PGC-1α attenuates hydrogen peroxide-induced apoptotic cell death by upregulating Nrf-2 via GSK3β inactivation mediated by activated p38 in HK-2 Cells

Protective Effect of the Total Flavonoids from Rosa laevigata Michx Fruit on Renal Ischemia-Reperfusion Injury through Suppression of Oxidative Stress and Inflammation

(2016) Lisha Zhao et al.   MOLECULES

Dual regulation of transcription factor Nrf2 by Keap1 and by the combined actions of β-TrCP and GSK-3

(2015) John D. Hayes et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Nrf2 regulates ROS production by mitochondria and NADPH oxidase

(2015) Stjepana Kovac et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

The emerging role of Nrf2 in mitochondrial function

(2015) Albena T. Dinkova-Kostova et al.   FREE RADICAL BIOLOGY AND MEDICINE

The protein kinase 2 inhibitor tetrabromobenzotriazole protects against renal ischemia reperfusion injury

(2015) Sun-O Ka et al.   Scientific Reports

N-Acetylcysteine improves mitochondrial function and ameliorates behavioral deficits in the R6/1 mouse model of Huntington's disease

(2015) D J Wright et al.   Translational Psychiatry

Mitochondria-targeted therapies for acute kidney injury

(2014) Luis Carlos Tábara et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Hrd1 suppresses Nrf2-mediated cellular protection during liver cirrhosis

(2014) T. Wu et al.   GENES & DEVELOPMENT

Targeting inflammation: New therapeutic approaches in chronic kidney disease (CKD)

(2014) Daniela Impellizzeri et al.   PHARMACOLOGICAL RESEARCH

PGC-1α buffers ROS-mediated removal of mitochondria during myogenesis

(2014) S Baldelli et al.   Cell Death & Disease

Mitochondrial reactive oxygen species: A double edged sword in ischemia/reperfusion vs preconditioning

(2014) Theodore Kalogeris et al.   Redox Biology

Caloric restriction ameliorates kidney ischaemia/reperfusion injury through PGC-1α-eNOS pathway and enhanced autophagy

(2013) J. Lempiäinen et al.   Acta Physiologica

Punctum on two different transcription factors regulated by PGC-1α: Nuclear factor erythroid-derived 2-like 2 and nuclear respiratory factor 2

(2013) Sara Baldelli et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Peroxisome Proliferator-activated Receptor γ Co-activator 1-α as a Critical Co-activator of the Murine Hepatic Oxidative Stress Response and Mitochondrial Biogenesis inStaphylococcus aureusSepsis

(2013) Anne D. Cherry et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metabolomics Reveals Signature of Mitochondrial Dysfunction in Diabetic Kidney Disease

(2013) K. Sharma et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Accelerated recovery of renal mitochondrial and tubule homeostasis with SIRT1/PGC-1α activation following ischemia–reperfusion injury

(2013) Jason A. Funk et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The Keap1-Nrf2 pathway: Mechanisms of activation and dysregulation in cancer

(2013) Emilia Kansanen et al.   Redox Biology

p53 Orchestrates the PGC-1α-Mediated Antioxidant Response Upon Mild Redox and Metabolic Imbalance

(2012) Katia Aquilano et al.   ANTIOXIDANTS & REDOX SIGNALING

Mitochondrial reactive oxygen species generation triggers inflammatory response and tissue injury associated with hepatic ischemia–reperfusion: Therapeutic potential of mitochondrially targeted antioxidants

(2012) Partha Mukhopadhyay et al.   FREE RADICAL BIOLOGY AND MEDICINE

The effects of PPAR-γ agonist pioglitazone on renal ischemia/reperfusion injury in rats

(2012) Buket Reel et al.   JOURNAL OF SURGICAL RESEARCH

Specific deletion of glycogen synthase kinase-3β in the renal proximal tubule protects against acute nephrotoxic injury in mice

(2012) Christiana Howard et al.   KIDNEY INTERNATIONAL

Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity

(2012) S Chowdhry et al.   ONCOGENE

Mitochondrial ROS production under cellular stress: comparison of different detection methods

(2011) Andrey V. Kuznetsov et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Mitochondrial-targeted antioxidants represent a promising approach for prevention of cisplatin-induced nephropathy

(2011) Partha Mukhopadhyay et al.   FREE RADICAL BIOLOGY AND MEDICINE

Translocation of Heme Oxygenase-1 to Mitochondria Is a Novel Cytoprotective Mechanism against Non-steroidal Anti-inflammatory Drug-induced Mitochondrial Oxidative Stress, Apoptosis, and Gastric Mucosal Injury

(2011) Samik Bindu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cellular pathophysiology of ischemic acute kidney injury

(2011) Joseph V. Bonventre et al.   JOURNAL OF CLINICAL INVESTIGATION

N-acetylcysteine as a mitochondrial enhancer: a new class of psychoactive drugs?

(2011) Gabriel Rodrigo Fries et al.   REVISTA BRASILEIRA DE PSIQUIATRIA

Selective depletion of mouse kidney proximal straight tubule cells causes acute kidney injury

(2011) Michiko Sekine et al.   TRANSGENIC RESEARCH

When NRF2 Talks, Who's Listening?

(2010) Nobunao Wakabayashi et al.   ANTIOXIDANTS & REDOX SIGNALING

Cancer Chemoprevention Mechanisms Mediated Through the Keap1–Nrf2 Pathway

(2010) John D. Hayes et al.   ANTIOXIDANTS & REDOX SIGNALING

Transient upregulation of PGC-1α diminishes cardiac ischemia tolerance via upregulation of ANT1

(2010) Edward G. Lynn et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Transcriptional Regulation of Renal Cytoprotective Genes by Nrf2 and Its Potential Use as a Therapeutic Target to Mitigate Cisplatin-Induced Nephrotoxicity

(2010) L. M. Aleksunes et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Allostatic load in bipolar disorder: Implications for pathophysiology and treatment

(2007) Flavio Kapczinski et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS