Nuclear lamins: Structure and function in mechanobiology

Computational analyses reveal spatial relationships between nuclear pore complexes and specific lamins

(2021) Mark Kittisopikul et al.   JOURNAL OF CELL BIOLOGY

A lamin A/C variant causing striated muscle disease provides insights into filament organization

(2021) Rafael Kronenberg-Tenga et al.   JOURNAL OF CELL SCIENCE

LINC complex regulation of genome organization and function

(2021) Xianrong Wong et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

HP1α is a chromatin crosslinker that controls nuclear and mitotic chromosome mechanics

(2021) Amy R Strom et al.   eLife

Bend, Push, Stretch: Remarkable Structure and Mechanics of Single Intermediate Filaments and Meshworks

(2021) K. Tanuj Sapra et al.   Cells

The cellular environment shapes the nuclear pore complex architecture

(2021) Anthony P. Schuller et al.   NATURE

A Unified Linear Viscoelastic Model of the Cell Nucleus Defines the Mechanical Contributions of Lamins and Chromatin

(2020) Oren Wintner et al.   Advanced Science

Nesprin‐2 accumulates at the front of the nucleus during confined cell migration

(2020) Patricia M Davidson et al.   EMBO REPORTS

Nuclear Mechanics within Intact Cells Is Regulated by Cytoskeletal Network and Internal Nanostructures

(2020) Jitao Zhang et al.   Small

Structure and unique mechanical aspects of nuclear lamin filaments

(2020) Rafael Tenga et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Nonlinear mechanics of lamin filaments and the meshwork topology build an emergent nuclear lamina

(2020) K. Tanuj Sapra et al.   Nature Communications

The Nuclear Lamina as an Organizer of Chromosome Architecture

(2019) Yuri Y. Shevelyov et al.   Cells

Nuclear lamina integrity is required for proper spatial organization of chromatin in Drosophila

(2019) Sergey V. Ulianov et al.   Nature Communications

Concentric organization of A- and B-type lamins predicts their distinct roles in the spatial organization and stability of the nuclear lamina

(2019) Bruce Nmezi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Driving Force: Nuclear Mechanotransduction in Cellular Function, Fate, and Disease

(2019) Melanie Maurer et al.   Annual Review of Biomedical Engineering

Chromatin’s physical properties shape the nucleus and its functions

(2019) Andrew D Stephens et al.   CURRENT OPINION IN CELL BIOLOGY

The nucleus feels the force, LINCed in or not!

(2019) Zeinab Jahed et al.   CURRENT OPINION IN CELL BIOLOGY

Regulation of nuclear architecture, mechanics, and nucleocytoplasmic shuttling of epigenetic factors by cell geometric constraints

(2019) Farid Alisafaei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vimentin Intermediate Filament Rings Deform the Nucleus During the First Steps of Adhesion

(2019) Emmanuel Terriac et al.   Frontiers in Cell and Developmental Biology

The LINC complex, mechanotransduction, and mesenchymal stem cell function and fate

(2019) Tasneem Bouzid et al.   Journal of Biological Engineering

Vimentin protects cells against nuclear rupture and DNA damage during migration

(2019) Alison E. Patteson et al.   JOURNAL OF CELL BIOLOGY

Mutant lamins cause nuclear envelope rupture and DNA damage in skeletal muscle cells

(2019) Ashley J. Earle et al.   NATURE MATERIALS

Nuclear Lamin Protein C Is Linked to Lineage-Specific, Whole-Cell Mechanical Properties

(2018) Rafael D. González-Cruz et al.   Cellular and Molecular Bioengineering

Insight into the functional organization of nuclear lamins in health and disease

(2018) Meltem Tatli et al.   CURRENT OPINION IN CELL BIOLOGY

Dynein pulling forces counteract lamin-mediated nuclear stability during nuclear envelope repair

(2018) Lauren Penfield et al.   MOLECULAR BIOLOGY OF THE CELL

Chromatin histone modifications and rigidity affect nuclear morphology independent of lamins

(2018) Andrew D. Stephens et al.   MOLECULAR BIOLOGY OF THE CELL

Lamins Organize the Global Three-Dimensional Genome from the Nuclear Periphery

(2018) Xiaobin Zheng et al.   MOLECULAR CELL

Emerging views of the nucleus as a cellular mechanosensor

(2018) Tyler J. Kirby et al.   NATURE CELL BIOLOGY

Nuclear Lamins: Thin Filaments with Major Functions

(2018) Rebecca de Leeuw et al.   TRENDS IN CELL BIOLOGY

Lamin B1 mapping reveals the existence of dynamic and functional euchromatin lamin B1 domains

(2018) Laura Pascual-Reguant et al.   Nature Communications

Coaching from the sidelines: the nuclear periphery in genome regulation

(2018) Abigail Buchwalter et al.   NATURE REVIEWS GENETICS

Lamins in the nuclear interior − life outside the lamina

(2017) Nana Naetar et al.   JOURNAL OF CELL SCIENCE

Nucleosome–nucleosome interactions via histone tails and linker DNA regulate nuclear rigidity

(2017) Yuta Shimamoto et al.   MOLECULAR BIOLOGY OF THE CELL

Chromatin and lamin A determine two different mechanical response regimes of the cell nucleus

(2017) Andrew D. Stephens et al.   MOLECULAR BIOLOGY OF THE CELL

The molecular architecture of lamins in somatic cells

(2017) Yagmur Turgay et al.   NATURE

On the origin of shape fluctuations of the cell nucleus

(2017) Fang-Yi Chu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ChromEMT: Visualizing 3D chromatin structure and compaction in interphase and mitotic cells

(2017) Horng D. Ou et al.   SCIENCE

LINC complexes and nuclear positioning

(2017) Yin Loon Lee et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The Nucleoskeleton

(2017) Stephen A. Adam   Cold Spring Harbor Perspectives in Biology

Nuclear lamin A/C harnesses the perinuclear apical actin cables to protect nuclear morphology

(2017) Jeong-Ki Kim et al.   Nature Communications

Separate roles for chromatin and lamins in nuclear mechanics

(2017) Andrew D. Stephens et al.   Nucleus

Nuclear membrane stretch and its role in mechanotransduction

(2017) Balázs Enyedi et al.   Nucleus

Separate roles for chromatin and lamins in nuclear mechanics

(2017) Andrew D. Stephens et al.   Nucleus

Nuclear membrane stretch and its role in mechanotransduction

(2017) Balázs Enyedi et al.   Nucleus

The IsoStretcher : An isotropic cell stretch device to study mechanical biosensor pathways in living cells

(2016) S Schürmann et al.   BIOSENSORS & BIOELECTRONICS

The 3D Genome as Moderator of Chromosomal Communication

(2016) Job Dekker et al.   CELL

A-type Lamins Form Distinct Filamentous Networks with Differential Nuclear Pore Complex Associations

(2016) Wei Xie et al.   CURRENT BIOLOGY

A-type lamins bind both hetero- and euchromatin, the latter being regulated by lamina-associated polypeptide 2 alpha

(2016) Kevin Gesson et al.   GENOME RESEARCH

Nuclear envelope rupture is induced by actin-based nucleus confinement

(2016) Emily M. Hatch et al.   JOURNAL OF CELL BIOLOGY

Lamin-B1 contributes to the proper timing of epicardial cell migration and function during embryonic heart development

(2016) Joseph R. Tran et al.   MOLECULAR BIOLOGY OF THE CELL

Transcription upregulation via force-induced direct stretching of chromatin

(2016) Arash Tajik et al.   NATURE MATERIALS

The nuclear pore complex: understanding its function through structural insight

(2016) Martin Beck et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Visualizing the molecular sociology at the HeLa cell nuclear periphery

(2016) J. Mahamid et al.   SCIENCE

Nuclear envelope rupture and repair during cancer cell migration

(2016) C. M. Denais et al.   SCIENCE

Intermediate Filaments: Structure and Assembly

(2016) Harald Herrmann et al.   Cold Spring Harbor Perspectives in Biology

Perinuclear Arp2/3-driven actin polymerization enables nuclear deformation to facilitate cell migration through complex environments

(2016) Hawa-Racine Thiam et al.   Nature Communications

SUN1 splice variants, SUN1_888, SUN1_785, and predominant SUN1_916, variably function in directional cell migration

(2016) Yu Nishioka et al.   Nucleus

SUN1 splice variants, SUN1_888, SUN1_785, and predominant SUN1_916, variably function in directional cell migration

(2016) Yu Nishioka et al.   Nucleus

Extracellular Forces Cause the Nucleus to Deform in a Highly Controlled Anisotropic Manner

(2016) Kristina Haase et al.   Scientific Reports

In silico synchronization reveals regulators of nuclear ruptures in lamin A/C deficient model cells

(2016) J. Robijns et al.   Scientific Reports

Lamins: Nuclear Intermediate Filament Proteins with Fundamental Functions in Nuclear Mechanics and Genome Regulation

(2015) Yosef Gruenbaum et al.   Annual Review of Biochemistry

Physical properties of cytoplasmic intermediate filaments

(2015) Johanna Block et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Moving Cell Boundaries Drive Nuclear Shaping during Cell Spreading

(2015) Yuan Li et al.   BIOPHYSICAL JOURNAL

Migration in Confined 3D Environments Is Determined by a Combination of Adhesiveness, Nuclear Volume, Contractility, and Cell Stiffness

(2015) Lena A. Lautscham et al.   BIOPHYSICAL JOURNAL

Accessorizing and anchoring the LINC complex for multifunctionality

(2015) Wakam Chang et al.   JOURNAL OF CELL BIOLOGY

Structural organization of nuclear lamins A, C, B1, and B2 revealed by superresolution microscopy

(2015) Takeshi Shimi et al.   MOLECULAR BIOLOGY OF THE CELL

Differential basal-to-apical accessibility of lamin A/C epitopes in the nuclear lamina regulated by changes in cytoskeletal tension

(2015) Teemu O. Ihalainen et al.   NATURE MATERIALS

Direct force probe reveals the mechanics of nuclear homeostasis in the mammalian cell

(2015) Srujana Neelam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nuclear stiffening and chromatin softening with progerin expression leads to an attenuated nuclear response to force

(2015) Elizabeth A. Booth et al.   Soft Matter

Chromatin decompaction by the nucleosomal binding protein HMGN5 impairs nuclear sturdiness

(2015) Takashi Furusawa et al.   Nature Communications

The tethering of chromatin to the nuclear envelope supports nuclear mechanics

(2015) Sarah M. Schreiner et al.   Nature Communications

Loss of lamin A function increases chromatin dynamics in the nuclear interior

(2015) I. Bronshtein et al.   Nature Communications

The Cardiomyopathy Lamin A/C D192G Mutation Disrupts Whole-Cell Biomechanics in Cardiomyocytes as Measured by Atomic Force Microscopy Loading-Unloading Curve Analysis

(2015) Thomas Lanzicher et al.   Scientific Reports

Phosphorylation of lamins determine their structural properties and signaling functions

(2015) Elin Torvaldson et al.   Nucleus

Distinct features of lamin A-interacting chromatin domains mapped by ChIP-sequencing from sonicated or micrococcal nuclease-digested chromatin

(2015) Eivind G Lund et al.   Nucleus

Phosphorylation of lamins determine their structural properties and signaling functions

(2015) Elin Torvaldson et al.   Nucleus

Distinct features of lamin A-interacting chromatin domains mapped by ChIP-sequencing from sonicated or micrococcal nuclease-digested chromatin

(2015) Eivind G Lund et al.   Nucleus

Matrix Elasticity Regulates Lamin-A,C Phosphorylation and Turnover with Feedback to Actomyosin

(2014) Amnon Buxboim et al.   CURRENT BIOLOGY

Lamin B1 overexpression increases nuclear rigidity in autosomal dominant leukodystrophy fibroblasts

(2014) Denise Ferrera et al.   FASEB JOURNAL

Loss of lamin B1 results in prolongation of S phase and decondensation of chromosome territories

(2014) Jordi Camps et al.   FASEB JOURNAL

Nuclear lamin stiffness is a barrier to 3D migration, but softness can limit survival

(2014) Takamasa Harada et al.   JOURNAL OF CELL BIOLOGY

Isolated nuclei adapt to force and reveal a mechanotransduction pathway in the nucleus

(2014) Christophe Guilluy et al.   NATURE CELL BIOLOGY

Chemical Inhibition of NAT10 Corrects Defects of Laminopathic Cells

(2014) D. Larrieu et al.   SCIENCE

LINCing lamin B2 to neuronal migration

(2014) Catherine Coffinier et al.   Nucleus

Developmentally Regulated Subnuclear Genome Reorganization Restricts Neural Progenitor Competence in Drosophila

(2013) Minoree Kohwi et al.   CELL

Nuclear Positioning

(2013) Gregg G. Gundersen et al.   CELL

LBR and Lamin A/C Sequentially Tether Peripheral Heterochromatin and Inversely Regulate Differentiation

(2013) Irina Solovei et al.   CELL

Catastrophic Nuclear Envelope Collapse in Cancer Cell Micronuclei

(2013) Emily M. Hatch et al.   CELL

Nuclear Envelope Composition Determines the Ability of Neutrophil-type Cells to Passage through Micron-scale Constrictions

(2013) Amy C. Rowat et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nesprin-3 connects plectin and vimentin to the nuclear envelope of Sertoli cells but is not required for Sertoli cell function in spermatogenesis

(2013) Mirjam Ketema et al.   MOLECULAR BIOLOGY OF THE CELL

Lamins regulate cell trafficking and lineage maturation of adult human hematopoietic cells

(2013) J.-W. Shin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ring cycle for dilating and constricting the nuclear pore

(2013) S. R. Solmaz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nuclear Lamin-A Scales with Tissue Stiffness and Enhances Matrix-Directed Differentiation

(2013) J. Swift et al.   SCIENCE

The multi-faceted role of the actin cap in cellular mechanosensation and mechanotransduction

(2013) Dong-Hwee Kim et al.   Soft Matter

Chromatin Decondensation and Nuclear Softening Accompany Nanog Downregulation in Embryonic Stem Cells

(2012) Kevin J. Chalut et al.   BIOPHYSICAL JOURNAL

Step-Wise Methylation of Histone H3K9 Positions Heterochromatin at the Nuclear Periphery

(2012) Benjamin D. Towbin et al.   CELL

Correlated alterations in genome organization, histone methylation, and DNA-lamin A/C interactions in Hutchinson-Gilford progeria syndrome

(2012) R. P. McCord et al.   GENOME RESEARCH

Histone modifications and lamin A regulate chromatin protein dynamics in early embryonic stem cell differentiation

(2012) Shai Melcer et al.   Nature Communications

Actin cap associated focal adhesions and their distinct role in cellular mechanosensing

(2012) Dong-Hwee Kim et al.   Scientific Reports

The nuclear envelope protein Nesprin-2 has roles in cell proliferation and differentiation during wound healing

(2012) R.N. Rashmi et al.   Nucleus

Transient nuclear envelope rupturing during interphase in human cancer cells

(2012) Jesse D. Vargas et al.   Nucleus

Nesprin-3: a versatile connector between the nucleus and the cytoskeleton

(2011) Mirjam Ketema et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Repetitive disruptions of the nuclear envelope invoke temporary loss of cellular compartmentalization in laminopathies

(2011) Winnok H. De Vos et al.   HUMAN MOLECULAR GENETICS

The Interaction between Nesprins and Sun Proteins at the Nuclear Envelope Is Critical for Force Transmission between the Nucleus and Cytoskeleton

(2011) Maria L. Lombardi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nuclear lamins and laminopathies

(2011) Howard J. Worman   JOURNAL OF PATHOLOGY

Deficiencies in lamin B1 and lamin B2 cause neurodevelopmental defects and distinct nuclear shape abnormalities in neurons

(2011) Catherine Coffinier et al.   MOLECULAR BIOLOGY OF THE CELL

Abnormal development of the cerebral cortex and cerebellum in the setting of lamin B2 deficiency

(2010) C. Coffinier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Linear Arrays of Nuclear Envelope Proteins Harness Retrograde Actin Flow for Nuclear Movement

(2010) G. W. G. Luxton et al.   SCIENCE

Nuclear Lamins

(2010) T. Dechat et al.   Cold Spring Harbor Perspectives in Biology

Dynamics and molecular interactions of linker of nucleoskeleton and cytoskeleton (LINC) complex proteins

(2009) C. Ostlund et al.   JOURNAL OF CELL SCIENCE

Nuclear lamins: key regulators of nuclear structure and activities

(2009) Miron Prokocimer et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

SUN1/2 and Syne/Nesprin-1/2 Complexes Connect Centrosome to the Nucleus during Neurogenesis and Neuronal Migration in Mice

(2009) Xiaochang Zhang et al.   NEURON

Hierarchical Structure Controls Nanomechanical Properties of Vimentin Intermediate Filaments

(2009) Zhao Qin et al.   PLoS One

A Comparative Study of Drosophila and Human A-Type Lamins

(2009) Sandra R. Schulze et al.   PLoS One

A perinuclear actin cap regulates nuclear shape

(2009) Shyam B. Khatau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Disturbed nuclear orientation and cellular migration in A-type lamin deficient cells

(2008) F. Houben et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Tensile Properties of Single Desmin Intermediate Filaments

(2008) Laurent Kreplak et al.   BIOPHYSICAL JOURNAL

The A- and B-type nuclear lamin networks: microdomains involved in chromatin organization and transcription

(2008) T. Shimi et al.   GENES & DEVELOPMENT

Nuclear lamins: major factors in the structural organization and function of the nucleus and chromatin

(2008) T. Dechat et al.   GENES & DEVELOPMENT

The Supramolecular Organization of the C. elegans Nuclear Lamin Filament

(2008) Kfir Ben-Harush et al.   JOURNAL OF MOLECULAR BIOLOGY

Domain organization of human chromosomes revealed by mapping of nuclear lamina interactions

(2008) Lars Guelen et al.   NATURE

Micromechanical properties of keratin intermediate filament networks

(2008) S. Sivaramakrishnan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA