Chromatin and lamin A determine two different mechanical response regimes of the cell nucleus

The second decade of 3C technologies: detailed insights into nuclear organization

(2016) Annette Denker et al.   GENES & DEVELOPMENT

Nongenetic functions of the genome

(2016) M. Bustin et al.   SCIENCE

Visualizing the molecular sociology at the HeLa cell nuclear periphery

(2016) J. Mahamid et al.   SCIENCE

Nuclear envelope rupture and repair during cancer cell migration

(2016) C. M. Denais et al.   SCIENCE

Lamin A/C deficiency reduces circulating tumor cell resistance to fluid shear stress

(2015) Michael J. Mitchell et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Moving Cell Boundaries Drive Nuclear Shaping during Cell Spreading

(2015) Yuan Li et al.   BIOPHYSICAL JOURNAL

Intermediate filament mechanics in vitro and in the cell: from coiled coils to filaments, fibers and networks

(2015) Sarah Köster et al.   CURRENT OPINION IN CELL BIOLOGY

Structural organization of nuclear lamins A, C, B1, and B2 revealed by superresolution microscopy

(2015) Takeshi Shimi et al.   MOLECULAR BIOLOGY OF THE CELL

Loss of lamin A but not lamin C expression in epithelial ovarian cancer cells is associated with metastasis and poor prognosis

(2015) Guanghui Gong et al.   PATHOLOGY RESEARCH AND PRACTICE

Nuclear stiffening and chromatin softening with progerin expression leads to an attenuated nuclear response to force

(2015) Elizabeth A. Booth et al.   Soft Matter

Chromatin decompaction by the nucleosomal binding protein HMGN5 impairs nuclear sturdiness

(2015) Takashi Furusawa et al.   Nature Communications

The tethering of chromatin to the nuclear envelope supports nuclear mechanics

(2015) Sarah M. Schreiner et al.   Nature Communications

Differential Predictive Roles of A- and B-Type Nuclear Lamins in Prostate Cancer Progression

(2015) Irena Saarinen et al.   PLoS One

Nuclear lamin stiffness is a barrier to 3D migration, but softness can limit survival

(2014) Takamasa Harada et al.   JOURNAL OF CELL BIOLOGY

Role of Lamin B1 in Chromatin Instability

(2014) Veronika Butin-Israeli et al.   MOLECULAR AND CELLULAR BIOLOGY

Isolated nuclei adapt to force and reveal a mechanotransduction pathway in the nucleus

(2014) Christophe Guilluy et al.   NATURE CELL BIOLOGY

The DNA intercalators ethidium bromide and propidium iodide also bind to core histones

(2014) Amrita Banerjee et al.   FEBS Open Bio

Nuclear Mechanics and Mechanotransduction in Health and Disease

(2013) Philipp Isermann et al.   CURRENT BIOLOGY

Myopathic lamin mutations impair nuclear stability in cells and tissue and disrupt nucleo-cytoskeletal coupling

(2013) Monika Zwerger et al.   HUMAN MOLECULAR GENETICS

Nuclear Envelope Composition Determines the Ability of Neutrophil-type Cells to Passage through Micron-scale Constrictions

(2013) Amy C. Rowat et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Physical limits of cell migration: Control by ECM space and nuclear deformation and tuning by proteolysis and traction force

(2013) Katarina Wolf et al.   JOURNAL OF CELL BIOLOGY

Lamin A/C and emerin regulate MKL1–SRF activity by modulating actin dynamics

(2013) Chin Yee Ho et al.   NATURE

HDAC Up-Regulation in Early Colon Field Carcinogenesis Is Involved in Cell Tumorigenicity through Regulation of Chromatin Structure

(2013) Yolanda Stypula-Cyrus et al.   PLoS One

Lamins regulate cell trafficking and lineage maturation of adult human hematopoietic cells

(2013) J.-W. Shin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Micron-scale coherence in interphase chromatin dynamics

(2013) A. Zidovska et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanical model of blebbing in nuclear lamin meshworks

(2013) Chloe M. Funkhouser et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nuclear Lamin-A Scales with Tissue Stiffness and Enhances Matrix-Directed Differentiation

(2013) J. Swift et al.   SCIENCE

Fine control of nuclear confinement identifies a threshold deformation leading to lamina rupture and induction of specific genes

(2012) Maël Le Berre et al.   Integrative Biology

Generalized Lévy walks and the role of chemokines in migration of effector CD8+ T cells

(2012) Tajie H. Harris et al.   NATURE

Nuclear lamin functions and disease

(2012) Veronika Butin-Israeli et al.   TRENDS IN GENETICS

The nuclear lamina and heterochromatin: a complex relationship: Table 1

(2011) Erin M. Bank et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Modeling Nuclear Blebs in a Nucleoskeleton of Independent Filament Networks

(2011) Nicholas S. Wren et al.   Cellular and Molecular Bioengineering

Simian virus 40 induces lamin A/C fluctuations and nuclear envelope deformation during cell entry

(2011) Veronika Butin-Israeli et al.   Nucleus

Nuclear mechanics during cell migration

(2010) Peter Friedl et al.   CURRENT OPINION IN CELL BIOLOGY

Vimentin induces changes in cell shape, motility, and adhesion during the epithelial to mesenchymal transition

(2010) Melissa G. Mendez et al.   FASEB JOURNAL

Mitotic chromosomes are constrained by topoisomerase II–sensitive DNA entanglements

(2010) Ryo Kawamura et al.   JOURNAL OF CELL BIOLOGY

Linear Arrays of Nuclear Envelope Proteins Harness Retrograde Actin Flow for Nuclear Movement

(2010) G. W. G. Luxton et al.   SCIENCE

Influence of Lamin A on the Mechanical Properties of Amphibian Oocyte Nuclei Measured by Atomic Force Microscopy

(2009) Jens Schäpe et al.   BIOPHYSICAL JOURNAL

An oestrogen-receptor-α-bound human chromatin interactome

(2009) Melissa J. Fullwood et al.   NATURE

A progeria mutation reveals functions for lamin A in nuclear assembly, architecture, and chromosome organization

(2009) P. Taimen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comprehensive Mapping of Long-Range Interactions Reveals Folding Principles of the Human Genome

(2009) E. Lieberman-Aiden et al.   SCIENCE

Increased mechanosensitivity and nuclear stiffness in Hutchinson–Gilford progeria cells: effects of farnesyltransferase inhibitors

(2008) Valerie L. R. M. Verstraeten et al.   AGING CELL

Dynamics of Chromatin Decondensation Reveals the Structural Integrity of a Mechanically Prestressed Nucleus

(2008) Aprotim Mazumder et al.   BIOPHYSICAL JOURNAL

The A- and B-type nuclear lamin networks: microdomains involved in chromatin organization and transcription

(2008) T. Shimi et al.   GENES & DEVELOPMENT

Domain organization of human chromosomes revealed by mapping of nuclear lamina interactions

(2008) Lars Guelen et al.   NATURE