Oxygen battle in the gut: Hypoxia and hypoxia-inducible factors in metabolic and inflammatory responses in the intestine

Hypoxia and Innate Immunity: Keeping Up with the HIFsters

(2020) Sean P. Colgan et al.   Annual Review of Immunology

Presenting symptoms in inflammatory bowel disease: descriptive analysis of a community-based inception cohort

(2019) Bryce Perler et al.   BMC GASTROENTEROLOGY

PRDM16 Maintains Homeostasis of the Intestinal Epithelium by Controlling Region-Specific Metabolism

(2019) Rachel R. Stine et al.   Cell Stem Cell

Intestinal gases: influence on gut disorders and the role of dietary manipulations

(2019) Kourosh Kalantar-Zadeh et al.   Nature Reviews Gastroenterology & Hepatology

Microbial Metabolite Signaling Is Required for Systemic Iron Homeostasis

(2019) Nupur K. Das et al.   Cell Metabolism

Impact of delivery mode-associated gut microbiota dynamics on health in the first year of life

(2019) Marta Reyman et al.   Nature Communications

Heme oxygenase-1/carbon monoxide as modulators of autophagy and inflammation

(2019) Stefan W. Ryter   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Metabolic adaptation of cancer and immune cells mediated by hypoxia-inducible factors

(2018) Debangshu Samanta et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Advances in Hypoxia-Inducible Factor Biology

(2018) Hani Choudhry et al.   Cell Metabolism

Fasting Activates Fatty Acid Oxidation to Enhance Intestinal Stem Cell Function during Homeostasis and Aging

(2018) Maria M. Mihaylova et al.   Cell Stem Cell

Epigenetic modifiers: activities in renal cell carcinoma

(2018) Aguirre A. de Cubas et al.   Nature Reviews Urology

Hypoxic tumor microenvironment activates GLI2 via HIF-1α and TGF-β2 to promote chemoresistance in colorectal cancer

(2018) Yen-An Tang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genomic characterization of colitis-associated colorectal cancer

(2018) Hitoshi Kameyama et al.   World Journal of Surgical Oncology

Cysteine-derived hydrogen sulfide and gut health

(2018) François Blachier et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Hepatic hepcidin/intestinal HIF-2α axis maintains iron absorption during iron deficiency and overload

(2018) Andrew J. Schwartz et al.   JOURNAL OF CLINICAL INVESTIGATION

The ectonucleotidases CD39 and CD73: Novel checkpoint inhibitor targets

(2017) Bertrand Allard et al.   IMMUNOLOGICAL REVIEWS

Hypoxia-inducible factor 2α (HIF-2α) promotes colon cancer growth by potentiating Yes-associated protein 1 (YAP1) activity

(2017) Xiaoya Ma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oxygen availability and metabolic reprogramming in cancer

(2017) Hong Xie et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Multiple Roles of APC and its Therapeutic Implications in Colorectal Cancer

(2017) Lu Zhang et al.   JNCI-Journal of the National Cancer Institute

Interplay between metabolic identities in the intestinal crypt supports stem cell function

(2017) Maria J. Rodríguez-Colman et al.   NATURE

Activation of intestinal hypoxia-inducible factor 2α during obesity contributes to hepatic steatosis

(2017) Cen Xie et al.   NATURE MEDICINE

The resilience of the intestinal microbiota influences health and disease

(2017) Felix Sommer et al.   NATURE REVIEWS MICROBIOLOGY

Hypoxia-inducible factor-1α promotes cell survival during ammonia stress response in ovarian cancer stem-like cells

(2017) Shojiro Kitajima et al.   Oncotarget

Multiple Roles of APC and its Therapeutic Implications in Colorectal Cancer

(2017) Lu Zhang et al.   JNCI-Journal of the National Cancer Institute

Transit-Amplifying Cells in the Fast Lane from Stem Cells towards Differentiation

(2017) Emma Rangel-Huerta et al.   Stem Cells International

Oral absorption of peptides and nanoparticles across the human intestine: Opportunities, limitations and studies in human tissues

(2016) P. Lundquist et al.   ADVANCED DRUG DELIVERY REVIEWS

Hypoxia and Mucosal Inflammation

(2016) Sean P. Colgan et al.   Annual Review of Pathology-Mechanisms of Disease

Role of Intestinal HIF-2α in Health and Disease

(2016) Sadeesh K. Ramakrishnan et al.   Annual Review of Physiology

TP53 mutation at early stage of colorectal cancer progression from two types of laterally spreading tumors

(2016) Eiji Sakai et al.   CANCER SCIENCE

Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages

(2016) Evanna L. Mills et al.   CELL

Depletion of Butyrate-Producing Clostridia from the Gut Microbiota Drives an Aerobic Luminal Expansion of Salmonella

(2016) Fabian Rivera-Chávez et al.   Cell Host & Microbe

Iron Uptake via DMT1 Integrates Cell Cycle with JAK-STAT3 Signaling to Promote Colorectal Tumorigenesis

(2016) Xiang Xue et al.   Cell Metabolism

Hypercapnia Suppresses the HIF-dependent Adaptive Response to Hypoxia

(2016) Andrew C. Selfridge et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reducing radiation-induced gastrointestinal toxicity — the role of the PHD/HIF axis

(2016) Monica M. Olcina et al.   JOURNAL OF CLINICAL INVESTIGATION

Hypoxia-dependent regulation of inflammatory pathways in immune cells

(2016) Cormac T. Taylor et al.   JOURNAL OF CLINICAL INVESTIGATION

Colorectal cancer is a leading cause of cancer incidence and mortality among adults younger than 50 years in the USA: a SEER-based analysis with comparison to other young-onset cancers

(2016) Abhishek Bhandari et al.   JOURNAL OF INVESTIGATIVE MEDICINE

Epithelial Hypoxia-Inducible Factor 2α Facilitates the Progression of Colon Tumors through Recruiting Neutrophils

(2016) Daniel Triner et al.   MOLECULAR AND CELLULAR BIOLOGY

Pharmacological targeting of the HIF hydroxylases – A new field in medicine development

(2016) Mun Chiang Chan et al.   MOLECULAR ASPECTS OF MEDICINE

TCA Cycle and Mitochondrial Membrane Potential Are Necessary for Diverse Biological Functions

(2016) Inmaculada Martínez-Reyes et al.   MOLECULAR CELL

Gut Bacteria and Hydrogen Sulfide: The New Old Players in Circulatory System Homeostasis

(2016) Lenka Tomasova et al.   MOLECULES

Targeting renal cell carcinoma with a HIF-2 antagonist

(2016) Wenfang Chen et al.   NATURE

High-fat diet enhances stemness and tumorigenicity of intestinal progenitors

(2016) Semir Beyaz et al.   NATURE

On-target efficacy of a HIF-2α antagonist in preclinical kidney cancer models

(2016) Hyejin Cho et al.   NATURE

Crosstalk between Microbiota-Derived Short-Chain Fatty Acids and Intestinal Epithelial HIF Augments Tissue Barrier Function

(2015) Caleb J. Kelly et al.   Cell Host & Microbe

Intestine-specific Disruption of Hypoxia-inducible Factor (HIF)-2α Improves Anemia in Sickle Cell Disease

(2015) Nupur Das et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HIF-dependent regulation of claudin-1 is central to intestinal epithelial tight junction integrity

(2015) Bejan J. Saeedi et al.   MOLECULAR BIOLOGY OF THE CELL

Epithelial-specific A2B adenosine receptor signaling protects the colonic epithelial barrier during acute colitis

(2015) C M Aherne et al.   Mucosal Immunology

Structural integration in hypoxia-inducible factors

(2015) Dalei Wu et al.   NATURE

Gut biogeography of the bacterial microbiota

(2015) Gregory P. Donaldson et al.   NATURE REVIEWS MICROBIOLOGY

Ammonia-induced oxidative damage in neurons is prevented by resveratrol and lipoic acid with participation of heme oxygenase 1

(2015) Larissa Daniele Bobermin et al.   NEUROTOXICOLOGY

Differential diagnosis in inflammatory bowel disease colitis: State of the art and future perspectives

(2015) Gian Eugenio Tontini   WORLD JOURNAL OF GASTROENTEROLOGY

Hypoxia promotes colon cancer dissemination through up-regulation of cell migration-inducing protein (CEMIP)

(2015) Nikki A. Evensen et al.   Oncotarget

Nitrate Reduction to Nitrite, Nitric Oxide and Ammonia by Gut Bacteria under Physiological Conditions

(2015) Mauro Tiso et al.   PLoS One

K63 linked ubiquitin chain formation is a signal for HIF1A degradation by Chaperone-Mediated Autophagy

(2015) Joao Vasco Ferreira et al.   Scientific Reports

Activation of HIF-1α does not increase intestinal tumorigenesis

(2014) Xiang Xue et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Sulfur as a Signaling Nutrient Through Hydrogen Sulfide

(2014) Omer Kabil et al.   Annual Review of Nutrition

Correlation Between Intraluminal Oxygen Gradient and Radial Partitioning of Intestinal Microbiota

(2014) Lindsey Albenberg et al.   GASTROENTEROLOGY

Hypoxia-Inducible Factors Link Iron Homeostasis and Erythropoiesis

(2014) Yatrik M. Shah et al.   GASTROENTEROLOGY

Transmigrating Neutrophils Shape the Mucosal Microenvironment through Localized Oxygen Depletion to Influence Resolution of Inflammation

(2014) Eric L. Campbell et al.   IMMUNITY

Hypoxia inducible factors in liver disease and hepatocellular carcinoma: Current understanding and future directions

(2014) Garrick K. Wilson et al.   JOURNAL OF HEPATOLOGY

Hypoxia-Inducible Factor/MAZ-Dependent Induction of Caveolin-1 Regulates Colon Permeability through Suppression of Occludin, Leading to Hypoxia-Induced Inflammation

(2014) Liwei Xie et al.   MOLECULAR AND CELLULAR BIOLOGY

Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS

(2014) Edward T. Chouchani et al.   NATURE

PHD Inhibition Mitigates and Protects Against Radiation-Induced Gastrointestinal Toxicity via HIF2

(2014) C. M. Taniguchi et al.   Science Translational Medicine

Hydrogen Sulfide Signaling in the Gastrointestinal Tract

(2013) David R. Linden   ANTIOXIDANTS & REDOX SIGNALING

STUB1/CHIP is required for HIF1A degradation by chaperone-mediated autophagy

(2013) João Vasco Ferreira et al.   Autophagy

Regulation of mitochondrial bioenergetic function by hydrogen sulfide. Part I. Biochemical and physiological mechanisms

(2013) Csaba Szabo et al.   BRITISH JOURNAL OF PHARMACOLOGY

Noninvasive Monitoring of Small Intestinal Oxygen in a Rat Model of Chronic Mesenteric Ischemia

(2013) Elaine M. Fisher et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Bacterial Urease and its Role in Long-Lasting Human Diseases

(2013) Iwona Konieczna et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Landscape of Genetic Aberrations Detected in Human Colorectal Cancers

(2013) Tomoyuki Goto et al.   GASTROENTEROLOGY

Endothelial PAS Domain Protein 1 Activates the Inflammatory Response in the Intestinal Epithelium to Promote Colitis in Mice

(2013) Xiang Xue et al.   GASTROENTEROLOGY

Structure and Kinetic Analysis of H2S Production by Human Mercaptopyruvate Sulfurtransferase

(2013) Pramod Kumar Yadav et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism

(2013) Gijs den Besten et al.   JOURNAL OF LIPID RESEARCH

The Proto-oncometabolite Fumarate Binds Glutathione to Amplify ROS-Dependent Signaling

(2013) Lucas B. Sullivan et al.   MOLECULAR CELL

Fundamental role for HIF-1α in constitutive expression of human β defensin-1

(2013) C J Kelly et al.   Mucosal Immunology

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

(2013) G. M. Tannahill et al.   NATURE

Allosteric inhibition of hypoxia inducible factor-2 with small molecules

(2013) Thomas H Scheuermann et al.   Nature Chemical Biology

Hydrogen sulfide chemical biology: Pathophysiological roles and detection

(2013) Gopi K. Kolluru et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Intestinal HIF2  promotes tissue-iron accumulation in disorders of iron overload with anemia

(2013) E. R. Anderson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Control of creatine metabolism by HIF is an endogenous mechanism of barrier regulation in colitis

(2013) L. E. Glover et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypoxia-Inducible Factor-2  Activation Promotes Colorectal Cancer Progression by Dysregulating Iron Homeostasis

(2012) X. Xue et al.   CANCER RESEARCH

Adult mammalian stem cells: the role of Wnt, Lgr5 and R-spondins

(2012) Jurian Schuijers et al.   EMBO JOURNAL

Cytochrome c oxidase dysfunction in oxidative stress

(2012) Satish Srinivasan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation

(2012) Peppi Koivunen et al.   NATURE

Comprehensive molecular characterization of human colon and rectal cancer

(2012)   NATURE

The Quantitative Significance of the Transsulfuration Enzymes for H2S Production in Murine Tissues

(2011) Omer Kabil et al.   ANTIOXIDANTS & REDOX SIGNALING

Hydrogen Sulfide Inhibits Hypoxia- But Not Anoxia-Induced Hypoxia-Inducible Factor 1 Activation in a von Hippel-Lindau- and Mitochondria-Dependent Manner

(2011) Shinichi Kai et al.   ANTIOXIDANTS & REDOX SIGNALING

Ammonia increases nitric oxide, free Zn2+, and metallothionein mRNA expression in cultured rat astrocytes

(2011) Carolin Kruczek et al.   BIOLOGICAL CHEMISTRY

Deletion of HIF-2  in the enterocytes decreases the severity of tissue iron loading in hepcidin knockout mice

(2011) M. Mastrogiannaki et al.   BLOOD

The Microbiome and Butyrate Regulate Energy Metabolism and Autophagy in the Mammalian Colon

(2011) Dallas R. Donohoe et al.   Cell Metabolism

Hypoxia-Inducible Factor-2α Mediates the Adaptive Increase of Intestinal Ferroportin During Iron Deficiency in Mice

(2011) Matthew Taylor et al.   GASTROENTEROLOGY

The Response ofCaenorhabditis elegansto Hydrogen Sulfide and Hydrogen Cyanide

(2011) Mark W. Budde et al.   GENETICS

Why is the partial oxygen pressure of human tissues a crucial parameter? Small molecules and hypoxia

(2011) Aude Carreau et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

MicroRNA-155 Promotes Resolution of Hypoxia-Inducible Factor 1  Activity during Prolonged Hypoxia

(2011) U. Bruning et al.   MOLECULAR AND CELLULAR BIOLOGY

Interactions between nitric oxide and hypoxia-inducible factor signaling pathways in inflammatory disease

(2011) Nels Olson et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Wound healing of intestinal epithelial cells

(2011) Masahiro Iizuka   WORLD JOURNAL OF GASTROENTEROLOGY

Hypoxia-Inducible Factor-1α Is Involved in the Pro-angiogenic Effect of Hydrogen Sulfide under Hypoxic Stress

(2010) XinHua Liu et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

How does PKMζ maintain long-term memory?

(2010) Todd C. Sacktor   NATURE REVIEWS NEUROSCIENCE

Suppression of Hypoxia-Inducible Factor 1α (HIF-1α) by Tirapazamine Is Dependent on eIF2α Phosphorylation Rather Than the mTORC1/4E-BP1 Pathway

(2010) Jun Zhang et al.   PLoS One

Nitric Oxide, Cytochrome C Oxidase, and the Cellular Response to Hypoxia

(2009) Cormac T. Taylor et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Intestinal Hypoxia-Inducible Transcription Factors Are Essential for Iron Absorption following Iron Deficiency

(2009) Yatrik M. Shah et al.   Cell Metabolism

HIF-2α, but not HIF-1α, promotes iron absorption in mice

(2009) Maria Mastrogiannaki et al.   JOURNAL OF CLINICAL INVESTIGATION

Artificial ligand binding within the HIF2  PAS-B domain of the HIF2 transcription factor

(2009) T. H. Scheuermann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Acriflavine inhibits HIF-1 dimerization, tumor growth, and vascularization

(2009) K. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glioma-Derived Mutations in IDH1 Dominantly Inhibit IDH1 Catalytic Activity and Induce HIF-1 

(2009) S. Zhao et al.   SCIENCE

The intestinal stem cell

(2008) N. Barker et al.   GENES & DEVELOPMENT

HIF-1α and HIF-2α have divergent roles in colon cancer

(2008) Takaaki Imamura et al.   INTERNATIONAL JOURNAL OF CANCER

Small-Molecule Inhibitors of HIF-2a Translation Link Its 5′UTR Iron-Responsive Element to Oxygen Sensing

(2008) Michael Zimmer et al.   MOLECULAR CELL

The Hydroxylase Inhibitor Dimethyloxalylglycine Is Protective in a Murine Model of Colitis

(2007) Eoin P. Cummins et al.   GASTROENTEROLOGY

Mucosal Protection by Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibition

(2007) Andreas Robinson et al.   GASTROENTEROLOGY