Nuclear Mechanics within Intact Cells Is Regulated by Cytoskeletal Network and Internal Nanostructures

Long-term Brillouin imaging of live cells with reduced absorption-mediated damage at 660nm wavelength

(2019) Miloš Nikolić et al.   Biomedical Optics Express

Imaging mechanical properties of sub-micron ECM in live zebrafish using Brillouin microscopy

(2019) Carlo Bevilacqua et al.   Biomedical Optics Express

Deformation Microscopy for Dynamic Intracellular and Intranuclear Mapping of Mechanics with High Spatiotemporal Resolution

(2019) Soham Ghosh et al.   Cell Reports

Regulation of nuclear architecture, mechanics, and nucleocytoplasmic shuttling of epigenetic factors by cell geometric constraints

(2019) Farid Alisafaei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Assessment of corneal substrate biomechanics and its effect on epithelial stem cell maintenance and differentiation

(2019) Ricardo M. Gouveia et al.   Nature Communications

Free-energy-based framework for early forecasting of stem cell differentiation

(2019) H. Suresh et al.   Journal of the Royal Society Interface

Emerging views of the nucleus as a cellular mechanosensor

(2018) Tyler J. Kirby et al.   NATURE CELL BIOLOGY

Reply to ‘Water content, not stiffness, dominates Brillouin spectroscopy measurements in hydrated materials’

(2018) Giuliano Scarcelli et al.   NATURE METHODS

Compressive force induces reversible chromatin condensation and cell geometry dependent transcriptional response

(2018) Karthik Damodaran et al.   MOLECULAR BIOLOGY OF THE CELL

Tissue biomechanics during cranial neural tube closure measured by Brillouin microscopy and optical coherence tomography

(2018) Jitao Zhang et al.   Birth Defects Research

Thermodynamic Modeling of the Statistics of Cell Spreading on Ligand-Coated Elastic Substrates

(2018) Eoin McEvoy et al.   BIOPHYSICAL JOURNAL

Three-dimensional correlative single-cell imaging utilizing fluorescence and refractive index tomography

(2017) Mirjam Schürmann et al.   Journal of Biophotonics

Free energy analysis of cell spreading

(2017) Eóin McEvoy et al.   Journal of the Mechanical Behavior of Biomedical Materials

Brillouin flow cytometry for label-free mechanical phenotyping of the nucleus

(2017) Jitao Zhang et al.   LAB ON A CHIP

Nucleosome–nucleosome interactions via histone tails and linker DNA regulate nuclear rigidity

(2017) Yuta Shimamoto et al.   MOLECULAR BIOLOGY OF THE CELL

Chromatin and lamin A determine two different mechanical response regimes of the cell nucleus

(2017) Andrew D. Stephens et al.   MOLECULAR BIOLOGY OF THE CELL

The molecular architecture of lamins in somatic cells

(2017) Yagmur Turgay et al.   NATURE

Regulation of genome organization and gene expression by nuclear mechanotransduction

(2017) Caroline Uhler et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cell volume change through water efflux impacts cell stiffness and stem cell fate

(2017) Ming Guo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Non-contact mechanical and chemical analysis of single living cells by microspectroscopic techniques

(2017) Sara Mattana et al.   Light-Science & Applications

In Vivo Multiscale and Spatially-Dependent Biomechanics Reveals Differential Strain Transfer Hierarchy in Skeletal Muscle

(2017) Soham Ghosh et al.   ACS Biomaterials-Science & Engineering

In Vivo Multiscale and Spatially-Dependent Biomechanics Reveals Differential Strain Transfer Hierarchy in Skeletal Muscle

(2017) Soham Ghosh et al.   ACS Biomaterials Science & Engineering

A Chemomechanical Model for Nuclear Morphology and Stresses during Cell Transendothelial Migration

(2016) Xuan Cao et al.   BIOPHYSICAL JOURNAL

Cell nuclei have lower refractive index and mass density than cytoplasm

(2016) Mirjam Schürmann et al.   Journal of Biophotonics

Fibrous nonlinear elasticity enables positive mechanical feedback between cells and ECMs

(2016) Matthew S. Hall et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mapping the subcellular mechanical properties of live cells in tissues with fluorescence emission-Brillouin imaging

(2016) K. Elsayad et al.   Science Signaling

Mapping the subcellular mechanical properties of live cells in tissues with fluorescence emission-Brillouin imaging

(2016) K. Elsayad et al.   Science Signaling

Cytoskeletal prestress regulates nuclear shape and stiffness in cardiac myocytes

(2015) Hyungsuk Lee et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Volume regulation and shape bifurcation in the cell nucleus

(2015) D.-H. Kim et al.   JOURNAL OF CELL SCIENCE

Matrix stiffness drives epithelial–mesenchymal transition and tumour metastasis through a TWIST1–G3BP2 mechanotransduction pathway

(2015) Spencer C. Wei et al.   NATURE CELL BIOLOGY

Noncontact three-dimensional mapping of intracellular hydromechanical properties by Brillouin microscopy

(2015) Giuliano Scarcelli et al.   NATURE METHODS

Vertical nanopillars for in situ probing of nuclear mechanics in adherent cells

(2015) Lindsey Hanson et al.   Nature Nanotechnology

Nuclear stiffening and chromatin softening with progerin expression leads to an attenuated nuclear response to force

(2015) Elizabeth A. Booth et al.   Soft Matter

In Situ Mechanical Characterization of the Cell Nucleus by Atomic Force Microscopy

(2014) Haijiao Liu et al.   ACS Nano

Geometry Regulates Traction Stresses in Adherent Cells

(2014) Patrick W. Oakes et al.   BIOPHYSICAL JOURNAL

Combining AFM and Acoustic Probes to Reveal Changes in the Elastic Stiffness Tensor of Living Cells

(2014) Nadja Nijenhuis et al.   BIOPHYSICAL JOURNAL

Nuclear Deformability Constitutes a Rate-Limiting Step During Cell Migration in 3-D Environments

(2014) Patricia M. Davidson et al.   Cellular and Molecular Bioengineering

Probing the compressibility of tumor cell nuclei by combined atomic force–confocal microscopy

(2013) Marina Krause et al.   PHYSICAL BIOLOGY

Cell geometric constraints induce modular gene-expression patterns via redistribution of HDAC3 regulated by actomyosin contractility

(2013) N. Jain et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nuclear Lamin-A Scales with Tissue Stiffness and Enhances Matrix-Directed Differentiation

(2013) J. Swift et al.   SCIENCE

Chromatin Decondensation and Nuclear Softening Accompany Nanog Downregulation in Embryonic Stem Cells

(2012) Kevin J. Chalut et al.   BIOPHYSICAL JOURNAL

Nuclear Mechanics in Disease

(2011) Monika Zwerger et al.   Annual Review of Biomedical Engineering

Mesenchymal Stem Cell Mechanics from the Attached to the Suspended State

(2010) John M. Maloney et al.   BIOPHYSICAL JOURNAL

The role of chromatin structure in cell migration

(2010) Gabi Gerlitz et al.   TRENDS IN CELL BIOLOGY

A perinuclear actin cap regulates nuclear shape

(2009) Shyam B. Khatau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell Stiffening in Response to External Stress is Correlated to Actin Recruitment

(2008) Delphine Icard-Arcizet et al.   BIOPHYSICAL JOURNAL

GEF-H1 Couples Nocodazole-induced Microtubule Disassembly to Cell Contractility via RhoA

(2008) Yuan-Chen Chang et al.   MOLECULAR BIOLOGY OF THE CELL

Mechanotransduction at a distance: mechanically coupling the extracellular matrix with the nucleus

(2008) Ning Wang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY