Fate‐mapping of erythropoietin‐producing cells in mouse models of hypoxaemia and renal tissue remodelling reveals repeated recruitment and persistent functionality

Inhibition of transforming growth factor β1 signaling in resident interstitial cells attenuates profibrotic gene expression and preserves erythropoietin production during experimental kidney fibrosis in mice.

(2021) Michaela A.A. Fuchs et al.   KIDNEY INTERNATIONAL

Roxadustat attenuates hyperoxia-induced lung injury by upregulating proangiogenic factors in newborn mice

(2021) Liang-Ti Huang et al.   Pediatrics and Neonatology

Hypoxia-inducible factor–prolyl hydroxylase inhibitors in the treatment of anemia of chronic kidney disease

(2021) Volker H. Haase   Kidney International Supplements

Different subpopulations of kidney interstitial cells produce erythropoietin and factors supporting tissue oxygenation in response to hypoxia in vivo.

(2020) Katharina A.E. Broeker et al.   KIDNEY INTERNATIONAL

Cre-mediated, loxP independent sequential recombination of a tripartite transcriptional stop cassette allows for partial read-through transcription

(2020) Andreas M. Bapst et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Nonclinical Characterization of the Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor Roxadustat, a Novel Treatment of Anemia of Chronic Kidney Disease

(2020) Ughetta del Balzo et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Hypoxia in chronic kidney disease: towards a paradigm shift?

(2020) Anna Faivre et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Optimization of tamoxifen-induced Cre activity and its effect on immune cell populations

(2020) Rachel S. Donocoff et al.   Scientific Reports

Hypoxia-Inducible Factor Activators in Renal Anemia: Current Clinical Experience

(2019) Neil S. Sanghani et al.   ADVANCES IN CHRONIC KIDNEY DISEASE

Good publication practice in physiology 2019

(2019) Pontus B. Persson   Acta Physiologica

An immortalized cell line derived from renal erythropoietin-producing (REP) cells demonstrates their potential to transform into myofibroblasts

(2019) Koji Sato et al.   Scientific Reports

Alteration of the DNA Methylation Signature of Renal Erythropoietin-Producing Cells Governs the Sensitivity to Drugs Targeting the Hypoxia-Response Pathway in Kidney Disease Progression

(2019) Koji Sato et al.   Frontiers in Genetics

Source and microenvironmental regulation of erythropoietin in the kidney

(2018) Karen A. Nolan et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Generation of renal Epo-producing cell lines by conditional gene tagging reveals rapid HIF-2 driven Epo kinetics, cell autonomous feedback regulation, and a telocyte phenotype

(2018) Faik Imeri et al.   KIDNEY INTERNATIONAL

Renal epithelium regulates erythropoiesis via HIF-dependent suppression of erythropoietin

(2016) Navid M. Farsijani et al.   JOURNAL OF CLINICAL INVESTIGATION

Distinct subpopulations of FOXD1 stroma-derived cells regulate renal erythropoietin

(2016) Hanako Kobayashi et al.   JOURNAL OF CLINICAL INVESTIGATION

DNA methyltransferase inhibition restores erythropoietin production in fibrotic murine kidneys

(2016) Yu-Ting Chang et al.   JOURNAL OF CLINICAL INVESTIGATION

Erythropoietin production by PDGFR-β+ cells

(2016) Katharina Gerl et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Comparative systems pharmacology of HIF stabilization in the prevention of retinopathy of prematurity

(2016) George Hoppe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Erythropoietin Synthesis in Renal Myofibroblasts Is Restored by Activation of Hypoxia Signaling

(2015) T. Souma et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Anaemia in kidney disease: harnessing hypoxia responses for therapy

(2015) Mark J. Koury et al.   Nature Reviews Nephrology

Roles of renal erythropoietin-producing (REP) cells in the maintenance of systemic oxygen homeostasis

(2015) Norio Suzuki et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Renal erythropoietin-producing cells in health and disease

(2015) Tomokazu Souma et al.   Frontiers in Physiology

Plasticity of Renal Erythropoietin-Producing Cells Governs Fibrosis

(2013) T. Souma et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

A mouse model of adult-onset anaemia due to erythropoietin deficiency

(2013) Shun Yamazaki et al.   Nature Communications

Tamoxifen-Induced Cre-loxP Recombination Is Prolonged in Pancreatic Islets of Adult Mice

(2012) Rachel B. Reinert et al.   PLoS One

Dysfunction of fibroblasts of extrarenal origin underlies renal fibrosis and renal anemia in mice

(2011) Nariaki Asada et al.   JOURNAL OF CLINICAL INVESTIGATION

Isolation and Characterization of Renal Erythropoietin-Producing Cells from Genetically Produced Anemia Mice

(2011) Xiaoqing Pan et al.   PLoS One

Hepatic HIF-2 regulates erythropoietic responses to hypoxia in renal anemia

(2010) P. P. Kapitsinou et al.   BLOOD

Inhibition of Prolyl Hydroxylases Increases Erythropoietin Production in ESRD

(2010) W. M. Bernhardt et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Fate Tracing Reveals the Pericyte and Not Epithelial Origin of Myofibroblasts in Kidney Fibrosis

(2009) Benjamin D. Humphreys et al.   AMERICAN JOURNAL OF PATHOLOGY

Repression via the GATA box is essential for tissue-specific erythropoietin gene expression

(2008) N. Obara et al.   BLOOD

Prolyl hydroxylase inhibition during hyperoxia prevents oxygen-induced retinopathy

(2008) J. E. Sears et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA