The vacuolar-ATPase complex and assembly factors, TMEM199 and CCDC115, control HIF1α prolyl hydroxylation by regulating cellular iron levels

TMEM199 Deficiency Is a Disorder of Golgi Homeostasis Characterized by Elevated Aminotransferases, Alkaline Phosphatase, and Cholesterol and Abnormal Glycosylation

(2016) Jos C. Jansen et al.   AMERICAN JOURNAL OF HUMAN GENETICS

CCDC115 Deficiency Causes a Disorder of Golgi Homeostasis with Abnormal Protein Glycosylation

(2016) Jos C. Jansen et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Mitochondrial Protein Lipoylation and the 2-Oxoglutarate Dehydrogenase Complex Controls HIF1α Stability in Aerobic Conditions

(2016) Stephen P. Burr et al.   Cell Metabolism

Endolysosomes Are the Principal Intracellular Sites of Acid Hydrolase Activity

(2016) Nicholas A. Bright et al.   CURRENT BIOLOGY

Hypercapnia Suppresses the HIF-dependent Adaptive Response to Hypoxia

(2016) Andrew C. Selfridge et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ATP6AP1 deficiency causes an immunodeficiency with hepatopathy, cognitive impairment and abnormal protein glycosylation

(2016) Eric J. R. Jansen et al.   Nature Communications

Meta- and Orthogonal Integration of Influenza “OMICs” Data Defines a Role for UBR4 in Virus Budding

(2015) Shashank Tripathi et al.   Cell Host & Microbe

Iron and oxygen sensing: a tale of 2 interacting elements?

(2015) Robert J. Simpson et al.   Metallomics

Catalytic in vivo protein knockdown by small-molecule PROTACs

(2015) Daniel P Bondeson et al.   Nature Chemical Biology

The Phyre2 web portal for protein modeling, prediction and analysis

(2015) Lawrence A Kelley et al.   Nature Protocols

K63 linked ubiquitin chain formation is a signal for HIF1A degradation by Chaperone-Mediated Autophagy

(2015) Joao Vasco Ferreira et al.   Scientific Reports

Cezanne (OTUD7B) regulates HIF-1  homeostasis in a proteasome-independent manner

(2014) A. Bremm et al.   EMBO REPORTS

The vacuolar-type H+-ATPase at a glance - more than a proton pump

(2014) M. E. Maxson et al.   JOURNAL OF CELL SCIENCE

Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy

(2014) Joseph D. Mancias et al.   NATURE

Improved vectors and genome-wide libraries for CRISPR screening

(2014) Neville E Sanjana et al.   NATURE METHODS

Cyclin-dependent kinases regulate lysosomal degradation of hypoxia-inducible factor 1  to promote cell-cycle progression

(2014) M. E. Hubbi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

VMA21 deficiency prevents vacuolar ATPase assembly and causes autophagic vacuolar myopathy

(2013) Nivetha Ramachandran et al.   ACTA NEUROPATHOLOGICA

STUB1/CHIP is required for HIF1A degradation by chaperone-mediated autophagy

(2013) João Vasco Ferreira et al.   Autophagy

V-ATPase as an effective therapeutic target for sarcomas

(2013) Francesca Perut et al.   EXPERIMENTAL CELL RESEARCH

Chaperone-mediated Autophagy Targets Hypoxia-inducible Factor-1α (HIF-1α) for Lysosomal Degradation

(2013) Maimon E. Hubbi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Function of Vacuolar ATPase (V-ATPase) a Subunit Isoforms in Invasiveness of MCF10a and MCF10CA1a Human Breast Cancer Cells

(2013) Joseph Capecci et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanisms of Mammalian Iron Homeostasis

(2012) Kostas Pantopoulos et al.   BIOCHEMISTRY

Bafilomycin A1 activates HIF-dependent signalling in human colon cancer cells via mitochondrial uncoupling

(2012) Alexander V. Zhdanov et al.   BIOSCIENCE REPORTS

A human genome-wide screen for regulators of clathrin-coated vesicle formation reveals an unexpected role for the V-ATPase

(2012) Patrycja Kozik et al.   NATURE CELL BIOLOGY

How the binding of human transferrin primes the transferrin receptor potentiating iron release at endosomal pH

(2011) Brian E. Eckenroth et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of the hypoxia inducible factors HIF in iron metabolism

(2010) Carole Peyssonnaux et al.   CELL CYCLE

Inhibition of Iron Uptake Is Responsible for Differential Sensitivity to V-ATPase Inhibitors in Several Cancer Cell Lines

(2010) Sarah Straud et al.   PLoS One

HIF2  inhibition promotes p53 pathway activity, tumor cell death, and radiation responses

(2009) J. A. Bertout et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An E3 Ligase Possessing an Iron-Responsive Hemerythrin Domain Is a Regulator of Iron Homeostasis

(2009) A. A. Salahudeen et al.   SCIENCE

Control of Iron Homeostasis by an Iron-Regulated Ubiquitin Ligase

(2009) A. A. Vashisht et al.   SCIENCE

UBXD7 Binds Multiple Ubiquitin Ligases and Implicates p97 in HIF1α Turnover

(2008) Gabriela Alexandru et al.   CELL