Mitochondria and lipid peroxidation in the mechanism of neurodegeneration: Finding ways for prevention

CRISPR deletion of the C9ORF72 promoter in ALS/FTD patient motor neurons abolishes production of dipeptide repeat proteins and rescues neurodegeneration

(2020) Gopinath Krishnan et al.   ACTA NEUROPATHOLOGICA

Insoluble tau aggregates induce neuronal death through modification of membrane ion conductance, activation of voltage‐gated calcium channels and NADPH oxidase

(2020) Noemi Esteras et al.   FEBS Journal

Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases

(2019) Antonio Cuadrado et al.   NATURE REVIEWS DRUG DISCOVERY

NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis

(2019) Matthew Dodson et al.   Redox Biology

Brain iron is associated with accelerated cognitive decline in people with Alzheimer pathology

(2019) Scott Ayton et al.   MOLECULAR PSYCHIATRY

Insights into the Potential Role of Mercury in Alzheimer’s Disease

(2019) Geir Bjørklund et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Zn2+ Aggravates Tau Aggregation and Neurotoxicity

(2019) Xuexia Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Excitotoxicity, neuroinflammation and oxidant stress as molecular bases of epileptogenesis and epilepsy-derived neurodegeneration: The role of vitamin E

(2019) Patrizia Ambrogini et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Silencing of the Mutant Huntingtin Gene through CRISPR-Cas9 Improves the Mitochondrial Biomarkers in an In Vitro Model of Huntington’s Disease

(2019) Gary L. Dunbar et al.   CELL TRANSPLANTATION

Free radicals in Alzheimer's disease: Lipid peroxidation biomarkers

(2019) Carmen Peña-Bautista et al.   CLINICA CHIMICA ACTA

Copper and zinc ions govern the trans‐directed dimerization of APP family members in multiple ways

(2019) Alexander August et al.   JOURNAL OF NEUROCHEMISTRY

Targeting Huntingtin Expression in Patients with Huntington’s Disease

(2019) Sarah J. Tabrizi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Multiple pathways for natural product treatment of Parkinson's disease: A mini review

(2019) Jingwen Li et al.   PHYTOMEDICINE

Natural Dietary Supplementation of Curcumin Protects Mice Brains against Ethanol-Induced Oxidative Stress-Mediated Neurodegeneration and Memory Impairment via Nrf2/TLR4/RAGE Signaling

(2019) Muhammad Ikram et al.   Nutrients

Caffeine Modulates Cadmium-Induced Oxidative Stress, Neuroinflammation, and Cognitive Impairments by Regulating Nrf-2/HO-1 In Vivo and In Vitro

(2019) Amjad Khan et al.   Journal of Clinical Medicine

Interrogating Parkinson's disease associated redox targets: Potential application of CRISPR editing

(2019) M.A. Artyukhova et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cellular mechanisms of complex I-associated pathology

(2019) Andrey Y. Abramov et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Naringenin Ameliorates Drosophila ReepA Hereditary Spastic Paraplegia-Linked Phenotypes

(2019) Barbara Napoli et al.   Frontiers in Neuroscience

Lipid peroxidation is involved in calcium dependent upregulation of mitochondrial metabolism in skeletal muscle

(2019) Afnan Saleh Al-Menhali et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Mini-Review: Oxidative stress, redox stress or redox success ?

(2018) John M.C. Gutteridge et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

KEAP1 inhibition is neuroprotective and suppresses the development of epilepsy

(2018) Tawfeeq Shekh-Ahmad et al.   BRAIN

Deuterium-reinforced linoleic acid lowers lipid peroxidation and mitigates cognitive impairment in the Q140 knock in mouse model of Huntington's disease

(2018) Asa Hatami et al.   FEBS Journal

Iron and Alzheimer’s Disease: An Update on Emerging Mechanisms

(2018) Darius J.R. Lane et al.   JOURNAL OF ALZHEIMERS DISEASE

Randomized, clinical trial of RT001: Early signals of efficacy in Friedreich's ataxia

(2018) Theresa Zesiewicz et al.   MOVEMENT DISORDERS

Deuterated polyunsaturated fatty acids reduce brain lipid peroxidation and hippocampal amyloid β-peptide levels, without discernable behavioral effects in an APP/PS1 mutant transgenic mouse model of Alzheimer's disease

(2018) Sophia M. Raefsky et al.   NEUROBIOLOGY OF AGING

Specific visualization of neuromelanin-iron complex and ferric iron in the human post-mortem substantia nigra using MR relaxometry at 7T

(2018) Hansol Lee et al.   NEUROIMAGE

Novel Nrf2-Inducer Prevents Mitochondrial Defects and Oxidative Stress in Friedreich’s Ataxia Models

(2018) Rosella Abeti et al.   Frontiers in Cellular Neuroscience

α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson’s disease

(2018) Marthe H. R. Ludtmann et al.   Nature Communications

Adeno-Associated Viral Vector (Serotype 2)–Nerve Growth Factor for Patients With Alzheimer Disease

(2018) Michael S. Rafii et al.   JAMA Neurology

α-Lipoic acid improves abnormal behavior by mitigation of oxidative stress, inflammation, ferroptosis, and tauopathy in P301S Tau transgenic mice

(2018) Yan-Hui Zhang et al.   Redox Biology

Mitochondrial dysfunction in Parkinsonian mesenchymal stem cells impairs differentiation

(2018) Plamena R. Angelova et al.   Redox Biology

Iron chelator deferiprone rescues memory deficits, hippocampal BDNF levels and antioxidant defenses in an experimental model of memory impairment

(2018) Luisa Azambuja Alcalde et al.   BIOMETALS

Iron quantification in Parkinson's disease using an age-based threshold on susceptibility maps: The advantage of local versus entire structure iron content measurements

(2018) Sean K. Sethi et al.   MAGNETIC RESONANCE IMAGING

Naringenin targets on astroglial Nrf2 to support dopaminergic neurons

(2018) Guo-Qing Wang et al.   PHARMACOLOGICAL RESEARCH

Advances in Multi-Functional Ligands and the Need for Metal-Related Pharmacology for the Management of Alzheimer Disease

(2018) Abha Sharma et al.   Frontiers in Pharmacology

Safety, pharmacodynamics, and potential benefit of omaveloxolone in Friedreich ataxia

(2018) David R. Lynch et al.   Annals of Clinical and Translational Neurology

Reductive Stress in Inflammation-Associated Diseases and the Pro-Oxidant Effect of Antioxidant Agents

(2017) Israel Pérez-Torres et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Subcellular compartmentalisation of copper, iron, manganese, and zinc in the Parkinson's disease brain

(2017) Sian Genoud et al.   Metallomics

Therapeutic reduction of ataxin-2 extends lifespan and reduces pathology in TDP-43 mice

(2017) Lindsay A. Becker et al.   NATURE

iPSC-derived neuronal models of PANK2-associated neurodegeneration reveal mitochondrial dysfunction contributing to early disease

(2017) Charles Arber et al.   PLoS One

Mitochondrial hyperpolarization in iPSC-derived neurons from patients of FTDP-17 with 10+16 MAPT mutation leads to oxidative stress and neurodegeneration

(2017) Noemí Esteras et al.   Redox Biology

Pathogenic p62/SQSTM1 mutations impair energy metabolism through limitation of mitochondrial substrates

(2017) Fernando Bartolome et al.   Scientific Reports

Alpha-Synuclein Oligomers Interact with Metal Ions to Induce Oxidative Stress and Neuronal Death in Parkinson's Disease

(2016) Emma Deas et al.   ANTIOXIDANTS & REDOX SIGNALING

Nrf2 activation in the treatment of neurodegenerative diseases: a focus on its role in mitochondrial bioenergetics and function

(2016) Noemí Esteras et al.   BIOLOGICAL CHEMISTRY

Functional role of mitochondrial reactive oxygen species in physiology

(2016) Plamena R. Angelova et al.   FREE RADICAL BIOLOGY AND MEDICINE

Iron chelation in the treatment of neurodegenerative diseases

(2016) Petr Dusek et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

(2016) Valerian E Kagan et al.   Nature Chemical Biology

Neuroprotective Activity of Curcumin in Combination with Piperine against Quinolinic Acid Induced Neurodegeneration in Rats

(2016) Shamsher Singh et al.   PHARMACOLOGY

Effect of Quercetin Supplementation on Repeated-Sprint Performance, Xanthine Oxidase Activity, and Inflammation

(2016) Elizabeth L. Abbey et al.   INTERNATIONAL JOURNAL OF SPORT NUTRITION AND EXERCISE METABOLISM

The spatiotemporal regulation of the Keap1–Nrf2 pathway and its importance in cellular bioenergetics

(2015) Albena T. Dinkova-Kostova et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Nrf2 regulates ROS production by mitochondria and NADPH oxidase

(2015) Stjepana Kovac et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Non-electrophilic modulators of the canonical Keap1/Nrf2 pathway

(2015) B.G. Richardson et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Loss ofPLA2G6leads to elevated mitochondrial lipid peroxidation and mitochondrial dysfunction

(2015) Kerri J. Kinghorn et al.   BRAIN

Naringenin improves learning and memory in an Alzheimer's disease rat model: Insights into the underlying mechanisms

(2015) Saeed Ghofrani et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

N-acetyl cysteine reduces oxidative toxicity, apoptosis, and calcium entry through TRPV1 channels in the neutrophils of patients with polycystic ovary syndrome

(2015) S. A. Köse et al.   FREE RADICAL RESEARCH

Lipid peroxidation is essential for α-synuclein-induced cell death

(2015) Plamena R. Angelova et al.   JOURNAL OF NEUROCHEMISTRY

Cell-Permeable Peptide Targeting the Nrf2-Keap1 Interaction: A Potential Novel Therapy for Global Cerebral Ischemia

(2015) J. Tu et al.   JOURNAL OF NEUROSCIENCE

Functional Oxygen Sensitivity of Astrocytes

(2015) P. R. Angelova et al.   JOURNAL OF NEUROSCIENCE

Polyphenol Stilbenes: Molecular Mechanisms of Defence against Oxidative Stress and Aging-Related Diseases

(2015) Mika Reinisalo et al.   Oxidative Medicine and Cellular Longevity

Aggregated α-synuclein and complex I deficiency: exploration of their relationship in differentiated neurons

(2015) A K Reeve et al.   Cell Death & Disease

Dimethyl fumarate in the treatment of relapsing–remitting multiple sclerosis: an overview

(2015) Roberto Bomprezzi   Therapeutic Advances in Neurological Disorders

Human GAPDH Is a Target of Aspirin’s Primary Metabolite Salicylic Acid and Its Derivatives

(2015) Hyong Woo Choi et al.   PLoS One

Interaction of neurons and astrocytes underlies the mechanism of Aβ-induced neurotoxicity

(2014) Plamena R. Angelova et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Rare Individual Amyloid-β Oligomers Act on Astrocytes to Initiate Neuronal Damage

(2014) Priyanka Narayan et al.   BIOCHEMISTRY

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

(2014) Jose Pedro Friedmann Angeli et al.   NATURE CELL BIOLOGY

(−)-Epigallocatechin Gallate Protects Against Cerebral Ischemia-Induced Oxidative Stress via Nrf2/ARE Signaling

(2014) Jie Han et al.   NEUROCHEMICAL RESEARCH

Nrf2 affects the efficiency of mitochondrial fatty acid oxidation

(2013) Marthe H. R. Ludtmann et al.   BIOCHEMICAL JOURNAL

Behavioral and Neurochemical Effects of Alpha-Lipoic Acid in the Model of Parkinson’s Disease Induced by Unilateral Stereotaxic Injection of 6-Ohda in Rat

(2013) Dayane Pessoa de Araújo et al.   Evidence-based Complementary and Alternative Medicine

Lipid peroxidation is essential for phospholipase C activity and the inositol-trisphosphate-related Ca2+ signal

(2013) A.-M. Domijan et al.   JOURNAL OF CELL SCIENCE

An antisense oligonucleotide against SOD1 delivered intrathecally for patients with SOD1 familial amyotrophic lateral sclerosis: a phase 1, randomised, first-in-man study

(2013) Timothy M Miller et al.   LANCET NEUROLOGY

(−)-Epigallocatechin-3-Gallate Ameliorates Learning and Memory Deficits by Adjusting the Balance of TrkA/p75NTR Signaling in APP/PS1 Transgenic Mice

(2013) Mingyan Liu et al.   MOLECULAR NEUROBIOLOGY

RNA Toxicity from the ALS/FTD C9ORF72 Expansion Is Mitigated by Antisense Intervention

(2013) Christopher J. Donnelly et al.   NEURON

Naringenin protects against 6-OHDA-induced neurotoxicity via activation of the Nrf2/ARE signaling pathway

(2013) Haiyan Lou et al.   NEUROPHARMACOLOGY

Long-chain polyunsaturated fatty acids (LCPUFA) from genesis to senescence: The influence of LCPUFA on neural development, aging, and neurodegeneration

(2013) Carola I.F. Janssen et al.   PROGRESS IN LIPID RESEARCH

Oxidative modification of lipoic acid by HNE in Alzheimer disease brain

(2013) Sarita S. Hardas et al.   Redox Biology

Cell signalling by reactive lipid species: new concepts and molecular mechanisms

(2012) Ashlee Higdon et al.   BIOCHEMICAL JOURNAL

Chelating Agents for Neurodegenerative Diseases

(2012) R. J. Ward et al.   CURRENT MEDICINAL CHEMISTRY

Mechanism of Oxidative Stress in Neurodegeneration

(2012) Sonia Gandhi et al.   Oxidative Medicine and Cellular Longevity

Reversal of Experimental Ethanol-induced Liver Steatosis by Borage Oil

(2012) O. Ya. Lukivskaya et al.   PHYTOTHERAPY RESEARCH

Dopamine Induced Neurodegeneration in a PINK1 Model of Parkinson's Disease

(2012) Sonia Gandhi et al.   PLoS One

Pharmacological Targeting of the Transcription Factor Nrf2 at the Basal Ganglia Provides Disease Modifying Therapy for Experimental Parkinsonism

(2011) Agnieszka Jazwa et al.   ANTIOXIDANTS & REDOX SIGNALING

Green tea catechin, epigallocatechin-3-gallate (EGCG): Mechanisms, perspectives and clinical applications

(2011) Brahma N. Singh et al.   BIOCHEMICAL PHARMACOLOGY

Transition metal abnormalities in progressive dementias

(2011) Hiroyasu Akatsu et al.   BIOMETALS

Free Radical Lipid Peroxidation: Mechanisms and Analysis

(2011) Huiyong Yin et al.   CHEMICAL REVIEWS

AAV2-GAD gene therapy for advanced Parkinson's disease: a double-blind, sham-surgery controlled, randomised trial

(2011) Peter A LeWitt et al.   LANCET NEUROLOGY

Isotopic reinforcement of essential polyunsaturated fatty acids diminishes nigrostriatal degeneration in a mouse model of Parkinson's disease

(2011) Mikhail S. Shchepinov et al.   TOXICOLOGY LETTERS

Curcumin as a therapeutic agent: the evidence from in vitro, animal and human studies

(2010) Jenny Epstein et al.   BRITISH JOURNAL OF NUTRITION

Isotope-reinforced polyunsaturated fatty acids protect yeast cells from oxidative stress

(2010) Shauna Hill et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nanolipidic particles improve the bioavailability and α-secretase inducing ability of epigallocatechin-3-gallate (EGCG) for the treatment of Alzheimer's disease

(2010) Adam Smith et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

An Exceptionally Potent Inducer of Cytoprotective Enzymes

(2010) Albena T. Dinkova-Kostova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dopamine Induces Ca2+Signaling in Astrocytes through Reactive Oxygen Species Generated by Monoamine Oxidase

(2010) Annika Vaarmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gene delivery of AAV2-neurturin for Parkinson's disease: a double-blind, randomised, controlled trial

(2010) William J Marks et al.   LANCET NEUROLOGY

A Phase I Study of Aromatic L-Amino Acid Decarboxylase Gene Therapy for Parkinson's Disease

(2010) Shin-ichi Muramatsu et al.   MOLECULAR THERAPY

Arachidonic acid potently inhibits both postsynaptic-type Kv4.2 and presynaptic-type Kv1.4 IApotassium channels

(2009) Plamena R. Angelova et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

The multiple faces of quercetin in neuroprotection

(2009) Bernardino Ossola et al.   Expert Opinion On Drug Safety

Health effects of quercetin: From antioxidant to nutraceutical

(2008) Agnes W. Boots et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

A mitochondria-targeted nitroxide is reduced to its hydroxylamine by ubiquinol in mitochondria

(2008) Jan Trnka et al.   FREE RADICAL BIOLOGY AND MEDICINE

Type-Dependent Oxidative Damage in Frontotemporal Lobar Degeneration: Cortical Astrocytes Are Targets of Oxidative Damage

(2008) Anna Martínez et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY