Microcrystalline silica particles induce inflammatory response via pyroptosis in primary human respiratory epithelial cells

Long noncoding RNA NEAT1 is involved in the protective effect of Klotho on renal tubular epithelial cells in diabetic kidney disease through the ERK1/2 signaling pathway

(2020) Yan-Lin Yang et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Depression of lncRNA NEAT1 Antagonizes LPS-Evoked Acute Injury and Inflammatory Response in Alveolar Epithelial Cells via HMGB1-RAGE Signaling

(2020) Hongchao Zhou et al.   MEDIATORS OF INFLAMMATION

Exosomes derived from human umbilical cord mesenchymal stem cells ameliorate IL-6-induced acute liver injury through miR-455-3p

(2020) Mingyang Shao et al.   Stem Cell Research & Therapy

Circ_BMP2K enhances the regulation of miR-455-3p on its target gene SUMO1 to inhibit the activation of cardiac fibroblasts

(2020) Lei Zhang et al.   Biochemistry and Cell Biology

LncRNA promoted inflammatory response in ischemic heart failure through regulation of miR-455-3p/TRAF6 axis

(2020) Qianqian Gu et al.   INFLAMMATION RESEARCH

Pro-inflammatory effects of crystalline- and nano-sized non-crystalline silica particles in a 3D alveolar model

(2020) Tonje Skuland et al.   Particle and Fibre Toxicology

Upregulated long noncoding RNA LOC105375913 induces tubulointerstitial fibrosis in focal segmental glomerulosclerosis

(2019) Runhong Han et al.   Scientific Reports

Recent advances in the mechanisms of NLRP3 inflammasome activation and its inhibitors

(2019) Yang Yang et al.   Cell Death & Disease

Mitochondria Permeability Transition versus Necroptosis in Oxalate-Induced AKI

(2019) Shrikant Ramesh Mulay et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

miR-455-3p Alleviates Hepatic Stellate Cell Activation and Liver Fibrosis by Suppressing HSF1 Expression

(2019) Song Wei et al.   Molecular Therapy-Nucleic Acids

Protective effect of bicyclol against pulmonary fibrosis via regulation of microRNA‐455‐3p in rats

(2019) Ying Zhou et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Profiling long non-coding RNA changes in silica-induced pulmonary fibrosis in rat

(2019) Linlin Sai et al.   TOXICOLOGY LETTERS

MiR-326 Inhibits Inflammation and Promotes Autophagy in Silica-Induced Pulmonary Fibrosis through Targeting TNFSF14 and PTBP1

(2019) Tiantian Xu et al.   CHEMICAL RESEARCH IN TOXICOLOGY

The lncRNA NEAT1/miR-29b/Atg9a axis regulates IGFBPrP1-induced autophagy and activation of mouse hepatic stellate cells

(2019) Yangyang Kong et al.   LIFE SCIENCES

MiR-455-3p suppresses renal fibrosis through repression of ROCK2 expression in diabetic nephropathy

(2018) Jian Wu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Long non-coding RNA-ATB promotes EMT during silica-induced pulmonary fibrosis by competitively binding miR-200c

(2018) Yi Liu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

NLRP3 inflammasome inhibition attenuates silica-induced epithelial to mesenchymal transition (EMT) in human bronchial epithelial cells

(2018) Xiang Li et al.   EXPERIMENTAL CELL RESEARCH

Global microRNA expression profiling in the liver biopsies of hepatitis B virus-infected patients suggests specific microRNA signatures for viral persistence and hepatocellular injury

(2018) Avishek Kumar Singh et al.   HEPATOLOGY

The Crosstalk between Nrf2 and Inflammasomes

(2018) Paulina Hennig et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A functional splice variant associated with decreased asthma risk abolishes the ability of gasdermin B to induce epithelial cell pyroptosis

(2018) Ronald A. Panganiban et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Mechanisms of Gasdermin Family Members in Inflammasome Signaling and Cell Death

(2018) Shouya Feng et al.   JOURNAL OF MOLECULAR BIOLOGY

Influenza A Virus Infection Triggers Pyroptosis and Apoptosis of Respiratory Epithelial Cells through the Type I Interferon Signaling Pathway in a Mutually Exclusive Manner

(2018) SangJoon Lee et al.   JOURNAL OF VIROLOGY

Transplantation of adipose-derived mesenchymal stem cells attenuates pulmonary fibrosis of silicosis via anti-inflammatory and anti-apoptosis effects in rats

(2018) Shangya Chen et al.   Stem Cell Research & Therapy

Caspase-11-dependent pyroptosis of lung epithelial cells protects from melioidosis while caspase-1 mediates macrophage pyroptosis and production of IL-18

(2018) Jinyong Wang et al.   PLoS Pathogens

SnapShot: Unconventional miRNA Functions

(2018) Mihnea Paul Dragomir et al.   CELL

CARD14/CARMA2 Signaling and its Role in Inflammatory Skin Disorders

(2018) Tiziana Zotti et al.   Frontiers in Immunology

Long noncoding RNA NEAT1 accelerates the proliferation and fibrosis in diabetic nephropathy through activating Akt/mTOR signaling pathway

(2018) Shan Huang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Bone marrow mesenchymal stromal cells attenuate silica-induced pulmonary fibrosis potentially by attenuating Wnt/β-catenin signaling in rats

(2018) Enguo Zhang et al.   Stem Cell Research & Therapy

MicroRNAs-mediated epithelial-mesenchymal transition in fibrotic diseases

(2017) Xiao-Zhou Zou et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Cutting Edge: Eosinophils Undergo Caspase-1–Mediated Pyroptosis in Response to Necrotic Liver Cells

(2017) Daphne Palacios-Macapagal et al.   JOURNAL OF IMMUNOLOGY

Frontline Science: Multiple cathepsins promote inflammasome-independent, particle-induced cell death during NLRP3-dependent IL-1β activation

(2017) Gregory M. Orlowski et al.   JOURNAL OF LEUKOCYTE BIOLOGY

NEAT1 accelerates the progression of liver fibrosis via regulation of microRNA-122 and Kruppel-like factor 6

(2017) Fujun Yu et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Imipramine blocks acute silicosis in a mouse model

(2017) Rupa Biswas et al.   Particle and Fibre Toxicology

Cyclooxygenase 2: protein-protein interactions and posttranslational modifications

(2017) Anna Alexanian et al.   PHYSIOLOGICAL GENOMICS

LincRNA-Gm4419 knockdown ameliorates NF-κB/NLRP3 inflammasome-mediated inflammation in diabetic nephropathy

(2017) Hong Yi et al.   Cell Death & Disease

MiR-503 modulates epithelial-mesenchymal transition in silica-induced pulmonary fibrosis by targeting PI3K p85 and is sponged by lncRNA MALAT1

(2017) Weiwen Yan et al.   Scientific Reports

Pyroptosis

(2016) Lieselotte Vande Walle et al.   CURRENT BIOLOGY

Pore-forming activity and structural autoinhibition of the gasdermin family

(2016) Jingjin Ding et al.   NATURE

GSDMB induces an asthma phenotype characterized by increased airway responsiveness and remodeling without lung inflammation

(2016) Sudipta Das et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanism and Regulation of NLRP3 Inflammasome Activation

(2016) Yuan He et al.   TRENDS IN BIOCHEMICAL SCIENCES

miR-489 inhibits silica-induced pulmonary fibrosis by targeting MyD88 and Smad3 and is negatively regulated by lncRNA CHRF

(2016) Qiuyun Wu et al.   Scientific Reports

Development of a high-content screen for the identification of inhibitors directed against the early steps of the cytomegalovirus infectious cycle

(2015) Thomas J. Gardner et al.   ANTIVIRAL RESEARCH

Loss of conservedGsdma3self-regulation causes autophagy and cell death

(2015) Peiliang Shi et al.   BIOCHEMICAL JOURNAL

IL-1α and inflammasome-independent IL-1β promote neutrophil infiltration following alum vaccination

(2015) Ewa Oleszycka et al.   FEBS Journal

Extracellular cathepsin S and intracellular caspase 1 activation are surrogate biomarkers of particulate-induced lysosomal disruption in macrophages

(2015) Caroline S. Hughes et al.   Particle and Fibre Toxicology

Airway Epithelium Interactions with Aeroallergens: Role of Secreted Cytokines and Chemokines in Innate Immunity

(2015) Vivek D. Gandhi et al.   Frontiers in Immunology

The Anti-fibrotic Effects and Mechanisms of MicroRNA-486-5p in Pulmonary Fibrosis

(2015) Xiaoming Ji et al.   Scientific Reports

Influenza A Virus Uses Intercellular Connections To Spread to Neighboring Cells

(2014) Kari L. Roberts et al.   JOURNAL OF VIROLOGY

Silica-induced NLRP3 inflammasome activation in vitro and in rat lungs

(2014) Paul M Peeters et al.   Particle and Fibre Toxicology

Effects of macro- versus nanoporous silicon substrates on human aortic endothelial cell behavior

(2014) Pilar Formentín et al.   Nanoscale Research Letters

Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection

(2013) Gilad Doitsh et al.   NATURE

Silica induces NLRP3 inflammasome activation in human lung epithelial cells

(2013) Paul M Peeters et al.   Particle and Fibre Toxicology

Rare and Common Variants in CARD14, Encoding an Epidermal Regulator of NF-kappaB, in Psoriasis

(2012) Catherine T. Jordan et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Differences in gene expression and cytokine production by crystalline vs. amorphous silica in human lung epithelial cells

(2012) Timothy N Perkins et al.   Particle and Fibre Toxicology

Coding-Independent Regulation of the Tumor Suppressor PTEN by Competing Endogenous mRNAs

(2011) Yvonne Tay et al.   CELL

A ceRNA Hypothesis: The Rosetta Stone of a Hidden RNA Language?

(2011) Leonardo Salmena et al.   CELL