The transcription factor HIF-1α mediates plasticity of NKp46+ innate lymphoid cells in the gut

Hypoxia enhances ILC3 responses through HIF-1α-dependent mechanism

(2021) J. L. Fachi et al.   Mucosal Immunology

Detection of differentially abundant cell subpopulations in scRNA-seq data

(2021) Jun Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NK cells in hypoxic skin mediate a trade-off between wound healing and antibacterial defence

(2021) Michal Sobecki et al.   Nature Communications

Sustained Post-Developmental T-Bet Expression Is Critical for the Maintenance of Type One Innate Lymphoid Cells In Vivo

(2021) Jan-Hendrik Schroeder et al.   Frontiers in Immunology

Feeding-dependent VIP neuron–ILC3 circuit regulates the intestinal barrier

(2020) Jhimmy Talbot et al.   NATURE

Innate Lymphoid Cell-Epithelial Cell Modules Sustain Intestinal Homeostasis

(2020) Andreas Diefenbach et al.   IMMUNITY

The Conserved Non-coding Sequences CNS6 and CNS9 Control Cytokine-Induced Rorc Transcription during T Helper 17 Cell Differentiation

(2020) Dehui Chang et al.   IMMUNITY

Innate lymphoid cells support regulatory T cells in the intestine through interleukin-2

(2019) Lei Zhou et al.   NATURE

ILC3s integrate glycolysis and mitochondrial production of reactive oxygen species to fulfill activation demands

(2019) Blanda Di Luccia et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The neuropeptide VIP confers anticipatory mucosal immunity by regulating ILC3 activity

(2019) Cyril Seillet et al.   NATURE IMMUNOLOGY

Innate Lymphoid Cells: Diversity, Plasticity, and Unique Functions in Immunity

(2018) Marco Colonna   IMMUNITY

Innate and adaptive lymphocytes sequentially shape the gut microbiota and lipid metabolism

(2018) Kairui Mao et al.   NATURE

Interplay of innate lymphoid cells and the microbiota

(2017) Liudmila Britanova et al.   IMMUNOLOGICAL REVIEWS

Determinants of hypoxia-inducible factor activity in the intestinal mucosa

(2017) Raphael R. Fagundes et al.   JOURNAL OF APPLIED PHYSIOLOGY

Knockdown of myeloid cell hypoxia-inducible factor-1α ameliorates the acute pathology in DSS-induced colitis

(2017) Veronika Bäcker et al.   PLoS One

The intestinal microbiota regulates body composition through NFIL3 and the circadian clock

(2017) Yuhao Wang et al.   SCIENCE

Loss of HIF-1α in natural killer cells inhibits tumour growth by stimulating non-productive angiogenesis

(2017) Ewelina Krzywinska et al.   Nature Communications

Compartment-specific distribution of human intestinal innate lymphoid cells is altered in HIV patients under effective therapy

(2017) Benjamin Krämer et al.   PLoS Pathogens

The Spectrum and Regulatory Landscape of Intestinal Innate Lymphoid Cells Are Shaped by the Microbiome

(2016) Meital Gury-BenAri et al.   CELL

Dysregulation of Group 3 Innate Lymphoid Cells in the Pathogenesis of Inflammatory Bowel Disease

(2016) Marianne Forkel et al.   CURRENT ALLERGY AND ASTHMA REPORTS

Ikaros Inhibits Group 3 Innate Lymphoid Cell Development and Function by Suppressing the Aryl Hydrocarbon Receptor Pathway

(2016) Shiyang Li et al.   IMMUNITY

Hypoxia-dependent regulation of inflammatory pathways in immune cells

(2016) Cormac T. Taylor et al.   JOURNAL OF CLINICAL INVESTIGATION

Phenotypic and Functional Plasticity of Murine Intestinal NKp46+Group 3 Innate Lymphoid Cells

(2016) Thomas Verrier et al.   JOURNAL OF IMMUNOLOGY

Innate lymphoid cells as regulators of immunity, inflammation and tissue homeostasis

(2016) Christoph S N Klose et al.   NATURE IMMUNOLOGY

Transforming growth factor–β and Notch ligands act as opposing environmental cues in regulating the plasticity of type 3 innate lymphoid cells

(2016) Charlotte Viant et al.   Science Signaling

Transforming growth factor–β and Notch ligands act as opposing environmental cues in regulating the plasticity of type 3 innate lymphoid cells

(2016) Charlotte Viant et al.   Science Signaling

Interleukin-12 and -23 Control Plasticity of CD127+ Group 1 and Group 3 Innate Lymphoid Cells in the Intestinal Lamina Propria

(2015) Jochem H. Bernink et al.   IMMUNITY

Targeted delivery of the hydroxylase inhibitor DMOG provides enhanced efficacy with reduced systemic exposure in a murine model of colitis

(2015) Murtaza M. Tambuwala et al.   JOURNAL OF CONTROLLED RELEASE

Type 3 innate lymphoid cells maintain intestinal epithelial stem cells after tissue damage

(2015) Patricia Aparicio-Domingo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Hypoxia-inducible factor 1 in dendritic cells is crucial for the activation of protective regulatory T cells in murine colitis

(2015) K Flück et al.   Mucosal Immunology

Oxygen sensing in intestinal mucosal inflammation

(2015) Katharina Flück et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Innate lymphoid cells: A new paradigm in immunology

(2015) G. Eberl et al.   SCIENCE

Transmigrating Neutrophils Shape the Mucosal Microenvironment through Localized Oxygen Depletion to Influence Resolution of Inflammation

(2014) Eric L. Campbell et al.   IMMUNITY

Development, Differentiation, and Diversity of Innate Lymphoid Cells

(2014) Andreas Diefenbach et al.   IMMUNITY

Optimization of murine small intestine leukocyte isolation for global immune phenotype analysis

(2014) Andrew W. Goodyear et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Interleukin-22 alleviates metabolic disorders and restores mucosal immunity in diabetes

(2014) Xiaoting Wang et al.   NATURE

CluePedia Cytoscape plugin: pathway insights using integrated experimental and in silico data

(2013) Gabriela Bindea et al.   BIOINFORMATICS

Targeting the HIF pathway in inflammation and immunity

(2013) Carsten C Scholz et al.   CURRENT OPINION IN PHARMACOLOGY

A T-bet gradient controls the fate and function of CCR6−RORγt+ innate lymphoid cells

(2013) Christoph S. N. Klose et al.   NATURE

The transcription factor T-bet is essential for the development of NKp46+ innate lymphocytes via the Notch pathway

(2013) Lucille C Rankin et al.   NATURE IMMUNOLOGY

Hypoxia-Inducible Factors in Physiology and Medicine

(2012) Gregg L. Semenza   CELL

Distinct requirements for T-bet in gut innate lymphoid cells

(2012) Giuseppe Sciumé et al.   JOURNAL OF EXPERIMENTAL MEDICINE

High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq

(2011) J. Schodel et al.   BLOOD

Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1

(2011) Eric V. Dang et al.   CELL

Control of epithelial cell function by interleukin-22-producing RORγt+ innate lymphoid cells

(2011) Stephanie L. Sanos et al.   IMMUNOLOGY

A novel Ncr1-Cre mouse reveals the essential role of STAT5 for NK-cell survival and development

(2010) E. Eckelhart et al.   BLOOD

Loss of Prolyl Hydroxylase-1 Protects Against Colitis Through Reduced Epithelial Cell Apoptosis and Increased Barrier Function

(2010) Murtaza M. Tambuwala et al.   GASTROENTEROLOGY

Differential activation and antagonistic function of HIF-  isoforms in macrophages are essential for NO homeostasis

(2010) N. Takeda et al.   GENES & DEVELOPMENT

Regulated Expression of Nuclear Receptor RORγt Confers Distinct Functional Fates to NK Cell Receptor-Expressing RORγt+ Innate Lymphocytes

(2010) Cedric Vonarbourg et al.   IMMUNITY

Hypoxia: an alarm signal during intestinal inflammation

(2010) Sean P. Colgan et al.   Nature Reviews Gastroenterology & Hepatology

ClueGO: a Cytoscape plug-in to decipher functionally grouped gene ontology and pathway annotation networks

(2009) Gabriela Bindea et al.   BIOINFORMATICS

Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway

(2008) William G. Kaelin et al.   MOLECULAR CELL