Regulation of Mitochondrial Biogenesis as a Way for Active Longevity: Interaction Between the Nrf2 and PGC-1α Signaling Pathways

Therapeutic Approaches to Alzheimer’s Disease Through Modulation of NRF2

(2019) Gahee Bahn et al.   NEUROMOLECULAR MEDICINE

Pterostilbene Decreases Cardiac Oxidative Stress and Inflammation via Activation of AMPK/Nrf2/HO-1 Pathway in Fructose-Fed Diabetic Rats

(2018) Ramoji Kosuru et al.   CARDIOVASCULAR DRUGS AND THERAPY

Benfotiamine treatment activates the Nrf2/ARE pathway and is neuroprotective in a transgenic mouse model of tauopathy

(2018) Victor Tapias et al.   HUMAN MOLECULAR GENETICS

Prepregnancy maternal diabetes combined with obesity impairs placental mitochondrial function involving Nrf2/ARE pathway and detrimentally alters metabolism of offspring

(2018) Yang Duan et al.   Obesity Research & Clinical Practice

Burn Trauma Acutely Increases the Respiratory Capacity and Function of Liver Mitochondria

(2018) Fredrick J. Bohanon et al.   SHOCK

Pharmacological targeting of GSK-3 and NRF2 provides neuroprotection in a preclinical model of tauopathy

(2018) Antonio Cuadrado et al.   Redox Biology

The role of mitochondria in aging

(2018) Ji Yong Jang et al.   JOURNAL OF CLINICAL INVESTIGATION

Regulatory crosstalk between the oxidative stress-related transcription factor Nfe2l2/Nrf2 and mitochondria

(2018) In-geun Ryoo et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Meldonium improves Huntington’s disease mitochondrial dysfunction by restoring peroxisome proliferator-activated receptor γ coactivator 1α expression

(2018) Francesca Di Cristo et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The role of mitochondrial ROS in the aging brain

(2017) Rhoda Stefanatos et al.   FEBS LETTERS

Sulforaphane induces differential modulation of mitochondrial biogenesis and dynamics in normal cells and tumor cells

(2017) Mario Negrette-Guzmán et al.   FOOD AND CHEMICAL TOXICOLOGY

Dimethyl fumarate mediates Nrf2-dependent mitochondrial biogenesis in mice and humans

(2017) Genki Hayashi et al.   HUMAN MOLECULAR GENETICS

NADPH Oxidase 4 (Nox4) Suppresses Mitochondrial Biogenesis and Bioenergetics in Lung Fibroblasts via a Nuclear Factor Erythroid-derived 2-like 2 (Nrf2)-dependent Pathway

(2017) Karen Bernard et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Anti-Aging Effect of Erythropoietin via the ERK/Nrf2-ARE Pathway in Aging Rats

(2017) Haiqin Wu et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Genetic or pharmacological activation of the Drosophila PGC-1α ortholog spargel rescues the disease phenotypes of genetic models of Parkinson's disease

(2017) Chee-Hoe Ng et al.   NEUROBIOLOGY OF AGING

Mitophagy in neurodegeneration and aging

(2017) Elayne M. Fivenson et al.   NEUROCHEMISTRY INTERNATIONAL

Hydralazine induces stress resistance and extends C. elegans lifespan by activating the NRF2/SKN-1 signalling pathway

(2017) Esmaeil Dehghan et al.   Nature Communications

PGC-1α attenuates hydrogen peroxide-induced apoptotic cell death by upregulating Nrf-2 via GSK3β inactivation mediated by activated p38 in HK-2 Cells

(2017) Hoon-In Choi et al.   Scientific Reports

Mitochondria and ageing: role in heart, skeletal muscle and adipose tissue

(2017) Kerstin Boengler et al.   Journal of Cachexia Sarcopenia and Muscle

Role of Nrf2 and protective effects of Metformin against tobacco smoke-induced cerebrovascular toxicity

(2017) Shikha Prasad et al.   Redox Biology

Effect of temperature on fatty acid metabolism in skeletal muscle mitochondria of untrained and endurance-trained rats

(2017) Jerzy A. Zoladz et al.   PLoS One

Tomatidine enhances lifespan and healthspan in C. elegans through mitophagy induction via the SKN-1/Nrf2 pathway

(2017) Evandro F. Fang et al.   Scientific Reports

Repurposing the NRF2 Activator Dimethyl Fumarate as Therapy Against Synucleinopathy in Parkinson's Disease

(2016) Isabel Lastres-Becker et al.   ANTIOXIDANTS & REDOX SIGNALING

Oxidant Mechanisms in Renal Injury and Disease

(2016) Brian B. Ratliff et al.   ANTIOXIDANTS & REDOX SIGNALING

Pyrroloquinoline quinone enhances the resistance to oxidative stress and extends lifespan upon DAF-16 and SKN-1 activities in C. elegans

(2016) J.Z. Wu et al.   EXPERIMENTAL GERONTOLOGY

Impaired Nrf2 regulation of mitochondrial biogenesis in rostral ventrolateral medulla on hypertension induced by systemic inflammation

(2016) Kay L.H. Wu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nrf2-mediated liver protection by esculentoside A against acetaminophen toxicity through the AMPK/Akt/GSK3β pathway

(2016) Lidong Wang et al.   FREE RADICAL BIOLOGY AND MEDICINE

The resveratrol derivatives trans-3,5-dimethoxy-4-fluoro-4′-hydroxystilbene and trans-2,4′,5-trihydroxystilbene decrease oxidative stress and prolong lifespan inCaenorhabditis elegans

(2016) Nadine Fischer et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Nuclear factor erythroid-derived 2-like 2 (NFE2L2, Nrf2) mediates exercise-induced mitochondrial biogenesis and the anti-oxidant response in mice

(2016) Troy L. Merry et al.   JOURNAL OF PHYSIOLOGY-LONDON

AMPK Facilitates Nuclear Accumulation of Nrf2 by Phosphorylating at Serine 550

(2016) Min Sung Joo et al.   MOLECULAR AND CELLULAR BIOLOGY

Methylene blue improves sensorimotor phenotype and decreases anxiety in parallel with activating brain mitochondria biogenesis in mid-age mice

(2016) Artem P. Gureev et al.   NEUROSCIENCE RESEARCH

Grape Powder Improves Age-Related Decline in Mitochondrial and Kidney Functions in Fischer 344 Rats

(2016) Indira Pokkunuri et al.   Oxidative Medicine and Cellular Longevity

Delta-9-tetrahydrocannabinol protects against MPP+ toxicity in SH-SY5Y cells by restoring proteins involved in mitochondrial biogenesis

(2016) Marie-Louise Zeissler et al.   Oncotarget

Attenuation of synaptic toxicity and MARK4/PAR1-mediated Tau phosphorylation by methylene blue for Alzheimer’s disease treatment

(2016) Wenchao Sun et al.   Scientific Reports

Fisetin stimulates autophagic degradation of phosphorylated tau via the activation of TFEB and Nrf2 transcription factors

(2016) Sunhyo Kim et al.   Scientific Reports

Vitamin D Promotes Protein Homeostasis and Longevity via the Stress Response Pathway Genes skn-1 , ire-1 , and xbp-1

(2016) Karla A. Mark et al.   Cell Reports

Lithium Promotes Longevity through GSK3/NRF2-Dependent Hormesis

(2016) Jorge Iván Castillo-Quan et al.   Cell Reports

D-beta-hydroxybutyrate extends lifespan in C. elegans

(2016) Clare Edwards et al.   Aging-US

Increased mitochondrial biogenesis preserves intestinal stem cell homeostasis and contributes to longevity in Indy mutant flies

(2016) Ryan P. Rogers et al.   Aging-US

Protective Effects of Quercetin on Mitochondrial Biogenesis in Experimental Traumatic Brain Injury via the Nrf2 Signaling Pathway

(2016) Xiang Li et al.   PLoS One

Natural thioallyl compounds increase oxidative stress resistance and lifespan in Caenorhabditis elegans by modulating SKN-1/Nrf

(2016) Takahiro Ogawa et al.   Scientific Reports

Cilostazol attenuates murine hepatic ischemia and reperfusion injury via heme oxygenase-dependent activation of mitochondrial biogenesis

(2015) Yeonsoo Joe et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

spargel, the PGC-1α homologue, in models of Parkinson disease in Drosophila melanogaster

(2015) Eric M. Merzetti et al.   BMC NEUROSCIENCE

The cAMP phosphodiesterase Prune localizes to the mitochondrial matrix and promotes mtDNA replication by stabilizing TFAM

(2015) F. Zhang et al.   EMBO REPORTS

Allicin improves endoplasmic reticulum stress-related cognitive deficits via PERK/Nrf2 antioxidative signaling pathway

(2015) Yao-Feng Zhu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Catalpol Modulates Lifespan via DAF-16/FOXO and SKN-1/Nrf2 Activation inCaenorhabditis elegans

(2015) Hyun Won Seo et al.   Evidence-based Complementary and Alternative Medicine

Curcumin Attenuates Gentamicin-Induced Kidney Mitochondrial Alterations: Possible Role of a Mitochondrial Biogenesis Mechanism

(2015) Mario Negrette-Guzmán et al.   Evidence-based Complementary and Alternative Medicine

Treadmill exercise activates Nrf2 antioxidant system to protect the nigrostriatal dopaminergic neurons from MPP+ toxicity

(2015) Yi-Hsien Tsou et al.   EXPERIMENTAL NEUROLOGY

Oxidative stress response and Nrf2 signaling in aging

(2015) Hongqiao Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease

(2015) Lauren E. Tebay et al.   FREE RADICAL BIOLOGY AND MEDICINE

The emerging role of Nrf2 in mitochondrial function

(2015) Albena T. Dinkova-Kostova et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondrial and lysosomal biogenesis are activated following PINK1/parkin-mediated mitophagy

(2015) Davor Ivankovic et al.   JOURNAL OF NEUROCHEMISTRY

SIRT1 Deficiency in Microglia Contributes to Cognitive Decline in Aging and Neurodegeneration via Epigenetic Regulation of IL-1 

(2015) S.-H. Cho et al.   JOURNAL OF NEUROSCIENCE

Methylene Blue Improves Brain Mitochondrial ABAD Functions and Decreases Aβ in a Neuroinflammatory Alzheimer’s Disease Mouse Model

(2015) Aya Zakaria et al.   MOLECULAR NEUROBIOLOGY

Coordination of mitophagy and mitochondrial biogenesis during ageing in C. elegans

(2015) Konstantinos Palikaras et al.   NATURE

Moderate-Intensity Physical Exercise Protects Against Experimental 6-Hydroxydopamine-Induced Hemiparkinsonism Through Nrf2-Antioxidant Response Element Pathway

(2015) Aderbal Silva Aguiar et al.   NEUROCHEMICAL RESEARCH

Parkin loss leads to PARIS-dependent declines in mitochondrial mass and respiration

(2015) Daniel A. Stevens et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial function and lifespan of mice with controlled ubiquinone biosynthesis

(2015) Ying Wang et al.   Nature Communications

Glitazone Treatment and Incidence of Parkinson’s Disease among People with Diabetes: A Retrospective Cohort Study

(2015) Ruth Brauer et al.   PLOS MEDICINE

Combined activation of the energy and cellular-defense pathways may explain the potent anti-senescence activity of methylene blue

(2015) Hani Atamna et al.   Redox Biology

NRF2 Regulates PINK1 Expression under Oxidative Stress Conditions

(2015) Hitoshi Murata et al.   PLoS One

Metformin Pharmacogenomics: Current Status and Future Directions

(2014) A. C. Pawlyk et al.   DIABETES

PGC-1α overexpression exacerbates β-amyloid and tau deposition in a transgenic mouse model of Alzheimer's disease

(2014) Magali Dumont et al.   FASEB JOURNAL

The neuroprotective effects of β-hydroxybutyrate on Aβ-injected rat hippocampus in vivo and in Aβ-treated PC-12 cells in vitro

(2014) G. Xie et al.   FREE RADICAL RESEARCH

Hrd1 suppresses Nrf2-mediated cellular protection during liver cirrhosis

(2014) T. Wu et al.   GENES & DEVELOPMENT

Age-related structural alterations in human skeletal muscle fibers and mitochondria are sex specific: relationship to single-fiber function

(2014) Damien M. Callahan et al.   JOURNAL OF APPLIED PHYSIOLOGY

Age-dependent tissue expression patterns of Sirt1 in senescence-accelerated mice

(2014) HUAN GONG et al.   Molecular Medicine Reports

Respiratory chain deficiency in aged spinal motor neurons

(2014) Karolina A. Rygiel et al.   NEUROBIOLOGY OF AGING

Mitochondrial Involvement and Impact in Aging Skeletal Muscle

(2014) Russell T. Hepple   Frontiers in Aging Neuroscience

Emerging functional similarities and divergences between Drosophila Spargel/dPGC-1 and mammalian PGC-1 protein

(2014) Subhas Mukherjee et al.   Frontiers in Genetics

Mitochondrial hormesis links low-dose arsenite exposure to lifespan extension

(2013) Sebastian Schmeisser et al.   AGING CELL

The Crosstalk Between Nrf2 and AMPK Signal Pathways Is Important for the Anti-Inflammatory Effect of Berberine in LPS-Stimulated Macrophages and Endotoxin-Shocked Mice

(2013) Chunfen Mo et al.   ANTIOXIDANTS & REDOX SIGNALING

Punctum on two different transcription factors regulated by PGC-1α: Nuclear factor erythroid-derived 2-like 2 and nuclear respiratory factor 2

(2013) Sara Baldelli et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Nrf2 modulates contractile and metabolic properties of skeletal muscle in streptozotocin-induced diabetic atrophy

(2013) Samantha A Whitman et al.   EXPERIMENTAL CELL RESEARCH

Nrf2 deficiency impairs the barrier function of mouse oesophageal epithelium

(2013) Hao Chen et al.   GUT

Erythropoietin contributes to slow oxidative muscle fiber specification via PGC-1α and AMPK activation

(2013) Li Wang et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Puerarin alleviates cognitive impairment and oxidative stress in APP/PS1 transgenic mice

(2013) Yanyan Zhou et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Peroxisome Proliferator-activated Receptor γ Co-activator 1-α as a Critical Co-activator of the Murine Hepatic Oxidative Stress Response and Mitochondrial Biogenesis inStaphylococcus aureusSepsis

(2013) Anne D. Cherry et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Keap1-Nrf2 pathway: Mechanisms of activation and dysregulation in cancer

(2013) Emilia Kansanen et al.   Redox Biology

Activation of Mitochondrial Biogenesis by Heme Oxygenase-1–mediated NF-E2–related Factor-2 Induction Rescues Mice from LethalStaphylococcusaureusSepsis

(2012) Nancy Chou MacGarvey et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Amelioration of Alzheimer’s disease by neuroprotective effect of sulforaphane in animal model

(2012) Hyunjin Vincent Kim et al.   AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS

p53 Orchestrates the PGC-1α-Mediated Antioxidant Response Upon Mild Redox and Metabolic Imbalance

(2012) Katia Aquilano et al.   ANTIOXIDANTS & REDOX SIGNALING

Nrf2 promotes alveolar mitochondrial biogenesis and resolution of lung injury in Staphylococcus aureus pneumonia in mice

(2012) Janhavi Athale et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nitric Oxide in Skeletal Muscle: Role on Mitochondrial Biogenesis and Function

(2012) Celia Tengan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Metformin-inclusive sulfonylurea therapy reduces the risk of Parkinson's disease occurring with Type 2 diabetes in a Taiwanese population cohort

(2012) Mark L. Wahlqvist et al.   PARKINSONISM & RELATED DISORDERS

Age associated low mitochondrial biogenesis may be explained by lack of response of PGC-1α to exercise training

(2011) Frederic Derbré et al.   AGE

Regulation of PGC-1α, a nodal regulator of mitochondrial biogenesis

(2011) Pablo J Fernandez-Marcos et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

PARIS (ZNF746) Repression of PGC-1α Contributes to Neurodegeneration in Parkinson's Disease

(2011) Joo-Ho Shin et al.   CELL

Modulation of Longevity and Tissue Homeostasis by the Drosophila PGC-1 Homolog

(2011) Michael Rera et al.   Cell Metabolism

Parkin' control: regulation of PGC-1  through PARIS in Parkinson's disease

(2011) J. I. Castillo-Quan   Disease Models & Mechanisms

The garlic constituent diallyl trisulfide increases the lifespan of C. elegans via skn-1 activation

(2011) Anna A. Powolny et al.   EXPERIMENTAL GERONTOLOGY

Acetyl-L-carnitine-mediated neuroprotection during hypoxia is attributed to ERK1/2-Nrf2-regulated mitochondrial biosynthesis

(2011) Kalpana Barhwal Hota et al.   HIPPOCAMPUS

Mitochondrial DNA transcription regulation and nucleoid organization

(2011) Adriana P. Rebelo et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Age-Associated Vascular Oxidative Stress, Nrf2 Dysfunction, and NF- B Activation in the Nonhuman Primate Macaca mulatta

(2011) Z. Ungvari et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Curcumin-mediated lifespan extension in Caenorhabditis elegans

(2011) Vivian Hsiu-Chuan Liao et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Efficacy of Fumaric Acid Esters in the R6/2 and YAC128 Models of Huntington's Disease

(2011) Gisa Ellrichmann et al.   PLoS One

The PINK1/Parkin-mediated mitophagy is compromised by PD-associated mutations

(2010) Sven Geisler et al.   Autophagy

Erythropoietin induces nuclear translocation of Nrf2 and heme oxygenase-1 expression in SH-SY5Y cells

(2010) Kursad Genc et al.   CELL BIOCHEMISTRY AND FUNCTION

Genetic and Pharmacologic Hydrogen Sulfide Therapy Attenuates Ischemia-Induced Heart Failure in Mice

(2010) John W. Calvert et al.   CIRCULATION

Erythropoietin Activates Mitochondrial Biogenesis and Couples Red Cell Mass to Mitochondrial Mass in the Heart

(2010) Martha S. Carraway et al.   CIRCULATION RESEARCH

Triterpenoids CDDO-ethyl amide and CDDO-trifluoroethyl amide improve the behavioral phenotype and brain pathology in a transgenic mouse model of Huntington's disease

(2010) Cliona Stack et al.   FREE RADICAL BIOLOGY AND MEDICINE

p62/SQSTM1Is a Target Gene for Transcription Factor NRF2 and Creates a Positive Feedback Loop by Inducing Antioxidant Response Element-driven Gene Transcription

(2010) Ashish Jain et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial DNA Mutations Induce Mitochondrial Dysfunction, Apoptosis and Sarcopenia in Skeletal Muscle of Mitochondrial DNA Mutator Mice

(2010) Asimina Hiona et al.   PLoS One

Dynamic regulation of PGC-1α localization and turnover implicates mitochondrial adaptation in calorie restriction and the stress response

(2009) Rozalyn M. Anderson et al.   AGING CELL

PGC-1α Expression Decreases in the Alzheimer Disease Brain as a Function of Dementia

(2009) Weiping Qin et al.   ARCHIVES OF NEUROLOGY

Regulation of neuron mitochondrial biogenesis and relevance to brain health

(2009) Isaac G. Onyango et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

About “Origin and evolution of the free radical theory of aging: a brief personal history, 1954–2009”

(2009) Denham Harman   BIOGERONTOLOGY

Methylation of 12S rRNA Is Necessary for In Vivo Stability of the Small Subunit of the Mammalian Mitochondrial Ribosome

(2009) Metodi D. Metodiev et al.   Cell Metabolism

The Drosophila PGC-1 homologue Spargel coordinates mitochondrial activity to insulin signalling

(2009) Stefanie K Tiefenböck et al.   EMBO JOURNAL

Nrf2 activity is lost in the spinal cord and its astrocytes of aged mice

(2009) Weisong Duan et al.   IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL

Triterpenoid CDDO-methylamide improves memory and decreases amyloid plaques in a transgenic mouse model of Alzheimer’s disease

(2009) Magali Dumont et al.   JOURNAL OF NEUROCHEMISTRY

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

(2009) Carles Cantó et al.   NATURE

Morphometric Changes Induced by Amino Acid Supplementation in Skeletal and Cardiac Muscles of Old Mice

(2008) Giovanni Corsetti et al.   AMERICAN JOURNAL OF CARDIOLOGY

Keap1/Nrf2 Signaling Regulates Oxidative Stress Tolerance and Lifespan in Drosophila

(2008) Gerasimos P. Sykiotis et al.   DEVELOPMENTAL CELL

What causes mitochondrial DNA deletions in human cells?

(2008) Kim J Krishnan et al.   NATURE GENETICS

Transcriptional Paradigms in Mammalian Mitochondrial Biogenesis and Function

(2008) Richard C. Scarpulla   PHYSIOLOGICAL REVIEWS

Mitochondrial function and apoptotic susceptibility in aging skeletal muscle

(2007) Béatrice Chabi et al.   AGING CELL