HypoxamiRs and Cancer: From Biology to Targeted Therapy

Circulating miR-210 as a Novel Hypoxia Marker in Pancreatic Cancer

(2014) Allen S. Ho et al.   Translational Oncology

miR-210 is a target of hypoxia-inducible factors 1 and 2 in renal cancer, regulates ISCU and correlates with good prognosis

(2013) R I McCormick et al.   BRITISH JOURNAL OF CANCER

Xist RNA Is a Potent Suppressor of Hematologic Cancer in Mice

(2013) Eda Yildirim et al.   CELL

MicroRNA-93 Controls Perfusion Recovery After Hindlimb Ischemia by Modulating Expression of Multiple Genes in the Cell Cycle Pathway

(2013) Surovi Hazarika et al.   CIRCULATION

MicroRNA-138 suppresses ovarian cancer cell invasion and metastasis by targeting SOX4 and HIF-1α

(2013) Yu-Ming Yeh et al.   INTERNATIONAL JOURNAL OF CANCER

Hypoxia-responsive miRNAs target argonaute 1 to promote angiogenesis

(2013) Zhen Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Dichloroacetate reverses the hypoxic adaptation to bevacizumab and enhances its antitumor effects in mouse xenografts

(2013) Krishan Kumar et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Interactions of miR-323/miR-326/miR-329 and miR-130a/miR-155/miR-210 as prognostic indicators for clinical outcome of glioblastoma patients

(2013) Shuwei Qiu et al.   Journal of Translational Medicine

Prognostic evaluation of microRNA-210 expression in pediatric osteosarcoma

(2013) Haiqing Cai et al.   MEDICAL ONCOLOGY

EGFR modulates microRNA maturation in response to hypoxia through phosphorylation of AGO2

(2013) Jia Shen et al.   NATURE

Effects of knockdown of miR-210 in combination with ionizing radiation on human hepatoma xenograft in nude mice

(2013) Wei Yang et al.   Radiation Oncology

MiR-210 promotes a hypoxic phenotype and increases radioresistance in human lung cancer cell lines

(2013) S Grosso et al.   Cell Death & Disease

Reactive oxygen species-responsive miR-210 regulates proliferation and migration of adipose-derived stem cells via PTPN2

(2013) J H Kim et al.   Cell Death & Disease

miR-210 has an antiapoptotic effect in pulmonary artery smooth muscle cells during hypoxia

(2012) Deming Gou et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Concomitant Activation of miR-107/PDCD10 and Hypoxamir-210/Casp8ap2 and Their Role in Cytoprotection During Ischemic Preconditioning of Stem Cells

(2012) Ha Won Kim et al.   ANTIOXIDANTS & REDOX SIGNALING

MicroRNA-210 targets antiapoptotic Bcl-2 expression and mediates hypoxia-induced apoptosis of neuroblastoma cells

(2012) Chung-Ching Chio et al.   ARCHIVES OF TOXICOLOGY

Hypoxic enhancement of exosome release by breast cancer cells

(2012) Hamish W King et al.   BMC CANCER

MicroRNA profiling of peripheral nerve sheath tumours identifies miR-29c as a tumour suppressor gene involved in tumour progression

(2012) N Presneau et al.   BRITISH JOURNAL OF CANCER

miR-103/107 Promote Metastasis of Colorectal Cancer by Targeting the Metastasis Suppressors DAPK and KLF4

(2012) H.-Y. Chen et al.   CANCER RESEARCH

Hypoxia-Inducible Factors in Physiology and Medicine

(2012) Gregg L. Semenza   CELL

HIF-1α downregulates miR-17/20a directly targeting p21 and STAT3: a role in myeloid leukemic cell differentiation

(2012) M He et al.   CELL DEATH AND DIFFERENTIATION

MicroRNA dysregulation in cancer: diagnostics, monitoring and therapeutics. A comprehensive review

(2012) Marilena V. Iorio et al.   EMBO Molecular Medicine

Serum miR-210 as a novel biomarker for molecular diagnosis of clear cell renal cell carcinoma

(2012) An Zhao et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Downregulation of miR-210 expression inhibits proliferation, induces apoptosis and enhances radiosensitivity in hypoxic human hepatoma cells in vitro

(2012) Wei Yang et al.   EXPERIMENTAL CELL RESEARCH

High expression of miR-210 predicts poor survival in patients with breast cancer: A meta-analysis

(2012) Liu Hong et al.   GENE

Circulating microRNAs: New biomarkers in diagnosis, prognosis and treatment of cancer (Review)

(2012) ALESSANDRO ALLEGRA et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

High Expression of MicroRNA-210 is an Independent Factor Indicating a Poor Prognosis in Japanese Triple-negative Breast Cancer Patients

(2012) T. Toyama et al.   JAPANESE JOURNAL OF CLINICAL ONCOLOGY

Hypoxia-inducible Factor 1-α Induces miR-210 in Normoxic Differentiating Myoblasts

(2012) Lucia Cicchillitti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Up-regulation of miR-210 by vascular endothelial growth factor inex vivoexpanded CD34+ cells enhances cell-mediated angiogenesis

(2012) Mohamad Amer Alaiti et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Hypoxia-Induced MicroRNA-20a Expression Increases ERK Phosphorylation and Angiogenic Gene Expression in Endometriotic Stromal Cells

(2012) Shih-Chieh Lin et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Identification of a Signaling Axis HIF-1α/MicroRNA-210/ISCU Independent ofSDHMutation That Defines a Subgroup of Head and Neck Paragangliomas

(2012) Anna Merlo et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Accelerated Radiotherapy With Carbogen and Nicotinamide for Laryngeal Cancer: Results of a Phase III Randomized Trial

(2012) Geert O. Janssens et al.   JOURNAL OF CLINICAL ONCOLOGY

miR-210 activates notch signaling pathway in angiogenesis induced by cerebral ischemia

(2012) Yuan-Lei Lou et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

MiR-210 disturbs mitotic progression through regulating a group of mitosis-related genes

(2012) Jie He et al.   NUCLEIC ACIDS RESEARCH

MicroRNA-145 inhibits the growth, invasion, metastasis and angiogenesis of neuroblastoma cells through targeting hypoxia-inducible factor 2 alpha

(2012) H Zhang et al.   ONCOGENE

Hypoxia-Induced Down-Regulation of microRNA-34a Promotes EMT by Targeting the Notch Signaling Pathway in Tubular Epithelial Cells

(2012) Rui Du et al.   PLoS One

ROD1 Is a Seedless Target Gene of Hypoxia-Induced miR-210

(2012) Pasquale Fasanaro et al.   PLoS One

Synthetic miRNA-Mowers Targeting miR-183-96-182 Cluster or miR-210 Inhibit Growth and Migration and Induce Apoptosis in Bladder Cancer Cells

(2012) Yuchen Liu et al.   PLoS One

Deep-sequencing of endothelial cells exposed to hypoxia reveals the complexity of known and novel microRNAs

(2012) C. Voellenkle et al.   RNA

miRNA-Mediated Gene Silencing by Translational Repression Followed by mRNA Deadenylation and Decay

(2012) S. Djuranovic et al.   SCIENCE

MiR-210 expression in tumor tissue and in vitro effects of its silencing in renal cell carcinoma

(2012) Martina Redova et al.   TUMOR BIOLOGY

microRNA-210 is upregulated in hypoxic cardiomyocytes through Akt- and p53-dependent pathways and exerts cytoprotective effects

(2011) R. Kannan Mutharasan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Targeting microRNAs involved in human diseases: A novel approach for modification of gene expression and drug development

(2011) Roberto Gambari et al.   BIOCHEMICAL PHARMACOLOGY

Plasma microRNA 210 levels correlate with sensitivity to trastuzumab and tumor presence in breast cancer patients

(2011) Eun-Jung Jung et al.   CANCER

EMT: A new vision of hypoxia promoting cancer progression

(2011) Jian Jiang et al.   CANCER BIOLOGY & THERAPY

Akt2 Regulates All Akt Isoforms and Promotes Resistance to Hypoxia through Induction of miR-21 upon Oxygen Deprivation

(2011) C. Polytarchou et al.   CANCER RESEARCH

microRNA-Associated Progression Pathways and Potential Therapeutic Targets Identified by Integrated mRNA and microRNA Expression Profiling in Breast Cancer

(2011) F. M. Buffa et al.   CANCER RESEARCH

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

A set of miRNAs participates in the cellular senescence program in human diploid fibroblasts

(2011) R Faraonio et al.   CELL DEATH AND DIFFERENTIATION

Hypoxia-inducible MicroRNA-210 augments the metastatic potential of tumor cells by targeting vacuole membrane protein 1 in hepatocellular carcinoma

(2011) Qiao Ying et al.   HEPATOLOGY

Expression of microRNA 210 associates with poor survival and age of tumor onset of soft-tissue sarcoma patients

(2011) T. Greither et al.   INTERNATIONAL JOURNAL OF CANCER

Elevated levels of hypoxia-inducible microRNA-210 in pre-eclampsia: new insights into molecular mechanisms for the disease

(2011) Yi Zhang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Overexpression of miR-210, a downstream target of HIF1α, causes centrosome amplification in renal carcinoma cells

(2011) Chisato Nakada et al.   JOURNAL OF PATHOLOGY

miRNA Profiling for Clear Cell Renal Cell Carcinoma: Biomarker Discovery and Identification of Potential Controls and Consequences of miRNA Dysregulation

(2011) Nicole M.A. White et al.   JOURNAL OF UROLOGY

Hypoxia-microRNA-16 downregulation induces VEGF expression in anaplastic lymphoma kinase (ALK)-positive anaplastic large-cell lymphomas

(2011) E Dejean et al.   LEUKEMIA

Hypoxia Potentiates MicroRNA-Mediated Gene Silencing through Posttranslational Modification of Argonaute2

(2011) C. Wu et al.   MOLECULAR AND CELLULAR BIOLOGY

A Hypoxia-Induced Positive Feedback Loop Promotes Hypoxia-Inducible Factor 1  Stability through miR-210 Suppression of Glycerol-3-Phosphate Dehydrogenase 1-Like

(2011) T. J. Kelly et al.   MOLECULAR AND CELLULAR BIOLOGY

MicroRNA-155 Promotes Resolution of Hypoxia-Inducible Factor 1  Activity during Prolonged Hypoxia

(2011) U. Bruning et al.   MOLECULAR AND CELLULAR BIOLOGY

The ATM Kinase Induces MicroRNA Biogenesis in the DNA Damage Response

(2011) Xinna Zhang et al.   MOLECULAR CELL

MicroRNAs in body fluids—the mix of hormones and biomarkers

(2011) Maria Angelica Cortez et al.   Nature Reviews Clinical Oncology

Global MicroRNA Expression Profiling Identifies MiR-210 Associated with Tumor Proliferation, Invasion and Poor Clinical Outcome in Breast Cancer

(2011) Françoise Rothé et al.   PLoS One

A Parsimonious Model for Gene Regulation by miRNAs

(2011) S. Djuranovic et al.   SCIENCE

MicroRNAs in Mutagenesis, Genomic Instability, and DNA Repair

(2011) Dan-Avi Landau et al.   SEMINARS IN ONCOLOGY

miRNA response to DNA damage

(2011) Guohui Wan et al.   TRENDS IN BIOCHEMICAL SCIENCES

miRNA therapeutics: delivery and biological activity of peptide nucleic acids targeting miRNAs

(2011) Enrica Fabbri et al.   Epigenomics

MicroRNA-21 plays a role in hypoxia-mediated pulmonary artery smooth muscle cell proliferation and migration

(2010) Joy Sarkar et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

miR-210 links hypoxia with cell cycle regulation and is deleted in human epithelial ovarian cancer

(2010) Antonis Giannakakis et al.   CANCER BIOLOGY & THERAPY

MicroRNA-519c Suppresses Hypoxia-Inducible Factor-1α Expression and Tumor Angiogenesis

(2010) Shih-Ting Cha et al.   CANCER RESEARCH

MicroRNA miR-210 modulates cellular response to hypoxia through the MYC antagonist MNT

(2010) Zhan Zhang et al.   CELL CYCLE

miR-210 is overexpressed in late stages of lung cancer and mediates mitochondrial alterations associated with modulation of HIF-1 activity

(2010) M-P Puisségur et al.   CELL DEATH AND DIFFERENTIATION

MicroRNA-210 as a Novel Therapy for Treatment of Ischemic Heart Disease

(2010) S. Hu et al.   CIRCULATION

Reactive Oxygen Species Originating From Mitochondria Regulate the Cardiac Sodium Channel

(2010) Man Liu et al.   CIRCULATION RESEARCH

The MicroRNA Spectrum in 12 Body Fluids

(2010) J. A. Weber et al.   CLINICAL CHEMISTRY

MicroRNA-21 Is a Downstream Effector of AKT That Mediates Its Antiapoptotic Effects via Suppression of Fas Ligand

(2010) Danish Sayed et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MicroRNA-210 Regulates Cancer Cell Proliferation through Targeting Fibroblast Growth Factor Receptor-like 1 (FGFRL1)

(2010) Soken Tsuchiya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

miRNA profiling along tumour progression in ovarian carcinoma

(2010) Olga Vaksman et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Hypoxia-induced microRNA-424 expression in human endothelial cells regulates HIF-α isoforms and promotes angiogenesis

(2010) Goutam Ghosh et al.   JOURNAL OF CLINICAL INVESTIGATION

Tirapazamine, Cisplatin, and Radiation Versus Cisplatin and Radiation for Advanced Squamous Cell Carcinoma of the Head and Neck (TROG 02.02, HeadSTART): A Phase III Trial of the Trans-Tasman Radiation Oncology Group

(2010) Danny Rischin et al.   JOURNAL OF CLINICAL ONCOLOGY

Accurate Molecular Classification of Renal Tumors Using MicroRNA Expression

(2010) Eddie Fridman et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

Early detection of squamous cell lung cancer in sputum by a panel of microRNA markers

(2010) Lingxiao Xing et al.   MODERN PATHOLOGY

Mammalian microRNAs predominantly act to decrease target mRNA levels

(2010) Huili Guo et al.   NATURE

Hypoxia-regulated microRNA-210 modulates mitochondrial function and decreases ISCU and COX10 expression

(2010) Z Chen et al.   ONCOGENE

MicroRNA-210 Regulates Mitochondrial Free Radical Response to Hypoxia and Krebs Cycle in Cancer Cells by Targeting Iron Sulfur Cluster Protein ISCU

(2010) Elena Favaro et al.   PLoS One

Hypoxia inducible microRNA 210 attenuates keratinocyte proliferation and impairs closure in a murine model of ischemic wounds

(2010) S. Biswas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

P53-induced microRNA-107 inhibits HIF-1 and tumor angiogenesis

(2010) M. Yamakuchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MiR-210 – micromanager of the hypoxia pathway

(2010) Xin Huang et al.   TRENDS IN MOLECULAR MEDICINE

MicroRNAs in Cancer

(2009) Ramiro Garzon et al.   Annual Review of Medicine

Role of specific microRNAs for endothelial function and angiogenesis

(2009) Fusheng Wu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Identification and Functional Characterization of microRNAs Involved in the Malignant Progression of Gliomas

(2009) Bastian Malzkorn et al.   BRAIN PATHOLOGY

MicroRNAs in Plasma of Pancreatic Ductal Adenocarcinoma Patients as Novel Blood-Based Biomarkers of Disease

(2009) J. Wang et al.   Cancer Prevention Research

MicroRNA Regulation of DNA Repair Gene Expression in Hypoxic Stress

(2009) M. E. Crosby et al.   CANCER RESEARCH

MicroRNAs: Target Recognition and Regulatory Functions

(2009) David P. Bartel   CELL

MicroRNAs and Cancer: Short RNAs Go a Long Way

(2009) Andrea Ventura et al.   CELL

MicroRNA-210 Controls Mitochondrial Metabolism during Hypoxia by Repressing the Iron-Sulfur Cluster Assembly Proteins ISCU1/2

(2009) Stephen Y. Chan et al.   Cell Metabolism

AngiomiRs—Key regulators of angiogenesis

(2009) Shusheng Wang et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Repression of the miR-17-92 cluster by p53 has an important function in hypoxia-induced apoptosis

(2009) Hong-li Yan et al.   EMBO JOURNAL

Integrative molecular bioinformatics study of human adrenocortical tumors: microRNA, tissue-specific target prediction, and pathway analysis

(2009) Zsófia Tömböl et al.   ENDOCRINE-RELATED CANCER

Restoration of tumour suppressor hsa-miR-145 inhibits cancer cell growth in lung adenocarcinoma patients with epidermal growth factor receptor mutation

(2009) William C.S. Cho et al.   EUROPEAN JOURNAL OF CANCER

MicroRNAs: Predictors and modifiers of chemo- and radiotherapy in different tumour types

(2009) Richard Hummel et al.   EUROPEAN JOURNAL OF CANCER

DIFFERENTIALLY EXPRESSED MicroRNAs IN SMALL CELL LUNG CANCER

(2009) Edit Miko et al.   EXPERIMENTAL LUNG RESEARCH

Elevated expression of microRNAs 155, 203, 210 and 222 in pancreatic tumors is associated with poorer survival

(2009) Thomas Greither et al.   INTERNATIONAL JOURNAL OF CANCER

Ischemic Preconditioning Augments Survival of Stem Cells via miR-210 Expression by Targeting Caspase-8-associated Protein 2

(2009) Ha Won Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An Integrated Approach for Experimental Target Identification of Hypoxia-induced miR-210

(2009) Pasquale Fasanaro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of hypoxia in the hallmarks of human cancer

(2009) Kai Ruan et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Hypoxia-Inducible mir-210 Regulates Normoxic Gene Expression Involved in Tumor Initiation

(2009) Xin Huang et al.   MOLECULAR CELL

Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics

(2009) G L Semenza   ONCOGENE

Ionizing Radiation-Induced Oxidative Stress Alters miRNA Expression

(2009) Nicole L. Simone et al.   PLoS One

Regulation of HIF-1α and VEGF by miR-20b Tunes Tumor Cells to Adapt to the Alteration of Oxygen Concentration

(2009) Zhang Lei et al.   PLoS One

Therapeutic Silencing of MicroRNA-122 in Primates with Chronic Hepatitis C Virus Infection

(2009) R. E. Lanford et al.   SCIENCE

Identification of a MicroRNA Panel for Clear-cell Kidney Cancer

(2009) David Juan et al.   UROLOGY

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

Detection of elevated levels of tumour-associated microRNAs in serum of patients with diffuse large B-cell lymphoma

(2008) Charles H. Lawrie et al.   BRITISH JOURNAL OF HAEMATOLOGY

The Pervasive Presence of Fluctuating Oxygenation in Tumors

(2008) L. I. Cardenas-Navia et al.   CANCER RESEARCH

Identification of Hypoxia-Inducible Factor-1  as a Novel Target for miR-17-92 MicroRNA Cluster

(2008) A. Taguchi et al.   CANCER RESEARCH

A microRNA component of the hypoxic response

(2008) R Kulshreshtha et al.   CELL DEATH AND DIFFERENTIATION

Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases

(2008) Xi Chen et al.   CELL RESEARCH

Role of Protein Tyrosine Phosphatase 1B in Vascular Endothelial Growth Factor Signaling and Cell–Cell Adhesions in Endothelial Cells

(2008) Yoshimasa Nakamura et al.   CIRCULATION RESEARCH

hsa-miR-210 Is Induced by Hypoxia and Is an Independent Prognostic Factor in Breast Cancer

(2008) C. Camps et al.   CLINICAL CANCER RESEARCH

Cellular uptake of PET tracers of glucose metabolism and hypoxia and their linkage

(2008) Morten Busk et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

MicroRNA signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer

(2008) Douglas D. Taylor et al.   GYNECOLOGIC ONCOLOGY

MicroRNA-210 Modulates Endothelial Cell Response to Hypoxia and Inhibits the Receptor Tyrosine Kinase Ligand Ephrin-A3

(2008) Pasquale Fasanaro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hypoxia response and microRNAs: no longer two separate worlds

(2008) Mircea Ivan et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The impact of microRNAs on protein output

(2008) Daehyun Baek et al.   NATURE

Widespread changes in protein synthesis induced by microRNAs

(2008) Matthias Selbach et al.   NATURE

Serum MicroRNAs Are Promising Novel Biomarkers

(2008) Shlomit Gilad et al.   PLoS One

MicroRNA-373 induces expression of genes with complementary promoter sequences

(2008) R. F. Place et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Four miRNAs associated with aggressiveness of lymph node-negative, estrogen receptor-positive human breast cancer

(2008) J. A. Foekens et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Circulating microRNAs as stable blood-based markers for cancer detection

(2008) P. S. Mitchell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The utility of LNA in microRNA-based cancer diagnostics and therapeutics

(2008) Jan Stenvang et al.   SEMINARS IN CANCER BIOLOGY