Hypercapnia Suppresses the HIF-dependent Adaptive Response to Hypoxia

Treatment of respiratory failure in COPD

(2016) Stephan Budweiser   International Journal of Chronic Obstructive Pulmonary Disease

Permissive hypercapnia

(2015) Maya Contreras et al.   Current Opinion in Anesthesiology

Hypoxia signaling during acute lung injury

(2015) Christine U. Vohwinkel et al.   JOURNAL OF APPLIED PHYSIOLOGY

Targeted delivery of the hydroxylase inhibitor DMOG provides enhanced efficacy with reduced systemic exposure in a murine model of colitis

(2015) Murtaza M. Tambuwala et al.   JOURNAL OF CONTROLLED RELEASE

Hypercapnia Inhibits Autophagy and Bacterial Killing in Human Macrophages by Increasing Expression of Bcl-2 and Bcl-xL

(2015) S. Marina Casalino-Matsuda et al.   JOURNAL OF IMMUNOLOGY

K63 linked ubiquitin chain formation is a signal for HIF1A degradation by Chaperone-Mediated Autophagy

(2015) Joao Vasco Ferreira et al.   Scientific Reports

Transcutaneous Carbon Dioxide Induces Mitochondrial Apoptosis and Suppresses Metastasis of Oral Squamous Cell Carcinoma In Vivo

(2014) Daisuke Takeda et al.   PLoS One

Cyclin-dependent kinases regulate lysosomal degradation of hypoxia-inducible factor 1  to promote cell-cycle progression

(2014) M. E. Hubbi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypo- and hypercapnia predict mortality in oxygen-dependent chronic obstructive pulmonary disease: a population-based prospective study

(2014) Zainab Ahmadi et al.   RESPIRATORY RESEARCH

Hypercapnia Impairs Lung Neutrophil Function and Increases Mortality in MurinePseudomonasPneumonia

(2013) Khalilah L. Gates et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

STUB1/CHIP is required for HIF1A degradation by chaperone-mediated autophagy

(2013) João Vasco Ferreira et al.   Autophagy

Carbon dioxide-sensing in organisms and its implications for human disease

(2013) Eoin P. Cummins et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Transcriptional regulation by hypoxia inducible factors

(2013) Veronica L. Dengler et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Chaperone-mediated Autophagy Targets Hypoxia-inducible Factor-1α (HIF-1α) for Lysosomal Degradation

(2013) Maimon E. Hubbi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of autophagy with chloroquine is effective in melanoma

(2013) Michael E. Egger et al.   JOURNAL OF SURGICAL RESEARCH

Hypoxia Modulates Infection of Epithelial Cells by Pseudomonas aeruginosa

(2013) Bettina Schaible et al.   PLoS One

Chloroquine enhances cobalt chloride-induced leukemic cell differentiation via the suppression of autophagy at the late phase

(2012) Zhao-Wen Yan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Hypoxia-Inducible Factors in Physiology and Medicine

(2012) Gregg L. Semenza   CELL

Hypercapnia Induces Cleavage and Nuclear Localization of RelB Protein, Giving Insight into CO2Sensing and Signaling

(2012) Kathryn M. Oliver et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transcutaneous Application of Carbon Dioxide (CO2) Induces Mitochondrial Apoptosis in Human Malignant Fibrous Histiocytoma In Vivo

(2012) Yasuo Onishi et al.   PLoS One

Evolutionary Conserved Role of c-Jun-N-Terminal Kinase in CO2-Induced Epithelial Dysfunction

(2012) István Vadász et al.   PLoS One

Chaperone-mediated autophagy: a unique way to enter the lysosome world

(2012) Susmita Kaushik et al.   TRENDS IN CELL BIOLOGY

NFκB and HIF display synergistic behaviour during hypoxic inflammation

(2011) Ulrike Bruning et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Defect of Adaptation to Hypoxia in Patients With COPD Due to Reduction of Histone Deacetylase 7

(2011) Masako To et al.   CHEST

Why is the partial oxygen pressure of human tissues a crucial parameter? Small molecules and hypoxia

(2011) Aude Carreau et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Regulation of gene expression by carbon dioxide

(2011) Cormac T. Taylor et al.   JOURNAL OF PHYSIOLOGY-LONDON

Pharmacological Characterization of 1-(5-Chloro-6-(trifluoromethoxy)-1H-benzoimidazol-2-yl)-1H-pyrazole-4-carboxylic Acid (JNJ-42041935), a Potent and Selective Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor

(2011) T. D. Barrett et al.   MOLECULAR PHARMACOLOGY

NF- B Links CO2 Sensing to Innate Immunity and Inflammation in Mammalian Cells

(2010) E. P. Cummins et al.   JOURNAL OF IMMUNOLOGY

Hypoxia: an alarm signal during intestinal inflammation

(2010) Sean P. Colgan et al.   Nature Reviews Gastroenterology & Hepatology

Principles of lysosomal membrane degradation

(2008) Heike Schulze et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The Hydroxylase Inhibitor Dimethyloxalylglycine Is Protective in a Murine Model of Colitis

(2007) Eoin P. Cummins et al.   GASTROENTEROLOGY