KEAP1 inhibition is neuroprotective and suppresses the development of epilepsy

Carvacrol after status epilepticus (SE) prevents recurrent SE, early seizures, cell death, and cognitive decline

(2017) Aytakin Khalil et al.   EPILEPSIA

Increased seizure susceptibility and other toxicity symptoms following acute sulforaphane treatment in mice

(2017) Katarzyna Socała et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Characterization of novel small-molecule NRF2 activators: Structural and biochemical validation of stereospecific KEAP1 binding

(2016) Carlos Huerta et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Nrf2 activation in the treatment of neurodegenerative diseases: a focus on its role in mitochondrial bioenergetics and function

(2016) Noemí Esteras et al.   BIOLOGICAL CHEMISTRY

Sodium selenate retards epileptogenesis in acquired epilepsy models reversing changes in protein phosphatase 2A and hyperphosphorylated tau

(2016) Shi-jie Liu et al.   BRAIN

Functional role of mitochondrial reactive oxygen species in physiology

(2016) Plamena R. Angelova et al.   FREE RADICAL BIOLOGY AND MEDICINE

Pharmacokinetics and pharmacodynamics of orally administered acetylenic tricyclic bis (cyanoenone), a highly potent Nrf2 activator with a reversible covalent mode of action

(2015) Rumen V. Kostov et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Nrf2 regulates ROS production by mitochondria and NADPH oxidase

(2015) Stjepana Kovac et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

The emerging role of Nrf2 in mitochondrial function

(2015) Albena T. Dinkova-Kostova et al.   FREE RADICAL BIOLOGY AND MEDICINE

Sulforaphane is anticonvulsant and improves mitochondrial function

(2015) Catalina Carrasco-Pozo et al.   JOURNAL OF NEUROCHEMISTRY

Mitochondrial respiration deficits driven by reactive oxygen species in experimental temporal lobe epilepsy

(2015) Shane Rowley et al.   NEUROBIOLOGY OF DISEASE

Status epilepticus results in persistent overproduction of reactive oxygen species, inhibition of which is neuroprotective

(2015) S. Williams et al.   NEUROSCIENCE

Identification and quantification of the basal and inducible Nrf2-dependent proteomes in mouse liver: Biochemical, pharmacological and toxicological implications

(2014) Joanne Walsh et al.   Journal of Proteomics

Structure of the BTB Domain of Keap1 and Its Interaction with the Triterpenoid Antagonist CDDO

(2014) Anne Cleasby et al.   PLoS One

Chemical Tuning Enhances Both Potency Toward Nrf2 and In Vitro Therapeutic Index of Triterpenoids

(2014) Ian M. Copple et al.   TOXICOLOGICAL SCIENCES

Seizure activity results in calcium- and mitochondria-independent ROS production via NADPH and xanthine oxidase activation

(2014) S Kovac et al.   Cell Death & Disease

Nrf2 defense pathway: Experimental evidence for its protective role in epilepsy

(2013) Manuela Mazzuferi et al.   ANNALS OF NEUROLOGY

Post-treatment of an NADPH oxidase inhibitor prevents seizure-induced neuronal death

(2013) Jin Hee Kim et al.   BRAIN RESEARCH

Activation of Nrf2-ARE signal pathway in hippocampus of amygdala kindling rats

(2013) Wei Wang et al.   NEUROSCIENCE LETTERS

Nrf2 impacts cellular bioenergetics by controlling substrate availability for mitochondrial respiration

(2013) K. M. Holmstrom et al.   Biology Open

Hypometabolism precedes limbic atrophy and spontaneous recurrent seizures in a rat model of TLE

(2012) Bianca Jupp et al.   EPILEPSIA

Identification of new epilepsy treatments: Issues in preclinical methodology

(2012) Aristea S. Galanopoulou et al.   EPILEPSIA

Blood-brain barrier dysfunction, TGFβ signaling, and astrocyte dysfunction in epilepsy

(2012) Uwe Heinemann et al.   GLIA

Prolonged seizure activity impairs mitochondrial bioenergetics and induces cell death

(2012) S. Kovac et al.   JOURNAL OF CELL SCIENCE

Post-Translational Oxidative Modification and Inactivation of Mitochondrial Complex I in Epileptogenesis

(2012) K. Ryan et al.   JOURNAL OF NEUROSCIENCE

Increased perivascular laminin predicts damage to astrocytes in CA3 and piriform cortex following chemoconvulsive treatments

(2012) F. Gualtieri et al.   NEUROSCIENCE

The cytoprotective role of the Keap1–Nrf2 pathway

(2011) Liam Baird et al.   ARCHIVES OF TOXICOLOGY

Tricyclic Compounds Containing Nonenolizable Cyano Enones. A Novel Class of Highly Potent Anti-Inflammatory and Cytoprotective Agents(79)

(2011) Tadashi Honda et al.   JOURNAL OF MEDICINAL CHEMISTRY

A novel telemetry system for recording EEG in small animals

(2011) Pishan Chang et al.   JOURNAL OF NEUROSCIENCE METHODS

Mechanisms of epileptogenesis and potential treatment targets

(2011) Asla Pitkänen et al.   LANCET NEUROLOGY

Metabolism and Tissue Distribution of Sulforaphane in Nrf2 Knockout and Wild-Type Mice

(2011) John D. Clarke et al.   PHARMACEUTICAL RESEARCH

The cap’n’collar transcription factor Nrf2 mediates both intrinsic resistance to environmental stressors and an adaptive response elicited by chemopreventive agents that determines susceptibility to electrophilic xenobiotics

(2010) Larry G. Higgins et al.   CHEMICO-BIOLOGICAL INTERACTIONS

The role of inflammation in epilepsy

(2010) Annamaria Vezzani et al.   Nature Reviews Neurology

Development of Spontaneous Recurrent Seizures after Kainate-Induced Status Epilepticus

(2009) P. A. Williams et al.   JOURNAL OF NEUROSCIENCE

The global burden and stigma of epilepsy

(2008) Hanneke M. de Boer et al.   EPILEPSY & BEHAVIOR