Dimethyl fumarate induces necroptosis in colon cancer cells through GSH depletion/ROS increase/MAPKs activation pathway

MLN4924 sensitizes monocytes and maturing dendritic cells for TNF-dependent and -independent necroptosis

(2015) Mohamed El-Mesery et al.   BRITISH JOURNAL OF PHARMACOLOGY

Mitochondrial protein cyclophilin-D-mediated programmed necrosis attributes to berberine-induced cytotoxicity in cultured prostate cancer cells

(2014) Long-yang Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

(4-[6-(4-isopropoxyphenyl)pyrazolo [1,5-a]pyrimidin-3-yl] quinoline) is a novel inhibitor of autophagy

(2014) Yue Sheng et al.   BRITISH JOURNAL OF PHARMACOLOGY

Dimethyl Fumarate: A Review of Its Use in Patients with Relapsing-Remitting Multiple Sclerosis

(2014) Celeste B. Burness et al.   CNS DRUGS

Intracellular Glutathione Depletion by Oridonin Leads to Apoptosis in Hepatic Stellate Cells

(2014) Liang-Mou Kuo et al.   MOLECULES

Necroptosis

(2014) Andreas Linkermann et al.   NEW ENGLAND JOURNAL OF MEDICINE

Fumaric Acid Esters Can Block Pro-Inflammatory Actions of Human CRP and Ameliorate Metabolic Disturbances in Transgenic Spontaneously Hypertensive Rats

(2014) Jan Šilhavý et al.   PLoS One

Therapeutic exploitation of necroptosis for cancer therapy

(2014) Simone Fulda   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Pharmacogenetics research on chemotherapy resistance in colorectal cancer over the last 20 years

(2014) Mariusz Panczyk   WORLD JOURNAL OF GASTROENTEROLOGY

3-Methyladenine induces cell death and its interaction with chemotherapeutic drugs is independent of autophagy

(2013) Yue Sheng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Concise Guide to PHARMACOLOGY 2013/14: Enzymes

(2013) Stephen P.H. Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

Smac mimetic primes apoptosis-resistant acute myeloid leukaemia cells for cytarabine-induced cell death by triggering necroptosis

(2013) Joerg Chromik et al.   CANCER LETTERS

Inhibition of GSK3B Bypass Drug Resistance of p53-Null Colon Carcinomas by Enabling Necroptosis in Response to Chemotherapy

(2013) E. Grassilli et al.   CLINICAL CANCER RESEARCH

Dimethyl Fumarate Modulation of Immune and Antioxidant Responses: Application to HIV Therapy

(2013) Alexander J. Gill et al.   CRITICAL REVIEWS IN IMMUNOLOGY

BG-12 (dimethyl fumarate): a review of mechanism of action, efficacy, and safety

(2013) Robert J. Fox et al.   CURRENT MEDICAL RESEARCH AND OPINION

Dimethylfumarate induces apoptosis in human mast cells

(2013) Anja Förster et al.   EXPERIMENTAL DERMATOLOGY

The IUPHAR/BPS Guide to PHARMACOLOGY: an expert-driven knowledgebase of drug targets and their ligands

(2013) Adam J. Pawson et al.   NUCLEIC ACIDS RESEARCH

Unearthing the secrets of mitochondrial ROS and glutathione in bioenergetics

(2013) Ryan J. Mailloux et al.   TRENDS IN BIOCHEMICAL SCIENCES

Resistance to hypoxia-induced necroptosis is conferred by glycolytic pyruvate scavenging of mitochondrial superoxide in colorectal cancer cells

(2013) C-Y Huang et al.   Cell Death & Disease

Smac mimetic and demethylating agents synergistically trigger cell death in acute myeloid leukemia cells and overcome apoptosis resistance by inducing necroptosis

(2013) L Steinhart et al.   Cell Death & Disease

Glutathione Efflux and Cell Death

(2012) Rodrigo Franco et al.   ANTIOXIDANTS & REDOX SIGNALING

p53 Opens the Mitochondrial Permeability Transition Pore to Trigger Necrosis

(2012) Angelina V. Vaseva et al.   CELL

Fumarate Is Cardioprotective via Activation of the Nrf2 Antioxidant Pathway

(2012) Houman Ashrafian et al.   Cell Metabolism

Autophagy and cancer

(2012) Kyeong Sook Choi   EXPERIMENTAL AND MOLECULAR MEDICINE

Strategies of targeting oral drug delivery systems to the colon and their potential use for the treatment of colorectal cancer

(2012) Yellela S. R. Krishnaiah et al.   PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY

The targeted inhibition of mitochondrial Hsp90 overcomes the apoptosis resistance conferred by Bcl-2 in Hep3B cells via necroptosis

(2012) Chunlan Yan et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway

(2011) Ralf A. Linker et al.   BRAIN

Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012

(2011) L Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Pharmacokinetics of anti-psoriatic fumaric acid esters in psoriasis patients

(2010) Martin Rostami-Yazdi et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

Necroptosis as an alternative form of programmed cell death

(2010) Dana E Christofferson et al.   CURRENT OPINION IN CELL BIOLOGY

Dual Role of 3-Methyladenine in Modulation of Autophagy via Different Temporal Patterns of Inhibition on Class I and III Phosphoinositide 3-Kinase

(2010) You-Tong Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dimethylfumarate inhibits microglial and astrocytic inflammation by suppressing the synthesis of nitric oxide, IL-1β, TNF-α and IL-6 in an in-vitro model of brain inflammation

(2010) Henrik Wilms et al.   Journal of Neuroinflammation

Molecular mechanisms of necroptosis: an ordered cellular explosion

(2010) Peter Vandenabeele et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Gallic acid-induced lung cancer cell death is related to glutathione depletion as well as reactive oxygen species increase

(2010) Bo Ra You et al.   TOXICOLOGY IN VITRO

Melatonin protects against heart ischemia-reperfusion injury by inhibiting mitochondrial permeability transition pore opening

(2009) Giuseppe Petrosillo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Dimethylfumarate inhibits tumor cell invasion and metastasis by suppressing the expression and activities of matrix metalloproteinases in melanoma cells

(2009) Yuzuru Yamazoe et al.   CELL BIOLOGY INTERNATIONAL

Mammalian autophagy: core molecular machinery and signaling regulation

(2009) Zhifen Yang et al.   CURRENT OPINION IN CELL BIOLOGY

Granulysin Induces Cathepsin B Release from Lysosomes of Target Tumor Cells to Attack Mitochondria through Processing of Bid Leading to Necroptosis

(2009) H. Zhang et al.   JOURNAL OF IMMUNOLOGY

Combination of Dacarbazine and Dimethylfumarate Efficiently Reduces Melanoma Lymph Node Metastasis

(2009) Teresa Valero et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Hemin-induced necroptosis involves glutathione depletion in mouse astrocytes

(2008) Melissa D. Laird et al.   FREE RADICAL BIOLOGY AND MEDICINE

Identification of RIP1 kinase as a specific cellular target of necrostatins

(2008) Alexei Degterev et al.   Nature Chemical Biology