Regulation of nuclear architecture, mechanics, and nucleocytoplasmic shuttling of epigenetic factors by cell geometric constraints

Dynamic fibroblast contractions attract remote macrophages in fibrillar collagen matrix

(2019) Pardis Pakshir et al.   Nature Communications

Chromatin histone modifications and rigidity affect nuclear morphology independent of lamins

(2018) Andrew D. Stephens et al.   MOLECULAR BIOLOGY OF THE CELL

Nuclear rupture at sites of high curvature compromises retention of DNA repair factors

(2018) Yuntao Xia et al.   JOURNAL OF CELL BIOLOGY

Compressive force induces reversible chromatin condensation and cell geometry dependent transcriptional response

(2018) Karthik Damodaran et al.   MOLECULAR BIOLOGY OF THE CELL

Lmna knockout mouse embryonic fibroblasts are less contractile than their wild-type counterparts

(2017) I. A. E. W. van Loosdregt et al.   Integrative Biology

Coordinated increase of nuclear tension and lamin-A with matrix stiffness outcompetes lamin-B receptor that favors soft tissue phenotypes

(2017) Amnon Buxboim et al.   MOLECULAR BIOLOGY OF THE CELL

Chromatin and lamin A determine two different mechanical response regimes of the cell nucleus

(2017) Andrew D. Stephens et al.   MOLECULAR BIOLOGY OF THE CELL

The molecular architecture of lamins in somatic cells

(2017) Yagmur Turgay et al.   NATURE

Cell geometry dictates TNFα-induced genome response

(2017) Aninda Mitra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

3D microniches reveal the importance of cell size and shape

(2017) Min Bao et al.   Nature Communications

Nuclear lamin A/C harnesses the perinuclear apical actin cables to protect nuclear morphology

(2017) Jeong-Ki Kim et al.   Nature Communications

Fibrous nonlinear elasticity enables positive mechanical feedback between cells and ECMs

(2016) Matthew S. Hall et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cytoskeletal prestress regulates nuclear shape and stiffness in cardiac myocytes

(2015) Hyungsuk Lee et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Intermediate Filaments Play a Pivotal Role in Regulating Cell Architecture and Function

(2015) Jason Lowery et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cytoskeletal Control of Nuclear Morphology and Chromatin Organization

(2015) Nisha M. Ramdas et al.   JOURNAL OF MOLECULAR BIOLOGY

Investigating cell mechanics with atomic force microscopy

(2015) K. Haase et al.   Journal of the Royal Society Interface

Nuclear deformability and telomere dynamics are regulated by cell geometric constraints

(2015) Ekta Makhija et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Geometry Regulates Traction Stresses in Adherent Cells

(2014) Patrick W. Oakes et al.   BIOPHYSICAL JOURNAL

Vimentin Enhances Cell Elastic Behavior and Protects against Compressive Stress

(2014) M.G. Mendez et al.   BIOPHYSICAL JOURNAL

Matrix Elasticity Regulates Lamin-A,C Phosphorylation and Turnover with Feedback to Actomyosin

(2014) Amnon Buxboim et al.   CURRENT BIOLOGY

Role of Actin Filaments in Correlating Nuclear Shape and Cell Spreading

(2014) Renu Vishavkarma et al.   PLoS One

Cell geometric constraints induce modular gene-expression patterns via redistribution of HDAC3 regulated by actomyosin contractility

(2013) N. Jain et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nuclear Lamin-A Scales with Tissue Stiffness and Enhances Matrix-Directed Differentiation

(2013) J. Swift et al.   SCIENCE

Spatial coordination between cell and nuclear shape within micropatterned endothelial cells

(2012) Marie Versaevel et al.   Nature Communications

Cell Shape and Substrate Rigidity Both Regulate Cell Stiffness

(2011) Shang-You Tee et al.   BIOPHYSICAL JOURNAL

Intermediate filament-deficient cells are mechanically softer at large deformation: A multi-scale simulation study

(2010) Jérémie Bertaud et al.   Acta Biomaterialia

Ultra-rapid activation of TRPV4 ion channels by mechanical forces applied to cell surface β1 integrins

(2010) Benjamin D. Matthews et al.   Integrative Biology

A multi-scale approach to understand the mechanobiology of intermediate filaments

(2009) Zhao Qin et al.   JOURNAL OF BIOMECHANICS

Cell Stiffening in Response to External Stress is Correlated to Actin Recruitment

(2008) Delphine Icard-Arcizet et al.   BIOPHYSICAL JOURNAL

Dynamics of Chromatin Decondensation Reveals the Structural Integrity of a Mechanically Prestressed Nucleus

(2008) Aprotim Mazumder et al.   BIOPHYSICAL JOURNAL

GEF-H1 Couples Nocodazole-induced Microtubule Disassembly to Cell Contractility via RhoA

(2008) Yuan-Chen Chang et al.   MOLECULAR BIOLOGY OF THE CELL