Mechanisms and Therapeutic Regulation of Pyroptosis in Inflammatory Diseases and Cancer

A PLK1 kinase inhibitor enhances the chemosensitivity of cisplatin by inducing pyroptosis in oesophageal squamous cell carcinoma

(2019) Mengjiao Wu et al.   EBioMedicine

Cleavage of GSDME by caspase-3 determines lobaplatin-induced pyroptosis in colon cancer cells

(2019) Junhui Yu et al.   Cell Death & Disease

Chemotherapeutic paclitaxel and cisplatin differentially induce pyroptosis in A549 lung cancer cells via caspase-3/GSDME activation

(2019) Cheng-cheng Zhang et al.   APOPTOSIS

Eukaryotic elongation factor-2 kinase regulates the cross-talk between autophagy and pyroptosis in doxorubicin-treated human melanoma cells in vitro

(2019) Pian Yu et al.   ACTA PHARMACOLOGICA SINICA

Metformin induces human esophageal carcinoma cell pyroptosis by targeting the miR-497/PELP1 axis

(2019) Lu Wang et al.   CANCER LETTERS

Gasdermin pores permeabilize mitochondria to augment caspase-3 activation during apoptosis and inflammasome activation

(2019) Corey Rogers et al.   Nature Communications

Butyrate Rather than LPS Subverts Gingival Epithelial Homeostasis by Downregulation of Intercellular Junctions and Triggering Pyroptosis

(2019) Juan Liu et al.   JOURNAL OF CLINICAL PERIODONTOLOGY

Activation of Pyroptotic Cell Death Pathways in Cancer: An Alternative Therapeutic Approach

(2019) Kanipandian Nagarajan et al.   Translational Oncology

Caspase-1 initiates apoptosis in the absence of gasdermin D

(2019) Kohsuke Tsuchiya et al.   Nature Communications

Dioscin inhibits the growth of human osteosarcoma by inducing G2/M‐phase arrest, apoptosis, and GSDME‐dependent cell death in vitro and in vivo

(2019) Qiuyue Ding et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The Natural Flavonoid Galangin Elicits Apoptosis, Pyroptosis, and Autophagy in Glioblastoma

(2019) Yang Kong et al.   Frontiers in Oncology

Kanglexin, a novel anthraquinone compound, protects against myocardial ischemic injury in mice by suppressing NLRP3 and pyroptosis

(2019) Yu Bian et al.   ACTA PHARMACOLOGICA SINICA

Long noncoding RNA KCNQ1OT1 induces pyroptosis in diabetic corneal endothelial keratopathy.

(2019) Yanyan Zhang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Huaier extract suppresses non‐small cell lung cancer progression through activating NLRP3‐dependent pyroptosis

(2019) Jun Xie et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

High glucose inhibits proliferation and differentiation of osteoblast in alveolar bone by inducing pyroptosis

(2019) Lina Yang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Ethyl pyruvate confers protection against endotoxemia and sepsis by inhibiting caspase-11-dependent cell pyroptosis

(2019) Xianhui Qiu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

MiR-135b protects cardiomyocytes from infarction through restraining the NLRP3/caspase-1/IL-1β pathway

(2019) Anqi Li et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Chitosan Hydrogel Enhances the Therapeutic Efficacy of BMSCs for Myocardial Infarction by Alleviating Vascular Endothelial Cell Pyroptosis

(2019) Yang Liu et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Epigenetics-Based Tumor Cells Pyroptosis for Enhancing the Immunological Effect of Chemotherapeutic Nanocarriers

(2019) Jin-Xuan Fan et al.   NANO LETTERS

Transcription Factor p53 Suppresses Tumor Growth by Prompting Pyroptosis in Non-Small-Cell Lung Cancer

(2019) Tianze Zhang et al.   Oxidative Medicine and Cellular Longevity

Endothelial pyroptosis underlies systemic inflammatory response following radiofrequency ablation of hepatic hemangiomas

(2019) Shaohong Wang et al.   SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION

Gasdermin D-mediated hepatocyte pyroptosis expands inflammatory responses that aggravate acute liver failure by upregulating monocyte chemotactic protein 1/CC chemokine receptor-2 to recruit macrophages

(2019) Hong Li et al.   WORLD JOURNAL OF GASTROENTEROLOGY

ALDH2 Overexpression Alleviates High Glucose-Induced Cardiotoxicity by Inhibiting NLRP3 Inflammasome Activation

(2019) Ruiping Cao et al.   Journal of Diabetes Research

Effectiveness of Huai Qi Huang Granules on Juvenile Collagen-induced Arthritis and Its Influence on Pyroptosis Pathway in Synovial Tissue

(2019) Ting He et al.   Current Medical Science

Atorvastatin inhibits pyroptosis through the lncRNA NEXN-AS1/NEXN pathway in human vascular endothelial cells

(2019) Li-Mei Wu et al.   ATHEROSCLEROSIS

Apolipoprotein M and sphingosine-1-phosphate complex alleviates TNF-α-induced endothelial cell injury and inflammation through PI3K/AKT signaling pathway

(2019) Yang Liu et al.   BMC Cardiovascular Disorders

Circulating biomarkers of cell death

(2019) Kerstin Wimmer et al.   CLINICA CHIMICA ACTA

Long non-coding RNA MEG3 promotes cerebral ischemia-reperfusion injury through increasing pyroptosis by targeting miR-485/AIM2 axis

(2019) Ji Liang et al.   EXPERIMENTAL NEUROLOGY

Dendrobium Alkaloids Promote Neural Function After Cerebral Ischemia–Reperfusion Injury Through Inhibiting Pyroptosis Induced Neuronal Death in both In Vivo and In Vitro Models

(2019) Daohang Liu et al.   NEUROCHEMICAL RESEARCH

Pyroptosis is a critical inflammatory pathway in the placenta from early onset preeclampsia and in human trophoblasts exposed to hypoxia and endoplasmic reticulum stressors

(2019) Shi-Bin Cheng et al.   Cell Death & Disease

Inhibition of AIM2 inflammasome-mediated pyroptosis by Andrographolide contributes to amelioration of radiation-induced lung inflammation and fibrosis

(2019) Jian Gao et al.   Cell Death & Disease

NEK7 interacts with NLRP3 to modulate the pyroptosis in inflammatory bowel disease via NF-κB signaling

(2019) Xueliang Chen et al.   Cell Death & Disease

Mutant BRAF and MEK Inhibitors Regulate the Tumor Immune Microenvironment via Pyroptosis

(2019) Dan A. Erkes et al.   Cancer Discovery

GSDME mediates caspase-3-dependent pyroptosis in gastric cancer

(2018) Yubin Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Single-cell analysis of pyroptosis dynamics reveals conserved GSDMD-mediated subcellular events that precede plasma membrane rupture

(2018) Nathalia M. de Vasconcelos et al.   CELL DEATH AND DIFFERENTIATION

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

(2018) Lorenzo Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

In situ formed reactive oxygen species–responsive scaffold with gemcitabine and checkpoint inhibitor for combination therapy

(2018) Chao Wang et al.   Science Translational Medicine

Anthocyanin is Involved in the Activation of Pyroptosis in Oral Squamous Cell Carcinoma

(2018) Er Yue et al.   PHYTOMEDICINE

Nanoparticle-Conjugate TLR7/8 Agonist Localized Immunotherapy Provokes Safe Antitumoral Responses

(2018) Lutz Nuhn et al.   ADVANCED MATERIALS

A thiopyran derivative with low murine toxicity with therapeutic potential on lung cancer acting through a NF-κB mediated apoptosis-to-pyroptosis switch

(2018) Liping Chen et al.   APOPTOSIS

Tom20 senses iron-activated ROS signaling to promote melanoma cell pyroptosis 

(2018) Bo Zhou et al.   CELL RESEARCH

Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during Yersinia infection

(2018) Joseph Sarhan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibiting the NLRP3 Inflammasome With MCC950 Ameliorates Isoflurane-Induced Pyroptosis and Cognitive Impairment in Aged Mice

(2018) Yunxia Fan et al.   Frontiers in Cellular Neuroscience

Inflammasome activation and assembly at a glance

(2017) Ankit Malik et al.   JOURNAL OF CELL SCIENCE

Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin

(2017) Yupeng Wang et al.   NATURE

Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death

(2017) Jianjin Shi et al.   TRENDS IN BIOCHEMICAL SCIENCES

Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death

(2017) Corey Rogers et al.   Nature Communications

Development of Drug Targeting and Delivery in Cervical Cancer

(2017) Urvashi Aggarwal et al.   CURRENT CANCER DRUG TARGETS

Preparation of a paclitaxel-loaded cationic nanoemulsome and its biodistribution via direct intratumoral injection

(2016) Yurui Xu et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death

(2016) Lorenzo Sborgi et al.   EMBO JOURNAL

Active Caspase-1 Induces Plasma Membrane Pores That Precede Pyroptotic Lysis and Are Blocked by Lanthanides

(2016) Hana M. Russo et al.   JOURNAL OF IMMUNOLOGY

Pore-forming activity and structural autoinhibition of the gasdermin family

(2016) Jingjin Ding et al.   NATURE

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

(2016) Xing Liu et al.   NATURE

GsdmD p30 elicited by caspase-11 during pyroptosis forms pores in membranes

(2016) Robin A. Aglietti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Balance between short and long isoforms of cFLIP regulates Fas-mediated apoptosis in vivo

(2016) Daniel R. Ram et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An endogenous caspase-11 ligand elicits interleukin-1 release from living dendritic cells

(2016) Ivan Zanoni et al.   SCIENCE

Programmed necrosis in inflammation: Toward identification of the effector molecules

(2016) D. Wallach et al.   SCIENCE

Pyroptosis is involved in the pathogenesis of human hepatocellular carcinoma

(2016) Qun Chu et al.   Oncotarget

Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion

(2015) Wan-ting He et al.   CELL RESEARCH

Pyroptotic cell death defends against intracellular pathogens

(2015) Ine Jorgensen et al.   IMMUNOLOGICAL REVIEWS

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

(2015) Nobuhiko Kayagaki et al.   NATURE

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

Inflammasomes: mechanism of action, role in disease and therapeutics

(2015) Haitao Guo et al.   NATURE MEDICINE

Mechanisms and Functions of Inflammasomes

(2014) Mohamed Lamkanfi et al.   CELL

Targeting elongation factor-2 kinase (eEF-2K) induces apoptosis in human pancreatic cancer cells

(2013) Ahmed A. Ashour et al.   APOPTOSIS

NLRP3 inflammasome activation results in hepatocyte pyroptosis, liver inflammation, and fibrosis in mice

(2013) Alexander Wree et al.   HEPATOLOGY

Programmed Cell Death: Molecular Mechanisms and Implications for Safety Assessment of Nanomaterials

(2012) Fernando Torres Andón et al.   ACCOUNTS OF CHEMICAL RESEARCH

Inflammasomes and Their Roles in Health and Disease

(2012) Mohamed Lamkanfi et al.   Annual Review of Cell and Developmental Biology

Programmed cell death pathways in cancer: a review of apoptosis, autophagy and programmed necrosis

(2012) L. Ouyang et al.   CELL PROLIFERATION

Regulation of the Inflammatory Response in Cardiac Repair

(2012) Nikolaos G. Frangogiannis   CIRCULATION RESEARCH

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012

(2011) L Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

The Nlrp3 inflammasome: contributions to intestinal homeostasis

(2011) Md. Hasan Zaki et al.   TRENDS IN IMMUNOLOGY

Mitochondria and cell death: outer membrane permeabilization and beyond

(2010) Stephen W. G. Tait et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Inflammation-induced tumorigenesis in the colon is regulated by caspase-1 and NLRC4

(2010) B. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Systems biology analysis of programmed cell death

(2010) Shani Bialik et al.   TRENDS IN BIOCHEMICAL SCIENCES

Toll-like receptors and innate immunity

(2009) Himanshu Kumar et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Programmed Cell Death Pathways and Current Antitumor Targets

(2009) Mei Lan Tan et al.   PHARMACEUTICAL RESEARCH