Prodrug-Based Versatile Nanomedicine with Simultaneous Physical and Physiological Tumor Penetration for Enhanced Cancer Chemo-Immunotherapy

Helix Self-Assembly Behavior of Amino Acid-Modified Camptothecin Prodrugs and Its Antitumor Effect

(2020) Zhaopei Guo et al.   ACS Applied Materials & Interfaces

Supramolecular prodrug hydrogelator as an immune booster for checkpoint blocker–based immunotherapy

(2020) Feihu Wang et al.   Science Advances

Supramolecular Tubustecan Hydrogel as Chemotherapeutic Carrier to Improve Tumor Penetration and Local Treatment Efficacy

(2020) Feihu Wang et al.   ACS Nano

Tumour sensitization via the extended intratumoural release of a STING agonist and camptothecin from a self-assembled hydrogel

(2020) Feihu Wang et al.   Nature Biomedical Engineering

An immune cocktail therapy to realize multiple boosting of the cancer-immunity cycle by combination of drug/gene delivery nanoparticles

(2020) Jiayan Wu et al.   Science Advances

DNA-mediated coordinative assembly of upconversion hetero-nanostructures for targeted dual-modality imaging of cancer cells

(2019) Wenting Xue et al.   CHINESE CHEMICAL LETTERS

Dual Functional Immunostimulatory Polymeric Prodrug Carrier with Pendent Indoximod for Enhanced Cancer Immunochemotherapy

(2019) Zhuoya Wan et al.   Acta Biomaterialia

Regulation of programmed death‐ligand 1 expression in response to DNA damage in cancer cells: Implications for precision medicine

(2019) Hiro Sato et al.   CANCER SCIENCE

Galactose-modified enzymatic synthesis of poly(amino-co-ester) micelles for co-delivery miR122 and sorafenib to inhibit hepatocellular carcinoma development

(2019) Jianhua Xie et al.   CHINESE CHEMICAL LETTERS

Macrocyclization of a Class of Camptothecin Analogues into Tubular Supramolecular Polymers

(2019) Hao Su et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Dynamic covalent chemistry-regulated stimuli-activatable drug delivery systems for improved cancer therapy

(2019) Qiwen Zhu et al.   CHINESE CHEMICAL LETTERS

Deciphering the impact of PEG antifouling layer on surface attached functional peptides in regulating cell behaviors

(2019) Fu-Jian Xu   CHINESE CHEMICAL LETTERS

Highly enhanced cancer immunotherapy by combining nanovaccine with hyaluronidase

(2018) Xiuwen Guan et al.   BIOMATERIALS

Morphology control of self-deliverable nanodrug with enhanced anticancer efficiency

(2018) Si-Yong Qin et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Combination of fucoidan-based magnetic nanoparticles and immunomodulators enhances tumour-localized immunotherapy

(2018) Chih-Sheng Chiang et al.   Nature Nanotechnology

Synergistic and low adverse effect cancer immunotherapy by immunogenic chemotherapy and locally expressed PD-L1 trap

(2018) Wantong Song et al.   Nature Communications

Trapping of Lipopolysaccharide to Promote Immunotherapy against Colorectal Cancer and Attenuate Liver Metastasis

(2018) Wantong Song et al.   ADVANCED MATERIALS

Efficient PD-L1 gene silence promoted by hyaluronidase for cancer immunotherapy

(2018) Xiuwen Guan et al.   JOURNAL OF CONTROLLED RELEASE

DNA double-strand break repair pathway regulates PD-L1 expression in cancer cells

(2017) Hiro Sato et al.   Nature Communications

Nanocarriers in advanced drug targeting: setting novel paradigm in cancer therapeutics

(2017) Md. Habban Akhter et al.   Artificial Cells Nanomedicine and Biotechnology

Hyaluronidase To Enhance Nanoparticle-Based Photodynamic Tumor Therapy

(2016) Hua Gong et al.   NANO LETTERS

Hyaluronidase Embedded in Nanocarrier PEG Shell for Enhanced Tumor Penetration and Highly Efficient Antitumor Efficacy

(2016) Hao Zhou et al.   NANO LETTERS

Breaching the Hyaluronan Barrier with PH20-Fc Facilitates Intratumoral Permeation and Enhances Antitumor Efficiency: A Comparative Investigation of Typical Therapeutic Agents in Different Nanoscales

(2016) Shan Liu et al.   Advanced Healthcare Materials

Ovarian Cancer Immunotherapy Using PD-L1 siRNA Targeted Delivery from Folic Acid-Functionalized Polyethylenimine: Strategies to Enhance T Cell Killing

(2015) Pei Yun Teo et al.   Advanced Healthcare Materials

Overview of Methods for Overcoming Hindrance to Drug Delivery to Tumors, with Special Attention to Tumor Interstitial Fluid

(2015) Gianfranco Baronzio et al.   Frontiers in Oncology

Margination of micro- and nano-particles in blood flow and its effect on drug delivery

(2014) Kathrin Müller et al.   Scientific Reports

Improving dendritic cell vaccine immunogenicity by silencing PD-1 ligands using siRNA-lipid nanoparticles combined with antigen mRNA electroporation

(2012) Willemijn Hobo et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer

(2012) Michael A Jacobetz et al.   GUT

Safety, Activity, and Immune Correlates of Anti–PD-1 Antibody in Cancer

(2012) Suzanne L. Topalian et al.   NEW ENGLAND JOURNAL OF MEDICINE

siRNA silencing of PD-L1 and PD-L2 on dendritic cells augments expansion and function of minor histocompatibility antigen-specific CD8+ T cells

(2010) W. Hobo et al.   BLOOD

Extracellular Matrix Molecules: Potential Targets in Pharmacotherapy

(2009) H. Jarvelainen et al.   PHARMACOLOGICAL REVIEWS