Nrf2 contributes to the benefits of exercise interventions on age-related skeletal muscle disorder via regulating Drp1 stability and mitochondrial fission

CHIP protects against MPP+/MPTP-induced damage by regulating Drp1 in two models of Parkinson’s disease

(2021) Zhengwei Hu et al.   Aging-US

Metformin attenuates hyperlipidaemia-associated vascular calcification through anti-ferroptotic effects

(2021) Wen-Qi Ma et al.   FREE RADICAL BIOLOGY AND MEDICINE

Exercise rescues mitochondrial coupling in aged skeletal muscle: a comparison of different modalities in preventing sarcopenia

(2021) Colin Harper et al.   Journal of Translational Medicine

Excessive exercise training causes mitochondrial functional impairment and decreases glucose tolerance in healthy volunteers

(2021) Mikael Flockhart et al.   Cell Metabolism

Transferrin receptor 1 ablation in satellite cells impedes skeletal muscle regeneration through activation of ferroptosis

(2021) Hongrong Ding et al.   Journal of Cachexia Sarcopenia and Muscle

Exercise-Stimulated ROS Sensitive Signaling Pathways in Skeletal Muscle

(2021) Jessica Bouviere et al.   Antioxidants

Age-related changes in muscle architecture and metabolism in humans: The likely contribution of physical inactivity to age-related functional decline

(2021) N.F. Shur et al.   AGEING RESEARCH REVIEWS

High intensity muscle stimulation activates a systemic Nrf2-mediated redox stress response

(2021) Ethan L. Ostrom et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mycobacterium bovis induces mitophagy to suppress host xenophagy for its intracellular survival

(2021) Yinjuan Song et al.   Autophagy

Muscle-generated BDNF (brain derived neurotrophic factor) maintains mitochondrial quality control in female mice

(2021) Palak Ahuja et al.   Autophagy

Nampt controls skeletal muscle development by maintaining Ca2+ homeostasis and mitochondrial integrity

(2021) Astrid L. Basse et al.   Molecular Metabolism

The autophagic-lysosomal and ubiquitin proteasome systems are simultaneously activated in the skeletal muscle of gastric cancer patients with cachexia

(2020) Ying Zhang et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Nrf2 deficiency promotes the increasing trend of autophagy during aging in skeletal muscle: a potential mechanism for the development of sarcopenia

(2020) Dong-Dong Huang et al.   Aging-US

PINK 1 phosphorylates Drp1 S616 to regulate mitophagy‐independent mitochondrial dynamics

(2020) Hailong Han et al.   EMBO REPORTS

Sulforaphane protects against skeletal muscle dysfunction in spontaneous type 2 diabetic db/db mice

(2020) Meili Wang et al.   LIFE SCIENCES

Sulforaphane prevents age‐associated cardiac and muscular dysfunction through Nrf2 signaling

(2020) Chhanda Bose et al.   AGING CELL

Quantitative evaluation of passive muscle stiffness by shear wave elastography in healthy individuals of different ages

(2020) Xiao Liu et al.   EUROPEAN RADIOLOGY

Functional, proteomic and bioinformatic analyses of Nrf2‐ and Keap1‐ null skeletal muscle

(2020) Lie Gao et al.   JOURNAL OF PHYSIOLOGY-LONDON

Sulforaphane suppresses obesity-related glomerulopathy-induced damage by enhancing autophagy via Nrf2

(2020) Yue Lu et al.   LIFE SCIENCES

Deubiquitinase OTUD6A promotes proliferation of cancer cells via regulating Drp1 stability and mitochondrial fission

(2020) Le Shi et al.   Molecular Oncology

Regulation of Nrf2/Keap1 signalling in human skeletal muscle during exercise to exhaustion in normoxia, severe acute hypoxia and post-exercise ischaemia: Influence of metabolite accumulation and oxygenation

(2020) Angel Gallego-Selles et al.   Redox Biology

Metformin alleviates lead-induced mitochondrial fragmentation via AMPK/Nrf2 activation in SH-SY5Y cells

(2020) Luoyao Yang et al.   Redox Biology

Nrf2: The Master and Captain of Beta Cell Fate

(2020) Sharon Baumel-Alterzon et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

The role of Nrf2 in acute and chronic muscle injury

(2020) Iwona Bronisz-Budzyńska et al.   Skeletal Muscle

The RNA-Binding Protein PUM2 Impairs Mitochondrial Dynamics and Mitophagy During Aging

(2019) Davide D’Amico et al.   MOLECULAR CELL

Exercise-induced AMPK activation is involved in delay of skeletal muscle senescence

(2019) Kyeong Jin Yoon et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Dual roles of ULK1 (unc-51 like autophagy activating kinase 1) in cytoprotection against lipotoxicity

(2019) Jeong Su Park et al.   Autophagy

mTORC1 underlies age‐related muscle fiber damage and loss by inducing oxidative stress and catabolism

(2019) Huibin Tang et al.   AGING CELL

Nrf2 deficiency exacerbates frailty and sarcopenia by impairing skeletal muscle mitochondrial biogenesis and dynamics in an age-dependent manner

(2019) Dong-Dong Huang et al.   EXPERIMENTAL GERONTOLOGY

(Pro)renin receptor accelerates development of sarcopenia via activation of Wnt/YAP signaling axis

(2019) Naohiro Yoshida et al.   AGING CELL

Bardoxolone ameliorates TGF-β1-associated renal fibrosis through Nrf2/Smad7 elevation

(2019) Min-Kyun Song et al.   FREE RADICAL BIOLOGY AND MEDICINE

Sarcopenia

(2019) Alfonso J Cruz-Jentoft et al.   LANCET

BDNF is a mediator of glycolytic fiber-type specification in mouse skeletal muscle

(2019) Julien Delezie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DRP1-mediated mitochondrial shape controls calcium homeostasis and muscle mass

(2019) Giulia Favaro et al.   Nature Communications

The role of SIRT1 in skeletal muscle function and repair of older mice

(2019) Matthew J. Myers et al.   Journal of Cachexia Sarcopenia and Muscle

Regular Endurance Exercise Promotes Fission, Mitophagy, and Oxidative Phosphorylation in Human Skeletal Muscle Independently of Age

(2019) Estelle Balan et al.   Frontiers in Physiology

Comparative profiling of skeletal muscle models reveals heterogeneity of transcriptome and metabolism

(2019) Ahmed M. Abdelmoez et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Mitochondrial oxidative capacity and NAD+ biosynthesis are reduced in human sarcopenia across ethnicities

(2019) Eugenia Migliavacca et al.   Nature Communications

Impairment of an Endothelial NAD + -H 2 S Signaling Network Is a Reversible Cause of Vascular Aging

(2018) Abhirup Das et al.   CELL

Testosterone and Cardiovascular Health

(2018) Andrew Elagizi et al.   MAYO CLINIC PROCEEDINGS

Contractile activity attenuates autophagy suppression and reverses mitochondrial defects in skeletal muscle cells

(2018) Alexa Parousis et al.   Autophagy

Pharmacological Interventions to Improve Muscle Mass, Muscle Strength and Physical Performance in Older People: An Umbrella Review of Systematic Reviews and Meta-analyses

(2018) Anton De Spiegeleer et al.   DRUGS & AGING

The exerkine apelin reverses age-associated sarcopenia

(2018) Claire Vinel et al.   NATURE MEDICINE

International Clinical Practice Guidelines for Sarcopenia (ICFSR): Screening, Diagnosis and Management

(2018) Elsa Dent et al.   Journal of Nutrition Health & Aging

The impact of exercise on mitochondrial dynamics and the role of Drp1 in exercise performance and training adaptations in skeletal muscle

(2018) Timothy M. Moore et al.   Molecular Metabolism

Promoting Drp1-mediated mitochondrial fission in midlife prolongs healthy lifespan of Drosophila melanogaster

(2017) Anil Rana et al.   Nature Communications

Sulforaphane is a Nrf2-independent inhibitor of mitochondrial fission

(2017) Gary B. O'Mealey et al.   Redox Biology

Mito-Morphosis: Mitochondrial Fusion, Fission, and Cristae Remodeling as Key Mediators of Cellular Function

(2016) Lena Pernas et al.   Annual Review of Physiology

Mfn2 deficiency links age‐related sarcopenia and impaired autophagy to activation of an adaptive mitophagy pathway

(2016) David Sebastián et al.   EMBO JOURNAL

Acute exercise stress promotes Ref1/Nrf2 signalling and increases mitochondrial antioxidant activity in skeletal muscle

(2016) Ping Wang et al.   EXPERIMENTAL PHYSIOLOGY

Exercise-induced Nrf2-signaling is impaired in aging

(2016) Aaron J. Done et al.   FREE RADICAL BIOLOGY AND MEDICINE

Sulforaphane mitigates muscle fibrosis in mdx mice via Nrf2-mediated inhibition of TGF-β/Smad signaling

(2016) Chengcao Sun et al.   JOURNAL OF APPLIED PHYSIOLOGY

Vitamin D supplementation and its influence on muscle strength and mobility in community-dwelling older persons: a systematic review and meta-analysis

(2016) H. Rosendahl-Riise et al.   JOURNAL OF HUMAN NUTRITION AND DIETETICS

Nrf2-Mediated Regulation of Skeletal Muscle Glycogen Metabolism

(2016) Akira Uruno et al.   MOLECULAR AND CELLULAR BIOLOGY

Effects of Testosterone Treatment in Older Men

(2016) Peter J. Snyder et al.   NEW ENGLAND JOURNAL OF MEDICINE

Downregulation of Dynamin-Related Protein 1 Contributes to Impaired Autophagic Flux and Angiogenic Function in Senescent Endothelial Cells

(2015) J.-R. Lin et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Sulforaphane alleviates muscular dystrophy in mdx mice by activation of Nrf2

(2015) Chengcao Sun et al.   JOURNAL OF APPLIED PHYSIOLOGY

Sulforaphane Attenuates Muscle Inflammation in Dystrophin-deficientmdxMice via NF-E2-related Factor 2 (Nrf2)-mediated Inhibition of NF-κB Signaling Pathway

(2015) Cheng-Cao Sun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Parkin‐independent mitophagy requires Drp1 and maintains the integrity of mammalian heart and brain

(2014) Yusuke Kageyama et al.   EMBO JOURNAL

Inhibitory Role of the KEAP1-NRF2 Pathway in TGFβ1-Stimulated Renal Epithelial Transition to Fibroblastic Cells: A Modulatory Effect on SMAD Signaling

(2014) In-geun Ryoo et al.   PLoS One

Does Vitamin D Improve Muscle Strength in Adults? A Randomized, Double-blind, Placebo-controlled Trial Among Ethnic Minorities in Norway

(2013) Kirsten V. Knutsen et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Clinically Relevant Frailty Index for Mice

(2013) H. Liu et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Nuclear Factor Erythroid 2-Related Factor 2 Nuclear Translocation Induces Myofibroblastic Dedifferentiation in Idiopathic Pulmonary Fibrosis

(2012) Elise Artaud-Macari et al.   ANTIOXIDANTS & REDOX SIGNALING

Correction: Impaired Transcriptional Activity of Nrf2 in Age-Related Myocardial Oxidative Stress Is Reversible by Moderate Exercise Training

(2012) Sellamuthu S. Gounder et al.   PLoS One

Dysfunctional Nrf2–Keap1 redox signaling in skeletal muscle of the sedentary old

(2010) Adeel Safdar et al.   FREE RADICAL BIOLOGY AND MEDICINE