Non-apoptotic cell death-based cancer therapy: Molecular mechanism, pharmacological modulators, and nanomedicine

FV-429 induces autophagy blockage and lysosome-dependent cell death of T-cell malignancies via lysosomal dysregulation

(2021) Po Hu et al.   Cell Death & Disease

The dark side of ferroptosis in pancreatic cancer

(2021) Jiao Liu et al.   OncoImmunology

Tumor microenvironments self-activated nanoscale metal organic frameworks for ferroptosis based cancer chemodynamic/photothermal/chemo therapy

(2021) Yu Liang et al.   Acta Pharmaceutica Sinica B

System Xc−: a key regulatory target of ferroptosis in cancer

(2021) Man-ru Liu et al.   INVESTIGATIONAL NEW DRUGS

Prodrug-Based Versatile Nanomedicine with Simultaneous Physical and Physiological Tumor Penetration for Enhanced Cancer Chemo-Immunotherapy

(2021) Zhaopei Guo et al.   NANO LETTERS

Identification of ferroptosis as a novel mechanism for antitumor activity of natural product derivative a2 in gastric cancer

(2021) Ying Liu et al.   Acta Pharmaceutica Sinica B

Gasdermin D in pyroptosis

(2021) Brandon Burdette et al.   Acta Pharmaceutica Sinica B

Self‐Delivered Supramolecular Nanomedicine with Transformable Shape for Ferrocene‐Amplified Photodynamic Therapy of Breast Cancer and Bone Metastases

(2021) Yi Qin et al.   ADVANCED FUNCTIONAL MATERIALS

Structure‐Based Programming of Supramolecular Assemblies in Living Cells for Selective Cancer Cell Inhibition

(2021) Liangbo Hu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Furin-instructed aggregated gold nanoparticles for re-educating tumor associated macrophages and overcoming breast cancer chemoresistance

(2021) Rou Xie et al.   BIOMATERIALS

Ferroptosis-Strengthened Metabolic and Inflammatory Regulation of Tumor-Associated Macrophages Provokes Potent Tumoricidal Activities

(2021) Zhengying Gu et al.   NANO LETTERS

Cucurbitacin B inhibits non-small cell lung cancer in vivo and in vitro by triggering TLR4/NLRP3/GSDMD-dependent pyroptosis

(2021) Renyikun Yuan et al.   PHARMACOLOGICAL RESEARCH

GOT1 inhibition promotes pancreatic cancer cell death by ferroptosis

(2021) Daniel M. Kremer et al.   Nature Communications

MS4A15 drives ferroptosis resistance through calcium-restricted lipid remodeling

(2021) Shan Xin et al.   CELL DEATH AND DIFFERENTIATION

Microcrystalline silica particles induce inflammatory response via pyroptosis in primary human respiratory epithelial cells

(2021) Shangya Chen et al.   ENVIRONMENTAL TOXICOLOGY

A targetable LIFR−NF-κB−LCN2 axis controls liver tumorigenesis and vulnerability to ferroptosis

(2021) Fan Yao et al.   Nature Communications

ROS-responsive fluorinated polyethyleneimine vector to co-deliver shMTHFD2 and shGPX4 plasmids induces ferroptosis and apoptosis for cancer therapy

(2021) Suleixin Yang et al.   Acta Biomaterialia

Gold nanorods and nanoprisms mediate different photothermal cell death mechanisms in vitro and in vivo

(2020) María Moros et al.   ACS Applied Materials & Interfaces

Autophagy-dependent ferroptosis drives tumor-associated macrophage polarization via release and uptake of oncogenic KRAS protein

(2020) Enyong Dai et al.   Autophagy

Mechanisms and Therapeutic Regulation of Pyroptosis in Inflammatory Diseases and Cancer

(2020) Zhaodi Zheng et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Differential effects of N‐TiO 2 nanoparticle and its photo‐activated form on autophagy and necroptosis in human melanoma A375 cells

(2020) Zahra Mohammadalipour et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Cytochrome P450 oxidoreductase contributes to phospholipid peroxidation in ferroptosis

(2020) Yilong Zou et al.   Nature Chemical Biology

Targeting necroptosis in anticancer therapy: mechanisms and modulators

(2020) Ying Wu et al.   Acta Pharmaceutica Sinica B

Specificity of Biogenic Selenium Nanoparticles for Prostate Cancer Therapy With Reduced Risk of Toxicity: An in vitro and in vivo Study

(2020) Praveen Sonkusre   Frontiers in Oncology

Hybrid magnetic nanovectors promote selective glioblastoma cell death through a combined effect of lysosomal membrane permeabilization and chemotherapy

(2020) Carlotta Pucci et al.   ACS Applied Materials & Interfaces

A novel 3’,5’-diprenylated chalcone induces concurrent apoptosis and GSDME-dependent pyroptosis through activating PKCδ/JNK signal in prostate cancer

(2020) Yongqiang Zhang et al.   Aging-US

Semiconducting Polycomplex Nanoparticles for Photothermal Ferrotherapy of Cancer

(2020) Shasha He et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The emerging role of paraptosis in tumor cell biology: Perspectives for cancer prevention and therapy with natural compounds

(2020) Fabrizio Fontana et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

New insights into the regulation of apoptosis, necroptosis, and pyroptosis by receptor interacting protein kinase 1 and caspase-8

(2020) Robin Schwarzer et al.   CURRENT OPINION IN CELL BIOLOGY

Lipid peroxidation and ferroptosis: The role of GSH and GPx4

(2020) Fulvio Ursini et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nanostructured toxins for the selective destruction of drug-resistant human CXCR4+ colorectal cancer stem cells

(2020) Naroa Serna et al.   JOURNAL OF CONTROLLED RELEASE

Mesoporous polydopamine carrying sorafenib and SPIO nanoparticles for MRI-guided ferroptosis cancer therapy

(2020) Qingqing Guan et al.   JOURNAL OF CONTROLLED RELEASE

CuS–NiS2 nanomaterials for MRI guided phototherapy of gastric carcinoma via triggering mitochondria-mediated apoptosis and MLKL/CAPG-mediated necroptosis

(2020) Jian Chen et al.   Nanotoxicology

Gasdermin E suppresses tumour growth by activating anti-tumour immunity

(2020) Zhibin Zhang et al.   NATURE

A bioorthogonal system reveals antitumour immune function of pyroptosis

(2020) Qinyang Wang et al.   NATURE

Targeted crystallization of mixed-charge nanoparticles in lysosomes induces selective death of cancer cells

(2020) Magdalena Borkowska et al.   Nature Nanotechnology

Trypsin‐Instructed Self‐Assembly on Endoplasmic Reticulum for Selectively Inhibiting Cancer Cells

(2020) Beom Jin Kim et al.   Advanced Healthcare Materials

Tumor microenvironment-activatable Fe-doxorubicin preloaded amorphous CaCO3 nanoformulation triggers ferroptosis in target tumor cells

(2020) Chen-Cheng Xue et al.   Science Advances

Near-Infrared-Activated Lysosome Pathway Death Induced by ROS Generated from Layered Double Hydroxides-Copper Sulfide Nanocomposites

(2020) Chen-Guang Liu et al.   ACS Applied Materials & Interfaces

Blocking drug-induced autophagy with chloroquine in HCT-116 colon cancer cells enhances DC maturation and T cell responses induced by tumor cell lysate

(2020) Jofer Andree Zamame Ramirez et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Ferroptosis, necroptosis, and pyroptosis in anticancer immunity

(2020) Rong Tang et al.   Journal of Hematology & Oncology

Ferroptosis: machinery and regulation

(2020) Xin Chen et al.   Autophagy

Specific-oxygen-supply functionalized core-shell nanoparticles for smart mutual-promotion between photodynamic therapy and gambogic acid-induced chemotherapy

(2020) Lingfei Han et al.   BIOMATERIALS

Programming cell pyroptosis with biomimetic nanoparticles for solid tumor immunotherapy

(2020) Pengfei Zhao et al.   BIOMATERIALS

Hierarchically constructed selenium-doped bone-mimetic nanoparticles promote ROS-mediated autophagy and apoptosis for bone tumor inhibition

(2020) Xiao Li et al.   BIOMATERIALS

RIP1 Kinase Drives Macrophage-Mediated Adaptive Immune Tolerance in Pancreatic Cancer

(2020) Wei Wang et al.   CANCER CELL

Hydroxychloroquine-loaded hollow mesoporous silica nanoparticles for enhanced autophagy inhibition and radiation therapy

(2020) Yan Li et al.   JOURNAL OF CONTROLLED RELEASE

PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis

(2020) Junwei Hou et al.   NATURE CELL BIOLOGY

Artemisinins as Anticancer Drugs: Novel Therapeutic Approaches, Molecular Mechanisms, and Clinical Trials

(2020) Cangcang Xu et al.   Frontiers in Pharmacology

Epigenetic reprogramming of epithelial-mesenchymal transition promotes ferroptosis of head and neck cancer

(2020) Jaewang Lee et al.   Redox Biology

Anti-glioblastoma Activity of Kaempferol via Programmed Cell Death Induction: Involvement of Autophagy and Pyroptosis

(2020) Suqin Chen et al.   Frontiers in Bioengineering and Biotechnology

Indirubin-3′-monoxime induces paraptosis in MDA-MB-231 breast cancer cells by transmitting Ca2+ from endoplasmic reticulum to mitochondria

(2020) Matharage Gayani Dilshara et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Nanolongan with Multiple On-Demand Conversions for Ferroptosis–Apoptosis Combined Anticancer Therapy

(2019) Weier Bao et al.   ACS Nano

The relationship between autophagy and the immune system and its applications for tumor immunotherapy

(2019) Guan-Min Jiang et al.   Molecular Cancer

Ferroptosis, a new form of cell death: opportunities and challenges in cancer

(2019) Yanhua Mou et al.   Journal of Hematology & Oncology

δ‐Tocotrienol induces apoptosis, involving endoplasmic reticulum stress and autophagy, and paraptosis in prostate cancer cells

(2019) Fabrizio Fontana et al.   CELL PROLIFERATION

Targeting autophagy using natural compounds for cancer prevention and therapy

(2019) Shuo Deng et al.   CANCER

Multifunctional nanoplatform for photoacoustic imaging-guided combined therapy enhanced by CO induced ferroptosis

(2019) Xianxian Yao et al.   BIOMATERIALS

Chemotherapeutic paclitaxel and cisplatin differentially induce pyroptosis in A549 lung cancer cells via caspase-3/GSDME activation

(2019) Cheng-cheng Zhang et al.   APOPTOSIS

Coordinatively Unsaturated Fe3+ Based Activable Probes for Enhanced MRI and Therapy of Tumors

(2019) Peisen Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Melanin-like nanoparticles decorated with an autophagy-inducing peptide for efficient targeted photothermal therapy

(2019) Zhengjie Zhou et al.   BIOMATERIALS

Metformin induces human esophageal carcinoma cell pyroptosis by targeting the miR-497/PELP1 axis

(2019) Lu Wang et al.   CANCER LETTERS

Artemisinin compounds sensitize cancer cells to ferroptosis by regulating iron homeostasis

(2019) Guo-Qing Chen et al.   CELL DEATH AND DIFFERENTIATION

Celastrol mediates autophagy and apoptosis via the ROS/JNK and Akt/mTOR signaling pathways in glioma cells

(2019) Xihong Liu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Autophagy-related 7 modulates tumor progression in triple-negative breast cancer

(2019) Mingyang Li et al.   LABORATORY INVESTIGATION

CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy

(2019) Weimin Wang et al.   NATURE

Actively priming autophagic cell death with novel transferrin receptor-targeted nanomedicine for synergistic chemotherapy against breast cancer

(2019) Dong Mei et al.   Acta Pharmaceutica Sinica B

Boosting the Ferroptotic Antitumor Efficacy via Site-specific Amplification of Tailored Lipid Peroxidation

(2019) Yang An et al.   ACS Applied Materials & Interfaces

In Situ Manipulation of Dendritic Cells by an Autophagy-Regulative Nanoactivator Enables Effective Cancer Immunotherapy

(2019) Yi Wang et al.   ACS Nano

Aspirin induces oncosis in tumor cells

(2019) Lu Wang et al.   APOPTOSIS

Myricetin Loaded Solid Lipid Nanoparticles Upregulate MLKL and RIPK3 in Human Lung Adenocarcinoma

(2019) Layasadat Khorsandi et al.   International Journal of Peptide Research and Therapeutics

Intercellular interaction dictates cancer cell ferroptosis via NF2–YAP signalling

(2019) Jiao Wu et al.   NATURE

BET inhibitor JQ1 suppresses cell proliferation via inducing autophagy and activating LKB1/AMPK in bladder cancer cells

(2019) Feng Li et al.   Cancer Medicine

Intratumoral activation of the necroptotic pathway components RIPK1 and RIPK3 potentiates antitumor immunity

(2019) Annelise G. Snyder et al.   Science Immunology

BHQ-Cyanine Based “Off-On” Long-Circulating Assembly as Ferroptosis Amplifier for Cancer Treatment: a Lipid-Peroxidation Burst Device

(2019) Mangmang Sang et al.   ACS Applied Materials & Interfaces

Plumbagin induces paraptosis in cancer cells by disrupting the sulfhydryl homeostasis and proteasomal function

(2019) Anupama Binoy et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Fe2+/Fe3+ Ions Chelated with Ultrasmall Polydopamine Nanoparticles Induce Ferroptosis for Cancer Therapy

(2019) Lu Chen et al.   ACS Biomaterials-Science & Engineering

Induction of Pyroptosis and Its Implications in Cancer Management

(2019) Yan-Yang Wang et al.   Frontiers in Oncology

Programmed Release of Dihydroartemisinin for Synergistic Cancer Therapy Using a CaCO3 Mineralized Metal-Organic Framework

(2019) Xiuyan Wan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Small-molecule compounds target paraptosis to improve cancer therapy

(2019) Yujia Wang et al.   BIOMEDICINE & PHARMACOTHERAPY

Targeted exosome‐encapsulated erastin induced ferroptosis in triple negative breast cancer cells

(2019) Mengyu Yu et al.   CANCER SCIENCE

Metal–Phenolic Network-Based Nanocomplexes that Evoke Ferroptosis by Apoptosis: Promoted Nuclear Drug Influx and Reversed Drug Resistance of Cancer

(2019) Yuxin Guo et al.   CHEMISTRY OF MATERIALS

Metal-organic framework-based nanomaterials for biomedical applications

(2019) Shu Zhang et al.   CHINESE CHEMICAL LETTERS

Epigenetics-Based Tumor Cells Pyroptosis for Enhancing the Immunological Effect of Chemotherapeutic Nanocarriers

(2019) Jin-Xuan Fan et al.   NANO LETTERS

Triggered All-Active Metal Organic Framework: Ferroptosis Machinery Contributes to the Apoptotic Photodynamic Antitumor Therapy

(2019) Xuan Meng et al.   NANO LETTERS

Aggregable Nanoparticles-Enabled Chemotherapy and Autophagy Inhibition Combined with Anti-PD-L1 Antibody for Improved Glioma Treatment

(2019) Shaobo Ruan et al.   NANO LETTERS

FSP1 is a glutathione-independent ferroptosis suppressor

(2019) Sebastian Doll et al.   NATURE

Caspase-8 is the molecular switch for apoptosis, necroptosis and pyroptosis

(2019) Melanie Fritsch et al.   NATURE

Molecular Insights into the Mechanism of Necroptosis: The Necrosome as a Potential Therapeutic Target

(2019) Jing Chen et al.   Cells

Triggered ferroptotic polymer micelles for reversing multidrug resistance to chemotherapy

(2019) Min Gao et al.   BIOMATERIALS

Dual GSH-exhausting sorafenib loaded manganese-silica nanodrugs for inducing the ferroptosis of hepatocellular carcinoma cells

(2019) Hongxia Tang et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Versatile cationic liposomes for RIP3 overexpression in colon cancer therapy and RIP3 downregulation in acute pancreatitis therapy

(2019) Lijing Zhang et al.   JOURNAL OF DRUG TARGETING

MOF Nanoparticles with Encapsulated Autophagy Inhibitor in Controlled Drug Delivery System for Antitumor

(2018) Xuerui Chen et al.   ACS Applied Materials & Interfaces

Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion

(2018) Mario Mauthe et al.   Autophagy

Oncosis-like cell death is induced by berberine through ERK1/2-mediated impairment of mitochondrial aerobic respiration in gliomas

(2018) Yuxue Sun et al.   BIOMEDICINE & PHARMACOTHERAPY

Non-apoptotic cell death in malignant tumor cells and natural compounds

(2018) Jing Ye et al.   CANCER LETTERS

CISD2 inhibition overcomes resistance to sulfasalazine-induced ferroptotic cell death in head and neck cancer

(2018) Eun Hye Kim et al.   CANCER LETTERS

Necroptosis of tumor cells leads to tumor necrosis and promotes tumor metastasis

(2018) Delong Jiao et al.   CELL RESEARCH

Simvastatin Suppresses Proliferation and Migration in Non-small Cell Lung Cancer via Pyroptosis

(2018) Fengjiao Wang et al.   International Journal of Biological Sciences

Curcumin regulates proliferation, autophagy, and apoptosis in gastric cancer cells by affecting PI3K and P53 signaling

(2018) Hongbing Fu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Metformin induces autophagy and G0/G1 phase cell cycle arrest in myeloma by targeting the AMPK/mTORC1 and mTORC2 pathways

(2018) Yan Wang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Programmed necrosis in heart disease: Molecular mechanisms and clinical implications

(2018) Hong Zhu et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Enzymatic Self-Assembly Confers Exceptionally Strong Synergism with NF-κB Targeting for Selective Necroptosis of Cancer Cells

(2018) Jie Zhou et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ferroptosis-Induced Endoplasmic Reticulum Stress: Cross-talk between Ferroptosis and Apoptosis

(2018) Young-Sun Lee et al.   MOLECULAR CANCER RESEARCH

FINO2 initiates ferroptosis through GPX4 inactivation and iron oxidation

(2018) Michael M. Gaschler et al.   Nature Chemical Biology

Paraptosis-Inducing Nanomedicine Overcomes Cancer Drug Resistance for a Potent Cancer Therapy

(2018) Yongcun Zhou et al.   Small

Paraptosis in human glioblastoma cell line induced by curcumin

(2018) Monika Garrido-Armas et al.   TOXICOLOGY IN VITRO

Modeling the effects of lipid peroxidation during ferroptosis on membrane properties

(2018) Eran Agmon et al.   Scientific Reports

Sarcoma-Targeting Peptide-Decorated Polypeptide Nanogel Intracellularly Delivers Shikonin for Upregulated Osteosarcoma Necroptosis and Diminished Pulmonary Metastasis

(2018) Suoyuan Li et al.   Theranostics

Unsolved mysteries: How does lipid peroxidation cause ferroptosis?

(2018) Huizhong Feng et al.   PLOS BIOLOGY

Exploitation of Apoptotic Regulation in Cancer

(2018) David S. Ucker et al.   Frontiers in Immunology

Role of GPX4 in ferroptosis and its pharmacological implication

(2018) Tobias M. Seibt et al.   FREE RADICAL BIOLOGY AND MEDICINE

Disulfiram Copper Nanoparticles Prepared with a Stabilized Metal Ion Ligand Complex Method for Treating Drug-Resistant Prostate Cancers

(2018) Wu Chen et al.   ACS Applied Materials & Interfaces

Fenton-Reaction-Acceleratable Magnetic Nanoparticles for Ferroptosis Therapy of Orthotopic Brain Tumors

(2018) Zheyu Shen et al.   ACS Nano

Arginine-Rich Manganese Silicate Nanobubbles as a Ferroptosis-Inducing Agent for Tumor-Targeted Theranostics

(2018) Shuaifei Wang et al.   ACS Nano

Ferrous-Supply-Regeneration Nanoengineering for Cancer-Cell-Specific Ferroptosis in Combination with Imaging-Guided Photodynamic Therapy

(2018) Tao Liu et al.   ACS Nano

A thiopyran derivative with low murine toxicity with therapeutic potential on lung cancer acting through a NF-κB mediated apoptosis-to-pyroptosis switch

(2018) Liping Chen et al.   APOPTOSIS

Artesunate alleviates liver fibrosis by regulating ferroptosis signaling pathway

(2018) Zhaoyan Kong et al.   BIOMEDICINE & PHARMACOTHERAPY

Tom20 senses iron-activated ROS signaling to promote melanoma cell pyroptosis 

(2018) Bo Zhou et al.   CELL RESEARCH

RSL3 Drives Ferroptosis Through GPX4 Inactivation and ROS Production in Colorectal Cancer

(2018) Xinbing Sui et al.   Frontiers in Pharmacology

Low-density lipoprotein docosahexaenoic acid nanoparticles induce ferroptotic cell death in hepatocellular carcinoma

(2017) Weijun Ou et al.   FREE RADICAL BIOLOGY AND MEDICINE

Regression of apoptosis-resistant colorectal tumors by induction of necroptosis in mice

(2017) Gui-Wei He et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Shikonin-induced necroptosis is enhanced by the inhibition of autophagy in non-small cell lung cancer cells

(2017) Hyo-Jin Kim et al.   Journal of Translational Medicine

Autophagy: The spotlight for cellular stress responses

(2017) Palaniyandi Ravanan et al.   LIFE SCIENCES

Nanoparticle Delivery of Artesunate Enhances the Anti-tumor Efficiency by Activating Mitochondria-Mediated Cell Apoptosis

(2017) Rui Liu et al.   Nanoscale Research Letters

AMPK: guardian of metabolism and mitochondrial homeostasis

(2017) Sébastien Herzig et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death

(2017) Jianjin Shi et al.   TRENDS IN BIOCHEMICAL SCIENCES

Silver nanoparticles of different sizes induce a mixed type of programmed cell death in human pancreatic ductal adenocarcinoma

(2017) Ewelina Zielinska et al.   Oncotarget

Biogenic selenium nanoparticles induce ROS-mediated necroptosis in PC-3 cancer cells through TNF activation

(2017) Praveen Sonkusre et al.   JOURNAL OF NANOBIOTECHNOLOGY

Nanoparticle Delivery of Artesunate Enhances the Anti-tumor Efficiency by Activating Mitochondria-Mediated Cell Apoptosis

(2017) Rui Liu et al.   Nanoscale Research Letters

Titania-Coated Gold Nano-Bipyramids for Blocking Autophagy Flux and Sensitizing Cancer Cells to Proteasome Inhibitor-Induced Death

(2017) Hong-Ye Wan et al.   Advanced Science

Nrf2 inhibition reverses the resistance of cisplatin-resistant head and neck cancer cells to artesunate-induced ferroptosis

(2017) Jong-Lyel Roh et al.   Redox Biology

Nanoceria-Mediated Drug Delivery for Targeted Photodynamic Therapy on Drug-Resistant Breast Cancer

(2016) Hong Li et al.   ACS Applied Materials & Interfaces

Ultrasound-Induced Reactive Oxygen Species Mediated Therapy and Imaging Using a Fenton Reaction Activable Polymersome

(2016) Wei-Peng Li et al.   ACS Nano

Azo polymeric micelles designed for colon-targeted dimethyl fumarate delivery for colon cancer therapy

(2016) Zhen-Gang Ma et al.   Acta Biomaterialia

Autophagy promotes ferroptosis by degradation of ferritin

(2016) Wen Hou et al.   Autophagy

Autophagy, Inflammation, and Immunity: A Troika Governing Cancer and Its Treatment

(2016) Zhenyu Zhong et al.   CELL

Cancer therapy in the necroptosis era

(2016) Z Su et al.   CELL DEATH AND DIFFERENTIATION

Activation of cell-surface proteases promotes necroptosis, inflammation and cell migration

(2016) Zhenyu Cai et al.   CELL RESEARCH

Pyroptosis is driven by non-selective gasdermin-D pore and its morphology is different from MLKL channel-mediated necroptosis

(2016) Xin Chen et al.   CELL RESEARCH

Pyroptosis

(2016) Lieselotte Vande Walle et al.   CURRENT BIOLOGY

Iron Oxide Nanoparticles Induce Autophagosome Accumulation through Multiple Mechanisms: Lysosome Impairment, Mitochondrial Damage, and ER Stress

(2016) Xudong Zhang et al.   MOLECULAR PHARMACEUTICS

The necrosome promotes pancreatic oncogenesis via CXCL1 and Mincle-induced immune suppression

(2016) Lena Seifert et al.   NATURE

Pore-forming activity and structural autoinhibition of the gasdermin family

(2016) Jingjin Ding et al.   NATURE

NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux

(2016) Yuan He et al.   NATURE

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

(2016) Sebastian Doll et al.   Nature Chemical Biology

Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis

(2016) Kenichi Shimada et al.   Nature Chemical Biology

Ultrasmall nanoparticles induce ferroptosis in nutrient-deprived cancer cells and suppress tumour growth

(2016) Sung Eun Kim et al.   Nature Nanotechnology

Paraptosis in the anti-cancer arsenal of natural products

(2016) Dongjoo Lee et al.   PHARMACOLOGY & THERAPEUTICS

pH-Sensitive Polymeric Nanoparticles Modulate Autophagic Effect via Lysosome Impairment

(2016) Yao-Xin Lin et al.   Small

Nanomaterial and toxicity: what can proteomics tell us about the nanotoxicology?

(2016) Dijendra Nath Roy et al.   XENOBIOTICA

Autophagy Promotes Focal Adhesion Disassembly and Cell Motility of Metastatic Tumor Cells through the Direct Interaction of Paxillin with LC3

(2016) Marina N. Sharifi et al.   Cell Reports

Dehydroabietic Acid Derivative QC4 Induces Gastric Cancer Cell Death via Oncosis and Apoptosis

(2016) Dongjun Luo et al.   Biomed Research International

Elaiophylin, a novel autophagy inhibitor, exerts antitumor activity as a single agent in ovarian cancer cells

(2015) Xuejiao Zhao et al.   Autophagy

Synergism through combination of chemotherapy and oxidative stress-induced autophagy in A549 lung cancer cells using redox-responsive nanohybrids: A new strategy for cancer therapy

(2015) Hsin-Yi Lu et al.   BIOMATERIALS

Dimethyl fumarate induces necroptosis in colon cancer cells through GSH depletion/ROS increase/MAPKs activation pathway

(2015) Xin Xie et al.   BRITISH JOURNAL OF PHARMACOLOGY

Activation of the p62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells

(2015) Xiaofang Sun et al.   HEPATOLOGY

mTOR: a pharmacologic target for autophagy regulation

(2015) Young Chul Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Cationic polystyrene nanospheres induce autophagic cell death through the induction of endoplasmic reticulum stress

(2015) Hui-Wen Chiu et al.   Nanoscale

RIPK1 and NF- B signaling in dying cells determines cross-priming of CD8+ T cells

(2015) N. Yatim et al.   SCIENCE

pH-Triggered burst intracellular release from hollow microspheres to induce autophagic cancer cell death

(2015) Xin Liang et al.   Journal of Materials Chemistry B

Design of magnetic nanoparticles for hepatocellular carcinoma treatment using the control mechanisms of the cell internal nucleus and external membrane

(2015) Xiuyu Zhan et al.   Journal of Materials Chemistry B

The natural compound oblongifolin C inhibits autophagic flux and enhances antitumor efficacy of nutrient deprivation

(2014) Yuanzhi Lao et al.   Autophagy

Two death pathways induced by sorafenib in myeloma cells: Puma-mediated apoptosis and necroptosis

(2014) A. Ramírez-Labrada et al.   Clinical & Translational Oncology

Autophagic Cell Death and Cancer

(2014) Shigeomi Shimizu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Artesunate induces necrotic cell death in schwannoma cells

(2014) R W Button et al.   Cell Death & Disease

Harnessing the lysosome-dependent antitumor activity of phenothiazines in human small cell lung cancer

(2014) D Zong et al.   Cell Death & Disease

Pharmacological inhibition of cystine–glutamate exchange induces endoplasmic reticulum stress and ferroptosis

(2014) Scott J Dixon et al.   eLife

Lysosomal Membrane Permeabilization by Targeted Magnetic Nanoparticles in Alternating Magnetic Fields

(2013) Maribella Domenech et al.   ACS Nano

Fluopsin C induces oncosis of human breast adenocarcinoma cells

(2013) Li-sha Ma et al.   ACTA PHARMACOLOGICA SINICA

The anti-tumor effect of shikonin on osteosarcoma by inducing RIP1 and RIP3 dependent necroptosis

(2013) Zeze Fu et al.   BMC CANCER

Lysosomal cell death at a glance

(2013) S. Aits et al.   JOURNAL OF CELL SCIENCE

ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase

(2013) Ryan C. Russell et al.   NATURE CELL BIOLOGY

Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis

(2013) Zhenyu Cai et al.   NATURE CELL BIOLOGY

Skeletal muscle autophagy: a new metabolic regulator

(2013) Brian A. Neel et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Paradoxical roles of autophagy in different stages of tumorigenesis: protector for normal or cancer cells

(2013) Kai Sun et al.   Cell and Bioscience

Viral modulation of programmed necrosis

(2013) William J Kaiser et al.   Current Opinion in Virology

Andrographolide sensitizes cisplatin-induced apoptosis via suppression of autophagosome-lysosome fusion in human cancer cells

(2012) Jing Zhou et al.   Autophagy

Induction of autophagic cell death of glioma-initiating cells by cell-penetrating d-isomer peptides consisting of Pas and the p53 C-terminus

(2012) Yutaka Ueda et al.   BIOMATERIALS

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

The RIP1/RIP3 Necrosome Forms a Functional Amyloid Signaling Complex Required for Programmed Necrosis

(2012) Jixi Li et al.   CELL

Oncosis: An important non-apoptotic mode of cell death

(2012) Priya Weerasinghe et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Antitumor Effects of Rapamycin in Pancreatic Cancer Cells by Inducing Apoptosis and Autophagy

(2012) Zhi-Jun Dai et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Induction of ROS, mitochondrial damage and autophagy in lung epithelial cancer cells by iron oxide nanoparticles

(2011) Mohd Imran Khan et al.   BIOMATERIALS

Deciphering the rules of programmed cell death to improve therapy of cancer and other diseases

(2011) Andreas Strasser et al.   EMBO JOURNAL

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Toll-like receptors activate programmed necrosis in macrophages through a receptor-interacting kinase-3-mediated pathway

(2011) S. He et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ginsenoside Rh2 induces apoptosis and paraptosis-like cell death in colorectal cancer cells through activation of p53

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