MCUR1 facilitates epithelial-mesenchymal transition and metastasis via the mitochondrial calcium dependent ROS/Nrf2/Notch pathway in hepatocellular carcinoma
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Title
MCUR1 facilitates epithelial-mesenchymal transition and metastasis via the mitochondrial calcium dependent ROS/Nrf2/Notch pathway in hepatocellular carcinoma
Authors
Keywords
Mitochondrial calcium uniporter regulator 1, Hepatocellular carcinoma, EMT, Metastasis, Notch 1
Journal
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
Volume 38, Issue 1, Pages -
Publisher
Springer Nature
Online
2019-03-25
DOI
10.1186/s13046-019-1135-x
References
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Note: Only part of the references are listed.- MCUR1-Mediated Mitochondrial Calcium Signaling Facilitates Cell Survival of Hepatocellular Carcinoma via Reactive Oxygen Species-Dependent P53 Degradation
- (2018) Tingting Ren et al. ANTIOXIDANTS & REDOX SIGNALING
- RIPK1 Binds MCU to Mediate Induction of Mitochondrial Ca2+Uptake and Promotes Colorectal Oncogenesis
- (2018) Fanxin Zeng et al. CANCER RESEARCH
- MCU-dependent mitochondrial Ca2+ inhibits NAD+/SIRT3/SOD2 pathway to promote ROS production and metastasis of HCC cells
- (2017) T Ren et al. ONCOGENE
- MICU1 drives glycolysis and chemoresistance in ovarian cancer
- (2017) Prabir K. Chakraborty et al. Nature Communications
- Increased mitochondrial fission promotes autophagy and hepatocellular carcinoma cell survival through the ROS-modulated coordinated regulation of the NFKB and TP53 pathways
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- Role of epithelial to mesenchymal transition in hepatocellular carcinoma
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- Mitochondrial Ca2+ uniporter is critical for store-operated Ca2+ entry-dependent breast cancer cell migration
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- From Fly Wings to Targeted Cancer Therapies: A Centennial for Notch Signaling
- (2014) Panagiotis Ntziachristos et al. CANCER CELL
- Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012
- (2014) Jacques Ferlay et al. INTERNATIONAL JOURNAL OF CANCER
- Remodelling of Ca2+ transport in cancer: how it contributes to cancer hallmarks?
- (2014) N. Prevarskaya et al. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
- Notch signaling in serous ovarian cancer
- (2014) Jolijn W Groeneweg et al. Journal of Ovarian Research
- Mitochondrial calcium uniporter silencing potentiates caspase-independent cell death in MDA-MB-231 breast cancer cells
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- Oncogenic functions of the transcription factor Nrf2
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- Yes-Associated Protein Up-regulates Jagged-1 and Activates the NOTCH Pathway in Human Hepatocellular Carcinoma
- (2013) Darjus Felix Tschaharganeh et al. GASTROENTEROLOGY
- The mitochondrial calcium uniporter complex: molecular components, structure and physiopathological implications
- (2013) Saverio Marchi et al. JOURNAL OF PHYSIOLOGY-LONDON
- MCUR1 is an essential component of mitochondrial Ca2+ uptake that regulates cellular metabolism
- (2012) Karthik Mallilankaraman et al. NATURE CELL BIOLOGY
- Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter
- (2011) Joshua M. Baughman et al. NATURE
- A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter
- (2011) Diego De Stefani et al. NATURE
- Role of Cationic Channel TRPV2 in Promoting Prostate Cancer Migration and Progression to Androgen Resistance
- (2010) M. Monet et al. CANCER RESEARCH
- Novel role for epidermal growth factor-like domain 7 in metastasis of human hepatocellular carcinoma
- (2009) Fan Wu et al. HEPATOLOGY
- Cooperation of Notch and Ras/MAPK signaling pathways in human breast carcinogenesis
- (2009) Suruchi Mittal et al. Molecular Cancer
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