Therapeutic targeting of mitophagy in Parkinson's disease

Identification of an autoinhibitory, mitophagy-inducing peptide derived from the transmembrane domain of USP30

(2022) Xuan Qin et al.   Autophagy

The SUMO protease SENP3 regulates mitochondrial autophagy mediated by Fis1

(2022) Emily Waters et al.   EMBO REPORTS

Ubiquitin signalling in neurodegeneration: mechanisms and therapeutic opportunities

(2021) Marlene F. Schmidt et al.   CELL DEATH AND DIFFERENTIATION

Oleh Hornykiewicz, a giant in the understanding and treatment of Parkinson disease

(2021) Luigi Zecca et al.   npj Parkinsons Disease

Sequence of clinical and neurodegeneration events in Parkinson’s disease progression

(2021) Neil P Oxtoby et al.   BRAIN

Function and regulation of the divisome for mitochondrial fission

(2021) Felix Kraus et al.   NATURE

AMPK/ULK1-mediated phosphorylation of Parkin ACT domain mediates an early step in mitophagy

(2021) Chien-Min Hung et al.   Science Advances

Niclosamide affects intracellular TDP-43 distribution in motor neurons, activates mitophagy, and attenuates morphological changes under stress

(2021) Yosuke Kato et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

Highly accurate protein structure prediction with AlphaFold

(2021) John Jumper et al.   NATURE

Highly accurate protein structure prediction for the human proteome

(2021) Kathryn Tunyasuvunakool et al.   NATURE

Pharmacological rescue of impaired mitophagy in Parkinson’s disease-related LRRK2 G2019S knock-in mice

(2021) Francois Singh et al.   eLife

Investigation of USP30 inhibition to enhance Parkin-mediated mitophagy: tools and approaches

(2021) Eliona Tsefou et al.   BIOCHEMICAL JOURNAL

Mechanism of PINK1 activation by autophosphorylation and insights into assembly on the TOM complex

(2021) Shafqat Rasool et al.   MOLECULAR CELL

Disruption of mitochondrial complex I induces progressive parkinsonism

(2021) Patricia González-Rodríguez et al.   NATURE

Activation mechanism of PINK1

(2021) Zhong Yan Gan et al.   NATURE

Global ubiquitylation analysis of mitochondria in primary neurons identifies endogenous Parkin targets following activation of PINK1

(2021) Odetta Antico et al.   Science Advances

Discovery of small-molecule positive allosteric modulators of Parkin E3 ligase

(2021) Evgeny Shlevkov et al.   iScience

Targeting selective autophagy by AUTAC degraders

(2020) Daiki Takahashi et al.   Autophagy

The cell biology of mitochondrial membrane dynamics

(2020) Marta Giacomello et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

ROCK inhibitors upregulate the neuroprotective Parkin-mediated mitophagy pathway

(2020) Natalia Moskal et al.   Nature Communications

Gemcitabine induces Parkin-independent mitophagy through mitochondrial-resident E3 ligase MUL1-mediated stabilization of PINK1

(2020) Ryoko Igarashi et al.   Scientific Reports

Dynamic Regulation of Mitochondrial Import by the Ubiquitin System

(2020) Lilian Phu et al.   MOLECULAR CELL

Global Landscape and Dynamics of Parkin and USP30-Dependent Ubiquitylomes in iNeurons during Mitophagic Signaling

(2020) Alban Ordureau et al.   MOLECULAR CELL

PINK1 and Parkin mitochondrial quality control: a source of regional vulnerability in Parkinson’s disease

(2020) Preston Ge et al.   Molecular Neurodegeneration

Chain reactions: molecular mechanisms of RBR ubiquitin ligases

(2020) Thomas R. Cotton et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Chemical inhibition of FBXO7 reduces inflammation and confers neuroprotection by stabilizing the mitochondrial kinase PINK1

(2020) Yuan Liu et al.   JCI Insight

A Cell-Based High-Throughput Screening Identified Two Compounds that Enhance PINK1-Parkin Signaling

(2020) Kahori Shiba-Fukushima et al.   iScience

USP30 sets a trigger threshold for PINK1–PARKIN amplification of mitochondrial ubiquitylation

(2020) Emma V Rusilowicz-Jones et al.   Life Science Alliance

Iron loss triggers mitophagy through induction of mitochondrial ferritin

(2020) Yuichi Hara et al.   EMBO REPORTS

Targeting mitophagy in Parkinson's disease

(2020) Emily H. Clark et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Spatiotemporal Control of ULK1 Activation by NDP52 and TBK1 during Selective Autophagy

(2019) Jose Norberto S. Vargas et al.   MOLECULAR CELL

LRRK2 mutations impair depolarization-induced mitophagy through inhibition of mitochondrial accumulation of RAB10

(2019) Fieke Wauters et al.   Autophagy

The Landscape of Parkin Variants Reveals Pathogenic Mechanisms and Therapeutic Targets in Parkinson’s Disease

(2019) Wei Yi et al.   HUMAN MOLECULAR GENETICS

Parkin recruitment to impaired mitochondria for nonselective ubiquitylation is facilitated by MITOL

(2019) Fumika Koyano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Intestinal infection triggers Parkinson’s disease-like symptoms in Pink1−/− mice

(2019) Diana Matheoud et al.   NATURE

Insights into ubiquitin chain architecture using Ub-clipping

(2019) Kirby N. Swatek et al.   NATURE

Ubiquitin and Receptor-Dependent Mitophagy Pathways and Their Implication in Neurodegeneration

(2019) Lauren E. Fritsch et al.   JOURNAL OF MOLECULAR BIOLOGY

Mitochondrial damage by α-synuclein causes cell death in human dopaminergic neurons

(2019) Goutham K. Ganjam et al.   Cell Death & Disease

The bimodal mechanism of interaction between dopamine and mitochondria as reflected in Parkinson’s disease and in schizophrenia

(2019) Dorit Ben-Shachar   JOURNAL OF NEURAL TRANSMISSION

AUTACs: Cargo-Specific Degraders Using Selective Autophagy

(2019) Daiki Takahashi et al.   MOLECULAR CELL

Loss of Parkin contributes to mitochondrial turnover and dopaminergic neuronal loss in aged mice

(2019) Sachiko Noda et al.   NEUROBIOLOGY OF DISEASE

Mitochondrial Ferritin Is a Hypoxia-Inducible Factor 1α-Inducible Gene That Protects from Hypoxia-Induced Cell Death in Brain

(2018) Qiong Wu et al.   ANTIOXIDANTS & REDOX SIGNALING

Novel highly selective inhibitors of ubiquitin specific protease 30 (USP30) accelerate mitophagy

(2018) Arthur F. Kluge et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

PINK1 import regulation; a fine system to convey mitochondrial stress to the cytosol

(2018) Shiori Sekine et al.   BMC BIOLOGY

Basal Mitophagy Occurs Independently of PINK1 in Mouse Tissues of High Metabolic Demand

(2018) Thomas G. McWilliams et al.   Cell Metabolism

The Anthelmintic Drug Niclosamide and Its Analogues Activate the Parkinson's Disease Associated Protein Kinase PINK1

(2018) Erica Barini et al.   CHEMBIOCHEM

The Potential of Stem Cells in Treatment of Traumatic Brain Injury

(2018) Nicole M. Weston et al.   Current Neurology and Neuroscience Reports

Mitochondrial dynamics: overview of molecular mechanisms

(2018) Lisa Tilokani et al.   Essays in Biochemistry

Dynamics of PARKIN-Dependent Mitochondrial Ubiquitylation in Induced Neurons and Model Systems Revealed by Digital Snapshot Proteomics

(2018) Alban Ordureau et al.   MOLECULAR CELL

Mechanism of parkin activation by PINK1

(2018) Christina Gladkova et al.   NATURE

Mechanism of parkin activation by phosphorylation

(2018) Véronique Sauvé et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis

(2018) Kate McArthur et al.   SCIENCE

Mechanism of parkin activation by phosphorylation

(2018) Véronique Sauvé et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Iron accumulation in senescent cells is coupled with impaired ferritinophagy and inhibition of ferroptosis

(2018) Shashank Masaldan et al.   Redox Biology

Striking while the iron is hot: Iron metabolism and Ferroptosis in neurodegeneration

(2018) Shashank Masaldan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Parkin and PINK1 mitigate STING-induced inflammation

(2018) Danielle A. Sliter et al.   NATURE

Parkin inhibits BAK and BAX apoptotic function by distinct mechanisms during mitophagy

(2018) Jonathan P Bernardini et al.   EMBO JOURNAL

Kinetin Riboside and Its ProTides Activate the Parkinson’s Disease Associated PTEN-Induced Putative Kinase 1 (PINK1) Independent of Mitochondrial Depolarization

(2017) Laura Osgerby et al.   JOURNAL OF MEDICINAL CHEMISTRY

Deubiquitylating enzymes and drug discovery: emerging opportunities

(2017) Jeanine A. Harrigan et al.   NATURE REVIEWS DRUG DISCOVERY

Mechanism and regulation of the Lys6-selective deubiquitinase USP30

(2017) Malte Gersch et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis for specific cleavage of Lys6-linked polyubiquitin chains by USP30

(2017) Yusuke Sato et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Long-term oral kinetin does not protect against α-synuclein-induced neurodegeneration in rodent models of Parkinson's disease

(2017) Adam L. Orr et al.   NEUROCHEMISTRY INTERNATIONAL

Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson’s disease

(2017) Lena F. Burbulla et al.   SCIENCE

Structure-guided mutagenesis reveals a hierarchical mechanism of Parkin activation

(2017) Matthew Y. Tang et al.   Nature Communications

Mechanism and regulation of the Lys6-selective deubiquitinase USP30

(2017) Malte Gersch et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis for specific cleavage of Lys6-linked polyubiquitin chains by USP30

(2017) Yusuke Sato et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Nix restores mitophagy and mitochondrial function to protect against PINK1/Parkin-related Parkinson’s disease

(2017) Brianada Koentjoro et al.   Scientific Reports

Brain iron chelation by deferiprone in a phase 2 randomised double-blinded placebo controlled clinical trial in Parkinson’s disease

(2017) Antonio Martin-Bastida et al.   Scientific Reports

Ferroptosis, a newly characterized form of cell death in Parkinson's disease that is regulated by PKC

(2016) Bruce Do Van et al.   NEUROBIOLOGY OF DISEASE

A Ubl/ubiquitin switch in the activation of Parkin

(2015) V. Sauve et al.   EMBO JOURNAL

The mitochondrial protein BNIP3L is the substrate of PARK2 and mediates mitophagy in PINK1/PARK2 pathway

(2015) Feng Gao et al.   HUMAN MOLECULAR GENETICS

Genes associated with Parkinson's disease: regulation of autophagy and beyond

(2015) Alexandra Beilina et al.   JOURNAL OF NEUROCHEMISTRY

Mechanism of phospho-ubiquitin-induced PARKIN activation

(2015) Tobias Wauer et al.   NATURE

The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy

(2015) Michael Lazarou et al.   NATURE

USP30 and parkin homeostatically regulate atypical ubiquitin chains on mitochondria

(2015) Christian N. Cunningham et al.   NATURE CELL BIOLOGY

Endogenous Parkin Preserves Dopaminergic Substantia Nigral Neurons following Mitochondrial DNA Mutagenic Stress

(2015) Alicia M. Pickrell et al.   NEURON

The Roles of PINK1, Parkin, and Mitochondrial Fidelity in Parkinson’s Disease

(2015) Alicia M. Pickrell et al.   NEURON

NRF2 Regulates PINK1 Expression under Oxidative Stress Conditions

(2015) Hitoshi Murata et al.   PLoS One

Ageing and Parkinson's disease: Why is advancing age the biggest risk factor?

(2014) Amy Reeve et al.   AGEING RESEARCH REVIEWS

A small natural molecule promotes mitochondrial fusion through inhibition of the deubiquitinase USP30

(2014) Wen Yue et al.   CELL RESEARCH

Parkin and PINK1 function in a vesicular trafficking pathway regulating mitochondrial quality control

(2014) Gian-Luca McLelland et al.   EMBO JOURNAL

A Regulatory Signaling Loop Comprising the PGAM5 Phosphatase and CK2 Controls Receptor-Mediated Mitophagy

(2014) Guo Chen et al.   MOLECULAR CELL

Quantitative Proteomics Reveal a Feedforward Mechanism for Mitochondrial PARKIN Translocation and Ubiquitin Chain Synthesis

(2014) Alban Ordureau et al.   MOLECULAR CELL

Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy

(2014) Joseph D. Mancias et al.   NATURE

The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy

(2014) Baris Bingol et al.   NATURE

Mitochondrial oxidant stress in locus coeruleus is regulated by activity and nitric oxide synthase

(2014) Javier Sanchez-Padilla et al.   NATURE NEUROSCIENCE

Parkin Sensitizes toward Apoptosis Induced by Mitochondrial Depolarization through Promoting Degradation of Mcl-1

(2014) Richard G. Carroll et al.   Cell Reports

Mitochondrial ferritin in the regulation of brain iron homeostasis and neurodegenerative diseases

(2014) Guofen Gao et al.   Frontiers in Pharmacology

Targeting Chelatable Iron as a Therapeutic Modality in Parkinson's Disease

(2013) David Devos et al.   ANTIOXIDANTS & REDOX SIGNALING

PINK1 is degraded through the N-end rule pathway

(2013) Koji Yamano et al.   Autophagy

A Neo-Substrate that Amplifies Catalytic Activity of Parkinson’s-Disease-Related Kinase PINK1

(2013) Nicholas T. Hertz et al.   CELL

Structure of the human Parkin ligase domain in an autoinhibited state

(2013) Tobias Wauer et al.   EMBO JOURNAL

Loss of iron triggers PINK1/Parkin-independent mitophagy

(2013) George F G Allen et al.   EMBO REPORTS

A Dimeric PINK1-containing Complex on Depolarized Mitochondria Stimulates Parkin Recruitment

(2013) Kei Okatsu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization

(2013) Shireen A. Sarraf et al.   NATURE

The PINK1-Parkin pathway promotes both mitophagy and selective respiratory chain turnover in vivo

(2013) E. S. Vincow et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of Parkin Reveals Mechanisms for Ubiquitin Ligase Activation

(2013) J.-F. Trempe et al.   SCIENCE

Structure and function of Parkin E3 ubiquitin ligase reveals aspects of RING and HECT ligases

(2013) B.E. Riley et al.   Nature Communications

Role of PINK1 Binding to the TOM Complex and Alternate Intracellular Membranes in Recruitment and Activation of the E3 Ligase Parkin

(2012) Michael Lazarou et al.   DEVELOPMENTAL CELL

Phenotypic variability ofparkinmutations in single kindred

(2012) Brianada Koentjoro et al.   MOVEMENT DISORDERS

Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells

(2012) Lei Liu et al.   NATURE CELL BIOLOGY

The ubiquitin E3 ligase parkin regulates the proapoptotic function of Bax

(2012) B. N. Johnson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial Fission, Fusion, and Stress

(2012) R. J. Youle et al.   SCIENCE

PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65

(2012) C. Kondapalli et al.   Open Biology

Rotenone, Paraquat, and Parkinson’s Disease

(2011) Caroline M. Tanner et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies

(2011)   LANCET

The role of calcium and mitochondrial oxidant stress in the loss of substantia nigra pars compacta dopaminergic neurons in Parkinson's disease

(2011) D.J. Surmeier et al.   NEUROSCIENCE

Mood disorders in Parkinson's disease

(2011) Louis C.S. Tan   PARKINSONISM & RELATED DISORDERS

Role of Mendelian genes in “sporadic” Parkinson's disease

(2011) Suzanne Lesage et al.   PARKINSONISM & RELATED DISORDERS

Neuroprotective Mechanism of Mitochondrial Ferritin on 6-Hydroxydopamine–Induced Dopaminergic Cell Damage: Implication for Neuroprotection in Parkinson's Disease

(2010) Zhen-Hua Shi et al.   ANTIOXIDANTS & REDOX SIGNALING

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

(2008) Derek Narendra et al.   JOURNAL OF CELL BIOLOGY

Essential role for Nix in autophagic maturation of erythroid cells

(2008) Hector Sandoval et al.   NATURE

Dopamine modulates mitochondrial function in viable SH-SY5Y cells possibly via its interaction with complex I: Relevance to dopamine pathology in schizophrenia

(2007) Hanit Brenner-Lavie et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS