Nonlinear mechanics of lamin filaments and the meshwork topology build an emergent nuclear lamina

Emergent functions of proteins in non-stoichiometric supramolecular assemblies

(2019) Rita Pancsa et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Lamin A molecular compression and sliding as mechanisms behind nucleoskeleton elasticity

(2019) Alex A. Makarov et al.   Nature Communications

Insight into the functional organization of nuclear lamins in health and disease

(2018) Meltem Tatli et al.   CURRENT OPINION IN CELL BIOLOGY

Nuclear Lamins: Thin Filaments with Major Functions

(2018) Rebecca de Leeuw et al.   TRENDS IN CELL BIOLOGY

Viscoelastic properties of vimentin originate from nonequilibrium conformational changes

(2018) Johanna Block et al.   Science Advances

The Rise of Hierarchical Nanostructured Materials from Renewable Sources: Learning from Nature

(2018) Francisco J. Martin-Martinez et al.   ACS Nano

Chromatin and lamin A determine two different mechanical response regimes of the cell nucleus

(2017) Andrew D. Stephens et al.   MOLECULAR BIOLOGY OF THE CELL

The molecular architecture of lamins in somatic cells

(2017) Yagmur Turgay et al.   NATURE

Nonlinear Loading-Rate-Dependent Force Response of Individual Vimentin Intermediate Filaments to Applied Strain

(2017) Johanna Block et al.   PHYSICAL REVIEW LETTERS

Squish and squeeze — the nucleus as a physical barrier during migration in confined environments

(2016) Alexandra Lynn McGregor et al.   CURRENT OPINION IN CELL BIOLOGY

Nuclear envelope rupture is induced by actin-based nucleus confinement

(2016) Emily M. Hatch et al.   JOURNAL OF CELL BIOLOGY

Impaired mechanical response of an EDMD mutation leads to motility phenotypes that are repaired by loss of prenylation

(2016) Noam Zuela et al.   JOURNAL OF CELL SCIENCE

Mechanics in human fibroblasts and progeria: Lamin A mutation E145K results in stiffening of nuclei

(2016) Ketaki Apte et al.   JOURNAL OF MOLECULAR RECOGNITION

Transcription upregulation via force-induced direct stretching of chromatin

(2016) Arash Tajik et al.   NATURE MATERIALS

Emergent structures and dynamics of cell colonies by contact inhibition of locomotion

(2016) Bart Smeets et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nuclear envelope rupture and repair during cancer cell migration

(2016) C. M. Denais et al.   SCIENCE

Toward correlating structure and mechanics of platelets

(2016) Simona Sorrentino et al.   Cell Adhesion & Migration

Lamins: Nuclear Intermediate Filament Proteins with Fundamental Functions in Nuclear Mechanics and Genome Regulation

(2015) Yosef Gruenbaum et al.   Annual Review of Biochemistry

Structural organization of nuclear lamins A, C, B1, and B2 revealed by superresolution microscopy

(2015) Takeshi Shimi et al.   MOLECULAR BIOLOGY OF THE CELL

Direct force probe reveals the mechanics of nuclear homeostasis in the mammalian cell

(2015) Srujana Neelam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanical control of mitotic progression in single animal cells

(2015) Cedric J. Cattin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Emergent Properties of the Metaphase Spindle

(2015) Simone Reber et al.   Cold Spring Harbor Perspectives in Biology

In Situ Mechanical Characterization of the Cell Nucleus by Atomic Force Microscopy

(2014) Haijiao Liu et al.   ACS Nano

Isolated nuclei adapt to force and reveal a mechanotransduction pathway in the nucleus

(2014) Christophe Guilluy et al.   NATURE CELL BIOLOGY

Emergent complexity of the cytoskeleton: from single filaments to tissue

(2013) F. Huber et al.   ADVANCES IN PHYSICS

When Lamins Go Bad: Nuclear Structure and Disease

(2013) Katherine H. Schreiber et al.   CELL

Nuclear Mechanics and Mechanotransduction in Health and Disease

(2013) Philipp Isermann et al.   CURRENT BIOLOGY

Mechanical model of blebbing in nuclear lamin meshworks

(2013) Chloe M. Funkhouser et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nuclear Lamin-A Scales with Tissue Stiffness and Enhances Matrix-Directed Differentiation

(2013) J. Swift et al.   SCIENCE

Broken nuclei – lamins, nuclear mechanics, and disease

(2013) Patricia M. Davidson et al.   TRENDS IN CELL BIOLOGY

The α-Helix to β-Sheet Transition in Stretched and Compressed Hydrated Fibrin Clots

(2012) Rustem I. Litvinov et al.   BIOPHYSICAL JOURNAL

Mechanical Transition from α-Helical Coiled Coils to β-Sheets in Fibrin(ogen)

(2012) Artem Zhmurov et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nuclear lamin functions and disease

(2012) Veronika Butin-Israeli et al.   TRENDS IN GENETICS

Flaw Tolerance of Nuclear Intermediate Filament Lamina under Extreme Mechanical Deformation

(2011) Zhao Qin et al.   ACS Nano

Nuclear Mechanics in Disease

(2011) Monika Zwerger et al.   Annual Review of Biomedical Engineering

Filaments assembly of ectopically expressed Caenorhabditis elegans lamin within Xenopus oocytes

(2011) Einat Grossman et al.   JOURNAL OF STRUCTURAL BIOLOGY

A de novo peptide hexamer with a mutable channel

(2011) Nathan R Zaccai et al.   Nature Chemical Biology

Amphibian oocyte nuclei expressing lamin A with the progeria mutation E145K exhibit an increased elastic modulus

(2011) Anna Kaufmann et al.   Nucleus

Nuclear mechanics during cell migration

(2010) Peter Friedl et al.   CURRENT OPINION IN CELL BIOLOGY

Oocytes as an experimental system to analyze the ultrastructure of endogenous and ectopically expressed nuclear envelope components by field-emission scanning electron microscopy

(2010) Reimer Stick et al.   METHODS

Molecular Dynamics Simulation of theα-Helix toβ-Sheet Transition in Coiled Protein Filaments: Evidence for a Critical Filament Length Scale

(2010) Zhao Qin et al.   PHYSICAL REVIEW LETTERS

Molecular crowding affects diffusion and binding of nuclear proteins in heterochromatin and reveals the fractal organization of chromatin

(2009) Aurélien Bancaud et al.   EMBO JOURNAL

Deformation and failure of protein materials in physiologically extreme conditions and disease

(2009) Markus J. Buehler et al.   NATURE MATERIALS

Orchestrating nuclear envelope disassembly and reassembly during mitosis

(2009) Stephan Güttinger et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Hierarchical Structure Controls Nanomechanical Properties of Vimentin Intermediate Filaments

(2009) Zhao Qin et al.   PLoS One

Towards an integrated understanding of the structure and mechanics of the cell nucleus

(2008) Amy C. Rowat et al.   BIOESSAYS

Tensile Properties of Single Desmin Intermediate Filaments

(2008) Laurent Kreplak et al.   BIOPHYSICAL JOURNAL

Dynamics of Chromatin Decondensation Reveals the Structural Integrity of a Mechanically Prestressed Nucleus

(2008) Aprotim Mazumder et al.   BIOPHYSICAL JOURNAL

Filaments made from A- and B-type lamins differ in structure and organization

(2008) M. W. Goldberg et al.   JOURNAL OF CELL SCIENCE

The Supramolecular Organization of the C. elegans Nuclear Lamin Filament

(2008) Kfir Ben-Harush et al.   JOURNAL OF MOLECULAR BIOLOGY

Tethering by lamin A stabilizes and targets the ING1 tumour suppressor

(2008) Xijing Han et al.   NATURE CELL BIOLOGY

Elasticity measurement of living cells with an atomic force microscope: data acquisition and processing

(2008) Philippe Carl et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Molecular Basis of Fibrin Clot Elasticity

(2008) Bernard B.C. Lim et al.   STRUCTURE