Kidney tissue hypoxia dictates T cell–mediated injury in murine lupus nephritis

Hypoxia-inducible factors in CD4+ T cells promote metabolism, switch cytokine secretion, and T cell help in humoral immunity

(2019) Sung Hoon Cho et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The immune cell landscape in kidneys of patients with lupus nephritis

(2019) Arnon Arazi et al.   NATURE IMMUNOLOGY

NADH Shuttling Couples Cytosolic Reductive Carboxylation of Glutamine with Glycolysis in Cells with Mitochondrial Dysfunction

(2018) Edoardo Gaude et al.   MOLECULAR CELL

Kidney-infiltrating T cells in murine lupus nephritis are metabolically and functionally exhausted

(2018) Jeremy S. Tilstra et al.   JOURNAL OF CLINICAL INVESTIGATION

Factors of the bone marrow microniche that support human plasma cell survival and immunoglobulin secretion

(2018) Doan C. Nguyen et al.   Nature Communications

A CD4+ T cell population expanded in lupus blood provides B cell help through interleukin-10 and succinate

(2018) Simone Caielli et al.   NATURE MEDICINE

Systemic and local granzyme B levels are associated with disease activity, kidney damage and interferon signature in systemic lupus erythematosus

(2017) Helena M. Kok et al.   RHEUMATOLOGY

HIF-1-mediated suppression of mitochondria electron transport chain function confers resistance to lidocaine-induced cell death

(2017) Akihisa Okamoto et al.   Scientific Reports

Oxygen Sensing by T Cells Establishes an Immunologically Tolerant Metastatic Niche

(2016) David Clever et al.   CELL

Germinal Center Hypoxia Potentiates Immunoglobulin Class Switch Recombination

(2016) Robert K. Abbott et al.   JOURNAL OF IMMUNOLOGY

Germinal centre hypoxia and regulation of antibody qualities by a hypoxia response system

(2016) Sung Hoon Cho et al.   NATURE

Reductive carboxylation supports redox homeostasis during anchorage-independent growth

(2016) Lei Jiang et al.   NATURE

Enrichr: a comprehensive gene set enrichment analysis web server 2016 update

(2016) Maxim V. Kuleshov et al.   NUCLEIC ACIDS RESEARCH

Bcl-2 as a Therapeutic Target in Human Tubulointerstitial Inflammation

(2016) Kichul Ko et al.   Arthritis & Rheumatology

Efficacy of PD-1 Blockade Is Potentiated by Metformin-Induced Reduction of Tumor Hypoxia

(2016) Nicole E. Scharping et al.   Cancer Immunology Research

Quantifying Memory CD8 T Cells Reveals Regionalization of Immunosurveillance

(2015) Elizabeth M. Steinert et al.   CELL

Reduced Expression of MYC Increases Longevity and Enhances Healthspan

(2015) Jeffrey W. Hofmann et al.   CELL

The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells

(2015) John P. Ray et al.   IMMUNITY

PDK2-mediated alternative splicing switches Bnip3 from cell death to cell survival

(2015) Hongying Gang et al.   JOURNAL OF CELL BIOLOGY

Spatial reconstruction of single-cell gene expression data

(2015) Rahul Satija et al.   NATURE BIOTECHNOLOGY

Diversity, cellular origin and autoreactivity of antibody-secreting cell population expansions in acute systemic lupus erythematosus

(2015) Christopher M Tipton et al.   NATURE IMMUNOLOGY

What is damaging the kidney in lupus nephritis?

(2015) Anne Davidson   Nature Reviews Rheumatology

Hypoxia Inducible Factor-1 Alpha Promotes Mesangial Cell Proliferation in Lupus Nephritis

(2014) Wei Deng et al.   AMERICAN JOURNAL OF NEPHROLOGY

Hypoxic Regulation of Glutamine Metabolism through HIF1 and SIAH2 Supports Lipid Synthesis that Is Necessary for Tumor Growth

(2014) Ramon C. Sun et al.   Cell Metabolism

CD4+ T Cell Help Guides Formation of CD103+ Lung-Resident Memory CD8+ T Cells during Influenza Viral Infection

(2014) Brian J. Laidlaw et al.   IMMUNITY

Endothelial HIF-2 mediates protection and recovery from ischemic kidney injury

(2014) Pinelopi P. Kapitsinou et al.   JOURNAL OF CLINICAL INVESTIGATION

Expanded Double Negative T Cells in Patients with Systemic Lupus Erythematosus Produce IL-17 and Infiltrate the Kidneys

(2014) J. C. Crispin et al.   JOURNAL OF IMMUNOLOGY

Cell Distance Mapping Identifies Functional T Follicular Helper Cells in Inflamed Human Renal Tissue

(2014) V. M. Liarski et al.   Science Translational Medicine

Oxidation of Alpha-Ketoglutarate Is Required for Reductive Carboxylation in Cancer Cells with Mitochondrial Defects

(2014) Andrew R. Mullen et al.   Cell Reports

Regulation of Glycolysis by Pdk Functions as a Metabolic Checkpoint for Cell Cycle Quiescence in Hematopoietic Stem Cells

(2013) Keiyo Takubo et al.   Cell Stem Cell

Cofactor Balance by Nicotinamide Nucleotide Transhydrogenase (NNT) Coordinates Reductive Carboxylation and Glucose Catabolism in the Tricarboxylic Acid (TCA) Cycle

(2013) Paulo A. Gameiro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hypoxia-inducible factors enhance the effector responses of CD8+ T cells to persistent antigen

(2013) Andrew L Doedens et al.   NATURE IMMUNOLOGY

miR-125b transcriptionally increased by Nrf2 inhibits AhR repressor, which protects kidney from cisplatin-induced injury

(2013) M S Joo et al.   Cell Death & Disease

Reductive glutamine metabolism is a function of the α-ketoglutarate to citrate ratio in cells

(2013) Sarah-Maria Fendt et al.   Nature Communications

Nrf2 activation supports cell survival during hypoxia and hypoxia/reoxygenation in cardiomyoblasts; the roles of reactive oxygen and nitrogen species

(2013) Rajitha T Kolamunne et al.   Redox Biology

HIF1  is required for survival maintenance of chronic myeloid leukemia stem cells

(2012) H. Zhang et al.   BLOOD

Proline Oxidase Promotes Tumor Cell Survival in Hypoxic Tumor Microenvironments

(2012) W. Liu et al.   CANCER RESEARCH

PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8+T cells

(2012) David K. Finlay et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Kidney-infiltrating CD4+ T-cell clones promote nephritis in lupus-prone mice

(2012) Akiko Okamoto et al.   KIDNEY INTERNATIONAL

Reprogramming of proline and glutamine metabolism contributes to the proliferative and metabolic responses regulated by oncogenic transcription factor c-MYC

(2012) W. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immunologic characteristics of intrarenal T cells: Trafficking of expanded CD8+ T cell β-chain clonotypes in progressive lupus nephritis

(2011) Robert Winchester et al.   ARTHRITIS AND RHEUMATISM

Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1

(2011) Eric V. Dang et al.   CELL

A Novel Hypoxia-Inducible Spliced Variant of Mitochondrial Death Gene Bnip3 Promotes Survival of Ventricular Myocytes

(2011) Hongying Gang et al.   CIRCULATION RESEARCH

The Transcription Factor Myc Controls Metabolic Reprogramming upon T Lymphocyte Activation

(2011) Ruoning Wang et al.   IMMUNITY

Reductive carboxylation supports growth in tumour cells with defective mitochondria

(2011) Andrew R. Mullen et al.   NATURE

Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia

(2011) Christian M. Metallo et al.   NATURE

Differential activation and antagonistic function of HIF-  isoforms in macrophages are essential for NO homeostasis

(2010) N. Takeda et al.   GENES & DEVELOPMENT

Laser microdissection-based analysis of cytokine balance in the kidneys of patients with lupus nephritis

(2009) Y. Wang et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Molecular mechanisms for the activity of PX-478, an antitumor inhibitor of the hypoxia-inducible factor-1 

(2008) M. Y. Koh et al.   MOLECULAR CANCER THERAPEUTICS