If it’s not one thing, HIF’s another: immunoregulation by hypoxia inducible factors in disease

Hypoxia and Innate Immunity: Keeping Up with the HIFsters

(2020) Sean P. Colgan et al.   Annual Review of Immunology

The Impact of Hypoxia on Neutrophil Degranulation and Consequences for the Host

(2020) Katharine M. Lodge et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Targeting potential drivers of COVID-19: Neutrophil extracellular traps

(2020) Betsy J. Barnes et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Absence of HIF-1α Increases Susceptibility to Leishmania donovani Infection via Activation of BNIP3/mTOR/SREBP-1c Axis

(2020) Inês Mesquita et al.   Cell Reports

Bidirectional crosstalk between Hypoxia-Inducible Factor and glucocorticoid signalling in zebrafish larvae

(2020) Davide Marchi et al.   PLoS Genetics

Polymersomes Eradicating Intracellular Bacteria

(2020) Federico Fenaroli et al.   ACS Nano

Hif‐1alpha stabilisation is protective against infection in zebrafish comorbid models

(2020) Yves Schild et al.   FEBS Journal

Hypoxia and the regulation of myeloid cell metabolic imprinting: consequences for the inflammatory response

(2019) Pranvera Sadiku et al.   EMBO REPORTS

HIF-1α regulates IL-1β and IL-17 in sarcoidosis

(2019) Jaya Talreja et al.   eLife

Roxadustat for Anemia in Patients with Kidney Disease Not Receiving Dialysis

(2019) Nan Chen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Specific Inhibition of the NLRP3 Inflammasome as an Anti-Inflammatory Strategy in Cystic Fibrosis

(2019) Oliver J McElvaney et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Hypoxia‐Inducible Factor (HIF)‐2α Reprograms Liver Macrophages to Protect Against Acute Liver Injury via the Production of Interleukin‐6

(2019) Rachel Y. Gao et al.   HEPATOLOGY

Hypoxia Induces Macrophage tnfa Expression via Cyclooxygenase and Prostaglandin E2 in vivo

(2019) Amy Lewis et al.   Frontiers in Immunology

HIF-1α as a central mediator of cellular resistance to intracellular pathogens

(2019) Matthew Knight et al.   CURRENT OPINION IN IMMUNOLOGY

The Impact of Hypoxia on the Host-Pathogen Interaction between Neutrophils and Staphylococcus aureus

(2019) Natalia H Hajdamowicz et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Intrabody against prolyl hydroxylase 2 promotes angiogenesis by stabilizing hypoxia-inducible factor-1α

(2019) Liangzhong Zhao et al.   Scientific Reports

Biochemical and genetic characterization of fungal proline hydroxylase in echinocandin biosynthesis

(2018) Feng Zhang et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

First-in-man-proof of concept study with molidustat: a novel selective oral HIF-prolyl hydroxylase inhibitor for the treatment of renal anaemia

(2018) M. Böttcher et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Interleukin 17 under hypoxia mimetic condition augments osteoclast mediated bone erosion and expression of HIF-1α and MMP-9

(2018) Snigdha Samarpita et al.   CELLULAR IMMUNOLOGY

Neutrophil extracellular traps are associated with disease severity and microbiota diversity in patients with chronic obstructive pulmonary disease

(2018) Alison J. Dicker et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Phase I Dose-Escalation Trial of PT2385, a First-in-Class Hypoxia-Inducible Factor-2α Antagonist in Patients With Previously Treated Advanced Clear Cell Renal Cell Carcinoma

(2018) Kevin D. Courtney et al.   JOURNAL OF CLINICAL ONCOLOGY

Hypoxia mimetic activity of VCE-004.8, a cannabidiol quinone derivative: implications for multiple sclerosis therapy

(2018) Carmen Navarrete et al.   Journal of Neuroinflammation

Hypoxia-inducible factor-1α is a critical transcription factor for IL-10-producing B cells in autoimmune disease

(2018) Xianyi Meng et al.   Nature Communications

HIF-1α hampers dendritic cell function and Th1 generation during chronic visceral leishmaniasis

(2018) Akil Hammami et al.   Scientific Reports

Lipid droplet formation in Mycobacterium tuberculosis infected macrophages requires IFN-γ/HIF-1α signaling and supports host defense

(2018) Matthew Knight et al.   PLoS Pathogens

Leishmania donovani Activates Hypoxia Inducible Factor-1α and miR-210 for Survival in Macrophages by Downregulation of NF-κB Mediated Pro-inflammatory Immune Response

(2018) Vinod Kumar et al.   Frontiers in Microbiology

Hypoxia Inducible Factor 1α Plays a Key Role in Remote Ischemic Preconditioning Against Stroke by Modulating Inflammatory Responses in Rats

(2018) Jian Yang et al.   Journal of the American Heart Association

Cobalt-mediated multi-functional dressings promote bacteria-infected wound healing

(2018) Qingying Shi et al.   Acta Biomaterialia

The E3 ligase VHL controls alveolar macrophage function via metabolic–epigenetic regulation

(2018) Wen Zhang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Development of Inflammatory Hypoxia and Prevalence of Glycolytic Metabolism in Progressing Herpes Stromal Keratitis Lesions

(2018) Pushpa Rao et al.   JOURNAL OF IMMUNOLOGY

Hif-1α–Induced Expression of Il-1β Protects against Mycobacterial Infection in Zebrafish

(2018) Nikolay V. Ogryzko et al.   JOURNAL OF IMMUNOLOGY

Correlation of serum levels of HIF-1α and IL-19 with the disease progression of COPD: a retrospective study

(2018) Biaoxue Rong et al.   International Journal of Chronic Obstructive Pulmonary Disease

Myeloid Cell Hypoxia-Inducible Factors Promote Resolution of Inflammation in Experimental Colitis

(2018) Nan Lin et al.   Frontiers in Immunology

Nitric Oxide Modulates Macrophage Responses toMycobacterium tuberculosisInfection through Activation of HIF-1α and Repression of NF-κB

(2017) Jonathan Braverman et al.   JOURNAL OF IMMUNOLOGY

Glucocorticoids promote Von Hippel Lindau degradation and Hif-1α stabilization

(2017) Andrea Vettori et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypoxia ameliorates intestinal inflammation through NLRP3/mTOR downregulation and autophagy activation

(2017) Jesus Cosin-Roger et al.   Nature Communications

Pharmacological HIF-inhibition attenuates postoperative adhesion formation

(2017) Moritz J. Strowitzki et al.   Scientific Reports

A Novel Hypoxia-Inducible Factor−Prolyl Hydroxylase Inhibitor (GSK1278863) for Anemia in CKD: A 28-Day, Phase 2A Randomized Trial

(2016) Richard A. Brigandi et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Hypoxia-inducible factor 3 biology: complexities and emerging themes

(2016) Cunming Duan   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Inverse Correlation between IL-10 and HIF-1α in Macrophages Infected withHistoplasma capsulatum

(2016) Roger A. Fecher et al.   JOURNAL OF IMMUNOLOGY

HIF-2α in Resting Macrophages Tempers Mitochondrial Reactive Oxygen Species To Selectively Repress MARCO-Dependent Phagocytosis

(2016) Shirley Dehn et al.   JOURNAL OF IMMUNOLOGY

HIF-1α Is an Essential Mediator of IFN-γ–Dependent Immunity toMycobacterium tuberculosis

(2016) Jonathan Braverman et al.   JOURNAL OF IMMUNOLOGY

Trypanosoma bruceimetabolite indolepyruvate decreases HIF-1α and glycolysis in macrophages as a mechanism of innate immune evasion

(2016) Anne F. McGettrick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypoxia upregulates neutrophil degranulation and potential for tissue injury

(2016) Kim Hoenderdos et al.   THORAX

Formation of Neutrophil Extracellular Traps under Low Oxygen Level

(2016) Katja Branitzki-Heinemann et al.   Frontiers in Immunology

Targeted delivery of the hydroxylase inhibitor DMOG provides enhanced efficacy with reduced systemic exposure in a murine model of colitis

(2015) Murtaza M. Tambuwala et al.   JOURNAL OF CONTROLLED RELEASE

Myeloid HIF-1 Is Protective inHelicobacter pylori–Mediated Gastritis

(2015) Pavle Matak et al.   JOURNAL OF IMMUNOLOGY

Activation of HIF-1α and LL-37 by commensal bacteria inhibits Candida albicans colonization

(2015) Di Fan et al.   NATURE MEDICINE

IRF-5-Mediated Inflammation Limits CD8+ T Cell Expansion by Inducing HIF-1α and Impairing Dendritic Cell Functions during Leishmania Infection

(2015) Akil Hammami et al.   PLoS Pathogens

Role of Hypoxia Inducible Factor-1α (HIF-1α) in Innate Defense against Uropathogenic Escherichia coli Infection

(2015) Ann E. Lin et al.   PLoS Pathogens

Hypoxia-Inducible Factor 3 Is an Oxygen-Dependent Transcription Activator and Regulates a Distinct Transcriptional Response to Hypoxia

(2014) Peng Zhang et al.   Cell Reports

Hypoxia, the HIF pathway and neutrophilic inflammatory responses

(2013) A.A. Roger Thompson et al.   BIOLOGICAL CHEMISTRY

Hypoxia-inducible factor 2  regulates key neutrophil functions in humans, mice, and zebrafish

(2013) A. A. R. Thompson et al.   BLOOD

Hypoxia Inducible Factor Signaling Modulates Susceptibility to Mycobacterial Infection via a Nitric Oxide Dependent Mechanism

(2013) Philip M. Elks et al.   PLoS Pathogens

Mammalian target of rapamycin regulates neutrophil extracellular trap formation via induction of hypoxia-inducible factor 1  

(2012) A. M. McInturff et al.   BLOOD

Therapeutic Delivery of siRNA Silencing HIF-1 Alpha with Micellar Nanoparticles Inhibits Hypoxic Tumor Growth

(2012) Xi-Qiu Liu et al.   MOLECULAR PHARMACEUTICS

Adaptive and Maladaptive Cardiorespiratory Responses to Continuous and Intermittent Hypoxia Mediated by Hypoxia-Inducible Factors 1 and 2

(2012) Nanduri R. Prabhakar et al.   PHYSIOLOGICAL REVIEWS

The pro- and anti-inflammatory properties of the cytokine interleukin-6

(2011) Jürgen Scheller et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH