Nrf2 stabilization prevents critical oxidative damage in Down syndrome cells

Oxidative Stress and Memory Decline in Adults with Down Syndrome: Longitudinal Study

(2018) Panagiotis Zis et al.   JOURNAL OF ALZHEIMERS DISEASE

Mitochondrial network complexity emerges from fission/fusion dynamics

(2018) Nahuel Zamponi et al.   Scientific Reports

Biophysical and biomolecular determination of cellular age in humans

(2017) Jude M. Phillip et al.   Nature Biomedical Engineering

Repression of the Antioxidant NRF2 Pathway in Premature Aging

(2016) Nard Kubben et al.   CELL

Metabolic and Growth Rate Alterations in Lymphoblastic Cell Lines Discriminate Between Down Syndrome and Alzheimer’s Disease

(2016) Pinar Coskun et al.   JOURNAL OF ALZHEIMERS DISEASE

An Integrated Human/Murine Transcriptome and Pathway Approach To Identify Prenatal Treatments For Down Syndrome

(2016) Faycal Guedj et al.   Scientific Reports

New Views on the Misconstrued: Executioner Caspases and Their Diverse Non-apoptotic Roles

(2015) Nicolas Unsain et al.   NEURON

Intracellular Oxidant Activity, Antioxidant Enzyme Defense System, and Cell Senescence in Fibroblasts with Trisomy 21

(2015) Víctor Rodríguez-Sureda et al.   Oxidative Medicine and Cellular Longevity

Perturbations of Heart Development and Function in Cardiomyocytes from Human Embryonic Stem Cells with Trisomy 21

(2015) Alexis Bosman et al.   STEM CELLS

Down Syndrome Cognitive Phenotypes Modeled in Mice Trisomic for All HSA 21 Homologues

(2015) Pavel V. Belichenko et al.   PLoS One

Mitochondrial form and function

(2014) Jonathan R. Friedman et al.   NATURE

Genetically enhancing mitochondrial antioxidant activity improves muscle function in aging

(2014) Alisa Umanskaya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adaptive Downregulation of Mitochondrial Function in Down Syndrome

(2013) Pablo Helguera et al.   Cell Metabolism

A multifunctional neurotrophin with reduced affinity to p75NTR enhances transplanted Schwann cell survival and axon growth after spinal cord injury

(2013) Mitsuhiro Enomoto et al.   EXPERIMENTAL NEUROLOGY

Regulation of Nrf2—an update

(2013) Suryakant K. Niture et al.   FREE RADICAL BIOLOGY AND MEDICINE

Modulation of oxidative stress as an anticancer strategy

(2013) Chiara Gorrini et al.   NATURE REVIEWS DRUG DISCOVERY

A Simple Assay for Measuring Catalase Activity: A Visual Approach

(2013) Tadayuki Iwase et al.   Scientific Reports

Mitochondria-targeted catalase reduces abnormal APP processing, amyloid   production and BACE1 in a mouse model of Alzheimer's disease: implications for neuroprotection and lifespan extension

(2012) P. Mao et al.   HUMAN MOLECULAR GENETICS

Transcriptional consequences of aneuploidy

(2012) J. M. Sheltzer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Four faces of cellular senescence

(2011) Francis Rodier et al.   JOURNAL OF CELL BIOLOGY

Reduction of Age-Associated Pathology in Old Mice by Overexpression of Catalase in Mitochondria

(2011) P. M. Treuting et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Evaluation of urinary biomarkers of oxidative/nitrosative stress in children with Down syndrome

(2011) Carlos Campos et al.   LIFE SCIENCES

Regulation of the Nrf2–Keap1 Antioxidant Response by the Ubiquitin Proteasome System: An Insight into Cullin-Ring Ubiquitin Ligases

(2010) Nicole F. Villeneuve et al.   ANTIOXIDANTS & REDOX SIGNALING

Effects of individual segmental trisomies of human chromosome 21 syntenic regions on hippocampal long-term potentiation and cognitive behaviors in mice

(2010) Tao Yu et al.   BRAIN RESEARCH

Targeted Expression of Catalase to Mitochondria Prevents Age-Associated Reductions in Mitochondrial Function and Insulin Resistance

(2010) Hui-Young Lee et al.   Cell Metabolism

The Nrf2-Antioxidant Response Element Signaling Pathway and Its Activation by Oxidative Stress

(2009) Truyen Nguyen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Antioxidant-induced modification of INrf2 cysteine 151 and PKC-δ-mediated phosphorylation of Nrf2 serine 40 are both required for stabilization and nuclear translocation of Nrf2 and increased drug resistance

(2009) Suryakant K. Niture et al.   JOURNAL OF CELL SCIENCE

Functional genomic analysis of amniotic fluid cell-free mRNA suggests that oxidative stress is significant in Down syndrome fetuses

(2009) D. K. Slonim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chymase mediates paraquat-induced collagen production in human lung fibroblasts

(2009) Yaw-Dong Lang et al.   TOXICOLOGY LETTERS