Nrf2 as a regulator of mitochondrial function: Energy metabolism and beyond

Nrf2 activation reprograms macrophage intermediary metabolism and suppresses the type I interferon response

(2022) Dylan G. Ryan et al.   iScience

Therapeutic targeting of mitophagy in Parkinson's disease

(2022) Shashank Masaldan et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Mitochondrial calcium uniporter drives metastasis and confers a targetable cystine dependency in pancreatic cancer

(2022) Xiuchao Wang et al.   CANCER RESEARCH

TAZ ameliorates the microglia-mediated inflammatory response via the Nrf2-ROS-NF-κB pathway

(2022) Ji-Cheng Huang et al.   Molecular Therapy-Nucleic Acids

MitoQ alleviates LPS-mediated acute lung injury through regulating Nrf2/Drp1 pathway

(2021) Lei Hou et al.   FREE RADICAL BIOLOGY AND MEDICINE

NRF2 is required for structural and metabolic maturation of human induced pluripotent stem cell-derived ardiomyocytes

(2021) Xinyuan Zhang et al.   Stem Cell Research & Therapy

Mitochondrial ROS control neuronal excitability and cell fate in frontotemporal dementia

(2021) Noemí Esteras et al.   Alzheimers & Dementia

Diroximel Fumarate in Relapsing Forms of Multiple Sclerosis: A Profile of Its Use

(2021) Julia Paik   CNS DRUGS

Nrf2 activation induces mitophagy and reverses Parkin/Pink1 knock down-mediated neuronal and muscle degeneration phenotypes

(2021) Sentiljana Gumeni et al.   Cell Death & Disease

MCU That Is Transcriptionally Regulated by Nrf2 Augments Malignant Biological Behaviors in Oral Squamous Cell Carcinoma Cells

(2021) Ran Wu et al.   Biomed Research International

Nrf2 contributes to the benefits of exercise interventions on age-related skeletal muscle disorder via regulating Drp1 stability and mitochondrial fission

(2021) Xialin Yan et al.   FREE RADICAL BIOLOGY AND MEDICINE

The assembly, regulation and function of the mitochondrial respiratory chain

(2021) Irene Vercellino et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A novel role of KEAP1/PGAM5 complex: ROS sensor for inducing mitophagy

(2021) Akbar Zeb et al.   Redox Biology

Molecular Mechanisms and Regulation of Mammalian Mitophagy

(2021) Vinay Choubey et al.   Cells

Diversity of Axonal and Dendritic Contributions to Neuronal Output

(2020) Jean-Marc Goaillard et al.   Frontiers in Cellular Neuroscience

Mitochondrial TCA cycle metabolites control physiology and disease

(2020) Inmaculada Martínez-Reyes et al.   Nature Communications

PINK1 and Parkin mitochondrial quality control: a source of regional vulnerability in Parkinson’s disease

(2020) Preston Ge et al.   Molecular Neurodegeneration

Activation of transcription factor Nrf2 to counteract mitochondrial dysfunction in Parkinson's disease

(2020) Claudia Bento‐Pereira et al.   MEDICINAL RESEARCH REVIEWS

Mitochondria and lipid peroxidation in the mechanism of neurodegeneration: Finding ways for prevention

(2020) Plamena R. Angelova et al.   MEDICINAL RESEARCH REVIEWS

Enhanced activity of glycolytic enzymes in Drosophila and human cell models of Parkinson's disease based on DJ-1 deficiency

(2020) Cristina Solana-Manrique et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitophagy pathways in health and disease

(2020) Samuel A. Killackey et al.   JOURNAL OF CELL BIOLOGY

Functional, proteomic and bioinformatic analyses of Nrf2‐ and Keap1‐ null skeletal muscle

(2020) Lie Gao et al.   JOURNAL OF PHYSIOLOGY-LONDON

Mitochondrial Calcium Deregulation in the Mechanism of Beta-Amyloid and Tau Pathology

(2020) Noemi Esteras et al.   Cells

Functions of outer mitochondrial membrane proteins: mediating the crosstalk between mitochondrial dynamics and mitophagy

(2020) Hongxu Xian et al.   CELL DEATH AND DIFFERENTIATION

Loss of NRF2 accelerates cognitive decline, exacerbates mitochondrial dysfunction, and is required for the cognitive enhancing effects of Centella asiatica during aging

(2020) Jonathan A. Zweig et al.   NEUROBIOLOGY OF AGING

Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases

(2019) Antonio Cuadrado et al.   NATURE REVIEWS DRUG DISCOVERY

MCUR1 facilitates epithelial-mesenchymal transition and metastasis via the mitochondrial calcium dependent ROS/Nrf2/Notch pathway in hepatocellular carcinoma

(2019) Mingpeng Jin et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Ilexgenin A inhibits mitochondrial fission and promote Drp1 degradation by Nrf2-induced PSMB5 in endothelial cells

(2019) Yingchao Zhu et al.   DRUG DEVELOPMENT RESEARCH

Nrf2 deficiency exacerbates frailty and sarcopenia by impairing skeletal muscle mitochondrial biogenesis and dynamics in an age-dependent manner

(2019) Dong-Dong Huang et al.   EXPERIMENTAL GERONTOLOGY

Regulation of Mitochondrial Biogenesis as a Way for Active Longevity: Interaction Between the Nrf2 and PGC-1α Signaling Pathways

(2019) Artem P. Gureev et al.   Frontiers in Genetics

Activators and Inhibitors of NRF2: A Review of Their Potential for Clinical Development

(2019) Natalia Robledinos-Antón et al.   Oxidative Medicine and Cellular Longevity

Mitochondrial Uncoupling: A Key Controller of Biological Processes in Physiology and Diseases

(2019) Demine et al.   Cells

The impact of acute and chronic exercise on Nrf2 expression in relation to markers of mitochondrial biogenesis in human skeletal muscle

(2019) Hashim Islam et al.   EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY

Regulation of PGC-1α expression by a GSK-3β-TFEB signaling axis in skeletal muscle

(2019) W.F. Theeuwes et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Tau inhibits mitochondrial calcium efflux and makes neurons vulnerable to calcium-induced cell death

(2019) Elena Britti et al.   CELL CALCIUM

Loss of NRF2 leads to impaired mitochondrial function, decreased synaptic density and exacerbated age-related cognitive deficits

(2019) Jonathan A. Zweig et al.   EXPERIMENTAL GERONTOLOGY

Nrf2 stabilization prevents critical oxidative damage in Down syndrome cells

(2018) Emiliano Zamponi et al.   AGING CELL

KEAP1 inhibition is neuroprotective and suppresses the development of epilepsy

(2018) Tawfeeq Shekh-Ahmad et al.   BRAIN

Basal Mitophagy Occurs Independently of PINK1 in Mouse Tissues of High Metabolic Demand

(2018) Thomas G. McWilliams et al.   Cell Metabolism

OUP accepted manuscript

(2018)   CEREBRAL CORTEX

Role of mitochondrial ROS in the brain: from physiology to neurodegeneration

(2018) Plamena R. Angelova et al.   FEBS LETTERS

Novel Nrf2-Inducer Prevents Mitochondrial Defects and Oxidative Stress in Friedreich’s Ataxia Models

(2018) Rosella Abeti et al.   Frontiers in Cellular Neuroscience

Mitochondrial Complex I activity signals antioxidant response through ERK5

(2018) Abrar Ul Haq Khan et al.   Scientific Reports

Hyperactivation of Nrf2 increases stress tolerance at the cost of aging acceleration due to metabolic deregulation

(2018) Eleni N. Tsakiri et al.   AGING CELL

Hyperactivity of the transcription factor Nrf2 causes metabolic reprogramming in mouse esophagus

(2018) Junsheng Fu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A metabolite-derived protein modification integrates glycolysis with KEAP1–NRF2 signalling

(2018) Michael J. Bollong et al.   NATURE

Sulforaphane enriched transcriptome of lung mitochondrial energy metabolism and provided pulmonary injury protection via Nrf2 in mice

(2018) Hye-Youn Cho et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Dimethyl fumarate mediates Nrf2-dependent mitochondrial biogenesis in mice and humans

(2017) Genki Hayashi et al.   HUMAN MOLECULAR GENETICS

Evaluating the gray and white matter energy budgets of human brain function

(2017) Yuguo Yu et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Keap1 loss promotes Kras-driven lung cancer and results in dependence on glutaminolysis

(2017) Rodrigo Romero et al.   NATURE MEDICINE

NRF2 regulates endothelial glycolysis and proliferation with miR-93 and mediates the effects of oxidized phospholipids on endothelial activation

(2017) Suvi M Kuosmanen et al.   NUCLEIC ACIDS RESEARCH

Reversible Keap1 inhibitors are preferential pharmacological tools to modulate cellular mitophagy

(2017) Nikolaos D. Georgakopoulos et al.   Scientific Reports

PGC-1α attenuates hydrogen peroxide-induced apoptotic cell death by upregulating Nrf-2 via GSK3β inactivation mediated by activated p38 in HK-2 Cells

(2017) Hoon-In Choi et al.   Scientific Reports

PINK1 Primes Parkin-Mediated Ubiquitination of PARIS in Dopaminergic Neuronal Survival

(2017) Yunjong Lee et al.   Cell Reports

Sulforaphane is a Nrf2-independent inhibitor of mitochondrial fission

(2017) Gary B. O'Mealey et al.   Redox Biology

NRF2 deficiency replicates transcriptomic changes in Alzheimer's patients and worsens APP and TAU pathology

(2017) Ana I. Rojo et al.   Redox Biology

Mitochondrial hyperpolarization in iPSC-derived neurons from patients of FTDP-17 with 10+16 MAPT mutation leads to oxidative stress and neurodegeneration

(2017) Noemí Esteras et al.   Redox Biology

Pathogenic p62/SQSTM1 mutations impair energy metabolism through limitation of mitochondrial substrates

(2017) Fernando Bartolome et al.   Scientific Reports

Repurposing the NRF2 Activator Dimethyl Fumarate as Therapy Against Synucleinopathy in Parkinson's Disease

(2016) Isabel Lastres-Becker et al.   ANTIOXIDANTS & REDOX SIGNALING

Nrf2 activation in the treatment of neurodegenerative diseases: a focus on its role in mitochondrial bioenergetics and function

(2016) Noemí Esteras et al.   BIOLOGICAL CHEMISTRY

Deficiency of Parkinson’s disease-related gene Fbxo7 is associated with impaired mitochondrial metabolism by PARP activation

(2016) Marta Delgado-Camprubi et al.   CELL DEATH AND DIFFERENTIATION

Lipid Use and Misuse by the Heart

(2016) P. Christian Schulze et al.   CIRCULATION RESEARCH

Nrf2 protects mitochondrial decay by oxidative stress

(2016) Joshua Strom et al.   FASEB JOURNAL

Functional role of mitochondrial reactive oxygen species in physiology

(2016) Plamena R. Angelova et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondrial generation of superoxide and hydrogen peroxide as the source of mitochondrial redox signaling

(2016) Martin D. Brand   FREE RADICAL BIOLOGY AND MEDICINE

The role of Nrf2 in skeletal muscle contractile and mitochondrial function

(2016) Matthew J. Crilly et al.   JOURNAL OF APPLIED PHYSIOLOGY

Distinct Nrf2 Signaling Mechanisms of Fumaric Acid Esters and Their Role in Neuroprotection against 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Induced Experimental Parkinson's-Like Disease

(2016) M. Ahuja et al.   JOURNAL OF NEUROSCIENCE

Nuclear factor erythroid-derived 2-like 2 (NFE2L2, Nrf2) mediates exercise-induced mitochondrial biogenesis and the anti-oxidant response in mice

(2016) Troy L. Merry et al.   JOURNAL OF PHYSIOLOGY-LONDON

Nrf2-Mediated Regulation of Skeletal Muscle Glycogen Metabolism

(2016) Akira Uruno et al.   MOLECULAR AND CELLULAR BIOLOGY

Regulation of Mitochondrial Biogenesis and Its Intersection with Inflammatory Responses

(2015) Anne D. Cherry et al.   ANTIOXIDANTS & REDOX SIGNALING

PINK1 activation–turning on a promiscuous kinase

(2015) Liesbeth Aerts et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The spatiotemporal regulation of the Keap1–Nrf2 pathway and its importance in cellular bioenergetics

(2015) Albena T. Dinkova-Kostova et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Nrf2 regulates ROS production by mitochondria and NADPH oxidase

(2015) Stjepana Kovac et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Structure and function of mitochondrial membrane protein complexes

(2015) Werner Kühlbrandt   BMC BIOLOGY

Activated AMPK boosts the Nrf2/HO-1 signaling axis—A role for the unfolded protein response

(2015) Kristin Zimmermann et al.   FREE RADICAL BIOLOGY AND MEDICINE

p62 links autophagy and Nrf2 signaling

(2015) Tao Jiang et al.   FREE RADICAL BIOLOGY AND MEDICINE

The emerging role of Nrf2 in mitochondrial function

(2015) Albena T. Dinkova-Kostova et al.   FREE RADICAL BIOLOGY AND MEDICINE

Functional Oxygen Sensitivity of Astrocytes

(2015) P. R. Angelova et al.   JOURNAL OF NEUROSCIENCE

Dimethyl fumarate in the treatment of relapsing–remitting multiple sclerosis: an overview

(2015) Roberto Bomprezzi   Therapeutic Advances in Neurological Disorders

Mitochondrial dynamics and mitochondrial quality control

(2015) Hong-Min Ni et al.   Redox Biology

NRF2 Regulates PINK1 Expression under Oxidative Stress Conditions

(2015) Hitoshi Murata et al.   PLoS One

PMI: A ΔΨm Independent Pharmacological Regulator of Mitophagy

(2014) Daniel A. East et al.   CHEMISTRY & BIOLOGY

Disturbed mitochondrial dynamics and neurodegenerative disorders

(2014) Florence Burté et al.   Nature Reviews Neurology

The Nrf2 regulatory network provides an interface between redox and intermediary metabolism

(2014) John D. Hayes et al.   TRENDS IN BIOCHEMICAL SCIENCES

Seizure activity results in calcium- and mitochondria-independent ROS production via NADPH and xanthine oxidase activation

(2014) S Kovac et al.   Cell Death & Disease

Mitochondrial reactive oxygen species regulate the strength of inhibitory GABA-mediated synaptic transmission

(2014) Michael V. Accardi et al.   Nature Communications

Nrf2 affects the efficiency of mitochondrial fatty acid oxidation

(2013) Marthe H. R. Ludtmann et al.   BIOCHEMICAL JOURNAL

Mitochondrial genetics

(2013) P. F. Chinnery et al.   BRITISH MEDICAL BULLETIN

Regulation of pyruvate metabolism and human disease

(2013) Lawrence R. Gray et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Transcription factor NRF2 regulates miR-1 and miR-206 to drive tumorigenesis

(2013) Anju Singh et al.   JOURNAL OF CLINICAL INVESTIGATION

Calcium-Regulation of Mitochondrial Respiration Maintains ATP Homeostasis and Requires ARALAR/AGC1-Malate Aspartate Shuttle in Intact Cortical Neurons

(2013) I. Llorente-Folch et al.   JOURNAL OF NEUROSCIENCE

Fis1, Mff, MiD49, and MiD51 mediate Drp1 recruitment in mitochondrial fission

(2013) Oliver C. Losón et al.   MOLECULAR BIOLOGY OF THE CELL

Cardiolipin externalization to the outer mitochondrial membrane acts as an elimination signal for mitophagy in neuronal cells

(2013) Charleen T. Chu et al.   NATURE CELL BIOLOGY

Nrf2 impacts cellular bioenergetics by controlling substrate availability for mitochondrial respiration

(2013) K. M. Holmstrom et al.   Biology Open

Glucose availability is a decisive factor for Nrf2-mediated gene expression

(2013) Elke H. Heiss et al.   Redox Biology

p53 Orchestrates the PGC-1α-Mediated Antioxidant Response Upon Mild Redox and Metabolic Imbalance

(2012) Katia Aquilano et al.   ANTIOXIDANTS & REDOX SIGNALING

Mitochondria as sensors and regulators of calcium signalling

(2012) Rosario Rizzuto et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mitochondrial transport in neurons: impact on synaptic homeostasis and neurodegeneration

(2012) Zu-Hang Sheng et al.   NATURE REVIEWS NEUROSCIENCE

Synaptic Energy Use and Supply

(2012) Julia J. Harris et al.   NEURON

Identification of novel NRF2-regulated genes by ChIP-Seq: influence on retinoid X receptor alpha

(2012) B. N. Chorley et al.   NUCLEIC ACIDS RESEARCH

Transcriptional integration of mitochondrial biogenesis

(2012) Richard C. Scarpulla et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Involvement of PGC-1α in the formation and maintenance of neuronal dendritic spines

(2012) Aiwu Cheng et al.   Nature Communications

Regulation of PGC-1α, a nodal regulator of mitochondrial biogenesis

(2011) Pablo J Fernandez-Marcos et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

PINK1 and Parkin Target Miro for Phosphorylation and Degradation to Arrest Mitochondrial Motility

(2011) Xinnan Wang et al.   CELL

Mitochondrial oxidative stress causes mitochondrial fragmentation via differential modulation of mitochondrial fission-fusion proteins

(2011) Shengnan Wu et al.   FEBS Journal

Sulforaphane inhibits mitochondrial permeability transition and oxidative stress

(2011) Tiffany Greco et al.   FREE RADICAL BIOLOGY AND MEDICINE

Acetyl-L-carnitine-mediated neuroprotection during hypoxia is attributed to ERK1/2-Nrf2-regulated mitochondrial biosynthesis

(2011) Kalpana Barhwal Hota et al.   HIPPOCAMPUS

Mitochondrial matrix Ca2+ as an intrinsic signal regulating mitochondrial motility in axons

(2011) K. T. Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ER Tubules Mark Sites of Mitochondrial Division

(2011) J. R. Friedman et al.   SCIENCE

Degradation of Paternal Mitochondria by Fertilization-Triggered Autophagy in C. elegans Embryos

(2011) M. Sato et al.   SCIENCE

Beneficial Role of Nrf2 in Regulating NADPH Generation and Consumption

(2011) Kai Connie Wu et al.   TOXICOLOGICAL SCIENCES

AMPK and SIRT1: a long-standing partnership?

(2010) Neil B. Ruderman et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Enhanced Hepatic Nrf2 Activation After Ursodeoxycholic Acid Treatment in Patients with Primary Biliary Cirrhosis

(2010) Kazuhito Kawata et al.   ANTIOXIDANTS & REDOX SIGNALING

Deficiency in the Nuclear Factor E2-related Factor-2 Transcription Factor Results in Impaired Adipogenesis and Protects against Diet-induced Obesity

(2010) Jingbo Pi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p62/SQSTM1Is a Target Gene for Transcription Factor NRF2 and Creates a Positive Feedback Loop by Inducing Antioxidant Response Element-driven Gene Transcription

(2010) Ashish Jain et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Noncanonical Mechanism of Nrf2 Activation by Autophagy Deficiency: Direct Interaction between Keap1 and p62

(2010) A. Lau et al.   MOLECULAR AND CELLULAR BIOLOGY

The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1

(2010) Masaaki Komatsu et al.   NATURE CELL BIOLOGY

Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis

(2010) Deepti Malhotra et al.   NUCLEIC ACIDS RESEARCH

Extracellular redox status regulates Nrf2 activation through mitochondrial reactive oxygen species

(2009) Barry R. Imhoff et al.   BIOCHEMICAL JOURNAL

The Mechanism of Ca2+-Dependent Regulation of Kinesin-Mediated Mitochondrial Motility

(2009) Xinnan Wang et al.   CELL

Coassembly of Mgm1 isoforms requires cardiolipin and mediates mitochondrial inner membrane fusion

(2009) Rachel M. DeVay et al.   JOURNAL OF CELL BIOLOGY

Drosophila Miro Is Required for Both Anterograde and Retrograde Axonal Mitochondrial Transport

(2009) G. J. Russo et al.   JOURNAL OF NEUROSCIENCE

PINK1-Associated Parkinson's Disease Is Caused by Neuronal Vulnerability to Calcium-Induced Cell Death

(2009) Sonia Gandhi et al.   MOLECULAR CELL

NCLX is an essential component of mitochondrial Na+/Ca2+ exchange

(2009) R. Palty et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transcribe to Survive: Transcriptional Control of Antioxidant Defense Programs for Neuroprotection in Parkinson’s Disease

(2008) Joanne Clark et al.   ANTIOXIDANTS & REDOX SIGNALING

Docking of Axonal Mitochondria by Syntaphilin Controls Their Mobility and Affects Short-Term Facilitation

(2008) Jian-Sheng Kang et al.   CELL

Heme Oxygenase-1 Regulates Cardiac Mitochondrial Biogenesis via Nrf2-Mediated Transcriptional Control of Nuclear Respiratory Factor-1

(2008) Claude A. Piantadosi et al.   CIRCULATION RESEARCH

PGAM5 tethers a ternary complex containing Keap1 and Nrf2 to mitochondria

(2008) Shih-Ching Lo et al.   EXPERIMENTAL CELL RESEARCH

The PPAR trio: Regulators of myocardial energy metabolism in health and disease

(2008) Jose A. Madrazo et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Essential role for Nix in autophagic maturation of erythroid cells

(2008) Hector Sandoval et al.   NATURE

Bidirectional Ca2+-dependent control of mitochondrial dynamics by the Miro GTPase

(2008) M. Saotome et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ΔΨm-Dependent and -independent production of reactive oxygen species by rat brain mitochondria

(2003) Tatyana V. Votyakova et al.   JOURNAL OF NEUROCHEMISTRY