Role of Hypoxia Inducible Factor-1α (HIF-1α) in Innate Defense against Uropathogenic Escherichia coli Infection

Guidelines for the diagnosis and management of recurrent urinary tract infection in women

(2016) Shawn Dason et al.   CUAJ-Canadian Urological Association Journal

Activation of HIF-1α does not increase intestinal tumorigenesis

(2014) Xiang Xue et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

The antibacterial effect of nitric oxide against ESBL-producing uropathogenic E. coli is improved by combination with miconazole and polymyxin B nonapeptide

(2014) Charlotte Bang et al.   BMC MICROBIOLOGY

Role of Urinary Cathelicidin LL-37 and Human β-Defensin 1 in Uncomplicated Escherichia coli Urinary Tract Infections

(2014) Karen L. Nielsen et al.   INFECTION AND IMMUNITY

Targeting hypoxia signalling for the treatment of ischaemic and inflammatory diseases

(2014) Holger K. Eltzschig et al.   NATURE REVIEWS DRUG DISCOVERY

Human β-defensin 2 may inhibit internalisation of bacillus Calmette-Guérin (BCG) in bladder cancer cells

(2013) Jung Hoon Kim et al.   BJU INTERNATIONAL

Human Milk Oligosaccharides Protect Bladder Epithelial Cells Against Uropathogenic Escherichia coli Invasion and Cytotoxicity

(2013) A. E. Lin et al.   JOURNAL OF INFECTIOUS DISEASES

Role of hypoxia inducible factor-1 in keratinocyte inflammatory response and neutrophil recruitment

(2013) Emma Leire et al.   Journal of Inflammation-London

Contribution of epithelial innate immunity to systemic protection afforded by prolyl hydroxylase inhibition in murine colitis

(2013) S Keely et al.   Mucosal Immunology

Hypoxia Inducible Factor Signaling Modulates Susceptibility to Mycobacterial Infection via a Nitric Oxide Dependent Mechanism

(2013) Philip M. Elks et al.   PLoS Pathogens

HIF-1α Is Essential for Effective PMN Bacterial Killing, Antimicrobial Peptide Production and Apoptosis in Pseudomonas aeruginosa Keratitis

(2013) Elizabeth A. Berger et al.   PLoS Pathogens

Nitric Oxide Activates IL-6 Production and Expression in Human Renal Epithelial Cells

(2012) Isak Demirel et al.   AMERICAN JOURNAL OF NEPHROLOGY

The UPEC Pore-Forming Toxin α-Hemolysin Triggers Proteolysis of Host Proteins to Disrupt Cell Adhesion, Inflammatory, and Survival Pathways

(2012) Bijaya K. Dhakal et al.   Cell Host & Microbe

Immune Modulation by Group B Streptococcus Influences Host Susceptibility to Urinary Tract Infection by Uropathogenic Escherichia coli

(2012) Kimberly A. Kline et al.   INFECTION AND IMMUNITY

Giving Anemia a Boost with Inhibitors of Prolyl Hydroxylase

(2012) William A. Denny   JOURNAL OF MEDICINAL CHEMISTRY

A new pharmacological agent (AKB-4924) stabilizes hypoxia inducible factor-1 (HIF-1) and increases skin innate defenses against bacterial infection

(2012) Cheryl Y. M. Okumura et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

HIF prolyl hydroxylase inhibitors for anemia

(2011) Eugene Muchnik et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Dynamin2- and endothelial nitric oxide synthase–regulated invasion of bladder epithelial cells by uropathogenicEscherichia coli

(2011) Zhimin Wang et al.   JOURNAL OF CELL BIOLOGY

Microglial p38α MAPK is a key regulator of proinflammatory cytokine up-regulation induced by toll-like receptor (TLR) ligands or beta-amyloid (Aβ)

(2011) Adam D Bachstetter et al.   Journal of Neuroinflammation

Effects of intravesical liposome-mediated human beta-defensin-2 gene transfection in a mouse urinary tract infection model

(2011) Junli Zhao et al.   MICROBIOLOGY AND IMMUNOLOGY

Hypoxia and Inflammation

(2011) Holger K. Eltzschig et al.   NEW ENGLAND JOURNAL OF MEDICINE

Tumor-associated CpG demethylation augments hypoxia-induced effects by positive autoregulation of HIF-1α

(2010) M Koslowski et al.   ONCOGENE

Vitamin D Induction of the Human Antimicrobial Peptide Cathelicidin in the Urinary Bladder

(2010) Olof Hertting et al.   PLoS One

Early Severe Inflammatory Responses to Uropathogenic E. coli Predispose to Chronic and Recurrent Urinary Tract Infection

(2010) Thomas J. Hannan et al.   PLoS Pathogens

Escherichia coli Global Gene Expression in Urine from Women with Urinary Tract Infection

(2010) Erin C. Hagan et al.   PLoS Pathogens

Bone Morphogenetic Protein 4 Signaling Regulates Epithelial Renewal in the Urinary Tract in Response to Uropathogenic Infection

(2009) Indira U. Mysorekar et al.   Cell Host & Microbe

Urothelial Cultures Support Intracellular Bacterial Community Formation by Uropathogenic Escherichia coli

(2009) R. E. Berry et al.   INFECTION AND IMMUNITY

Maintaining a Sterile Urinary Tract: The Role of Antimicrobial Peptides

(2009) Ased S.M. Ali et al.   JOURNAL OF UROLOGY

A murine model of urinary tract infection

(2009) Chia-Suei Hung et al.   Nature Protocols

Utilization of an Intracellular Bacterial Community Pathway in Klebsiella pneumoniae Urinary Tract Infection and the Effects of FimK on Type 1 Pilus Expression

(2008) D. A. Rosen et al.   INFECTION AND IMMUNITY

Hemolysin of Uropathogenic Escherichia coli Evokes Extensive Shedding of the Uroepithelium and Hemorrhage in Bladder Tissue within the First 24 Hours after Intraurethral Inoculation of Mice

(2008) Y. C. Smith et al.   INFECTION AND IMMUNITY

Pharmacologic Augmentation of Hypoxia‐Inducible Factor–1α with Mimosine Boosts the Bactericidal Capacity of Phagocytes

(2008) Annelies S. Zinkernagel et al.   JOURNAL OF INFECTIOUS DISEASES

Critical Role of HIF-1α in Keratinocyte Defense against Bacterial Infection

(2008) Carole Peyssonnaux et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

NF-κB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1α

(2008) Jordi Rius et al.   NATURE