOLOGY

A Review of Pesticide Exposure and Cancer Incidence in the Agricultural Health Study Cohort

(2010) Scott Weichenthal et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Signal transduction to the permeability transition pore

(2010) Andrea Rasola et al.   FEBS LETTERS

The hexosamine biosynthetic pathway couples growth factor-induced glutamine uptake to glucose metabolism

(2010) K. E. Wellen et al.   GENES & DEVELOPMENT

Tumour hypoxia induces a metabolic shift causing acidosis: a common feature in cancer

(2010) Johanna Chiche et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Metabolic Shifts in Immunity and Inflammation

(2010) D. J. Kominsky et al.   JOURNAL OF IMMUNOLOGY

Isocitrate Dehydrogenase 1 and 2 Mutations in Cancer: Alterations at a Crossroads of Cellular Metabolism

(2010) Z. J. Reitman et al.   JNCI-Journal of the National Cancer Institute

Metabolic flexibility and cell hierarchy in metastatic cancer

(2010) Michael V. Berridge et al.   MITOCHONDRION

COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer

(2010) S. A. Forbes et al.   NUCLEIC ACIDS RESEARCH

Signaling Kinase AMPK Activates Stress-Promoted Transcription via Histone H2B Phosphorylation

(2010) D. Bungard et al.   SCIENCE

Evidence for an Alternative Glycolytic Pathway in Rapidly Proliferating Cells

(2010) M. G. Vander Heiden et al.   SCIENCE

Chemical Carcinogenesis

(2010) S. M. Cohen et al.   TOXICOLOGICAL SCIENCES

Interleukin 6 Enhances Glycolysis through Expression of the Glycolytic Enzymes Hexokinase 2 and 6-Phosphofructo-2-kinase/Fructose-2,6-bisphosphatase-3

(2010) Masaru Ando et al.   JOURNAL OF NIPPON MEDICAL SCHOOL

Mitochondrial Complex I decrease is responsible for bioenergetic dysfunction in K-ras transformed cells

(2009) Alessandra Baracca et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

The do's and don'ts of p53 isoforms

(2009) Reiner U. Jänicke et al.   BIOLOGICAL CHEMISTRY

De novo fatty-acid synthesis and related pathways as molecular targets for cancer therapy

(2009) T Mashima et al.   BRITISH JOURNAL OF CANCER

Mitochondrial Uncoupling and the Warburg Effect: Molecular Basis for the Reprogramming of Cancer Cell Metabolism

(2009) I. Samudio et al.   CANCER RESEARCH

Monoacylglycerol Lipase Regulates a Fatty Acid Network that Promotes Cancer Pathogenesis

(2009) Daniel K. Nomura et al.   CELL

Lipophagy: Selective Catabolism Designed for Lipids

(2009) Hilla Weidberg et al.   DEVELOPMENTAL CELL

A Clash of Old and New Scientific Concepts in Toxicity, with Important Implications for Public Health

(2009) John Peterson Myers et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Regulation of glucose metabolism by 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatases in cancer

(2009) Abdullah Yalcin et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Epigenetic oxidative redox shift (EORS) theory of aging unifies the free radical and insulin signaling theories

(2009) Gregory J. Brewer   EXPERIMENTAL GERONTOLOGY

Early alterations in protein and gene expression in rat kidney following bromate exposure

(2009) Gene J. Ahlborn et al.   FOOD AND CHEMICAL TOXICOLOGY

Transgenerational genetic effects on phenotypic variation and disease risk

(2009) J. H. Nadeau   HUMAN MOLECULAR GENETICS

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

(2009) Lenny Dang et al.   NATURE

Metalloproteins and metal sensing

(2009) Kevin J. Waldron et al.   NATURE

Evidence for a separate mechanism of toxicity for the Type I and the Type II pyrethroid insecticides

(2009) Charles B. Breckenridge et al.   NEUROTOXICOLOGY

Q's next: the diverse functions of glutamine in metabolism, cell biology and cancer

(2009) R J DeBerardinis et al.   ONCOGENE

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Biochemical pathways that regulate acetyltransferase and deacetylase activity in mammalian cells

(2009) Hestia S. Mellert et al.   TRENDS IN BIOCHEMICAL SCIENCES

Cancer Cell Metabolism: Warburg and Beyond

(2008) Peggy P. Hsu et al.   CELL

The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation

(2008) Ralph J. DeBerardinis et al.   Cell Metabolism

Exposure of Neonatal Rats to Parathion Elicits Sex-Selective Reprogramming of Metabolism and Alters the Response to a High-Fat Diet in Adulthood

(2008) T. Leon Lassiter et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Regulation of fatty acid uptake into tissues: lipoprotein lipase- and CD36-mediated pathways: Fig. 1.

(2008) Ira J. Goldberg et al.   JOURNAL OF LIPID RESEARCH

Homogeneous reporter system enables quantitative functional assessment of multiple transcription factors

(2008) Sergei Romanov et al.   NATURE METHODS

Is Akt the “Warburg kinase”?—Akt-energy metabolism interactions and oncogenesis

(2008) R. Brooks Robey et al.   SEMINARS IN CANCER BIOLOGY