Chromatin histone modifications and rigidity affect nuclear morphology independent of lamins

The nucleus is irreversibly shaped by motion of cell boundaries in cancer and non-cancer cells

(2017) Vincent J. Tocco et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Chromatin and lamin A determine two different mechanical response regimes of the cell nucleus

(2017) Andrew D. Stephens et al.   MOLECULAR BIOLOGY OF THE CELL

The molecular architecture of lamins in somatic cells

(2017) Yagmur Turgay et al.   NATURE

A Chemomechanical Model for Nuclear Morphology and Stresses during Cell Transendothelial Migration

(2016) Xuan Cao et al.   BIOPHYSICAL JOURNAL

The second decade of 3C technologies: detailed insights into nuclear organization

(2016) Annette Denker et al.   GENES & DEVELOPMENT

Nuclear envelope rupture is induced by actin-based nucleus confinement

(2016) Emily M. Hatch et al.   JOURNAL OF CELL BIOLOGY

The molecular hallmarks of epigenetic control

(2016) C. David Allis et al.   NATURE REVIEWS GENETICS

ESCRT III repairs nuclear envelope ruptures during cell migration to limit DNA damage and cell death

(2016) M. Raab et al.   SCIENCE

Nuclear envelope rupture and repair during cancer cell migration

(2016) C. M. Denais et al.   SCIENCE

In silico synchronization reveals regulators of nuclear ruptures in lamin A/C deficient model cells

(2016) J. Robijns et al.   Scientific Reports

Moving Cell Boundaries Drive Nuclear Shaping during Cell Spreading

(2015) Yuan Li et al.   BIOPHYSICAL JOURNAL

Wash Interacts with Lamin and Affects Global Nuclear Organization

(2015) Jeffrey M. Verboon et al.   CURRENT BIOLOGY

Directed targeting of chromatin to the nuclear lamina is mediated by chromatin state and A-type lamins

(2015) Jennifer C. Harr et al.   JOURNAL OF CELL BIOLOGY

Structural organization of nuclear lamins A, C, B1, and B2 revealed by superresolution microscopy

(2015) Takeshi Shimi et al.   MOLECULAR BIOLOGY OF THE CELL

Direct force probe reveals the mechanics of nuclear homeostasis in the mammalian cell

(2015) Srujana Neelam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nuclear stiffening and chromatin softening with progerin expression leads to an attenuated nuclear response to force

(2015) Elizabeth A. Booth et al.   Soft Matter

Chromatin decompaction by the nucleosomal binding protein HMGN5 impairs nuclear sturdiness

(2015) Takashi Furusawa et al.   Nature Communications

The tethering of chromatin to the nuclear envelope supports nuclear mechanics

(2015) Sarah M. Schreiner et al.   Nature Communications

Loss of lamin B1 results in prolongation of S phase and decondensation of chromosome territories

(2014) Jordi Camps et al.   FASEB JOURNAL

Nuclear lamin stiffness is a barrier to 3D migration, but softness can limit survival

(2014) Takamasa Harada et al.   JOURNAL OF CELL BIOLOGY

Chemical Inhibition of NAT10 Corrects Defects of Laminopathic Cells

(2014) D. Larrieu et al.   SCIENCE

Mapping of protein- and chromatin-interactions at the nuclear lamina

(2014) Nard Kubben et al.   Nucleus

Diverse lamin-dependent mechanisms interact to control chromatin dynamics

(2014) Daria Camozzi et al.   Nucleus

Nuclear Shape Changes Are Induced by Knockdown of the SWI/SNF ATPase BRG1 and Are Independent of Cytoskeletal Connections

(2013) Karen M. Imbalzano et al.   PLoS One

HDAC Up-Regulation in Early Colon Field Carcinogenesis Is Involved in Cell Tumorigenicity through Regulation of Chromatin Structure

(2013) Yolanda Stypula-Cyrus et al.   PLoS One

Lamins regulate cell trafficking and lineage maturation of adult human hematopoietic cells

(2013) J.-W. Shin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanical model of blebbing in nuclear lamin meshworks

(2013) Chloe M. Funkhouser et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nuclear Lamin-A Scales with Tissue Stiffness and Enhances Matrix-Directed Differentiation

(2013) J. Swift et al.   SCIENCE

Soft substrates normalize nuclear morphology and prevent nuclear rupture in fibroblasts from a laminopathy patient with compound heterozygous LMNA mutations

(2013) Chiara Tamiello et al.   Nucleus

Chromatin Decondensation and Nuclear Softening Accompany Nanog Downregulation in Embryonic Stem Cells

(2012) Kevin J. Chalut et al.   BIOPHYSICAL JOURNAL

Mapping of lamin A- and progerin-interacting genome regions

(2012) Nard Kubben et al.   CHROMOSOMA

Correlated alterations in genome organization, histone methylation, and DNA-lamin A/C interactions in Hutchinson-Gilford progeria syndrome

(2012) R. P. McCord et al.   GENOME RESEARCH

Fine control of nuclear confinement identifies a threshold deformation leading to lamina rupture and induction of specific genes

(2012) Maël Le Berre et al.   Integrative Biology

Histone Lysine Methylation Dynamics: Establishment, Regulation, and Biological Impact

(2012) Joshua C. Black et al.   MOLECULAR CELL

Higher order chromatin organization in cancer

(2012) Karen L. Reddy et al.   SEMINARS IN CANCER BIOLOGY

Nuclear lamin functions and disease

(2012) Veronika Butin-Israeli et al.   TRENDS IN GENETICS

Transient nuclear envelope rupturing during interphase in human cancer cells

(2012) Jesse D. Vargas et al.   Nucleus

Modeling Nuclear Blebs in a Nucleoskeleton of Independent Filament Networks

(2011) Nicholas S. Wren et al.   Cellular and Molecular Bioengineering

Chromosomal regions associated with prostate cancer risk localize to lamin B-deficient microdomains and exhibit reduced gene transcription

(2011) Brian T Helfand et al.   JOURNAL OF PATHOLOGY

A Selective Inhibitor and Probe of the Cellular Functions of Jumonji C Domain-Containing Histone Demethylases

(2011) Xuelai Luo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Quantitative analysis of chromatin compaction in living cells using FLIM–FRET

(2009) David Llères et al.   JOURNAL OF CELL BIOLOGY

DZNep is a global histone methylation inhibitor that reactivates developmental genes not silenced by DNA methylation

(2009) T. B. Miranda et al.   MOLECULAR CANCER THERAPEUTICS

A perinuclear actin cap regulates nuclear shape

(2009) Shyam B. Khatau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A progeria mutation reveals functions for lamin A in nuclear assembly, architecture, and chromosome organization

(2009) P. Taimen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Increased mechanosensitivity and nuclear stiffness in Hutchinson–Gilford progeria cells: effects of farnesyltransferase inhibitors

(2008) Valerie L. R. M. Verstraeten et al.   AGING CELL

Dynamics of Chromatin Decondensation Reveals the Structural Integrity of a Mechanically Prestressed Nucleus

(2008) Aprotim Mazumder et al.   BIOPHYSICAL JOURNAL

The A- and B-type nuclear lamin networks: microdomains involved in chromatin organization and transcription

(2008) T. Shimi et al.   GENES & DEVELOPMENT

Nuclear lamins: major factors in the structural organization and function of the nucleus and chromatin

(2008) T. Dechat et al.   GENES & DEVELOPMENT

Nesprin-2 Giant (NUANCE) maintains nuclear envelope architecture and composition in skin

(2008) Y. Luke et al.   JOURNAL OF CELL SCIENCE

Domain organization of human chromosomes revealed by mapping of nuclear lamina interactions

(2008) Lars Guelen et al.   NATURE