Loss of NRF2 accelerates cognitive decline, exacerbates mitochondrial dysfunction, and is required for the cognitive enhancing effects of Centella asiatica during aging

Nrf2 activation through the PI3K/GSK-3 axis protects neuronal cells from Aβ-mediated oxidative and metabolic damage

(2020) Krystal Sotolongo et al.   Alzheimers Research & Therapy

3,4,5-Tricaffeoylquinic acid induces adult neurogenesis and improves deficit of learning and memory in aging model senescence-accelerated prone 8 mice

(2019) Kazunori Sasaki et al.   Aging-US

Redox regulation by NRF2 in aging and disease

(2019) Cody J. Schmidlin et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nrf2 deficiency exacerbates frailty and sarcopenia by impairing skeletal muscle mitochondrial biogenesis and dynamics in an age-dependent manner

(2019) Dong-Dong Huang et al.   EXPERIMENTAL GERONTOLOGY

Asiatic acid inhibits cardiac fibrosis throughNrf2/HO-1 and TGF-β1/Smads signaling pathways in spontaneous hypertension rats

(2019) Zhe Meng et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Madecassoside ameliorates lipopolysaccharide-induced neurotoxicity in rats by activating the Nrf2-HO-1 pathway

(2019) Sisi Liu et al.   NEUROSCIENCE LETTERS

Age-dependent effects of dimethyl fumarate on cognitive and neuropathological features in the streptozotocin-induced rat model of Alzheimer’s disease

(2018) Irena Majkutewicz et al.   BRAIN RESEARCH

Hallmarks of Brain Aging: Adaptive and Pathological Modification by Metabolic States

(2018) Mark P. Mattson et al.   Cell Metabolism

Ontogeny and aging of Nrf2 pathway genes in livers of rats

(2018) Shang-Fu Xu et al.   LIFE SCIENCES

Canonical and non-canonical mechanisms of Nrf2 activation

(2018) Carlos Alfredo Silva-Islas et al.   PHARMACOLOGICAL RESEARCH

Downregulated Nuclear Factor E2-Related Factor 2 (Nrf2) Aggravates Cognitive Impairments via Neuroinflammation and Synaptic Plasticity in the Senescence-Accelerated Mouse Prone 8 (SAMP8) Mouse: A Model of Accelerated Senescence

(2018) Hui Ling Ren et al.   MEDICAL SCIENCE MONITOR

Centella asiatica increases hippocampal synaptic density and improves memory and executive function in aged mice

(2018) Nora E. Gray et al.   Brain and Behavior

Nrf2 deletion results in impaired performance in memory tasks and hyperactivity in mature and aged mice

(2018) Mark M. Gergues et al.   BRAIN RESEARCH

Caffeoylquinic Acids in Centella asiatica Protect against Amyloid-β Toxicity

(2018) Nora E. Gray et al.   JOURNAL OF ALZHEIMERS DISEASE

Centella asiatica attenuates hippocampal mitochondrial dysfunction and improves memory and executive function in β-amyloid overexpressing mice

(2018) Nora E. Gray et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Effects of Long-Term Treatment with a Blend of Highly Purified Olive Secoiridoids on Cognition and Brain ATP Levels in Aged NMRI Mice

(2018) Martina Reutzel et al.   Oxidative Medicine and Cellular Longevity

Asiatic acid ameliorates CC l4-induced liver fibrosis in rats: involvement of Nrf2/ARE, NF-κB/IκBα, and JAK1/STAT3 signaling pathways

(2018) Jie Fan et al.   Drug Design Development and Therapy

Nrf2 deficiency in aged mice exacerbates cellular senescence promoting cerebrovascular inflammation

(2018) Gabor A. Fulop et al.   GeroScience

The crosstalk between Sirt1 and Keap1/Nrf2/ARE anti-oxidative pathway forms a positive feedback loop to inhibit FN and TGF-β1 expressions in rat glomerular mesangial cells

(2017) Kaipeng Huang et al.   EXPERIMENTAL CELL RESEARCH

Pathways to Brain Aging and Their Modifiers: Free-Radical-Induced Energetic and Neural Decline in Senescence (FRIENDS) Model - A Mini-Review

(2017) Naftali Raz et al.   GERONTOLOGY

Asiaticoside Mitigates the Allergic Inflammation by Abrogating the Degranulation of Mast Cells

(2017) Jing Zhi Jiang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Brain aging and neurodegeneration: from a mitochondrial point of view

(2017) Amandine Grimm et al.   JOURNAL OF NEUROCHEMISTRY

Asiatic acid prevents the quinolinic acid-induced oxidative stress and cognitive impairment

(2017) Chitra Loganathan et al.   METABOLIC BRAIN DISEASE

Neurotrophic Effect of Asiatic acid, a Triterpene of Centella asiatica Against Chronic 1-Methyl 4-Phenyl 1, 2, 3, 6-Tetrahydropyridine Hydrochloride/Probenecid Mouse Model of Parkinson’s disease: The Role of MAPK, PI3K-Akt-GSK3β and mTOR Signalling Pathways

(2017) Jagatheesan Nataraj et al.   NEUROCHEMICAL RESEARCH

Centella asiatica: phytochemistry and mechanisms of neuroprotection and cognitive enhancement

(2017) Nora E. Gray et al.   PHYTOCHEMISTRY REVIEWS

Age-Related Shift in Neuro-Activation during a Word-Matching Task

(2017) Ikram Methqal et al.   Frontiers in Aging Neuroscience

Asiatic acid protects against cognitive deficits and reductions in cell proliferation and survival in the rat hippocampus caused by 5-fluorouracil chemotherapy

(2017) Pornthip Chaisawang et al.   PLoS One

Dimethyl fumarate attenuates intracerebroventricular streptozotocin-induced spatial memory impairment and hippocampal neurodegeneration in rats

(2016) Irena Majkutewicz et al.   BEHAVIOURAL BRAIN RESEARCH

Madecassic Acid protects against hypoxia-induced oxidative stress in retinal microvascular endothelial cells via ROS-mediated endoplasmic reticulum stress

(2016) Boyu Yang et al.   BIOMEDICINE & PHARMACOTHERAPY

Centella asiatica modulates antioxidant and mitochondrial pathways and improves cognitive function in mice

(2016) Nora E. Gray et al.   JOURNAL OF ETHNOPHARMACOLOGY

The Mitochondrial Basis of Aging

(2016) Nuo Sun et al.   MOLECULAR CELL

Curcumin Ameliorates Memory Decline via Inhibiting BACE1 Expression and β-Amyloid Pathology in 5×FAD Transgenic Mice

(2016) Kunmu Zheng et al.   MOLECULAR NEUROBIOLOGY

Asiatic Acid Prevents the Deleterious Effects of Valproic Acid on Cognition and Hippocampal Cell Proliferation and Survival

(2016) Jariya Umka Welbat et al.   Nutrients

Activation of the Nrf2 Cell Defense Pathway by Ancient Foods: Disease Prevention by Important Molecules and Microbes Lost from the Modern Western Diet

(2016) Donald R. Senger et al.   PLoS One

Effects of Fatty Acids on CYP2A5 and Nrf2 Expression in Mouse Primary Hepatocytes

(2015) Yizhe Cui et al.   BIOCHEMICAL GENETICS

The emerging role of Nrf2 in mitochondrial function

(2015) Albena T. Dinkova-Kostova et al.   FREE RADICAL BIOLOGY AND MEDICINE

Effects of Asiatic Acid on Spatial Working Memory and Cell Proliferation in the Adult Rat Hippocampus

(2015) Apiwat Sirichoat et al.   Nutrients

Blueberry Supplementation Improves Memory in Middle-Aged Mice Fed a High-Fat Diet

(2014) Amanda N. Carey et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases

(2014) C. Franceschi et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Analysis of the role of Nrf2 in the expression of liver proteins in mice using two-dimensional gel-based proteomics

(2014) Azman Abdullah et al.   Pharmacological Reports

Seaweed extracts and unsaturated fatty acid constituents from the green alga Ulva lactuca as activators of the cytoprotective Nrf2–ARE pathway

(2013) Rui Wang et al.   FREE RADICAL BIOLOGY AND MEDICINE

A Role for Peroxisome Proliferator-activated Receptor γ Coactivator 1 (PGC-1) in the Regulation of Cardiac Mitochondrial Phospholipid Biosynthesis

(2013) Ling Lai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Asiatic acid, a pentacyclic triterpene in Centella asiatica, attenuates glutamate-induced cognitive deficits in mice and apoptosis in SH-SY5Y cells

(2012) Min-fang Xu et al.   ACTA PHARMACOLOGICA SINICA

The Nrf2-antioxidant response element pathway: a target for regulating energy metabolism

(2012) Emilie E. Vomhof-DeKrey et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Mitoprotective effect of Centella asiatica against aluminum-induced neurotoxicity in rats: possible relevance to its anti-oxidant and anti-apoptosis mechanism

(2012) Atish Prakash et al.   NEUROLOGICAL SCIENCES

Abnormal mitochondrial dynamics and synaptic degeneration as early events in Alzheimer's disease: Implications to mitochondria-targeted antioxidant therapeutics

(2011) P. Hemachandra Reddy et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Nrf2-regulated PPARγ Expression Is Critical to Protection against Acute Lung Injury in Mice

(2010) Hye-Youn Cho et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Effects of asiatic acid on passive and active avoidance task in male Spraque–Dawley rats

(2010) M.N. Nasir et al.   JOURNAL OF ETHNOPHARMACOLOGY

Magnolol and honokiol prevent learning and memory impairment and cholinergic deficit in SAMP8 mice

(2009) Nobuaki Matsui et al.   BRAIN RESEARCH

Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease

(2009) J. Yao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Episodic memory decay along the adult lifespan: A review of behavioral and neurophysiological evidence

(2008) Selene Cansino   INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY

Prophylactic neuroprotective property of Centella asiatica against 3-nitropropionic acid induced oxidative stress and mitochondrial dysfunctions in brain regions of prepubertal mice

(2008) George K. Shinomol et al.   NEUROTOXICOLOGY

Effect of Centella asiatica leaf powder on oxidative markers in brain regions of prepubertal mice in vivo and its in vitro efficacy to ameliorate 3-NPA-induced oxidative stress in mitochondria

(2008) George K. Shinomol et al.   PHYTOMEDICINE

Amyloid beta, mitochondrial dysfunction and synaptic damage: implications for cognitive decline in aging and Alzheimer's disease

(2008) P. Hemachandra Reddy et al.   TRENDS IN MOLECULAR MEDICINE