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Title
Gasdermin D in pyroptosis
Authors
Keywords
Pyroptosis, Inflammasome, Caspase, Gasdermin, Sepsis, Inflammation, Pathogen-associated molecular patterns (PAMPs), Damage-associated molecular patterns (DAMPs)
Journal
Acta Pharmaceutica Sinica B
Volume -, Issue -, Pages -
Publisher
Elsevier BV
Online
2021-04-28
DOI
10.1016/j.apsb.2021.02.006
References
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Note: Only part of the references are listed.- Structural Mechanism for GSDMD Targeting by Autoprocessed Caspases in Pyroptosis
- (2020) Kun Wang et al. CELL
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- (2020) Laxman Ghimire et al. Mucosal Immunology
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- (2020) Hui Zhang et al. Cell Host & Microbe
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- (2020) Robin Schwarzer et al. IMMUNITY
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- (2020) Long Shuang Huang et al. IMMUNITY
- NLRP6 inflammasome
- (2020) Runzhi Li et al. MOLECULAR ASPECTS OF MEDICINE
- Gasdermin E suppresses tumour growth by activating anti-tumour immunity
- (2020) Zhibin Zhang et al. NATURE
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- (2020) Jun Jacob Hu et al. NATURE IMMUNOLOGY
- Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells
- (2020) Zhiwei Zhou et al. SCIENCE
- Blocking GSDMD processing in innate immune cells but not in hepatocytes protects hepatic ischemia–reperfusion injury
- (2020) Jichang Li et al. Cell Death & Disease
- The role of lysosome in regulated necrosis
- (2020) Aqu Alu et al. Acta Pharmaceutica Sinica B
- Miltirone induces cell death in hepatocellular carcinoma cell through GSDME-dependent pyroptosis
- (2020) Xiaowei Zhang et al. Acta Pharmaceutica Sinica B
- NLRP12 in innate immunity and inflammation
- (2020) Shraddha Tuladhar et al. MOLECULAR ASPECTS OF MEDICINE
- Succination inactivates gasdermin D and blocks pyroptosis
- (2020) Fiachra Humphries et al. SCIENCE
- DPP8/9 inhibitors activate the CARD8 inflammasome in resting lymphocytes
- (2020) Darren C. Johnson et al. Cell Death & Disease
- Cardamonin from a medicinal herb protects against LPS-induced septic shock by suppressing NLRP3 inflammasome
- (2019) Zhilei Wang et al. Acta Pharmaceutica Sinica B
- Aspirin alleviates endothelial gap junction dysfunction through inhibition of NLRP3 inflammasome activation in LPS-induced vascular injury
- (2019) Xing Zhou et al. Acta Pharmaceutica Sinica B
- Recent advances in the mechanisms of NLRP3 inflammasome activation and its inhibitors
- (2019) Yang Yang et al. Cell Death & Disease
- Molecular mechanism for NLRP6 inflammasome assembly and activation
- (2019) Chen Shen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- SERPINB1-mediated checkpoint of inflammatory caspase activation
- (2019) Youn Jung Choi et al. NATURE IMMUNOLOGY
- Extrinsic and intrinsic apoptosis activate pannexin‐1 to drive NLRP3 inflammasome assembly
- (2019) Kaiwen W Chen et al. EMBO JOURNAL
- The NLRP3 inflammasome - interleukin 1 pathway as a therapeutic target in gout
- (2019) Zoltán Szekanecz et al. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
- 1007 – Abx464 is Safe and Efficacious in Proof of Concept Study in Ulcerative Colitis Patients
- (2019) Severine Vermeire et al. GASTROENTEROLOGY
- Crystal Structures of the Full-Length Murine and Human Gasdermin D Reveal Mechanisms of Autoinhibition, Lipid Binding, and Oligomerization
- (2019) Zhonghua Liu et al. IMMUNITY
- Inflammasome Activation Triggers Blood Clotting and Host Death through Pyroptosis
- (2019) Congqing Wu et al. IMMUNITY
- MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition
- (2019) Rebecca C. Coll et al. Nature Chemical Biology
- Innate immunity to intracellular LPS
- (2019) Vijay A. K. Rathinam et al. NATURE IMMUNOLOGY
- Pejvakin-mediated pexophagy protects auditory hair cells against noise-induced damage
- (2019) Jean Defourny et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- cAMP metabolism controls caspase-11 inflammasome activation and pyroptosis in sepsis
- (2019) Ruochan Chen et al. Science Advances
- The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation
- (2019) Nathan Kelley et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Structural mechanism for NEK7-licensed activation of NLRP3 inflammasome
- (2019) Humayun Sharif et al. NATURE
- Gasdermin D protects against noninfectious liver injury by regulating apoptosis and necroptosis
- (2019) Chenxuan Yang et al. Cell Death & Disease
- Cathepsin G Inhibition by Serpinb1 and Serpinb6 Prevents Programmed Necrosis in Neutrophils and Monocytes and Reduces GSDMD-Driven Inflammation
- (2019) Sabrina Sofia Burgener et al. Cell Reports
- α-NETA induces pyroptosis of epithelial ovarian cancer cells through the GSDMD/caspase-4 pathway
- (2019) Lianqiao Qiao et al. FASEB JOURNAL
- Omnipresence of inflammasome activities in inflammatory bone diseases
- (2019) Yael Alippe et al. Seminars in Immunopathology
- The Pyrin Inflammasome in Health and Disease
- (2019) Oskar Schnappauf et al. Frontiers in Immunology
- TLR4/NF-κB Signaling Induces GSDMD-Related Pyroptosis in Tubular Cells in Diabetic Kidney Disease
- (2019) Youliang Wang et al. Frontiers in Endocrinology
- Pyrin dephosphorylation is sufficient to trigger inflammasome activation in familial Mediterranean fever patients
- (2019) Flora Magnotti et al. EMBO Molecular Medicine
- Gasdermin D Drives the Nonexosomal Secretion of Galectin-3, an Insulin Signal Antagonist
- (2019) Yihui Chen et al. JOURNAL OF IMMUNOLOGY
- Activity of caspase-8 determines plasticity between cell death pathways
- (2019) Kim Newton et al. NATURE
- Emerging Activators and Regulators of Inflammasomes and Pyroptosis
- (2019) Yansong Xue et al. TRENDS IN IMMUNOLOGY
- Pyroptosis: A new frontier in cancer
- (2019) Yuan Fang et al. BIOMEDICINE & PHARMACOTHERAPY
- Inflammasome-mediated innate immunity in Alzheimer’s disease
- (2019) Carmen Venegas et al. FASEB JOURNAL
- Bacterial Endotoxin Activates the Coagulation Cascade through Gasdermin D-Dependent Phosphatidylserine Exposure
- (2019) Xinyu Yang et al. IMMUNITY
- NEK7 interacts with NLRP3 to modulate the pyroptosis in inflammatory bowel disease via NF-κB signaling
- (2019) Xueliang Chen et al. Cell Death & Disease
- AIM2 accelerates the atherosclerotic plaque progressions in ApoE−/− mice
- (2018) Jinyu Pan et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Single-cell analysis of pyroptosis dynamics reveals conserved GSDMD-mediated subcellular events that precede plasma membrane rupture
- (2018) Nathalia M. de Vasconcelos et al. CELL DEATH AND DIFFERENTIATION
- Lipid Peroxidation Drives Gasdermin D-Mediated Pyroptosis in Lethal Polymicrobial Sepsis
- (2018) Rui Kang et al. Cell Host & Microbe
- The Gasdermin-D pore acts as a conduit for IL-1β secretion in mice
- (2018) Rosalie Heilig et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- The Pore-Forming Protein Gasdermin D Regulates Interleukin-1 Secretion from Living Macrophages
- (2018) Charles L. Evavold et al. IMMUNITY
- Downregulation of gasdermin D promotes gastric cancer proliferation by regulating cell cycle-related proteins
- (2018) Wei Jie Wang et al. Journal of Digestive Diseases
- Gasdermin D plays a key role as a pyroptosis executor of non-alcoholic steatohepatitis in humans and mice
- (2018) Bing Xu et al. JOURNAL OF HEPATOLOGY
- Mechanisms of Gasdermin Family Members in Inflammasome Signaling and Cell Death
- (2018) Shouya Feng et al. JOURNAL OF MOLECULAR BIOLOGY
- Mechanism of gasdermin D recognition by inflammatory caspases and their inhibition by a gasdermin D-derived peptide inhibitor
- (2018) Jie Yang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Gasdermin D Exerts Anti-inflammatory Effects by Promoting Neutrophil Death
- (2018) Hiroto Kambara et al. Cell Reports
- Inflammatory caspase-related pyroptosis: mechanism, regulation and therapeutic potential for inflammatory bowel disease
- (2018) Yuan-Yuan Yuan et al. Gastroenterology Report
- Ion Man: GSDMD Punches Pores to Knock Out cGAS
- (2018) Rebecca Feltham et al. IMMUNITY
- Gasdermin D Restrains Type I Interferon Response to Cytosolic DNA by Disrupting Ionic Homeostasis
- (2018) Ishita Banerjee et al. IMMUNITY
- Caspase-11 auto-proteolysis is crucial for noncanonical inflammasome activation
- (2018) Bettina L. Lee et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Cryo-EM structure of the gasdermin A3 membrane pore
- (2018) Jianbin Ruan et al. NATURE
- Caspase-1 inhibition alleviates cognitive impairment and neuropathology in an Alzheimer’s disease mouse model
- (2018) Joseph Flores et al. Nature Communications
- PtdIns4P on dispersed trans-Golgi network mediates NLRP3 inflammasome activation
- (2018) Jueqi Chen et al. NATURE
- Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during Yersinia infection
- (2018) Joseph Sarhan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Pathogen blockade of TAK1 triggers caspase-8–dependent cleavage of gasdermin D and cell death
- (2018) Pontus Orning et al. SCIENCE
- ESCRT-dependent membrane repair negatively regulates pyroptosis downstream of GSDMD activation
- (2018) Sebastian Rühl et al. SCIENCE
- Gasdermin D mediates the pathogenesis of neonatal-onset multisystem inflammatory disease in mice
- (2018) Jianqiu Xiao et al. PLOS BIOLOGY
- The NLRC4 Inflammasome
- (2017) Joseph A. Duncan et al. IMMUNOLOGICAL REVIEWS
- Enterovirus 71 Inhibits Pyroptosis through Cleavage of Gasdermin D
- (2017) Xiaobo Lei et al. JOURNAL OF VIROLOGY
- Alcohol-abuse drug disulfiram targets cancer via p97 segregase adaptor NPL4
- (2017) Zdenek Skrott et al. NATURE
- Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin
- (2017) Yupeng Wang et al. NATURE
- Gene polymorphism linked to increased asthma and IBD risk alters gasdermin-B structure, a sulfatide and phosphoinositide binding protein
- (2017) Kinlin L. Chao et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structure insight of GSDMD reveals the basis of GSDMD autoinhibition in cell pyroptosis
- (2017) Siyun Kuang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death
- (2017) Corey Rogers et al. Nature Communications
- β-Hydroxybutyrate Deactivates Neutrophil NLRP3 Inflammasome to Relieve Gout Flares
- (2017) Emily L. Goldberg et al. Cell Reports
- Cell death is not essential for caspase-1-mediated interleukin-1β activation and secretion
- (2016) S A Conos et al. CELL DEATH AND DIFFERENTIATION
- IL-18 Production from the NLRP1 Inflammasome Prevents Obesity and Metabolic Syndrome
- (2016) Andrew J. Murphy et al. Cell Metabolism
- The intersection of cell death and inflammasome activation
- (2016) James E. Vince et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death
- (2016) Lorenzo Sborgi et al. EMBO JOURNAL
- Inhibition of NLRP3 Inflammasome Prevents LPS-Induced Inflammatory Hyperalgesia in Mice: Contribution of NF-κB, Caspase-1/11, ASC, NOX, and NOS Isoforms
- (2016) Abdurrahman Dolunay et al. INFLAMMATION
- Pore-forming activity and structural autoinhibition of the gasdermin family
- (2016) Jingjin Ding et al. NATURE
- Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores
- (2016) Xing Liu et al. NATURE
- NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux
- (2016) Yuan He et al. NATURE
- Pyrin inflammasome activation and RhoA signaling in the autoinflammatory diseases FMF and HIDS
- (2016) Yong Hwan Park et al. NATURE IMMUNOLOGY
- Site-specific phosphorylation and microtubule dynamics control Pyrin inflammasome activation
- (2016) Wenqing Gao et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- GsdmD p30 elicited by caspase-11 during pyroptosis forms pores in membranes
- (2016) Robin A. Aglietti et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- An endogenous caspase-11 ligand elicits interleukin-1 release from living dendritic cells
- (2016) Ivan Zanoni et al. SCIENCE
- Identification, Synthesis, and Biological Evaluation of the Major Human Metabolite of NLRP3 Inflammasome Inhibitor MCC950
- (2016) Manohar Salla et al. ACS Medicinal Chemistry Letters
- Gasdermin B expression predicts poor clinical outcome in HER2-positive breast cancer
- (2016) Marta Hergueta-Redondo et al. Oncotarget
- Functional and Evolutionary Analyses Identify Proteolysis as a General Mechanism for NLRP1 Inflammasome Activation
- (2016) Joseph Chavarría-Smith et al. PLoS Pathogens
- Updated Projected Prevalence of Self-Reported Doctor-Diagnosed Arthritis and Arthritis-Attributable Activity Limitation Among US Adults, 2015-2040
- (2016) Jennifer M. Hootman et al. Arthritis & Rheumatology
- Gasdermin C Is Upregulated by Inactivation of Transforming Growth Factor β Receptor Type II in the Presence of Mutated Apc, Promoting Colorectal Cancer Proliferation
- (2016) Masashi Miguchi et al. PLoS One
- Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion
- (2015) Wan-ting He et al. CELL RESEARCH
- Caspase-11 activates a canonical NLRP3 inflammasome by promoting K+efflux
- (2015) Sebastian Rühl et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- AIM2 inflammasome in infection, cancer, and autoimmunity: Role in DNA sensing, inflammation, and innate immunity
- (2015) Si Ming Man et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- The NLRP1 inflammasomes
- (2015) Joseph Chavarría-Smith et al. IMMUNOLOGICAL REVIEWS
- Pyroptotic cell death defends against intracellular pathogens
- (2015) Ine Jorgensen et al. IMMUNOLOGICAL REVIEWS
- Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling
- (2015) Nobuhiko Kayagaki et al. NATURE
- Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death
- (2015) Jianjin Shi et al. NATURE
- NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component
- (2015) Hexin Shi et al. NATURE IMMUNOLOGY
- The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome–mediated inflammatory disease
- (2015) Yun-Hee Youm et al. NATURE MEDICINE
- A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases
- (2015) Rebecca C Coll et al. NATURE MEDICINE
- Caspase-1: an integral regulator of innate immunity
- (2015) Stefan Winkler et al. Seminars in Immunopathology
- WHSC1 Promotes Oncogenesis through Regulation of NIMA-Related Kinase-7 in Squamous Cell Carcinoma of the Head and Neck
- (2014) Vassiliki Saloura et al. MOLECULAR CANCER RESEARCH
- Expression of GSDML Associates with Tumor Progression in Uterine Cervix Cancer
- (2014) Qiao Sun et al. Translational Oncology
- Damage control: cellular mechanisms of plasma membrane repair
- (2014) Norma W. Andrews et al. TRENDS IN CELL BIOLOGY
- Activation of the NLRP1b inflammasome independently of ASC-mediated caspase-1 autoproteolysis and speck formation
- (2014) Nina Van Opdenbosch et al. Nature Communications
- Inflammasome-mediated pyroptotic and apoptotic cell death, and defense against infection
- (2013) Youssef Aachoui et al. CURRENT OPINION IN MICROBIOLOGY
- Role of Nlrp6 and Nlrp12 in the maintenance of intestinal homeostasis
- (2013) Grace Y. Chen EUROPEAN JOURNAL OF IMMUNOLOGY
- Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection
- (2013) Gilad Doitsh et al. NATURE
- Chemical genetics reveals a kinase-independent role for protein kinase R in pyroptosis
- (2013) Erik C Hett et al. Nature Chemical Biology
- TRIF Licenses Caspase-11-Dependent NLRP3 Inflammasome Activation by Gram-Negative Bacteria
- (2012) Vijay A.K. Rathinam et al. CELL
- Regulation of Actin Dynamics by Protein Kinase R Control of Gelsolin Enforces Basal Innate Immune Defense
- (2012) Aaron T. Irving et al. IMMUNITY
- Caspase-11 increases susceptibility to Salmonella infection in the absence of caspase-1
- (2012) Petr Broz et al. NATURE
- A role for the NLRP3 inflammasome in metabolic diseases—did Warburg miss inflammation?
- (2012) Haitao Wen et al. NATURE IMMUNOLOGY
- Anthrax Lethal Factor Cleavage of Nlrp1 Is Required for Activation of the Inflammasome
- (2012) Jonathan L. Levinsohn et al. PLoS Pathogens
- Inhibition of the Plasma-Membrane-Associated Serine Protease Cathepsin G by Mycobacterium tuberculosis Rv3364c Suppresses Caspase-1 and Pyroptosis in Macrophages
- (2012) Lia Danelishvili et al. Frontiers in Microbiology
- Gsdma3 Mutation Causes Bulge Stem Cell Depletion and Alopecia Mediated by Skin Inflammation
- (2011) Yue Zhou et al. AMERICAN JOURNAL OF PATHOLOGY
- Non-canonical inflammasome activation targets caspase-11
- (2011) Nobuhiko Kayagaki et al. NATURE
- The Inflammasomes
- (2010) Kate Schroder et al. CELL
- A Highly Potent and Selective Caspase 1 Inhibitor that Utilizes a Key 3-Cyanopropanoic Acid Moiety
- (2010) Matthew B. Boxer et al. ChemMedChem
- Alu-derived cis-element regulates tumorigenesis-dependent gastric expression of GASDERMIN B (GSDMB)
- (2010) Hiromitsu Komiyama et al. GENES & GENETIC SYSTEMS
- Delineating Immune-Mediated Mechanisms Underlying Hair Follicle Destruction in the Mouse Mutant Defolliculated
- (2010) Fiona Ruge et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria
- (2010) Edward A Miao et al. NATURE IMMUNOLOGY
- AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA
- (2009) Teresa Fernandes-Alnemri et al. NATURE
- AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC
- (2009) Veit Hornung et al. NATURE
- Pyroptosis: host cell death and inflammation
- (2009) Tessa Bergsbaken et al. NATURE REVIEWS MICROBIOLOGY
- HIN-200 Proteins Regulate Caspase Activation in Response to Foreign Cytoplasmic DNA
- (2009) T. L. Roberts et al. SCIENCE
- NOD-like receptors (NLRs): bona fide intracellular microbial sensors
- (2008) Michael H Shaw et al. CURRENT OPINION IN IMMUNOLOGY
- Distinctive expression and function of fourGSDMfamily genes (GSDMA-D) in normal and malignant upper gastrointestinal epithelium
- (2008) Norihisa Saeki et al. GENES CHROMOSOMES & CANCER
- Function of Nod-like receptors in microbial recognition and host defense
- (2008) Luigi Franchi et al. IMMUNOLOGICAL REVIEWS
- A NOD2-NALP1 complex mediates caspase-1-dependent IL-1 secretion in response to Bacillus anthracis infection and muramyl dipeptide
- (2008) L.-C. Hsu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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