The anti-tumor effect of shikonin on osteosarcoma by inducing RIP1 and RIP3 dependent necroptosis

Shikonin, a natural product from the root of Lithospermum erythrorhizon, is a cytotoxic DNA-binding agent

(2013) Changmin Chen et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Anticancer Agent Shikonin Is an Incompetent Inducer of Cancer Drug Resistance

(2013) Hao Wu et al.   PLoS One

Shikonin Kills Glioma Cells through Necroptosis Mediated by RIP-1

(2013) Chuanjiang Huang et al.   PLoS One

TNF can activate RIPK3 and cause programmed necrosis in the absence of RIPK1

(2013) D M Moujalled et al.   Cell Death & Disease

The RIP1/RIP3 Necrosome Forms a Functional Amyloid Signaling Complex Required for Programmed Necrosis

(2012) Jixi Li et al.   CELL

cIAP1 and cIAP2 limit macrophage necroptosis by inhibiting Rip1 and Rip3 activation

(2012) S McComb et al.   CELL DEATH AND DIFFERENTIATION

Shikonin induces programmed necrosis-like cell death through the formation of receptor interacting protein 1 and 3 complex

(2012) Seungyeon Park et al.   FOOD AND CHEMICAL TOXICOLOGY

Molecular alterations as target for therapy in metastatic osteosarcoma: a review of literature

(2011) J. PosthumaDeBoer et al.   CLINICAL & EXPERIMENTAL METASTASIS

Shikonin extracted from medicinal Chinese herbs exerts anti-inflammatory effect via proteasome inhibition

(2011) Li Lu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Shikonin and its analogs inhibit cancer cell glycolysis by targeting tumor pyruvate kinase-M2

(2011) J Chen et al.   ONCOGENE

Shikonin Induces Apoptosis through Reactive Oxygen Species/Extracellular Signal-Regulated Kinase Pathway in Osteosarcoma Cells

(2010) I-Chang Chang et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Wnt Inhibitory Factor 1 Decreases Tumorigenesis and Metastasis in Osteosarcoma

(2010) E. M. Rubin et al.   MOLECULAR CANCER THERAPEUTICS

Necrostatin-1 reverts shikonin-induced necroptosis to apoptosis

(2009) Weidong Han et al.   APOPTOSIS

Phosphorylation-Driven Assembly of the RIP1-RIP3 Complex Regulates Programmed Necrosis and Virus-Induced Inflammation

(2009) YoungSik Cho et al.   CELL

Receptor Interacting Protein Kinase-3 Determines Cellular Necrotic Response to TNF-α

(2009) Sudan He et al.   CELL

Bone tumors: osteosarcoma and Ewingʼs sarcoma

(2009) Travis Heare et al.   CURRENT OPINION IN PEDIATRICS

Antitumor activity of natural compounds, curcumin and PKF118-310, as Wnt/β-catenin antagonists against human osteosarcoma cells

(2009) Pay-Chin Leow et al.   INVESTIGATIONAL NEW DRUGS

RIP3, an Energy Metabolism Regulator That Switches TNF-Induced Cell Death from Apoptosis to Necrosis

(2009) D.-W. Zhang et al.   SCIENCE

Identification of RIP1 kinase as a specific cellular target of necrostatins

(2008) Alexei Degterev et al.   Nature Chemical Biology