Perinuclear Arp2/3-driven actin polymerization enables nuclear deformation to facilitate cell migration through complex environments

Force Feedback Controls Motor Activity and Mechanical Properties of Self-Assembling Branched Actin Networks

(2016) Peter Bieling et al.   CELL

Non-muscle myosin IIB is critical for nuclear translocation during 3D invasion

(2015) Dustin G. Thomas et al.   JOURNAL OF CELL BIOLOGY

Nuclear–cytoskeletal linkages facilitate cross talk between the nucleus and intercellular adhesions

(2015) Rachel M. Stewart et al.   JOURNAL OF CELL BIOLOGY

Innate control of actin nucleation determines two distinct migration behaviours in dendritic cells

(2015) Pablo Vargas et al.   NATURE CELL BIOLOGY

Myosin II controls cellular branching morphogenesis and migration in three dimensions by minimizing cell-surface curvature

(2015) Hunter Elliott et al.   NATURE CELL BIOLOGY

Mechanical stimulation induces formin-dependent assembly of a perinuclear actin rim

(2015) Xiaowei Shao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell migration and antigen capture are antagonistic processes coupled by myosin II in dendritic cells

(2015) Mélanie Chabaud et al.   Nature Communications

Cancer cell migration in 3D tissue: Negotiating space by proteolysis and nuclear deformability

(2015) Marina Krause et al.   Cell Adhesion & Migration

ATR Mediates a Checkpoint at the Nuclear Envelope in Response to Mechanical Stress

(2014) Amit Kumar et al.   CELL

Water Permeation Drives Tumor Cell Migration in Confined Microenvironments

(2014) Kimberly M. Stroka et al.   CELL

Nuclear Deformability Constitutes a Rate-Limiting Step During Cell Migration in 3-D Environments

(2014) Patricia M. Davidson et al.   Cellular and Molecular Bioengineering

An Arp2/3 Nucleated F-Actin Shell Fragments Nuclear Membranes at Nuclear Envelope Breakdown in Starfish Oocytes

(2014) Masashi Mori et al.   CURRENT BIOLOGY

Nuclear lamin stiffness is a barrier to 3D migration, but softness can limit survival

(2014) Takamasa Harada et al.   JOURNAL OF CELL BIOLOGY

The PAR complex controls the spatiotemporal dynamics of F-actin and the MTOC in directionally migrating leukocytes

(2014) Carolina Lage Crespo et al.   JOURNAL OF CELL SCIENCE

Generation of compartmentalized pressure by a nuclear piston governs cell motility in a 3D matrix

(2014) R. J. Petrie et al.   SCIENCE

Mathematical Modeling of Eukaryotic Cell Migration: Insights Beyond Experiments

(2013) Gaudenz Danuser et al.   Annual Review of Cell and Developmental Biology

Determinants of Maximal Force Transmission in a Motor-Clutch Model of Cell Traction in a Compliant Microenvironment

(2013) Benjamin L. Bangasser et al.   BIOPHYSICAL JOURNAL

Small Molecules CK-666 and CK-869 Inhibit Actin-Related Protein 2/3 Complex by Blocking an Activating Conformational Change

(2013) Byron Hetrick et al.   CHEMISTRY & BIOLOGY

Nuclear Envelope Composition Determines the Ability of Neutrophil-type Cells to Passage through Micron-scale Constrictions

(2013) Amy C. Rowat et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Physical limits of cell migration: Control by ECM space and nuclear deformation and tuning by proteolysis and traction force

(2013) Katarina Wolf et al.   JOURNAL OF CELL BIOLOGY

Matrix geometry determines optimal cancer cell migration strategy and modulates response to interventions

(2013) Melda Tozluoğlu et al.   NATURE CELL BIOLOGY

Keratins significantly contribute to cell stiffness and impact invasive behavior

(2013) K. Seltmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nuclear Lamin-A Scales with Tissue Stiffness and Enhances Matrix-Directed Differentiation

(2013) J. Swift et al.   SCIENCE

The multi-faceted role of the actin cap in cellular mechanosensation and mechanotransduction

(2013) Dong-Hwee Kim et al.   Soft Matter

Connecting the nucleus to the cytoskeleton by SUN–KASH bridges across the nuclear envelope

(2012) Erin C Tapley et al.   CURRENT OPINION IN CELL BIOLOGY

Fine control of nuclear confinement identifies a threshold deformation leading to lamina rupture and induction of specific genes

(2012) Maël Le Berre et al.   Integrative Biology

Actin filament curvature biases branching direction

(2012) V. I. Risca et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

How actin network dynamics control the onset of actin-based motility

(2012) A. Kawska et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spatial coordination between cell and nuclear shape within micropatterned endothelial cells

(2012) Marie Versaevel et al.   Nature Communications

Mouse models of MYH9-related disease: mutations in nonmuscle myosin II-A

(2011) Y. Zhang et al.   BLOOD

RefilinB (FAM101B) targets FilaminA to organize perinuclear actin networks and regulates nuclear shape

(2011) O. Gay et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TAN lines

(2011) G.W. Gant Luxton et al.   Nucleus

Rho-mDia1 pathway is required for adhesion, migration, and T-cell stimulation in dendritic cells

(2010) H. Tanizaki et al.   BLOOD

Myosin II contributes to cell-scale actin network treadmilling through network disassembly

(2010) Cyrus A. Wilson et al.   NATURE

Confinement-optimized three-dimensional T cell amoeboid motility is modulated via myosin IIA–regulated adhesions

(2010) Jordan Jacobelli et al.   NATURE IMMUNOLOGY

Lifeact mice for studying F-actin dynamics

(2010) Julia Riedl et al.   NATURE METHODS

Linear Arrays of Nuclear Envelope Proteins Harness Retrograde Actin Flow for Nuclear Movement

(2010) G. W. G. Luxton et al.   SCIENCE

Cdc42-dependent leading edge coordination is essential for interstitial dendritic cell migration

(2009) T. Lammermann et al.   BLOOD

Preformed portals facilitate dendritic cell entry into afferent lymphatic vessels

(2009) Holger Pflicke et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A perinuclear actin cap regulates nuclear shape

(2009) Shyam B. Khatau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The regulatory role of cell mechanics for migration of differentiating myeloid cells

(2009) F. Lautenschlager et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Collagen-based cell migration models in vitro and in vivo

(2009) Katarina Wolf et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The Role of Myosin II in Glioma Invasion of the Brain

(2008) Christopher Beadle et al.   MOLECULAR BIOLOGY OF THE CELL

Rapid leukocyte migration by integrin-independent flowing and squeezing

(2008) Tim Lämmermann et al.   NATURE

Regulation of Dendritic Cell Migration by CD74, the MHC Class II-Associated Invariant Chain

(2008) G. Faure-Andre et al.   SCIENCE

Traction Dynamics of Filopodia on Compliant Substrates

(2008) C. E. Chan et al.   SCIENCE