- Home
- Publications
- Publication Search
- Publication Details
Title
Targeting LKB1 in cancer – exposing and exploiting vulnerabilities
Authors
Keywords
-
Journal
BRITISH JOURNAL OF CANCER
Volume 113, Issue 4, Pages 574-584
Publisher
Springer Nature
Online
2015-07-22
DOI
10.1038/bjc.2015.261
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- mTORC1 Activation Blocks BrafV600E-Induced Growth Arrest but Is Insufficient for Melanoma Formation
- (2015) William Damsky et al. CANCER CELL
- Degradation of AMPK by a Cancer-Specific Ubiquitin Ligase
- (2015) Carlos T. Pineda et al. CELL
- Organoid Models of Human and Mouse Ductal Pancreatic Cancer
- (2015) Sylvia F. Boj et al. CELL
- Bridging Tumor Genomics to Patient Outcomes Through an Integrated Patient-Derived Xenograft Platform
- (2015) David R. Gandara et al. Clinical Lung Cancer
- EZH2 inhibition sensitizes BRG1 and EGFR mutant lung tumours to TopoII inhibitors
- (2015) Christine M. Fillmore et al. NATURE
- Preclinical efficacy of maternal embryonic leucine-zipper kinase (MELK) inhibition in acute myeloid leukemia
- (2015) Houda Alachkar et al. Oncotarget
- Pre-clinical study of drug combinations that reduce breast cancer burden due to aberrant mTOR and metabolism promoted by LKB1 loss
- (2015) Rafaela Andrade-Vieira et al. Oncotarget
- Loss of Lkb1 and Pten Leads to Lung Squamous Cell Carcinoma with Elevated PD-L1 Expression
- (2014) Chunxiao Xu et al. CANCER CELL
- LKB1 inactivation sensitizes non-small cell lung cancer to pharmacological aggravation of ER stress
- (2014) Landon J. Inge et al. CANCER LETTERS
- Decreased expression and prognostic role of cytoplasmic BRSK1 in human breast carcinoma: Correlation with Jab1 stability and PI3K/Akt pathway
- (2014) Hua Wang et al. EXPERIMENTAL AND MOLECULAR PATHOLOGY
- LKB1 Loss Induces Characteristic Patterns of Gene Expression in Human Tumors Associated with NRF2 Activation and Attenuation of PI3K-AKT
- (2014) Jacob M. Kaufman et al. Journal of Thoracic Oncology
- Maternal embryonic leucine zipper kinase enhances gastric cancer progression via the FAK/Paxillin pathway
- (2014) Tao Du et al. Molecular Cancer
- Salt-Inducible Kinase 2 Regulates Mitotic Progression and Transcription in Prostate Cancer
- (2014) Hélène Bon et al. MOLECULAR CANCER RESEARCH
- An AMPK-Independent Signaling Pathway Downstream of the LKB1 Tumor Suppressor Controls Snail1 and Metastatic Potential
- (2014) Jonathan M. Goodwin et al. MOLECULAR CELL
- Oncogenic transformation of diverse gastrointestinal tissues in primary organoid culture
- (2014) Xingnan Li et al. NATURE MEDICINE
- Salt-Inducible Kinase 1 (SIK1) Is Induced by Gastrin and Inhibits Migration of Gastric Adenocarcinoma Cells
- (2014) Linn-Karina M. Selvik et al. PLoS One
- Functional epigenetics approach identifies BRM/SMARCA2 as a critical synthetic lethal target in BRG1-deficient cancers
- (2014) G. R. Hoffman et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Salt-inducible kinase 3 is a novel mitotic regulator and a target for enhancing antimitotic therapeutic-mediated cell death
- (2014) H Chen et al. Cell Death & Disease
- LKB1 Inactivation Dictates Therapeutic Response of Non-Small Cell Lung Cancer to the Metabolism Drug Phenformin
- (2013) David B. Shackelford et al. CANCER CELL
- A Genetic Mouse Model of Invasive Endometrial Cancer Driven by Concurrent Loss of Pten and Lkb1 Is Highly Responsive to mTOR Inhibition
- (2013) H. Cheng et al. CANCER RESEARCH
- Systematic Identification of Molecular Subtype-Selective Vulnerabilities in Non-Small-Cell Lung Cancer
- (2013) Hyun Seok Kim et al. CELL
- LKB1 Represses Focal Adhesion Kinase (FAK) Signaling via a FAK-LKB1 Complex to Regulate FAK Site Maturation and Directional Persistence
- (2013) Erik R. Kline et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions
- (2013) Jonathan M. Ostrem et al. NATURE
- A genetic screen identifies an LKB1–MARK signalling axis controlling the Hippo–YAP pathway
- (2013) Morvarid Mohseni et al. NATURE CELL BIOLOGY
- The LKB1 Tumor Suppressor as a Biomarker in Mouse and Human Tissues
- (2013) Yuji Nakada et al. PLoS One
- Incidence and risk of treatment-related mortality in cancer patients treated with EGFR-TKIs: A meta-analysis of 22 phase III randomized controlled trials
- (2013) Wei-Xiang Qi et al. RESPIRATORY MEDICINE
- Overexpression of ARK5 is associated with poor prognosis in hepatocellular carcinoma
- (2013) Jing Cui et al. TUMOR BIOLOGY
- Metabolic and Functional Genomic Studies Identify Deoxythymidylate Kinase as a Target in LKB1-Mutant Lung Cancer
- (2013) Y. Liu et al. Cancer Discovery
- Autophagy Sustains Mitochondrial Glutamine Metabolism and Growth of BrafV600E-Driven Lung Tumors
- (2013) A. M. Strohecker et al. Cancer Discovery
- LKB1/STK11 Inactivation Leads to Expansion of a Prometastatic Tumor Subpopulation in Melanoma
- (2012) Wenjin Liu et al. CANCER CELL
- Glycine Decarboxylase Activity Drives Non-Small Cell Lung Cancer Tumor-Initiating Cells and Tumorigenesis
- (2012) Wen Cai Zhang et al. CELL
- Mortality After Incident Cancer in People With and Without Type 2 Diabetes: Impact of metformin on survival
- (2012) C. J. Currie et al. DIABETES CARE
- ARK5 promotes glioma cell invasion, and its elevated expression is correlated with poor clinical outcome
- (2012) Shijun Lu et al. EUROPEAN JOURNAL OF CANCER
- Snf1-related kinase inhibits colon cancer cell proliferation through calcyclin-binding protein-dependent reduction of β-catenin
- (2012) Amy K. Rines et al. FASEB JOURNAL
- Metformin in cancer: translational challenges
- (2012) Ryan J O Dowling et al. JOURNAL OF MOLECULAR ENDOCRINOLOGY
- The maternal embryonic leucine zipper kinase (MELK) is upregulated in high-grade prostate cancer
- (2012) Ruprecht Kuner et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- A murine lung cancer co-clinical trial identifies genetic modifiers of therapeutic response
- (2012) Zhao Chen et al. NATURE
- The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity
- (2012) Jordi Barretina et al. NATURE
- Deregulated MYC expression induces dependence upon AMPK-related kinase 5
- (2012) Lidan Liu et al. NATURE
- A new model and modulator of pulmonary oedema
- (2012) Charlotte Harrison NATURE REVIEWS DRUG DISCOVERY
- AMPK: a nutrient and energy sensor that maintains energy homeostasis
- (2012) D. Grahame Hardie et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Safety, Activity, and Immune Correlates of Anti–PD-1 Antibody in Cancer
- (2012) Suzanne L. Topalian et al. NEW ENGLAND JOURNAL OF MEDICINE
- Differential Pathogenesis of Lung Adenocarcinoma Subtypes Involving Sequence Mutations, Copy Number, Chromosomal Instability, and Methylation
- (2012) Matthew D. Wilkerson et al. PLoS One
- Stromal Liver Kinase B1 [STK11] Signaling Loss Induces Oviductal Adenomas and Endometrial Cancer by Activating Mammalian Target of Rapamycin Complex 1
- (2012) Pradeep S. Tanwar et al. PLoS Genetics
- Relevance of the OCT1 transporter to the antineoplastic effect of biguanides
- (2011) Eric D. Segal et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis
- (2011) J. Y. Guo et al. GENES & DEVELOPMENT
- LKB1 Mutations Frequently Detected in Mucinous Bronchioloalveolar Carcinoma
- (2011) A. Osoegawa et al. JAPANESE JOURNAL OF CLINICAL ONCOLOGY
- Next-generation mTOR inhibitors in clinical oncology: how pathway complexity informs therapeutic strategy
- (2011) Seth A. Wander et al. JOURNAL OF CLINICAL INVESTIGATION
- Structure of mammalian AMPK and its regulation by ADP
- (2011) Bing Xiao et al. NATURE
- The AMPK signalling pathway coordinates cell growth, autophagy and metabolism
- (2011) Maria M. Mihaylova et al. NATURE CELL BIOLOGY
- Efficacy and Safety of Sirolimus in Lymphangioleiomyomatosis
- (2011) Francis X. McCormack et al. NEW ENGLAND JOURNAL OF MEDICINE
- Comparison of Expression Profiles in Ovarian Epithelium In Vivo and Ovarian Cancer Identifies Novel Candidate Genes Involved in Disease Pathogenesis
- (2011) Catherine Emmanuel et al. PLoS One
- Lkb1 and Pten Synergise to Suppress mTOR-Mediated Tumorigenesis and Epithelial-Mesenchymal Transition in the Mouse Bladder
- (2011) Boris Y. Shorning et al. PLoS One
- AMP kinase-related kinase NUAK2 affects tumor growth, migration, and clinical outcome of human melanoma
- (2011) T. Namiki et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- AMPK Is a Direct Adenylate Charge-Regulated Protein Kinase
- (2011) J. S. Oakhill et al. SCIENCE
- AMP-activated protein kinase: also regulated by ADP?
- (2011) D. Grahame Hardie et al. TRENDS IN BIOCHEMICAL SCIENCES
- The tumor suppressor kinase LKB1: lessons from mouse models
- (2011) S. Ollila et al. Journal of Molecular Cell Biology
- mTOR Kinase Inhibition Causes Feedback-Dependent Biphasic Regulation of AKT Signaling
- (2011) V. S. Rodrik-Outmezguine et al. Cancer Discovery
- The APL Paradigm and the “Co-Clinical Trial” Project
- (2011) Caterina Nardella et al. Cancer Discovery
- Proposal for dosage adjustment and timing of chemotherapy in hemodialyzed patients
- (2010) N. Janus et al. ANNALS OF ONCOLOGY
- Integrative Genomic and Proteomic Analyses Identify Targets for Lkb1-Deficient Metastatic Lung Tumors
- (2010) Julian Carretero et al. CANCER CELL
- SIK2 Is a Centrosome Kinase Required for Bipolar Mitotic Spindle Formation that Provides a Potential Target for Therapy in Ovarian Cancer
- (2010) Ahmed Ashour Ahmed et al. CANCER CELL
- Metformin and Other Biguanides in Oncology: Advancing the Research Agenda
- (2010) M. Pollak Cancer Prevention Research
- Use of Cells Expressing γ Subunit Variants to Identify Diverse Mechanisms of AMPK Activation
- (2010) Simon A. Hawley et al. Cell Metabolism
- Lkb1 inactivation is sufficient to drive endometrial cancers that are aggressive yet highly responsive to mTOR inhibitor monotherapy
- (2010) C. M. Contreras et al. Disease Models & Mechanisms
- Lactic Acidosis Induced by Metformin
- (2010) Jean-Daniel Lalau DRUG SAFETY
- Localization-specific LKB1 loss in head and neck squamous cell carcinoma metastasis
- (2010) Erik R. Kline et al. HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
- Growth and Invasion of Sporadic Colorectal Adenocarcinomas in Terms of Genetic Change
- (2010) Seon Ae Roh et al. JOURNAL OF KOREAN MEDICAL SCIENCE
- Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells
- (2010) Daisuke Nakada et al. NATURE
- The Lkb1 metabolic sensor maintains haematopoietic stem cell survival
- (2010) Sushma Gurumurthy et al. NATURE
- Lkb1 regulates quiescence and metabolic homeostasis of haematopoietic stem cells
- (2010) Boyi Gan et al. NATURE
- Diet and tumor LKB1 expression interact to determine sensitivity to anti-neoplastic effects of metformin in vivo
- (2010) C Algire et al. ONCOGENE
- LKB1 inhibits lung cancer progression through lysyl oxidase and extracellular matrix remodeling
- (2010) Y. Gao et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy
- (2010) D. F. Egan et al. SCIENCE
- Sunitinib Prolongs Survival in Genetically Engineered Mouse Models of Multistep Lung Carcinogenesis
- (2009) L. Gandhi et al. Cancer Prevention Research
- Oncogenic B-RAF Negatively Regulates the Tumor Suppressor LKB1 to Promote Melanoma Cell Proliferation
- (2009) Bin Zheng et al. MOLECULAR CELL
- TSC1 loss synergizes with KRAS activation in lung cancer development in the mouse and confers rapamycin sensitivity
- (2009) M-C Liang et al. ONCOGENE
- Somatic LKB1 Mutations Promote Cervical Cancer Progression
- (2009) Shana N. Wingo et al. PLoS One
- mTOR and HIF-1 -mediated tumor metabolism in an LKB1 mouse model of Peutz-Jeghers syndrome
- (2009) D. B. Shackelford et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- SIK1 Couples LKB1 to p53-Dependent Anoikis and Suppresses Metastasis
- (2009) H. Cheng et al. Science Signaling
- Active-Site Inhibitors of mTOR Target Rapamycin-Resistant Outputs of mTORC1 and mTORC2
- (2009) Morris E Feldman et al. PLOS BIOLOGY
- Suppression of Peutz-Jeghers Polyposis by Targeting Mammalian Target of Rapamycin Signaling
- (2008) C. Wei et al. CLINICAL CANCER RESEARCH
- Frequent BRG1/SMARCA4-inactivating mutations in human lung cancer cell lines
- (2008) Pedro P. Medina et al. HUMAN MUTATION
- Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity
- (2008) S.-M. Maira et al. MOLECULAR CANCER THERAPEUTICS
- AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint
- (2008) Dana M. Gwinn et al. MOLECULAR CELL
- Somatic mutations affect key pathways in lung adenocarcinoma
- (2008) Li Ding et al. NATURE
- Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases
- (2008) Beth Apsel et al. Nature Chemical Biology
- LKB1 signaling in mesenchymal cells required for suppression of gastrointestinal polyposis
- (2008) Pekka Katajisto et al. NATURE GENETICS
- Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers
- (2008) Jeffrey A Engelman et al. NATURE MEDICINE
- Sirolimus for Angiomyolipoma in Tuberous Sclerosis Complex or Lymphangioleiomyomatosis
- (2008) John J. Bissler et al. NEW ENGLAND JOURNAL OF MEDICINE
- Biguanide-induced mitochondrial dysfunction yields increased lactate production and cytotoxicity of aerobically-poised HepG2 cells and human hepatocytes in vitro
- (2008) James A. Dykens et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
Create your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create NowAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started